LIMES-Institut Bonn
@limes-bonn.bsky.social
Das Life & Medical Sciences-Institut (LIMES) ist eine international ausgerichtete Hochschul-Einrichtung für biomedizinische Grundlagen-Forschung an der Universität Bonn.
Glucose tasting depletes #intracellular #calcium stores and impairs #macrophage functionality #iSicence #BurgdorfLab #KiermaierLab #LangLab #KolanusLab @masslab.bsky.social @unibonn.bsky.social @immunosens.bsky.social #Cell #biology; #Health #sciences; #Immunology shorturl.at/Fahb3
Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality
Hyperglycemia or increased blood glucose concentrations is a characteristic and one of the diagnostic criteria for Diabetes mellitus and critically co…
shorturl.at
November 18, 2025 at 7:33 AM
Glucose tasting depletes #intracellular #calcium stores and impairs #macrophage functionality #iSicence #BurgdorfLab #KiermaierLab #LangLab #KolanusLab @masslab.bsky.social @unibonn.bsky.social @immunosens.bsky.social #Cell #biology; #Health #sciences; #Immunology shorturl.at/Fahb3
Reposted by LIMES-Institut Bonn
Happy to have contributed to this beautiful story on #macrophage #development in mice and in #iPSC derived cells.
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
Characterization of the mammalian prodefinitive angio-hematopoietic lineage
The identification of mammalian prodefinitive angio-hematopoietic progenitors clarifies early hematopoiesis and macrophage development.
www.science.org
November 11, 2025 at 11:27 AM
Happy to have contributed to this beautiful story on #macrophage #development in mice and in #iPSC derived cells.
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
A dynamic model for #Waddington's #landscape accounting for #cell-to-cell #communication. #MathBiosci @unibonn.bsky.social #HasenauerLab #SchlitzerLab; #Dendritic #cell #activation; #Stem #cell #regeneration shorturl.at/IEMsy
A dynamic model for Waddington’s landscape accounting for cell-to-cell communication
Waddington’s landscape provides a conceptual model for developmental processes. It is the basis of various mathematical models describing cell maturat…
shorturl.at
September 26, 2025 at 6:14 AM
A dynamic model for #Waddington's #landscape accounting for #cell-to-cell #communication. #MathBiosci @unibonn.bsky.social #HasenauerLab #SchlitzerLab; #Dendritic #cell #activation; #Stem #cell #regeneration shorturl.at/IEMsy
Individual lipid alterations at the origin of neuronal Ceramide Synthase defects #CerS. #PLoSGenet @unibonn.bsky.social #ThieleLab; #BauerLab; #SobaLab; #brain; #lipid #metabolism; shorturl.at/O6LBn
Individual lipid alterations at the origin of neuronal Ceramide Synthase defects
Authors summary The brain is the most lipid-enriched organ of our body. At the same time, it is highly susceptible to disturbances in lipid metabolism. In this context, ceramide metabolism deserves sp...
shorturl.at
September 26, 2025 at 6:10 AM
Individual lipid alterations at the origin of neuronal Ceramide Synthase defects #CerS. #PLoSGenet @unibonn.bsky.social #ThieleLab; #BauerLab; #SobaLab; #brain; #lipid #metabolism; shorturl.at/O6LBn
A dual nature of γδ T cell #immune #memory responses. #Elife #NeteaLab #PlacekK @unibonn.bsky.social #gamma #delta #Tcells; #immunology; #inflammation elifesciences.org/articles/104...
A dual nature of γδ T cell immune memory responses
Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain ...
elifesciences.org
July 24, 2025 at 12:30 PM
A dual nature of γδ T cell #immune #memory responses. #Elife #NeteaLab #PlacekK @unibonn.bsky.social #gamma #delta #Tcells; #immunology; #inflammation elifesciences.org/articles/104...
CD9-association with PIP2 areas is regulated by a CD9 salt bridge. #FEBSopenbio #LangLab @unibonn.bsky.social #EWI‐2; #second messengers; #signaling; #tetraspanin‐enriched #microdomains. shorturl.at/8cObV
FEBS Press
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open-CD9 moves from PIP2-rich areas to regions populated by its interaction partner EWI-2. Hence, the state of the salt bridge regu...
shorturl.at
July 21, 2025 at 6:16 AM
CD9-association with PIP2 areas is regulated by a CD9 salt bridge. #FEBSopenbio #LangLab @unibonn.bsky.social #EWI‐2; #second messengers; #signaling; #tetraspanin‐enriched #microdomains. shorturl.at/8cObV
Developmental #programming by #maternal #obesity alters offspring #lifespan and immune responses in a diet- and sex-specific manner. #Cells&Development @masslab.bsky.social #HasenauerLab #ThieleLab #BauerLab @unibonn.bsky.social #Hemocytes; #Macrophages; #Metabolism; #Plasmatocytes. rb.gy/pe6d15
Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner
Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative dis…
rb.gy
July 14, 2025 at 6:59 AM
Developmental #programming by #maternal #obesity alters offspring #lifespan and immune responses in a diet- and sex-specific manner. #Cells&Development @masslab.bsky.social #HasenauerLab #ThieleLab #BauerLab @unibonn.bsky.social #Hemocytes; #Macrophages; #Metabolism; #Plasmatocytes. rb.gy/pe6d15
Reposted by LIMES-Institut Bonn
🎉Congratulations to our graduates 2025!
Forever Uni Bonn - Over 2,000 graduates celebrated the 20th anniversary of its Universitätsfest — with over 5,000 of their friends and family — a new record. Read more www.uni-bonn.de/en/news/20-j...
(c) Marc John/Uni Bonn
#UniversityOfBonn #ForeverUniBonn
Forever Uni Bonn - Over 2,000 graduates celebrated the 20th anniversary of its Universitätsfest — with over 5,000 of their friends and family — a new record. Read more www.uni-bonn.de/en/news/20-j...
(c) Marc John/Uni Bonn
#UniversityOfBonn #ForeverUniBonn
July 8, 2025 at 9:40 AM
🎉Congratulations to our graduates 2025!
Forever Uni Bonn - Over 2,000 graduates celebrated the 20th anniversary of its Universitätsfest — with over 5,000 of their friends and family — a new record. Read more www.uni-bonn.de/en/news/20-j...
(c) Marc John/Uni Bonn
#UniversityOfBonn #ForeverUniBonn
Forever Uni Bonn - Over 2,000 graduates celebrated the 20th anniversary of its Universitätsfest — with over 5,000 of their friends and family — a new record. Read more www.uni-bonn.de/en/news/20-j...
(c) Marc John/Uni Bonn
#UniversityOfBonn #ForeverUniBonn
Reposted by LIMES-Institut Bonn
12/
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
June 18, 2025 at 4:41 PM
12/
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
Four individually identified paired #dopamine neurons signal taste #punishment in #larval #Drosophila. #Elife #PankratzLab @unibonn.bsky.social #classical #conditioning; #neuroscience; #olfaction shorturl.at/ciKxQ
Four individually identified paired dopamine neurons signal taste punishment in larval Drosophila
A neurogenetic approach reveals the cellular division of labor between individual Drosophila larval dopaminergic neurons encoding an averive teaching signal, reflecting principles in the adult insect ...
shorturl.at
June 17, 2025 at 6:02 AM
Four individually identified paired #dopamine neurons signal taste #punishment in #larval #Drosophila. #Elife #PankratzLab @unibonn.bsky.social #classical #conditioning; #neuroscience; #olfaction shorturl.at/ciKxQ
Morphology and ultrastructure of external #sense #organs of #Drosophila larvae #Elife #PankratzLab @unibonn.bsky.social #chemosensation; #electron #microscopy; #neuroscience shorturl.at/gBgCK
Morphology and ultrastructure of external sense organs of Drosophila larvae
Advanced electron microscopy techniques have been applied to comprehensively describe the cellular details and ultrastructural characteristics of all sensilla within the external sensory system of Dro...
shorturl.at
June 17, 2025 at 5:59 AM
Morphology and ultrastructure of external #sense #organs of #Drosophila larvae #Elife #PankratzLab @unibonn.bsky.social #chemosensation; #electron #microscopy; #neuroscience shorturl.at/gBgCK
Robotic-assisted #capture-SELEX of RNA #aptamers binding to small molecules #ChemBioChem #MayerLab @unibonn.bsky.social; #automation shorturl.at/rTzPm
shorturl.at
June 16, 2025 at 6:46 AM
Robotic-assisted #capture-SELEX of RNA #aptamers binding to small molecules #ChemBioChem #MayerLab @unibonn.bsky.social; #automation shorturl.at/rTzPm
Integrative #modeling of the spread of serious #infectious #diseases and corresponding #wastewater dynamics; #Epidemics #HasenauerLab @unibonn.bsky.social; #Agent-based model; #Hydrodynamic model shorturl.at/M9iqS
Integrative modeling of the spread of serious infectious diseases and corresponding wastewater dynamics
The COVID-19 pandemic has emphasized the critical need for accurate disease modeling to inform public health interventions. Traditional reliance on co…
shorturl.at
June 16, 2025 at 6:42 AM
Integrative #modeling of the spread of serious #infectious #diseases and corresponding #wastewater dynamics; #Epidemics #HasenauerLab @unibonn.bsky.social; #Agent-based model; #Hydrodynamic model shorturl.at/M9iqS
What a day!! We are so proud of being part @unibonn.bsky.social @immunosens.bsky.social! 😀
We are excellent! What a day - between hugs, applause and a lot of pride. Our rector? Jumping for joy. Our team? Overjoyed. Thank you to everyone who made this historic moment possible! @dependencybonn.de @immunosens.bsky.social @econtribute.bsky.social
© V. Lannert/G. Hübl/Uni Bonn
© V. Lannert/G. Hübl/Uni Bonn
May 23, 2025 at 7:53 AM
What a day!! We are so proud of being part @unibonn.bsky.social @immunosens.bsky.social! 😀
Reposted by LIMES-Institut Bonn
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Excellence Strategy Funds Bonn Cluster for Immune Research
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
www.immunosensation.de
May 22, 2025 at 3:55 PM
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Aptamer-engaged #nanotherapeutics against #SARS-CoV-2 #DiscoverNano #FamulokLab @unibonn.bsky.social #Aptamers; #COVID-19; #Neutralization shorturl.at/WGHWq
Aptamer-engaged nanotherapeutics against SARS-CoV-2 - Discover Nano
The COVID-19 pandemic, caused by the virus SARS-CoV-2 infection, has underscored the critical importance of rapid and accurate therapeutics. The neutralization of SARS-CoV-2 is paramount in controllin...
shorturl.at
May 5, 2025 at 7:11 AM
Aptamer-engaged #nanotherapeutics against #SARS-CoV-2 #DiscoverNano #FamulokLab @unibonn.bsky.social #Aptamers; #COVID-19; #Neutralization shorturl.at/WGHWq
Reposted by LIMES-Institut Bonn
Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
April 23, 2025 at 2:45 PM
Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
Reposted by LIMES-Institut Bonn
How reliable are #AI predictions in natural sciences? A new publication from #UniBonn shows: not everything that seems plausible is actually solid. How can relevant results be identified? When is validation worth it? Read more here: www.uni-bonn.de/en/news/063-...
© Thai Noipho/Colourbox [AI]
© Thai Noipho/Colourbox [AI]
April 8, 2025 at 9:24 AM
How reliable are #AI predictions in natural sciences? A new publication from #UniBonn shows: not everything that seems plausible is actually solid. How can relevant results be identified? When is validation worth it? Read more here: www.uni-bonn.de/en/news/063-...
© Thai Noipho/Colourbox [AI]
© Thai Noipho/Colourbox [AI]
Wie können #Naturwissenschaften von #KI profitieren? Publikation @unibonn.bsky.social warnt vor Missverständnissen im Umgang mit #Vorhersage-Algorithmen #BajorathLab shorturl.at/SaMkj
From scientific theory to duality of predictive artificial intelligence models
In studies employing explainable artificial intelligence (XAI), model explanation, interpretation, and causality are often not clearly distinguished, …
shorturl.at
April 7, 2025 at 10:30 AM
Wie können #Naturwissenschaften von #KI profitieren? Publikation @unibonn.bsky.social warnt vor Missverständnissen im Umgang mit #Vorhersage-Algorithmen #BajorathLab shorturl.at/SaMkj
#Immune and #metabolic effects of #African heritage diets versus #Western #diets in men: a randomized controlled trial @naturemedicine.bsky.social #RIMI-Radboud #KCMC-Tanzania @unibonn.bsky.social #SchultzeLab #NeteaLab shorturl.at/bpQA5
Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial - Nature Medicine
A randomized crossover trial showed that transition to a Western diet resulted in pro-inflammatory changes, whereas transition to an African heritage diet rich in fruits and vegetables, legumes and fe...
shorturl.at
April 4, 2025 at 6:12 AM
#Immune and #metabolic effects of #African heritage diets versus #Western #diets in men: a randomized controlled trial @naturemedicine.bsky.social #RIMI-Radboud #KCMC-Tanzania @unibonn.bsky.social #SchultzeLab #NeteaLab shorturl.at/bpQA5
Assessment of #uncertainty #quantification in #universal #differential #equations #PhilosTransAMathPhysEngSci #HasenauerLab @unibonn.bsky.social #scientific #machine #learning shorturl.at/UCDpU
Assessment of uncertainty quantification in universal differential equations | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Scientific machine learning is a new class of approaches that integrate physical knowledge
and mechanistic models with data-driven techniques to uncover the governing equations
of complex processes. A...
shorturl.at
April 3, 2025 at 6:33 AM
Phosphatidylcholine synthesis and remodeling in #brain #endothelial #cells #JLipidRes #ThieleLab @unibonn.bsky.social #alkyne #tracer; #lipidomics; #lysophosphatdiylcholine; #phospholipase shorturl.at/NGLyE
Phosphatidylcholine synthesis and remodeling in brain endothelial cells
Mammalian cells synthesize hundreds of different variants of their prominent membrane lipid phosphatidylcholine (PC), all differing in the side chain …
shorturl.at
March 13, 2025 at 12:09 PM
Phosphatidylcholine synthesis and remodeling in #brain #endothelial #cells #JLipidRes #ThieleLab @unibonn.bsky.social #alkyne #tracer; #lipidomics; #lysophosphatdiylcholine; #phospholipase shorturl.at/NGLyE
We thank all participants for another wonderful Joint Symposium with #WasedaUniversity Tokyo and @unibonn.bsky.social 😀
March 12, 2025 at 4:36 PM
We thank all participants for another wonderful Joint Symposium with #WasedaUniversity Tokyo and @unibonn.bsky.social 😀
PhD Positions in #Cellular #Immunology (within the RU 5775 MagNet): Two #PhD Student Positions (m/f/d) (65% E13 TV-L) #KiermaierLab @unibonn.bsky.social
March 12, 2025 at 1:45 PM
PhD Positions in #Cellular #Immunology (within the RU 5775 MagNet): Two #PhD Student Positions (m/f/d) (65% E13 TV-L) #KiermaierLab @unibonn.bsky.social
Loss formulations for assumption-free neural inference of #SDE #coefficient #functions #npj-SystemsBiologyandApplications #HasenauerLab @unibonn.bsky.social shorturl.at/hkDsB
Loss formulations for assumption-free neural inference of SDE coefficient functions - npj Systems Biology and Applications
npj Systems Biology and Applications - Loss formulations for assumption-free neural inference of SDE coefficient functions
shorturl.at
March 5, 2025 at 8:31 AM
Loss formulations for assumption-free neural inference of #SDE #coefficient #functions #npj-SystemsBiologyandApplications #HasenauerLab @unibonn.bsky.social shorturl.at/hkDsB