Aaron Logan, MD, PhD, MPhil
@hemedoc.bsky.social
Professor, UCSF hematology/BMT. Translational researcher interested in leukemia, MDS, HLH, MRD, post-HCT relapse, GVHD, & immune recon. Photos (Instagram): pyknosis
#tandem26 Ferrara: JAKi facilitates tissue repair whereas steroids actually inhibit it (even though, yes, they do inhibit alloimmune responses). Ferrara’s goal is to move steroids to 2nd line tx for GVHD!
February 7, 2026 at 1:16 AM
#tandem26 Ferrara: JAKi facilitates tissue repair whereas steroids actually inhibit it (even though, yes, they do inhibit alloimmune responses). Ferrara’s goal is to move steroids to 2nd line tx for GVHD!
#tandem26 Ferrara: thus far, most GVHD pox/treatment has focused on the intimation and persistence of the alloimmune response, but efforts to improve tissue resistance to damage are important. Eg, intestinal stem cells are damaged by GVHD cytokines. Rux prevents ISC apoptosis, but steroids don’t.
February 7, 2026 at 1:13 AM
#tandem26 Ferrara: thus far, most GVHD pox/treatment has focused on the intimation and persistence of the alloimmune response, but efforts to improve tissue resistance to damage are important. Eg, intestinal stem cells are damaged by GVHD cytokines. Rux prevents ISC apoptosis, but steroids don’t.
#tandem26 Ferrara: refinement of biomarker + clinical sx based aGVHD stratification (MAGIC composite) now gives greater clarity in predicting outcomes at onset of aGVHD.
February 7, 2026 at 1:04 AM
#tandem26 Ferrara: refinement of biomarker + clinical sx based aGVHD stratification (MAGIC composite) now gives greater clarity in predicting outcomes at onset of aGVHD.
#tandem26 Ferrara: beautiful and touching start to his E Don Thomas lecture by dedicating the talk to John Galvin, who we shockingly lost this past year at far, far too young an age.
February 7, 2026 at 12:58 AM
#tandem26 Ferrara: beautiful and touching start to his E Don Thomas lecture by dedicating the talk to John Galvin, who we shockingly lost this past year at far, far too young an age.
#tandem26 Unfortunately, I could only make the end of Stella Davies’s Bortin Lecture, but absolute respect to her for using her platform to speak out against the anti-immigrant, anti-democratic trajectory of our current course in America! “We can not sit this one out.” Agree 1000000% !!!
February 7, 2026 at 12:44 AM
#tandem26 Unfortunately, I could only make the end of Stella Davies’s Bortin Lecture, but absolute respect to her for using her platform to speak out against the anti-immigrant, anti-democratic trajectory of our current course in America! “We can not sit this one out.” Agree 1000000% !!!
#tandem26 #bmtsm Rafati: @cibmtr.bsky.social analysis of genetic predictors of alloHCT outcomes in myelofibrosis. Known high risk assoc w ASXL1+nonCALR/MPL muts. N=930 evaluated here w 95 gene assay.
February 6, 2026 at 11:38 PM
#tandem26 #bmtsm Rafati: @cibmtr.bsky.social analysis of genetic predictors of alloHCT outcomes in myelofibrosis. Known high risk assoc w ASXL1+nonCALR/MPL muts. N=930 evaluated here w 95 gene assay.
#tandem26 #bmtsm Popat: age and IPSS not correl w outcomes. TP53 mut status was assoc w 3yr PFS/OS 64% with TP53wt vs 50% with TP53m. Relapse >3x higher in TP53m. Impressive outcomes, but the high NRM is problematic, esp for TP53wt — ie at 12mos, only 6% relapse but OS 69% due to the high toxicity.
February 6, 2026 at 11:28 PM
#tandem26 #bmtsm Kongtim: @cibmtr.bsky.social analysis of Flu/Mel vs other RIC in pts age 50+ with AML/MDS relapse, total N=11,731 from 183 centers. ~94% PBSC
February 6, 2026 at 10:39 PM
#tandem26 #bmtsm Kongtim: @cibmtr.bsky.social analysis of Flu/Mel vs other RIC in pts age 50+ with AML/MDS relapse, total N=11,731 from 183 centers. ~94% PBSC
