Luca Mangherini
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lucamangherini.bsky.social
Luca Mangherini
@lucamangherini.bsky.social
PhD student | interested in metastasis & TME |UniTO/ DKFZ
Reposted by Luca Mangherini
Nature research paper: Functional synapses between neurons and small cell lung cancer

go.nature.com/3VwSy1L
Functional synapses between neurons and small cell lung cancer - Nature
Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
go.nature.com
September 11, 2025 at 4:06 PM
Reposted by Luca Mangherini
We have already received many interesting abstracts for the Cancer Neuroscience EACR Conference in Bilbao, Spain....

...and we are looking forward to reading *yours*! 🧠🔬

📢 Abstract Deadline June 30th 📢

#cancerneuroscience #neuroscience #cancer @helloeacr.bsky.social
June 24, 2025 at 8:10 AM
Reposted by Luca Mangherini
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling: Cell www.cell.com/cell/fulltex...
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner, mediated by muscarinic M...
www.cell.com
June 20, 2025 at 2:03 AM
Reposted by Luca Mangherini
Need a distraction to shift your TMEntality today?
If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...
Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity” - Cancer and Metastasis Reviews
Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upo...
link.springer.com
January 20, 2025 at 5:55 PM
Reposted by Luca Mangherini
It was my pleasure to write a Preview of the paper www.sciencedirect.com/science/arti... together with @venkataramanilab.bsky.social !

🧠 #cancerneuroscience #glioblastoma

The preview is now online @cp-neuron.bsky.social 👇
March 20, 2025 at 7:54 AM
Reposted by Luca Mangherini
📢 We are excited and honored to announce that Frank Winkler received #thebrainprize2025, together with @michellemonje.bsky.social, for pioneering the field of #cancerneuroscience. 💐

@brainprize.bsky.social
#neuroscience #cancer
brainprize.org
The Brain Prize
The Brain Prize is the world’s largest prize for brain research that is awarded each year by the Lundbeck Foundation.
brainprize.org
March 5, 2025 at 3:18 PM
Reposted by Luca Mangherini
Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
March 2, 2025 at 3:24 PM
Reposted by Luca Mangherini
Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
February 18, 2025 at 9:37 AM
Reposted by Luca Mangherini
📣 #OncogenicCompetence what are the factors regulating it? Have a look at our work led by our 🌟 postdoc @lisapavinato.bsky.social 🌟 now online doi.org/10.1016/j.tr...
February 12, 2025 at 1:42 AM
Reposted by Luca Mangherini
#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...
February 12, 2025 at 11:10 AM
Reposted by Luca Mangherini
Crick researchers have found that certain aggressive lung cancer cells can develop their own electric network, similar to the body’s nervous system.

This can allow tumour cells to go ‘off grid,’ making them harder to treat.
www.crick.ac.uk/news/2025-02...
Lung cancer cells can go ‘off grid’
Researchers from the Francis Crick Institute have found that some particularly aggressive lung cancer cells can develop their own electric network, like that seen in the body’s nervous system. This un...
www.crick.ac.uk
February 12, 2025 at 4:35 PM
Reposted by Luca Mangherini
New paper from our lab just out in @cp-cancercell.bsky.social! Integrating spatial omics, cell co-cultures and staining of clinical trial samples, we show that CD74 marks the right local microenvironment for #immunotherapy response. Excitingly, this may increase the number of treatable patients!
A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identify…
www.sciencedirect.com
January 16, 2025 at 4:17 PM
Reposted by Luca Mangherini
SAVE THE DATE

Discuss the interactions between the nervous system and cancer in our first @helloeacr.bsky.social conference on #CancerNeuroscience next year!

🗓️ Oct. 14-16, 2025
📍Bilbao, Spain

📥 Abstracts due June 30, 2025
📥 Register by Sept. 15, 2025

For more info, visit eacr.org/conference/c...
November 29, 2024 at 10:10 AM
Reposted by Luca Mangherini
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
Reposted by Luca Mangherini
If you are interested in #calciumimaging of #brainmetastases and cancer networks, come see my poster at #SNO2024 (CSIG-11) and listen to @nielsolshausen.bsky.social plenary talk tomorrow at 2:10pm! Happy to connect
November 22, 2024 at 8:12 PM
Reposted by Luca Mangherini
👋 Hello Bluesky!
Great to be here.

We are the Winkler Lab, at the UKHD and @dkfz.bsky.social Heidelberg 🇩🇪.

We work on the #cancerneuroscience of #braintumors, hoping to better understand these diseases and search for new treatments.

Looking forward to interact with many of you in the future!
November 20, 2024 at 3:39 PM