Kevin He
@kevinkh007.bsky.social
Research Assistant and Flow Cytometry Coordinator at St Vincent's Institute of Medical Research | Immunology and Type 1 Diabetes | Cell Therapy and Precision Medicine | T-Cell Enthusiast
Views are my own and NOT those of my employers/institutions.
Views are my own and NOT those of my employers/institutions.
Reposted by Kevin He
PhD candidate Angela (Yi) Wang and collaborators have revealed the hidden complexity of specialised thymic cells, paving the way for fresh insights into autoimmune diseases.
Find out how the discovery could help researchers stop autoimmune diseases before they start: www.svi.edu.au/news-events/...
Find out how the discovery could help researchers stop autoimmune diseases before they start: www.svi.edu.au/news-events/...
October 7, 2025 at 11:11 PM
PhD candidate Angela (Yi) Wang and collaborators have revealed the hidden complexity of specialised thymic cells, paving the way for fresh insights into autoimmune diseases.
Find out how the discovery could help researchers stop autoimmune diseases before they start: www.svi.edu.au/news-events/...
Find out how the discovery could help researchers stop autoimmune diseases before they start: www.svi.edu.au/news-events/...
Reposted by Kevin He
My initial assessment of this paper ⬇️ was brief, so let’s have a better look at it:
🧵
🧵
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains.
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains
A family of rationally designed time-resolved fluorescent proteins with controllable
lifetimes across the visible spectrum enables simultaneous multiplexed live imaging,
super-resolution microscopy, a...
www.cell.com
September 29, 2025 at 5:51 PM
My initial assessment of this paper ⬇️ was brief, so let’s have a better look at it:
🧵
🧵
Reposted by Kevin He
We're looking for a Lead Scientist to join Flow Cytometry Centre in Aberdeen! Fantastic opportunity to deliver services, work with varied research groups, promote cytometry and further develop the facility. Aberdeen is a great place to live/work- APPLY NOW www.abdnjobs.co.uk/vacancy/cyto...
Cytometry Facility Lead Scientist (IMS313A) | University of Aberdeen
A Lead Cytometry expert post is available for a highly motivated flow cytometrist to deliver cytometry services, promote and develop the Iain Fraser Cytometry Centre (IFCC). This post is for a highly...
www.abdnjobs.co.uk
September 25, 2025 at 7:19 AM
We're looking for a Lead Scientist to join Flow Cytometry Centre in Aberdeen! Fantastic opportunity to deliver services, work with varied research groups, promote cytometry and further develop the facility. Aberdeen is a great place to live/work- APPLY NOW www.abdnjobs.co.uk/vacancy/cyto...
Reposted by Kevin He
An atlas of NK cell receptor expression on healthy donor T and NK lymphocytes @biorxivpreprint.bsky.social @jeanetteeb.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 24, 2025 at 2:44 AM
An atlas of NK cell receptor expression on healthy donor T and NK lymphocytes @biorxivpreprint.bsky.social @jeanetteeb.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kevin He
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 19, 2025 at 2:39 PM
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Kevin He
SVI proudly celebrated the next generation of scientific leaders at the 2025 Rising Star Awards.
Find out how the program is shaping the treatments and cures of tomorrow: www.svi.edu.au/news-events/...
Find out how the program is shaping the treatments and cures of tomorrow: www.svi.edu.au/news-events/...
September 8, 2025 at 6:34 AM
SVI proudly celebrated the next generation of scientific leaders at the 2025 Rising Star Awards.
Find out how the program is shaping the treatments and cures of tomorrow: www.svi.edu.au/news-events/...
Find out how the program is shaping the treatments and cures of tomorrow: www.svi.edu.au/news-events/...
RIP, David Baltimore, one of the most influential scientist in molecular biology and virology.
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 8, 2025 at 8:28 AM
RIP, David Baltimore, one of the most influential scientist in molecular biology and virology.
Reposted by Kevin He
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
September 3, 2025 at 4:03 PM
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
Reposted by Kevin He
NEW Review online now
#immunosky
#immunosky
Targeting MHC-E as a new strategy for vaccines and immunotherapeutics - Nature Reviews Immunology
The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective vaccines and immunotherapies for inf...
www.nature.com
September 5, 2025 at 8:07 AM
NEW Review online now
#immunosky
#immunosky
Reposted by Kevin He
Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!
T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database
Banerjee et al. present a comprehensive T cell receptor cross-reactivity database
and a hierarchical Bayesian framework to predict T cell receptor targets. Together,
they reveal structural and biochem...
www.cell.com
July 25, 2025 at 3:00 PM
Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!
Reposted by Kevin He
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
July 3, 2025 at 3:39 PM
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
Reposted by Kevin He
🧬 CD28 vs. TCR: not a one-size-fits-all signal.
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
July 6, 2025 at 1:16 PM
🧬 CD28 vs. TCR: not a one-size-fits-all signal.
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
Reposted by Kevin He
Hello, Bluesky! 👋
We’re ArsenalBio, a programmable, clinical-stage cell therapy company with one clear purpose: defeat cancer.
Follow us to explore the future of solid tumor therapies, cutting-edge CRISPR tech, and how we’re Engineering Hope™ for patients everywhere.
We’re ArsenalBio, a programmable, clinical-stage cell therapy company with one clear purpose: defeat cancer.
Follow us to explore the future of solid tumor therapies, cutting-edge CRISPR tech, and how we’re Engineering Hope™ for patients everywhere.
June 26, 2025 at 6:14 PM
Hello, Bluesky! 👋
We’re ArsenalBio, a programmable, clinical-stage cell therapy company with one clear purpose: defeat cancer.
Follow us to explore the future of solid tumor therapies, cutting-edge CRISPR tech, and how we’re Engineering Hope™ for patients everywhere.
We’re ArsenalBio, a programmable, clinical-stage cell therapy company with one clear purpose: defeat cancer.
Follow us to explore the future of solid tumor therapies, cutting-edge CRISPR tech, and how we’re Engineering Hope™ for patients everywhere.
Reposted by Kevin He
To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025
bit.ly/SciImm_free
bit.ly/SciImm_free
June 25, 2025 at 1:56 PM
To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025
bit.ly/SciImm_free
bit.ly/SciImm_free
Reposted by Kevin He
In vivo CAR T cell generation to treat cancer and autoimmune disease | Science www.science.org/doi/10.1126/...
In vivo CAR T cell generation to treat cancer and autoimmune disease
Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity f...
www.science.org
June 19, 2025 at 7:06 PM
In vivo CAR T cell generation to treat cancer and autoimmune disease | Science www.science.org/doi/10.1126/...
Reposted by Kevin He
Can we prevent Type 1 autoimmune diabetes?
A new review of the prospects
www.nature.com/articles/s41...
A new review of the prospects
www.nature.com/articles/s41...
Type 1 diabetes mellitus prevention: present and future - Nature Reviews Endocrinology
This Review briefly outlines the pathophysiology of type 1 diabetes mellitus and discusses therapeutic targets that have reached clinical trials, including immunotherapy, and how these treatments migh...
www.nature.com
June 17, 2025 at 10:33 PM
Can we prevent Type 1 autoimmune diabetes?
A new review of the prospects
www.nature.com/articles/s41...
A new review of the prospects
www.nature.com/articles/s41...
Reposted by Kevin He
Ever wondered why T cell subsets are so complicated?
Here we discuss causes for the T cell definition and classification complexities.
www.cell.com/trends/immun...
@ki.se @uniregensburg.bsky.social @cellpress.bsky.social @cp-trendsimmuno.bsky.social
#flowcytometry #tcell #tcellsubsets
Here we discuss causes for the T cell definition and classification complexities.
www.cell.com/trends/immun...
@ki.se @uniregensburg.bsky.social @cellpress.bsky.social @cp-trendsimmuno.bsky.social
#flowcytometry #tcell #tcellsubsets
The T cell subsetting challenge
Exploiting specific T cell subset properties bears potential for T cell therapies
but is complicated by inconsistencies in T cell subset definitions and markers. Here,
we discuss causes for the defini...
www.cell.com
June 17, 2025 at 3:30 PM
Ever wondered why T cell subsets are so complicated?
Here we discuss causes for the T cell definition and classification complexities.
www.cell.com/trends/immun...
@ki.se @uniregensburg.bsky.social @cellpress.bsky.social @cp-trendsimmuno.bsky.social
#flowcytometry #tcell #tcellsubsets
Here we discuss causes for the T cell definition and classification complexities.
www.cell.com/trends/immun...
@ki.se @uniregensburg.bsky.social @cellpress.bsky.social @cp-trendsimmuno.bsky.social
#flowcytometry #tcell #tcellsubsets
Reposted by Kevin He
📢 PostDoc opportunity in our Bioinformatics & Cellular Genomics lab at SVI! 🧬
You’d join a welcoming, supportive, and brilliant team.
Why not spend a few years in Melbourne and be part of something exciting?
Apply here: www.seek.com.au/job/84737876
#ScienceCareers #PostDoc #Bioinformatics
You’d join a welcoming, supportive, and brilliant team.
Why not spend a few years in Melbourne and be part of something exciting?
Apply here: www.seek.com.au/job/84737876
#ScienceCareers #PostDoc #Bioinformatics
Research Officer - Bioinformatics Job in Fitzroy, Melbourne VIC - SEEK
Seeking a Postdoc to develop computational toolkits to enable large-scale studies of single-cell and spatial 'omics and statistical genetics
www.seek.com.au
June 16, 2025 at 7:07 AM
📢 PostDoc opportunity in our Bioinformatics & Cellular Genomics lab at SVI! 🧬
You’d join a welcoming, supportive, and brilliant team.
Why not spend a few years in Melbourne and be part of something exciting?
Apply here: www.seek.com.au/job/84737876
#ScienceCareers #PostDoc #Bioinformatics
You’d join a welcoming, supportive, and brilliant team.
Why not spend a few years in Melbourne and be part of something exciting?
Apply here: www.seek.com.au/job/84737876
#ScienceCareers #PostDoc #Bioinformatics
Reposted by Kevin He
Replacing PDCD1 with IL10 drives activation-induced IL-10 secretion and enhances human CAR Treg cell potency @mklevings.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 13, 2025 at 6:47 PM
Replacing PDCD1 with IL10 drives activation-induced IL-10 secretion and enhances human CAR Treg cell potency @mklevings.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Kevin He
Liver-targeting adeno-associated virus–mediated gene therapy led to stable long-term factor IX expression and a decrease in bleeding episodes for up to 13 years in 10 men with hemophilia B. Full study results: nej.md/3T7nxQN
#MedSky #Hematology #Genetics
#MedSky #Hematology #Genetics
Sustained Clinical Benefit of AAV Gene Therapy in Severe Hemophilia B | NEJM
Adeno-associated virus (AAV)–mediated gene therapy has emerged as a promising treatment
for hemophilia B. Data on safety and durability from 13 years of follow-up in a cohort
of patients who had be...
nej.md
June 11, 2025 at 9:07 PM
Liver-targeting adeno-associated virus–mediated gene therapy led to stable long-term factor IX expression and a decrease in bleeding episodes for up to 13 years in 10 men with hemophilia B. Full study results: nej.md/3T7nxQN
#MedSky #Hematology #Genetics
#MedSky #Hematology #Genetics
Reposted by Kevin He
We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.
www.science.org
June 9, 2025 at 11:22 AM
We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social
Reposted by Kevin He
Publication alert: "No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations" @natcomms.nature.com The backstory is particularly interesting-it's a tale of the conflicting needs of scientists & decision makers in times of disinformation ....1/n
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations
Nature Communications - Repeated vaccination is needed to maintain high levels of SARS-CoV-2 immunity in vulnerable populations, but there is concern that it could lead to immune exhaustion. Here,...
rdcu.be
June 6, 2025 at 7:04 PM
Publication alert: "No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations" @natcomms.nature.com The backstory is particularly interesting-it's a tale of the conflicting needs of scientists & decision makers in times of disinformation ....1/n
Reposted by Kevin He
SVI is proud to celebrate the achievement of Dr Jarmon G Lees, Team Leader, who was awarded the Early Career Investigator Best Talk Award at the 2025 World Congress of the International Society for Heart Research (ISHR) in Nara, Japan.
Find out more: www.svi.edu.au/news-events/...
Find out more: www.svi.edu.au/news-events/...
May 26, 2025 at 4:42 AM
SVI is proud to celebrate the achievement of Dr Jarmon G Lees, Team Leader, who was awarded the Early Career Investigator Best Talk Award at the 2025 World Congress of the International Society for Heart Research (ISHR) in Nara, Japan.
Find out more: www.svi.edu.au/news-events/...
Find out more: www.svi.edu.au/news-events/...
Reposted by Kevin He
The first manuscript by my lab has been published🥳🎉
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
npj Viruses - Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
rdcu.be
May 23, 2025 at 7:48 PM
The first manuscript by my lab has been published🥳🎉
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
Reposted by Kevin He
On Wednesday 21 May, SVI hosted its annual Equipped for Impact event, a celebration of donor generosity and the vital role equipment plays in pioneering medical research.
Find out how donor-driven discovery is accelerating life-saving research: www.svi.edu.au/news-events/...
Find out how donor-driven discovery is accelerating life-saving research: www.svi.edu.au/news-events/...
May 22, 2025 at 6:52 AM
On Wednesday 21 May, SVI hosted its annual Equipped for Impact event, a celebration of donor generosity and the vital role equipment plays in pioneering medical research.
Find out how donor-driven discovery is accelerating life-saving research: www.svi.edu.au/news-events/...
Find out how donor-driven discovery is accelerating life-saving research: www.svi.edu.au/news-events/...