Karina Lima
@karinarlima.bsky.social
A biotechnologist spreading the love for science🧪🔬| PhD in Immunology at UFCSPA (Brazil) and Massachusetts General Hospital/Harvard Medical School (USA) | Interested in Dendritic Cells and their role in Tumor and Transplant Immunology!
Reposted by Karina Lima
@simonyona.bsky.social et al show that quantify the ephemeral circulating lifespan of human cDC & propose functions of cDC & their precursors that are rapidly recruited to sites of #inflammation rupress.org/jem/article/...
📘 In Clinical #Immunology Collection: rupress.org/jem/collecti...
#FOCIS2025
📘 In Clinical #Immunology Collection: rupress.org/jem/collecti...
#FOCIS2025
June 26, 2025 at 3:15 PM
@simonyona.bsky.social et al show that quantify the ephemeral circulating lifespan of human cDC & propose functions of cDC & their precursors that are rapidly recruited to sites of #inflammation rupress.org/jem/article/...
📘 In Clinical #Immunology Collection: rupress.org/jem/collecti...
#FOCIS2025
📘 In Clinical #Immunology Collection: rupress.org/jem/collecti...
#FOCIS2025
Reposted by Karina Lima
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/4
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection
Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection in mice, offering a potential therapeutic target.
www.science.org
May 7, 2025 at 8:46 PM
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/4
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Karina Lima
A study in @ science immunology shows that Siglec-E regulates dendritic cell's activation and and their ability to trigger T cell–mediated transplant rejection. www.science.org/doi/abs/10.1...
The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection
Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection in mice, offering a potential therapeutic target.
www.science.org
May 13, 2025 at 12:12 PM
A study in @ science immunology shows that Siglec-E regulates dendritic cell's activation and and their ability to trigger T cell–mediated transplant rejection. www.science.org/doi/abs/10.1...
Reposted by Karina Lima
🔴 ÚLTIMA HORA | Muere a los 89 años el expresidente de Uruguay José ‘Pepe’ Mujica, el revolucionario tranquilo
Muere a los 89 años el expresidente de Uruguay José ‘Pepe’ Mujica, el revolucionario tranquilo
El exguerrillero y símbolo de la izquierda latinoamericana fallece tras una larga lucha contra el cáncer. Su carisma y su capacidad de ser un oráculo de la austeridad y la sencillez fascinaron al mundo
elpais.com
May 13, 2025 at 7:24 PM
🔴 ÚLTIMA HORA | Muere a los 89 años el expresidente de Uruguay José ‘Pepe’ Mujica, el revolucionario tranquilo
Reposted by Karina Lima
“No government — regardless of which party is in power — should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue,” Alan Garber, Harvard’s president, said about President Trump's demands. nyti.ms/4jzSS9W
April 14, 2025 at 8:46 PM
“No government — regardless of which party is in power — should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue,” Alan Garber, Harvard’s president, said about President Trump's demands. nyti.ms/4jzSS9W
Reposted by Karina Lima
Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...
www.nature.com
April 10, 2025 at 2:48 PM
Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Karina Lima
👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen
to process internalized blood-borne materials. Mauvais et al. find that these CD169+
macrophages cross-prime CD8+...
www.cell.com
April 9, 2025 at 9:10 AM
👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Karina Lima
Kicking off our journey on BlueSky! We're excited to share updates and connect with you. Follow us and help us get the word out! For more information about the Center for Immunology, go to our website: immunology.umn.edu
Center for Immunology
immunology.umn.edu
April 2, 2025 at 6:47 PM
Kicking off our journey on BlueSky! We're excited to share updates and connect with you. Follow us and help us get the word out! For more information about the Center for Immunology, go to our website: immunology.umn.edu
Reposted by Karina Lima
In this review, Jana Raynor and Hongbo Chi highlight the signaling and functional effects of nutrients as Signal 4 in T cell–mediated immunity. rupress.org/jem/article/...
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
March 12, 2025 at 7:53 PM
In this review, Jana Raynor and Hongbo Chi highlight the signaling and functional effects of nutrients as Signal 4 in T cell–mediated immunity. rupress.org/jem/article/...
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
📘 In Tumor #Metabolism 2025: rupress.org/jem/collecti...
#KSTumorMetab25
Reposted by Karina Lima
HEY BOSTON! 📣☀️
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
February 21, 2025 at 6:50 PM
HEY BOSTON! 📣☀️
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
MARCH 7TH, MASSACHUSETTS STATE CAPITOL!
Join us to #standupforscience2025 and make your voice heard!
SEE YOU THERE!
www.standupforscience2025.org #standupforscience20225
Reposted by Karina Lima
A truly depressing article in #Nature listing of all the damage done to #science in the US by the Trump administration in just one month
💔 for so many friends and colleagues there
#solidarityforscience 🧪
www.nature.com/articles/d41...
💔 for so many friends and colleagues there
#solidarityforscience 🧪
www.nature.com/articles/d41...
February 20, 2025 at 4:41 PM
A truly depressing article in #Nature listing of all the damage done to #science in the US by the Trump administration in just one month
💔 for so many friends and colleagues there
#solidarityforscience 🧪
www.nature.com/articles/d41...
💔 for so many friends and colleagues there
#solidarityforscience 🧪
www.nature.com/articles/d41...
Reposted by Karina Lima
Is someone going to tell them that viral infections play an important role in the development of many chronic conditions, including asthma, autoimmunity, and cancer? 🧪🩺
Establishing the President's Make America Healthy Again Commission
By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered: Section 1.
www.whitehouse.gov
February 18, 2025 at 6:20 PM
Is someone going to tell them that viral infections play an important role in the development of many chronic conditions, including asthma, autoimmunity, and cancer? 🧪🩺
Reposted by Karina Lima
To My Fellow Lab Rats: A Letter From a Postdoc Who Survived the Bolsonaro Years
www.reddit.com
February 11, 2025 at 1:48 AM
Reposted by Karina Lima
Reposted by Karina Lima
The entire archive of all CDC datasets uploaded before January 28th, 2025 has been backed up on Internet Archive.
Incredible work everyone. Science will never be silenced!
Incredible work everyone. Science will never be silenced!
February 3, 2025 at 4:37 AM
The entire archive of all CDC datasets uploaded before January 28th, 2025 has been backed up on Internet Archive.
Incredible work everyone. Science will never be silenced!
Incredible work everyone. Science will never be silenced!
Reposted by Karina Lima
Reposted by Karina Lima
A new #ScienceImmunology Review discusses the mechanisms through which dendritic cells influence cytotoxic CD8+ T cell responses against cancer. scim.ag/3PU7hRo
Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.
scim.ag
January 27, 2025 at 5:10 PM
A new #ScienceImmunology Review discusses the mechanisms through which dendritic cells influence cytotoxic CD8+ T cell responses against cancer. scim.ag/3PU7hRo
Reposted by Karina Lima
“I'm Still Here” got 3 Oscar nominations.
Brazilians are mentalizing this today.
Brazilians are mentalizing this today.
a man is holding an oscar statue in front of a hollywood sign
ALT: a man is holding an oscar statue in front of a hollywood sign
media.tenor.com
January 23, 2025 at 2:03 PM
“I'm Still Here” got 3 Oscar nominations.
Brazilians are mentalizing this today.
Brazilians are mentalizing this today.
Reposted by Karina Lima
It is dangerous and simply inexcusable to bury these reports. This information belongs to the public. As taxpayers, we pay for public health experts to research and compile all these reports so that we can have prompt and timely information about public health threats that could harm us.
“The CDC was scheduled to publish several MMWR reports this week, including three about the H5N1 avian influenza virus outbreak, according to one federal health official who spoke on the condition of anonymity to share internal discussions.”
Trump officials pause health agencies’ communications, citing review
The agencies are charged with making decisions that touch the lives of every American and are the source of crucial information to health-care providers.
www.washingtonpost.com
January 22, 2025 at 12:43 PM
It is dangerous and simply inexcusable to bury these reports. This information belongs to the public. As taxpayers, we pay for public health experts to research and compile all these reports so that we can have prompt and timely information about public health threats that could harm us.
Reposted by Karina Lima
Appropriate that cDC2 programs are as complex as CD4 T cells. Job security.
"Current debates focus on whether the functional heterogeneity of cDC2s is shaped by ontogenically distinct subsets or by the adaptability of precursor differentiation in response to signals from the tissue." #ImmunoSky
"Current debates focus on whether the functional heterogeneity of cDC2s is shaped by ontogenically distinct subsets or by the adaptability of precursor differentiation in response to signals from the tissue." #ImmunoSky
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?
Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that
sense a wide range of danger and homeostatic signals to induce appropriately targeted
T cell immune responses. Tra...
www.cell.com
January 22, 2025 at 2:24 PM
Appropriate that cDC2 programs are as complex as CD4 T cells. Job security.
"Current debates focus on whether the functional heterogeneity of cDC2s is shaped by ontogenically distinct subsets or by the adaptability of precursor differentiation in response to signals from the tissue." #ImmunoSky
"Current debates focus on whether the functional heterogeneity of cDC2s is shaped by ontogenically distinct subsets or by the adaptability of precursor differentiation in response to signals from the tissue." #ImmunoSky
Reposted by Karina Lima
RIP, David Lynch. Truly one of the great weirdoes in film and television history.
January 16, 2025 at 6:19 PM
RIP, David Lynch. Truly one of the great weirdoes in film and television history.
Reposted by Karina Lima
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer https://www.biorxiv.org/content/10.1101/2024.12.27.628014v1
December 28, 2024 at 8:19 AM
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer https://www.biorxiv.org/content/10.1101/2024.12.27.628014v1
New year, new social network! Looking forward to connecting with other scientists!
January 8, 2025 at 6:50 PM
New year, new social network! Looking forward to connecting with other scientists!