José María Santos-Pereira
@josemsanper.bsky.social
'Emergia' Researcher at the University of Seville-Biomedicine Institute of Seville (IBiS). Interested in chromatin and gene regulation in development and disease using #zebrafish
https://departamento.us.es/dbiocel/investigacion/esgendecel.htm
https://departamento.us.es/dbiocel/investigacion/esgendecel.htm
Reposted by José María Santos-Pereira
Glad to share that the website for the MZT EMBO workshop that I organize together with Ana Boskovic (EMBL, Rome), Antonio Giraldez (Yale U) and Melissa Harrison (U Wisconsin) is out: meetings.embo.org/event/26-awa...
Please spread the word and join us in beautiful Seville next 4-7 May!
Please spread the word and join us in beautiful Seville next 4-7 May!
Awakening the Genome During Developmental Reprogramming: From Embryos to Organoids
This EMBO Workshop explores the gene-regulatory mechanisms that drive developmental reprogramming upon fertilization. It focuses on the interplay of transcriptional, post-transcriptional, and develop…
meetings.embo.org
September 30, 2025 at 4:18 PM
Glad to share that the website for the MZT EMBO workshop that I organize together with Ana Boskovic (EMBL, Rome), Antonio Giraldez (Yale U) and Melissa Harrison (U Wisconsin) is out: meetings.embo.org/event/26-awa...
Please spread the word and join us in beautiful Seville next 4-7 May!
Please spread the word and join us in beautiful Seville next 4-7 May!
Reposted by José María Santos-Pereira
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
www.biorxiv.org
August 11, 2025 at 2:56 PM
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by José María Santos-Pereira
Dear all, PLEASE add comments on the importance of model organism research at this link:
July 11, 2025 at 4:34 PM
Dear all, PLEASE add comments on the importance of model organism research at this link:
Reposted by José María Santos-Pereira
Save de date! Join us at @cabimer.bsky.social on October 17th for the @GenomaHubCSIC Workshop in "Genome Dynamics in Development and Disease". Slots available for talks! Registration opens soon!!
May 30, 2025 at 12:44 PM
Save de date! Join us at @cabimer.bsky.social on October 17th for the @GenomaHubCSIC Workshop in "Genome Dynamics in Development and Disease". Slots available for talks! Registration opens soon!!
Reposted by José María Santos-Pereira
Registration is open! join us October 17th at @cabimer.bsky.social
in our #ConexiónGenoma. WorkShop! Limited spots avaible. Abstract submission possible for Poster Presentation or Oral Communication.
in our #ConexiónGenoma. WorkShop! Limited spots avaible. Abstract submission possible for Poster Presentation or Oral Communication.
June 3, 2025 at 11:13 AM
Registration is open! join us October 17th at @cabimer.bsky.social
in our #ConexiónGenoma. WorkShop! Limited spots avaible. Abstract submission possible for Poster Presentation or Oral Communication.
in our #ConexiónGenoma. WorkShop! Limited spots avaible. Abstract submission possible for Poster Presentation or Oral Communication.
Reposted by José María Santos-Pereira
Congratulations to the new PhD: María José López! Dr. López presented and discussed her PhD work marvellously! María José's thesis was done with @geneticsub.bsky.social co-supervised by Nacho Maeso from @geneticsub.bsky.social & @malmuedocas.bsky.social from #CABD
May 27, 2025 at 6:24 PM
Congratulations to the new PhD: María José López! Dr. López presented and discussed her PhD work marvellously! María José's thesis was done with @geneticsub.bsky.social co-supervised by Nacho Maeso from @geneticsub.bsky.social & @malmuedocas.bsky.social from #CABD
Reposted by José María Santos-Pereira
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
CellTalk HHD | Human Heart Development Research
CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.
www.heartdevelopment.org
May 16, 2025 at 10:10 AM
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
Reposted by José María Santos-Pereira
If you are attending #EMBLChromatin, go and check @mariamafau.bsky.social poster and learn more about how ZIC2 controls neural induction and patterning by playing a dual and sequential regulatory role.
#EMBLChromatin keeps being awesome: fantastic talks, lots of networking and troubleshooting! But guess who is also multitasking? ZIC2! Particularly during neural induction! Come by this afternoon to check poster 158 and I’ll tell you all about it 😉 @radaiglesiaslab.bsky.social
May 15, 2025 at 8:17 AM
If you are attending #EMBLChromatin, go and check @mariamafau.bsky.social poster and learn more about how ZIC2 controls neural induction and patterning by playing a dual and sequential regulatory role.
Ready to start the #EMBLChromatin Workshop in beautiful Heidelberg and enjoy a lot of fantastic science!
May 13, 2025 at 4:53 PM
Ready to start the #EMBLChromatin Workshop in beautiful Heidelberg and enjoy a lot of fantastic science!
May 13, 2025 at 9:21 AM
Ready to start the #EMBLChromatin Workshop in beautiful Heidelberg and enjoy a lot of fantastic science!
Reposted by José María Santos-Pereira
Published in today's issue! OPEN ACCESS article, FREE massive dataset, FREE code, FREE pre-trained AI/ML model. #OpenScience was a mountain of work to make this happen: check it out if you haven't already 😉
Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
www.nature.com
March 13, 2025 at 7:32 PM
Published in today's issue! OPEN ACCESS article, FREE massive dataset, FREE code, FREE pre-trained AI/ML model. #OpenScience was a mountain of work to make this happen: check it out if you haven't already 😉
Reposted by José María Santos-Pereira
Buscamos una persona candidata para solicitar un contrato predoctoral #FPU2024. Posibilidades para gente experimental o computacional para trabajar en alguno de nuestros proyectos.
Os dejo aquí la convocatoria. Se agradece mucho la difusión. (sigue)
www.ciencia.gob.es/Convocatoria...
Os dejo aquí la convocatoria. Se agradece mucho la difusión. (sigue)
www.ciencia.gob.es/Convocatoria...
January 17, 2025 at 8:54 AM
Buscamos una persona candidata para solicitar un contrato predoctoral #FPU2024. Posibilidades para gente experimental o computacional para trabajar en alguno de nuestros proyectos.
Os dejo aquí la convocatoria. Se agradece mucho la difusión. (sigue)
www.ciencia.gob.es/Convocatoria...
Os dejo aquí la convocatoria. Se agradece mucho la difusión. (sigue)
www.ciencia.gob.es/Convocatoria...
Reposted by José María Santos-Pereira
🚨🚨🚨
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
December 23, 2024 at 3:54 PM
🚨🚨🚨
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
Reposted by José María Santos-Pereira
Did you know CTCF has a life outside cohesin loop extrusion and 3D genome folding?
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
December 21, 2024 at 8:50 PM
Did you know CTCF has a life outside cohesin loop extrusion and 3D genome folding?
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social
www.sciencedirect.com/science/arti...
Reposted by José María Santos-Pereira
Such a nice review!! 🙌
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
The chromosome folding problem and how cells solve it
All cells must fold their chromosomes. The combined action of a small set of conserved molecular and biophysical mechanisms fold chromosomes in a variety of ways across the cell cycle and tree of life. We are increasingly understanding more about how chromosome structure relates to genome functions.
www.cell.com
December 12, 2024 at 10:57 AM
Such a nice review!! 🙌
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by José María Santos-Pereira
We’re recruiting a PhD student to use comparative omics to investigate why some viruses can efficiently infect both human and mosquito cells, but lead to different infection outcomes. Fully funded position by @evomg-bcn.bsky.social at our lab at UPF-CRG and the Diez lab.
www.crg.eu/en/content/t...
www.crg.eu/en/content/t...
December 10, 2024 at 11:33 AM
We’re recruiting a PhD student to use comparative omics to investigate why some viruses can efficiently infect both human and mosquito cells, but lead to different infection outcomes. Fully funded position by @evomg-bcn.bsky.social at our lab at UPF-CRG and the Diez lab.
www.crg.eu/en/content/t...
www.crg.eu/en/content/t...
Reposted by José María Santos-Pereira
Enhancer cooperativity can compensate for loss of activity over large genomic distances | Molecular Cell
#chromatin #enhancers
www.cell.com/molecular-ce...
#chromatin #enhancers
www.cell.com/molecular-ce...
Enhancer cooperativity can compensate for loss of activity over large genomic distances
Thomas, Feng, et al. introduce a synthetic platform that allows the building of complex
regulatory landscapes. Integrating the same enhancer at different distances from a
promoter uncovered that activ...
www.cell.com
December 3, 2024 at 5:43 AM
Enhancer cooperativity can compensate for loss of activity over large genomic distances | Molecular Cell
#chromatin #enhancers
www.cell.com/molecular-ce...
#chromatin #enhancers
www.cell.com/molecular-ce...
This method is really cool 👇🏼
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics
ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...
www.nature.com
November 27, 2024 at 1:06 PM
This method is really cool 👇🏼
Reposted by José María Santos-Pereira
La Sociedad Española de Bioquímica y Biología Molecular también abre su cuenta en @bsky.app A partir de ahora también publicitaremos y comentaremos nuestras actividades a través de este nuevo canal de comunicación del cielo azul.
sebbm.es
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Home
sebbm.es
November 21, 2024 at 4:29 PM
Reposted by José María Santos-Pereira
Looking to satisfy your fish fix? Begin with one of our Starter Packs covering the #zebrafish community: 🐟🧪
PIs/Group Leaders/Senior Scientists v1: go.bsky.app/2cHYybY
PIs/Group Leaders/Senior Scientists v2: go.bsky.app/4zBuxAF
Early-Career Researchers/Trainees: go.bsky.app/HwxuHey
PIs/Group Leaders/Senior Scientists v1: go.bsky.app/2cHYybY
PIs/Group Leaders/Senior Scientists v2: go.bsky.app/4zBuxAF
Early-Career Researchers/Trainees: go.bsky.app/HwxuHey
November 15, 2024 at 12:39 PM
Looking to satisfy your fish fix? Begin with one of our Starter Packs covering the #zebrafish community: 🐟🧪
PIs/Group Leaders/Senior Scientists v1: go.bsky.app/2cHYybY
PIs/Group Leaders/Senior Scientists v2: go.bsky.app/4zBuxAF
Early-Career Researchers/Trainees: go.bsky.app/HwxuHey
PIs/Group Leaders/Senior Scientists v1: go.bsky.app/2cHYybY
PIs/Group Leaders/Senior Scientists v2: go.bsky.app/4zBuxAF
Early-Career Researchers/Trainees: go.bsky.app/HwxuHey