Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.

Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs) that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived IL-13 supports AF function...

Shi et al. demonstrate that the mechanically activated ion channel Piezo1 serves as a critical sensor for innate immune cells, enabling them to distinguish the invasive hyphal form of C. albicans from...

The pathways regulating Th1 cell contraction are not well understood. Rahman et al. demonstrate that complement receptor C5aR2 controls T cell-intrinsic prostanoid metabolism as an integral component of Th1 cell contraction. Faulty C5aR2-prostanoid rewiring marks autoimmunity-associated hyper-Th1 cell responses in arthritis and Crohn’s disease. Therefore, prostanoid metabolism is a potentially druggable checkpoint for the cessation of Th1 cell effector responses.