leonidkruglyak.bsky.social
@leonidkruglyak.bsky.social
Reposted by leonidkruglyak.bsky.social
Defaulting to surgical masks in health care settings in 2025 is one of the most dissapointing examples of reluctance to change despite overwhelming evidence.
Even defaulting to KN95 style would significantly increase protection of the most vulnerable.
Infuriating inertia in the HC industry.
Even defaulting to KN95 style would significantly increase protection of the most vulnerable.
Infuriating inertia in the HC industry.
October 30, 2025 at 12:30 AM
Defaulting to surgical masks in health care settings in 2025 is one of the most dissapointing examples of reluctance to change despite overwhelming evidence.
Even defaulting to KN95 style would significantly increase protection of the most vulnerable.
Infuriating inertia in the HC industry.
Even defaulting to KN95 style would significantly increase protection of the most vulnerable.
Infuriating inertia in the HC industry.
Reposted by leonidkruglyak.bsky.social
![Vertical comic structured like flow chart. (1) Einstein had an insight that overturned physics, thus proving his value. (2) I hope *I* have value. I’ll try to have an insight that overturns physics, to check. (3) [Time Passes] (4) Oh no! My insight didn’t overturn physics! But I don’t think I’m worthless… [arrows to two different options] (5a) Healthy Path: Maybe this was not a well-thought-out test of my value. (5b) Path of Ruin: The establishment must be *suppressing* my insight!](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreihhxykbw72fblbjeupqscutarbdowk73mhsdkqrtzjwrpzqzamjem@jpeg)
October 16, 2025 at 8:12 PM
Reposted by leonidkruglyak.bsky.social
AI in biology: "I read about some new computational method...get excited because it’s exactly what I need...I try the method...Most of the time things don’t work...I have seen this play out so many times my default assumption is nothing is going to work" blog.genesmindsmachines.com/p/we-still-c...
We still can’t predict much of anything in biology
Biology is hard. Yes, even for AI.
blog.genesmindsmachines.com
October 9, 2025 at 6:13 PM
AI in biology: "I read about some new computational method...get excited because it’s exactly what I need...I try the method...Most of the time things don’t work...I have seen this play out so many times my default assumption is nothing is going to work" blog.genesmindsmachines.com/p/we-still-c...
Reposted by leonidkruglyak.bsky.social
![4-panel comic. (1) [person in front of window, shaped like a trapezoid with a curved top] This weekend, I had to make an oversized screen for a porch window. (2) [person sitting with hands on head surrounded by images of assorted equations and measurements] It involved countless tiny problems, each somehow way harder than it should be. Oblique angles. Curved edges. Noncoplanarity. (3) [person in front of window with screen on it, with building detritus strewn on the ground] ...I solved them all. I measured precisely. I did trigonometry. I made custom parts. And it fit *perfectly.* No gaps, no ripples. (4) [person typing at computer] I know that your foundation normally limits its purview to physics, medicine, peace, chemistry, and literature. However, if you review the attached photos showing how well the screen fits into the...](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreifiwgrkbhiwy4pflbhpba4x7ordt7w6sv7ihwxzqasx2jcgtnncgy@jpeg)
October 7, 2025 at 7:43 PM
Reposted by leonidkruglyak.bsky.social
Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵
October 1, 2025 at 3:51 PM
Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵
Reposted by leonidkruglyak.bsky.social
![Comic. [Building with large sign in front of it[ SIGN: Welcome to the *Biology Department* It has been [changeable sign: 3] days since we discovered something existentially horrifying about bugs that makes you question your whole reality](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreigvmzverlrjgqp4mazbkhm43fpvv2hdbkd2t2646dhihozrwdcy24@jpeg)
September 11, 2025 at 9:24 PM
Reposted by leonidkruglyak.bsky.social
The are many anecdotes for #ChatGPT helping patients. But here's one with fallacious A.I. guidance that resulted in serious complications
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/10.7326/...
August 11, 2025 at 5:33 PM
The are many anecdotes for #ChatGPT helping patients. But here's one with fallacious A.I. guidance that resulted in serious complications
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/10.7326/...
Reposted by leonidkruglyak.bsky.social
I've seen this on Bluesky and had to try it myself. The image below was the response to the prompt: "Show me a diagram of the US presidents since Herbert Hoover, with their names and years in office under their photos" Bravo, OpenAI, bravo.
August 8, 2025 at 7:08 PM
I've seen this on Bluesky and had to try it myself. The image below was the response to the prompt: "Show me a diagram of the US presidents since Herbert Hoover, with their names and years in office under their photos" Bravo, OpenAI, bravo.
Reposted by leonidkruglyak.bsky.social
One of the most memorable talks at the 2011 Joint Evolution Meeting in Ottawa was Rosie Redfield describing her attempts to replicate this work, chronicled in her epic blog (which deserves to be preserved in the internet history books):
rrresearch.fieldofscience.com/2010/12/arse...
rrresearch.fieldofscience.com/2010/12/arse...
July 24, 2025 at 7:21 PM
One of the most memorable talks at the 2011 Joint Evolution Meeting in Ottawa was Rosie Redfield describing her attempts to replicate this work, chronicled in her epic blog (which deserves to be preserved in the internet history books):
rrresearch.fieldofscience.com/2010/12/arse...
rrresearch.fieldofscience.com/2010/12/arse...
Reposted by leonidkruglyak.bsky.social
Science finally retracts the Arsenic life paper www.science.org/content/arti...
Fifteen years later, Science retracts ‘arsenic life’ paper despite study authors’ protests
Belated decision on widely disputed 2010 study pleases some critics but puzzles and dismays others
www.science.org
July 24, 2025 at 6:51 PM
Science finally retracts the Arsenic life paper www.science.org/content/arti...
Reposted by leonidkruglyak.bsky.social
![4-panel comic. (1) [Person 1 with ponytail flanked by person with short hair and another person speaking into microphone at podium] PERSON 1: In the early 2010s, researchers found that many major scientific results couldn’t be reproduced. (2) PERSON 1: Over a decade into the replication crisis, we wanted to see if today’s studies have become more robust. (3) PERSON 1: Unfortunately, our replication analysis has found exactly the same problems that those 2010s researchers did. (4) [newspaper with image of speakers from previous panels] Headline: Replication Crisis Solved](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreibwuu57ullc7vacjyno6c5z3gtyakkg2qub6cn3dbbjdpn2kaowmi@jpeg)
July 21, 2025 at 11:54 PM
Reposted by leonidkruglyak.bsky.social
My cartoon in this weeks @newyorker.com
June 30, 2025 at 2:40 PM
My cartoon in this weeks @newyorker.com
Reposted by leonidkruglyak.bsky.social
One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/
June 28, 2025 at 10:38 AM
One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/
Spotted in the wild today:
June 18, 2025 at 6:26 PM
Spotted in the wild today:
Reposted by leonidkruglyak.bsky.social
I wrote a review of a recent paper on false discovery and multiple testing correction. liorpachter.wordpress.com/2025/06/16/r...
Reply to: Reply to: False positives in the study of memory-related gene expression
In the Nature paper “Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory” published on March 14th, 2024, authors Sun et al. claimed to identify cell-type specifi…
liorpachter.wordpress.com
June 16, 2025 at 9:31 PM
I wrote a review of a recent paper on false discovery and multiple testing correction. liorpachter.wordpress.com/2025/06/16/r...
Reposted by leonidkruglyak.bsky.social
He resolved that he would not stop either, even though it was a huge sacrifice on his part. I believe this is what we owe our trainees: so long as they are invested in their work, we must be as well, even if it seems like the world is on fire around us, both literally and figuratively. 10/
June 8, 2025 at 7:00 PM
He resolved that he would not stop either, even though it was a huge sacrifice on his part. I believe this is what we owe our trainees: so long as they are invested in their work, we must be as well, even if it seems like the world is on fire around us, both literally and figuratively. 10/
Reposted by leonidkruglyak.bsky.social
Saw some physicists on here today talking about consciousness.
Reminded me of this. The last paragraph is 💛
Reminded me of this. The last paragraph is 💛
May 31, 2025 at 2:30 PM
Reposted by leonidkruglyak.bsky.social
May 31, 2025 at 2:28 PM
Reposted by leonidkruglyak.bsky.social
![Comic. PERSON: It’s weird how, despite being one of the main branches of the tree of life, no archaea species are known to cause disease in humans. PERSON WITH SHORT HAIR: Personally, I think it’s because those gross methane breathers are too weird and incompetent to figure out how to hurt us even if they wanted to. [from small point under microscope on desk]: *Hey!* [caption] Bad news: After overhearing a conversation in our lab, Archaea has finally started harming humans.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreibeun6ux6wr6w76uv3nubobmc2aydwd2onzh525sxr3soufnc52pe@jpeg)
Reposted by leonidkruglyak.bsky.social
Last call—hiring for my lab moving to UCLA!
Project scientist in computational population genetics (post PhD/postdoc experience usually expected). recruit.apo.ucla.edu/JPF10171
March 13, 2025 at 7:42 PM
Last call—hiring for my lab moving to UCLA!
Reposted by leonidkruglyak.bsky.social
Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program.
www.luxcapital.com/news/our-hel...
www.luxcapital.com/news/our-hel...
Our Helpline for American Scientists
www.luxcapital.com
May 9, 2025 at 10:10 PM
Lux Capital & @wolfejosh.bsky.social are launching the Lux Science Helpline - a $100M commitment to support American scientists whose research is threatened by funding cuts, bureaucratic hurdles, and career roadblocks - that expands our Lux Labs program.
www.luxcapital.com/news/our-hel...
www.luxcapital.com/news/our-hel...
Reposted by leonidkruglyak.bsky.social
Reposted by leonidkruglyak.bsky.social
🧪 ICYMI: $25,000 bridge funding for terminated NSF grants.
Major props for to the Spencer, Sloan, W. T. Grant, and Kapor Foundations for their swift action, even though we (and they) know this is a band-aid fix.
Due May 30. Applications are brief: a 2-3 page memo of 6-month plans & other docs.
Major props for to the Spencer, Sloan, W. T. Grant, and Kapor Foundations for their swift action, even though we (and they) know this is a band-aid fix.
Due May 30. Applications are brief: a 2-3 page memo of 6-month plans & other docs.
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
www.spencer.org
May 6, 2025 at 7:42 PM
🧪 ICYMI: $25,000 bridge funding for terminated NSF grants.
Major props for to the Spencer, Sloan, W. T. Grant, and Kapor Foundations for their swift action, even though we (and they) know this is a band-aid fix.
Due May 30. Applications are brief: a 2-3 page memo of 6-month plans & other docs.
Major props for to the Spencer, Sloan, W. T. Grant, and Kapor Foundations for their swift action, even though we (and they) know this is a band-aid fix.
Due May 30. Applications are brief: a 2-3 page memo of 6-month plans & other docs.
Reposted by leonidkruglyak.bsky.social
Upset about federal funding cuts in the US? Want some ideas of what to do? I wrote a long-ish blog post about it here
ecoevoevoeco.blogspot.com
summarizing things I learned meeting with Senate & House aides this week with the @aibsbiology.bsky.social Congressional Visits Day event.
ecoevoevoeco.blogspot.com
summarizing things I learned meeting with Senate & House aides this week with the @aibsbiology.bsky.social Congressional Visits Day event.
Eco-Evo Evo-Eco
Academic musing by Hendry, Bolnick, Gotanda, and awesome guests.
Opinions and statements expressed on this blog are the views of the author(s) and do not necessarily represent endorsement by the blog...
ecoevoevoeco.blogspot.com
May 2, 2025 at 4:28 PM
Upset about federal funding cuts in the US? Want some ideas of what to do? I wrote a long-ish blog post about it here
ecoevoevoeco.blogspot.com
summarizing things I learned meeting with Senate & House aides this week with the @aibsbiology.bsky.social Congressional Visits Day event.
ecoevoevoeco.blogspot.com
summarizing things I learned meeting with Senate & House aides this week with the @aibsbiology.bsky.social Congressional Visits Day event.
Reposted by leonidkruglyak.bsky.social
