Jimmy
@jimmymm.bsky.social
Hematologist at Cleveland Clinic. APD for Heme/Onc Fellowship Program. Interested in medical education and LGBTQ+ health. 🏳️🌈🩸#HemeSky
Reposted by Jimmy
If this person sat next to you on a bus or train and started ranting about Bruce Springsteen in this way, you would get up and move to a different seat.
In the United States, we have him the nuclear codes.
In the United States, we have him the nuclear codes.
May 16, 2025 at 2:47 PM
If this person sat next to you on a bus or train and started ranting about Bruce Springsteen in this way, you would get up and move to a different seat.
In the United States, we have him the nuclear codes.
In the United States, we have him the nuclear codes.
Reposted by Jimmy
Science does not work like this. The only way you can set a timeline is if you have rigged the results in advance.
April 10, 2025 at 9:55 PM
Science does not work like this. The only way you can set a timeline is if you have rigged the results in advance.
Reposted by Jimmy
They were careless people, Tom and Daisy- they smashed up things and creatures and then retreated back into their money or their vast carelessness or whatever it was that kept them together, and let other people clean up the mess they had made.
-FS Fitzgerald, The Great Gatsby, published 4/10/1925.
-FS Fitzgerald, The Great Gatsby, published 4/10/1925.
April 10, 2025 at 12:32 PM
They were careless people, Tom and Daisy- they smashed up things and creatures and then retreated back into their money or their vast carelessness or whatever it was that kept them together, and let other people clean up the mess they had made.
-FS Fitzgerald, The Great Gatsby, published 4/10/1925.
-FS Fitzgerald, The Great Gatsby, published 4/10/1925.
Reposted by Jimmy
The worst catastrophes of history are caused by men who are malevolent, ignorant, and have exceptional wills.
April 7, 2025 at 12:51 PM
The worst catastrophes of history are caused by men who are malevolent, ignorant, and have exceptional wills.
Reposted by Jimmy
Just learned that the entire division of blood disorders at the CDC was put on administrative leave or terminated effective immediately.
The people who figured out HIV was infecting people through the blood supply.
What could possibly go wrong?
The people who figured out HIV was infecting people through the blood supply.
What could possibly go wrong?
April 1, 2025 at 8:37 PM
Just learned that the entire division of blood disorders at the CDC was put on administrative leave or terminated effective immediately.
The people who figured out HIV was infecting people through the blood supply.
What could possibly go wrong?
The people who figured out HIV was infecting people through the blood supply.
What could possibly go wrong?
Reposted by Jimmy
“This is our documentary moment” @janefonda.com
February 24, 2025 at 4:26 PM
“This is our documentary moment” @janefonda.com
Reposted by Jimmy
Cleveland, Ohio Lit Tonight in Solidarity with Ukraine
February 25, 2025 at 3:01 AM
Cleveland, Ohio Lit Tonight in Solidarity with Ukraine
Reposted by Jimmy
New plan to fight back against private insurance denials:
Doctors when you plan to retire, go get hired by UHC, Anthem, etc, and then once you are in the door, approve absolutely everything until you are fired.
Doctors when you plan to retire, go get hired by UHC, Anthem, etc, and then once you are in the door, approve absolutely everything until you are fired.
February 22, 2025 at 4:01 PM
New plan to fight back against private insurance denials:
Doctors when you plan to retire, go get hired by UHC, Anthem, etc, and then once you are in the door, approve absolutely everything until you are fired.
Doctors when you plan to retire, go get hired by UHC, Anthem, etc, and then once you are in the door, approve absolutely everything until you are fired.
Reposted by Jimmy
Ice Melting on the Cuyahoga River in Cleveland, Ohio
February 7, 2025 at 1:46 PM
Ice Melting on the Cuyahoga River in Cleveland, Ohio
Reposted by Jimmy
Hey man sorry to hear about all your political turmoil. Would it help if I scrolled around on the computer all day and drove myself insane?
February 6, 2025 at 1:54 PM
Hey man sorry to hear about all your political turmoil. Would it help if I scrolled around on the computer all day and drove myself insane?
Reposted by Jimmy
Viewpoint: Medical students and residents need to be educated on health policy issues like insurance, payment models, and drug regulation to better understand the factors that impact patient health outcomes.
https://ja.ma/3BuTE7P
https://ja.ma/3BuTE7P
December 26, 2024 at 12:00 PM
Viewpoint: Medical students and residents need to be educated on health policy issues like insurance, payment models, and drug regulation to better understand the factors that impact patient health outcomes.
https://ja.ma/3BuTE7P
https://ja.ma/3BuTE7P
Reposted by Jimmy
Updates on #hemophilia gene therapy! 🩸 🧬
4 years post-treatment, valoctocogene roxaparvovec shows sustained bleed reduction, FVIII expression, and improved quality of life in severe hemophilia A patients. Safety remains acceptable, though some resumed prophylaxis.
https://buff.ly/3BBy3ui
4 years post-treatment, valoctocogene roxaparvovec shows sustained bleed reduction, FVIII expression, and improved quality of life in severe hemophilia A patients. Safety remains acceptable, though some resumed prophylaxis.
https://buff.ly/3BBy3ui
December 19, 2024 at 4:48 PM
Updates on #hemophilia gene therapy! 🩸 🧬
4 years post-treatment, valoctocogene roxaparvovec shows sustained bleed reduction, FVIII expression, and improved quality of life in severe hemophilia A patients. Safety remains acceptable, though some resumed prophylaxis.
https://buff.ly/3BBy3ui
4 years post-treatment, valoctocogene roxaparvovec shows sustained bleed reduction, FVIII expression, and improved quality of life in severe hemophilia A patients. Safety remains acceptable, though some resumed prophylaxis.
https://buff.ly/3BBy3ui
Reposted by Jimmy
That feeling when you see your former @ash-hematology.bsky.social mentee in systems-based hematology publishes a GREAT study on iron deficiency anemia in @bloodadvances.bsky.social. I'M SO PROUD OF YOU DR. COGAN!!!
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
Iron deficiency resolution and time to resolution in an American health system
Key PointsIn a statewide cohort, time to resolution of iron deficiency was 1.9 years, and 58% of patients did not achieve resolution within 3 years.Greater
doi.org
December 18, 2024 at 1:37 AM
That feeling when you see your former @ash-hematology.bsky.social mentee in systems-based hematology publishes a GREAT study on iron deficiency anemia in @bloodadvances.bsky.social. I'M SO PROUD OF YOU DR. COGAN!!!
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
Reposted by Jimmy
New in CA: A Cancer Journal for Clinicians! 📕 This review offers practical recommendations for delivering quality cancer care to transgender & gender-diverse individuals. Read for free: acsjournals.onlinelibrary.wiley.com/doi/10.3322/... @drdonsdizon.bsky.social @oncoalert.bsky.social #oncsky
December 10, 2024 at 2:11 PM
New in CA: A Cancer Journal for Clinicians! 📕 This review offers practical recommendations for delivering quality cancer care to transgender & gender-diverse individuals. Read for free: acsjournals.onlinelibrary.wiley.com/doi/10.3322/... @drdonsdizon.bsky.social @oncoalert.bsky.social #oncsky
Reposted by Jimmy
An amazing oral presentation of our #AMLsm #AYA #healthdisparities work by super-star resident Dr. Erin Feliciano 🌟#ASH24 #ASHTrainee #ASHKudos @ash-hematology.bsky.social
A 🧵 on some of the highlights of our findings:
1/x
A 🧵 on some of the highlights of our findings:
1/x
December 8, 2024 at 6:40 PM
An amazing oral presentation of our #AMLsm #AYA #healthdisparities work by super-star resident Dr. Erin Feliciano 🌟#ASH24 #ASHTrainee #ASHKudos @ash-hematology.bsky.social
A 🧵 on some of the highlights of our findings:
1/x
A 🧵 on some of the highlights of our findings:
1/x
Reposted by Jimmy
Honorable mention #MajorPROsASH: PROs pts with bleeding d/o of unknown cause (BDUC)
- 97 pts completed RAND-36
- significantly worse phys health, energy, social fxn & pain in BDUC vs general population
Important findings in wholly understudied pt population. #ASH24 #hemetwitter
- 97 pts completed RAND-36
- significantly worse phys health, energy, social fxn & pain in BDUC vs general population
Important findings in wholly understudied pt population. #ASH24 #hemetwitter
December 7, 2024 at 7:42 PM
Honorable mention #MajorPROsASH: PROs pts with bleeding d/o of unknown cause (BDUC)
- 97 pts completed RAND-36
- significantly worse phys health, energy, social fxn & pain in BDUC vs general population
Important findings in wholly understudied pt population. #ASH24 #hemetwitter
- 97 pts completed RAND-36
- significantly worse phys health, energy, social fxn & pain in BDUC vs general population
Important findings in wholly understudied pt population. #ASH24 #hemetwitter
Reposted by Jimmy
🩸Platelets!
Lifespan 7-10 days
150-450 × 10⁹/L
Stimulated by TPO
1/3 sequestered in spleen
Receptors:
GpIIbIIIa -> fibrinogen
GPIb-IX-V -> vWF
P2Y12 -> ADP
Granules:
Alpha = fibrinogen, vWF, V, VEGF, PF4, PDGF, P-selectin
Dense = ADP, Ca, Serotonin
#hemesky #MedSky
van der Meijden et al, 2019
Lifespan 7-10 days
150-450 × 10⁹/L
Stimulated by TPO
1/3 sequestered in spleen
Receptors:
GpIIbIIIa -> fibrinogen
GPIb-IX-V -> vWF
P2Y12 -> ADP
Granules:
Alpha = fibrinogen, vWF, V, VEGF, PF4, PDGF, P-selectin
Dense = ADP, Ca, Serotonin
#hemesky #MedSky
van der Meijden et al, 2019
December 1, 2024 at 1:05 PM
Reposted by Jimmy
🩸 A fresh review on ITP for #hemesky #MedSky #IMsky #hemepath #ITP #lowplatelets
American Journal of Hematology | Blood Research Journal | Wiley Online Library
doi.org/10.1002/ajh....
American Journal of Hematology | Blood Research Journal | Wiley Online Library
doi.org/10.1002/ajh....
2025 update on clinical trials in immune thrombocytopenia
Summary of major novel and repurposed agents currently in clinical development for immune thrombocytopenia.
doi.org
November 26, 2024 at 2:46 PM
🩸 A fresh review on ITP for #hemesky #MedSky #IMsky #hemepath #ITP #lowplatelets
American Journal of Hematology | Blood Research Journal | Wiley Online Library
doi.org/10.1002/ajh....
American Journal of Hematology | Blood Research Journal | Wiley Online Library
doi.org/10.1002/ajh....
Reposted by Jimmy
If we ignore Duffy-null associated neutrophil counts (DANC), we contribute to major disparities in oncology care and clinical trial enrollment. Whether you’re a clinical trialist or clinician, a must-read from @laurenmerzmd.bsky.social and coauthors #medsky #hemesky 🩸🧪
www.nejm.org/doi/abs/10.1...
www.nejm.org/doi/abs/10.1...
The Duffy Null Phenotype — Addressing a Source of Discrimination in Cancer Care | NEJM
Cancer research and care practices that adversely affect people with the Duffy null
phenotype are an underrecognized and widespread source of discrimination against people
of African or Arab ancestry.
www.nejm.org
November 25, 2024 at 9:34 PM
If we ignore Duffy-null associated neutrophil counts (DANC), we contribute to major disparities in oncology care and clinical trial enrollment. Whether you’re a clinical trialist or clinician, a must-read from @laurenmerzmd.bsky.social and coauthors #medsky #hemesky 🩸🧪
www.nejm.org/doi/abs/10.1...
www.nejm.org/doi/abs/10.1...
Reposted by Jimmy
ASCT in CR1 MCL MRD-adapted #ASH24 @timfenske:
650 pts, 73% AraC induction, mFU 2.7 yr
- A: uMRD6 ASCT + MR x 3 yr
- B: uMRD6 MR x 3 yr
3-yr PFS/OS:
- A: 76.6%/82.1%
- B: 77.4%/82.7%
No difference in OS based on futility analysis. CR1 with MRD-neg at 10-6 do not need ASCT! #lymsm
650 pts, 73% AraC induction, mFU 2.7 yr
- A: uMRD6 ASCT + MR x 3 yr
- B: uMRD6 MR x 3 yr
3-yr PFS/OS:
- A: 76.6%/82.1%
- B: 77.4%/82.7%
No difference in OS based on futility analysis. CR1 with MRD-neg at 10-6 do not need ASCT! #lymsm
November 25, 2024 at 8:43 PM
Reposted by Jimmy
10-15% of iTTP do not respond to rituximab. Targeting plasma cells can be promising.
In this study, durable responses to bortezomib were registered in 60% of multi-refractory iTTP patients, with mild-to-moderate toxicities.
www.jthjournal.org/article/S153...
#MedSky #HemeSky #TTP #bortezomib
In this study, durable responses to bortezomib were registered in 60% of multi-refractory iTTP patients, with mild-to-moderate toxicities.
www.jthjournal.org/article/S153...
#MedSky #HemeSky #TTP #bortezomib
November 23, 2024 at 10:09 AM
10-15% of iTTP do not respond to rituximab. Targeting plasma cells can be promising.
In this study, durable responses to bortezomib were registered in 60% of multi-refractory iTTP patients, with mild-to-moderate toxicities.
www.jthjournal.org/article/S153...
#MedSky #HemeSky #TTP #bortezomib
In this study, durable responses to bortezomib were registered in 60% of multi-refractory iTTP patients, with mild-to-moderate toxicities.
www.jthjournal.org/article/S153...
#MedSky #HemeSky #TTP #bortezomib