Saskia Middeldorp
@middeldorps.bsky.social
Head Department of Internal Medicine at Radboudumc, Nijmegen 🇳🇱. Professor fighting venous thromboembolism. Pregnancy, thrombosis, thrombophilia. Elected council member of ISTH. Feminist with ❤️ husband & 3 sons. 🚴🏼♀️🏃🏻♀️. #Hemesky #Thrombosky
Reposted by Saskia Middeldorp
📰 Check it out! The @ash.hematology.org and ISTH Updated Guidelines on the Treatment of Pediatric VTE are featured in Hematology Advisor.
Don’t miss this spotlight on our collaborative effort!
📖 Read the full feature: www.hematologyadvisor.com/news/pediatr...
#PediatricVTE #Hematology #ISTH
Don’t miss this spotlight on our collaborative effort!
📖 Read the full feature: www.hematologyadvisor.com/news/pediatr...
#PediatricVTE #Hematology #ISTH
ASH and ISTH Update Guidelines on Treatment of Pediatric VTE
The ASH and ISTH updated guidelines for treatment of pediatric venous thromboembolism, focusing on improved outcomes and patient quality of life.
www.hematologyadvisor.com
July 9, 2025 at 5:07 PM
📰 Check it out! The @ash.hematology.org and ISTH Updated Guidelines on the Treatment of Pediatric VTE are featured in Hematology Advisor.
Don’t miss this spotlight on our collaborative effort!
📖 Read the full feature: www.hematologyadvisor.com/news/pediatr...
#PediatricVTE #Hematology #ISTH
Don’t miss this spotlight on our collaborative effort!
📖 Read the full feature: www.hematologyadvisor.com/news/pediatr...
#PediatricVTE #Hematology #ISTH
Reposted by Saskia Middeldorp
What an inspiring #ISTH2025!
It was wonderful to host the global #thrombosis & #hemostasis community in DC.
From the latest science & innovations to networking & building new collabs - it had it all!
Look out for recordings & other post- @isth.org congress updates.
Goodbye & see you @ #ISTH2026!
It was wonderful to host the global #thrombosis & #hemostasis community in DC.
From the latest science & innovations to networking & building new collabs - it had it all!
Look out for recordings & other post- @isth.org congress updates.
Goodbye & see you @ #ISTH2026!
June 25, 2025 at 7:37 PM
What an inspiring #ISTH2025!
It was wonderful to host the global #thrombosis & #hemostasis community in DC.
From the latest science & innovations to networking & building new collabs - it had it all!
Look out for recordings & other post- @isth.org congress updates.
Goodbye & see you @ #ISTH2026!
It was wonderful to host the global #thrombosis & #hemostasis community in DC.
From the latest science & innovations to networking & building new collabs - it had it all!
Look out for recordings & other post- @isth.org congress updates.
Goodbye & see you @ #ISTH2026!
Marc Rodger highlighting the #Highlow study and providing guidance on how to implement the results 👌🏼
June 25, 2025 at 1:52 PM
Now my favourite topic presented eloquently by prof Marc Rodger.
Answering all the questions needed for providing well-informed information to your patients.
Put the #LMWH needles away in patients with placenta-mediated complications in inherited #thrombophilia!
#AFFIRM #ALIFE2
#ISTH2025
Answering all the questions needed for providing well-informed information to your patients.
Put the #LMWH needles away in patients with placenta-mediated complications in inherited #thrombophilia!
#AFFIRM #ALIFE2
#ISTH2025
June 25, 2025 at 1:44 PM
Now my favourite topic presented eloquently by prof Marc Rodger.
Answering all the questions needed for providing well-informed information to your patients.
Put the #LMWH needles away in patients with placenta-mediated complications in inherited #thrombophilia!
#AFFIRM #ALIFE2
#ISTH2025
Answering all the questions needed for providing well-informed information to your patients.
Put the #LMWH needles away in patients with placenta-mediated complications in inherited #thrombophilia!
#AFFIRM #ALIFE2
#ISTH2025
It took 7 years to recruit 51 patients for the IMPACT single-arm study on certiluzomab on top of LMWH-aspirin shows adverse outcome in 20% which is lower than non-contemporary controls.
#ISTH2025
#ISTH2025
June 25, 2025 at 1:25 PM
It took 7 years to recruit 51 patients for the IMPACT single-arm study on certiluzomab on top of LMWH-aspirin shows adverse outcome in 20% which is lower than non-contemporary controls.
#ISTH2025
#ISTH2025
Reposted by Saskia Middeldorp
Implementation matters!
A guideline-driven VTE prevention program (Vermont Model) led to ~60% of high-risk cancer patients receiving prophylactic anticoagulation—resulting in a 60% reduction in VTE and 56% reduction in death. #ISTH2025 #VTEprevention 🩸
@marycushmanmd.bsky.social
A guideline-driven VTE prevention program (Vermont Model) led to ~60% of high-risk cancer patients receiving prophylactic anticoagulation—resulting in a 60% reduction in VTE and 56% reduction in death. #ISTH2025 #VTEprevention 🩸
@marycushmanmd.bsky.social
June 24, 2025 at 7:45 PM
Implementation matters!
A guideline-driven VTE prevention program (Vermont Model) led to ~60% of high-risk cancer patients receiving prophylactic anticoagulation—resulting in a 60% reduction in VTE and 56% reduction in death. #ISTH2025 #VTEprevention 🩸
@marycushmanmd.bsky.social
A guideline-driven VTE prevention program (Vermont Model) led to ~60% of high-risk cancer patients receiving prophylactic anticoagulation—resulting in a 60% reduction in VTE and 56% reduction in death. #ISTH2025 #VTEprevention 🩸
@marycushmanmd.bsky.social
Reposted by Saskia Middeldorp
📣 ARIVA Trial at #ISTH2025:
🧪 First RCT on antithrombotic therapy post-venous stenting for PTS
🔵 6-month primary patency rate was higher than expected
💊 No added benefit of aspirin + rivaroxaban vs. rivaroxaban alone
www.ahajournals.org/doi/10.1161/...
🧪 First RCT on antithrombotic therapy post-venous stenting for PTS
🔵 6-month primary patency rate was higher than expected
💊 No added benefit of aspirin + rivaroxaban vs. rivaroxaban alone
www.ahajournals.org/doi/10.1161/...
June 24, 2025 at 2:04 PM
📣 ARIVA Trial at #ISTH2025:
🧪 First RCT on antithrombotic therapy post-venous stenting for PTS
🔵 6-month primary patency rate was higher than expected
💊 No added benefit of aspirin + rivaroxaban vs. rivaroxaban alone
www.ahajournals.org/doi/10.1161/...
🧪 First RCT on antithrombotic therapy post-venous stenting for PTS
🔵 6-month primary patency rate was higher than expected
💊 No added benefit of aspirin + rivaroxaban vs. rivaroxaban alone
www.ahajournals.org/doi/10.1161/...
Reposted by Saskia Middeldorp
Meta-analysis on GLP-1RA (vs. placebo) and VTE:
🔹 PE rates significantly lower 📉
🔹 VTE rates lower but not statistically significant
🔹 No difference in DVT
🔹 Study design matters: RCTs vs. observational data
Accepted for publication in JTH!
#ISTH2025 #VTE #GLP1RA #Thrombosis
@jthjournal.bsky.social
🔹 PE rates significantly lower 📉
🔹 VTE rates lower but not statistically significant
🔹 No difference in DVT
🔹 Study design matters: RCTs vs. observational data
Accepted for publication in JTH!
#ISTH2025 #VTE #GLP1RA #Thrombosis
@jthjournal.bsky.social
June 23, 2025 at 7:43 PM
Meta-analysis on GLP-1RA (vs. placebo) and VTE:
🔹 PE rates significantly lower 📉
🔹 VTE rates lower but not statistically significant
🔹 No difference in DVT
🔹 Study design matters: RCTs vs. observational data
Accepted for publication in JTH!
#ISTH2025 #VTE #GLP1RA #Thrombosis
@jthjournal.bsky.social
🔹 PE rates significantly lower 📉
🔹 VTE rates lower but not statistically significant
🔹 No difference in DVT
🔹 Study design matters: RCTs vs. observational data
Accepted for publication in JTH!
#ISTH2025 #VTE #GLP1RA #Thrombosis
@jthjournal.bsky.social
There is more to established #thrombophilia defects in understanding the genetics of venous thromboembolism #VTE.
Plenary lecture by Prof Pierre Morange
#ISTH2025
Plenary lecture by Prof Pierre Morange
#ISTH2025
June 23, 2025 at 3:43 PM
There is more to established #thrombophilia defects in understanding the genetics of venous thromboembolism #VTE.
Plenary lecture by Prof Pierre Morange
#ISTH2025
Plenary lecture by Prof Pierre Morange
#ISTH2025
Reposted by Saskia Middeldorp
Tips for asking ?s as moderator #ISTH2025
Clinical talk: what future directions do you see this work taking?
Basic science: how do you envision this translating to the clinic?
Next level pro tip: contact author beforehand to see what they didn’t have time to present that they’d like you to ask
Clinical talk: what future directions do you see this work taking?
Basic science: how do you envision this translating to the clinic?
Next level pro tip: contact author beforehand to see what they didn’t have time to present that they’d like you to ask
June 23, 2025 at 4:09 AM
Tips for asking ?s as moderator #ISTH2025
Clinical talk: what future directions do you see this work taking?
Basic science: how do you envision this translating to the clinic?
Next level pro tip: contact author beforehand to see what they didn’t have time to present that they’d like you to ask
Clinical talk: what future directions do you see this work taking?
Basic science: how do you envision this translating to the clinic?
Next level pro tip: contact author beforehand to see what they didn’t have time to present that they’d like you to ask
The effects of andexanet on enoxaparin are in line with effects on oral factorXa inhibitors.
Great presentation by PhD student Thijs van Haaps
#ISTH2025
Great presentation by PhD student Thijs van Haaps
#ISTH2025
June 23, 2025 at 1:58 PM
The effects of andexanet on enoxaparin are in line with effects on oral factorXa inhibitors.
Great presentation by PhD student Thijs van Haaps
#ISTH2025
Great presentation by PhD student Thijs van Haaps
#ISTH2025
June 23, 2025 at 1:09 PM
There is still taboo about discussing menstruation 🩸
There are differences between assessment of abnormal uterine bleeding between professional societies.
This is important to realisme and underscores the need to collaborate multidisciplinary.
Dr Roseline d’Oiron
#ISTH2025
There are differences between assessment of abnormal uterine bleeding between professional societies.
This is important to realisme and underscores the need to collaborate multidisciplinary.
Dr Roseline d’Oiron
#ISTH2025
June 23, 2025 at 12:52 PM
There is still taboo about discussing menstruation 🩸
There are differences between assessment of abnormal uterine bleeding between professional societies.
This is important to realisme and underscores the need to collaborate multidisciplinary.
Dr Roseline d’Oiron
#ISTH2025
There are differences between assessment of abnormal uterine bleeding between professional societies.
This is important to realisme and underscores the need to collaborate multidisciplinary.
Dr Roseline d’Oiron
#ISTH2025
Good morning everyone! Another exciting day ahead #ISTH2025.
Thirty years ago I visited my first @isth.org Congress.
📣 This morning, I can switch sessions to see two of my former PhD students shine in State-of-the-Art sessions.
We take good care of the next generation @isth.org!
Thirty years ago I visited my first @isth.org Congress.
📣 This morning, I can switch sessions to see two of my former PhD students shine in State-of-the-Art sessions.
We take good care of the next generation @isth.org!
June 23, 2025 at 11:32 AM
Interesting data on influence of race from the RIETE registry. After correction for treatment etc, these differences did not show in multi-variate analysis.
#ISTH2025
#ISTH2025
June 22, 2025 at 7:13 PM
Interesting data on influence of race from the RIETE registry. After correction for treatment etc, these differences did not show in multi-variate analysis.
#ISTH2025
#ISTH2025
Reposted by Saskia Middeldorp
VTE isn’t “over” at discharge.
Many patients face lasting symptoms & distress.
🗣️ PROMs help reveal what matters, if we use them right.
✅ Ask
✅ Act
✅ Guide care
Structured models like Attend-PE show the way.
#ISTH2025 #Thrombosis #PatientVoice
Many patients face lasting symptoms & distress.
🗣️ PROMs help reveal what matters, if we use them right.
✅ Ask
✅ Act
✅ Guide care
Structured models like Attend-PE show the way.
#ISTH2025 #Thrombosis #PatientVoice
June 22, 2025 at 1:11 PM
VTE isn’t “over” at discharge.
Many patients face lasting symptoms & distress.
🗣️ PROMs help reveal what matters, if we use them right.
✅ Ask
✅ Act
✅ Guide care
Structured models like Attend-PE show the way.
#ISTH2025 #Thrombosis #PatientVoice
Many patients face lasting symptoms & distress.
🗣️ PROMs help reveal what matters, if we use them right.
✅ Ask
✅ Act
✅ Guide care
Structured models like Attend-PE show the way.
#ISTH2025 #Thrombosis #PatientVoice