Saskia Middeldorp
banner
middeldorps.bsky.social
Saskia Middeldorp
@middeldorps.bsky.social
Head Department of Internal Medicine at Radboudumc, Nijmegen 🇳🇱. Professor fighting venous thromboembolism. Pregnancy, thrombosis, thrombophilia. Elected council member of ISTH. Feminist with ❤️ husband & 3 sons. 🚴🏼‍♀️🏃🏻‍♀️. #Hemesky #Thrombosky
Marc Rodger highlighting the #Highlow study and providing guidance on how to implement the results 👌🏼
June 25, 2025 at 1:51 PM
Now my favourite topic presented eloquently by prof Marc Rodger.

Answering all the questions needed for providing well-informed information to your patients.

Put the #LMWH needles away in patients with placenta-mediated complications in inherited #thrombophilia!
#AFFIRM #ALIFE2

#ISTH2025
June 25, 2025 at 1:44 PM
It took 7 years to recruit 51 patients for the IMPACT single-arm study on certiluzomab on top of LMWH-aspirin shows adverse outcome in 20% which is lower than non-contemporary controls.

#ISTH2025
June 25, 2025 at 1:25 PM
More on pregnancy and #APS, now from obstetric perspective.

Only 1% of recurrent miscarriage patients had APS antibodies, similar to controls.

#ISTH2025
June 25, 2025 at 1:13 PM
Why do we have so little data on pregnancy and thrombotic outcomes in #APS??

Well-illustrated by State-of-the-Art lecture by dr Karen Breen.

We MUST do better!

#ISTH2025
June 25, 2025 at 12:47 PM
It’s really worth stopping by our @isth.org booth and get inspired for next year’s meeting in….. Paris!

#ISTH2025
June 23, 2025 at 5:18 PM
What started as strong Mendelian observations, has now evolved to a strongly polygenenic etiology of #VTE. Inside and outside the coagulation cascade.

#ISTH2025
June 23, 2025 at 3:49 PM
There is more to established #thrombophilia defects in understanding the genetics of venous thromboembolism #VTE.

Plenary lecture by Prof Pierre Morange

#ISTH2025
June 23, 2025 at 3:43 PM
Adjust-DVT study. Only 5% of patients with suspected #DVT had an age-adjusted d-dimer that omits the need for compression ultrasound.

I don’t think it is worth it. What do you think?

#ISTH2025
June 23, 2025 at 2:40 PM
This is why diagnosing, treating and investigating #APS is so complicated.
Massive differences in classification between Sydney 2006 and ACR/EULAR 2023. Only 40% of patients fulfilled the new criteria.
What are the implications for future research?

#ISTH2025
June 23, 2025 at 2:27 PM
The effects of andexanet on enoxaparin are in line with effects on oral factorXa inhibitors.

Great presentation by PhD student Thijs van Haaps

#ISTH2025
June 23, 2025 at 1:58 PM
Excellent points ⬇️

Exclusion of pregnant people from trials leads to paradoxical effects!

#ISTH2025
June 23, 2025 at 1:09 PM
State-of-the-Art talk bij de Luuk Scheres

Despite hormone use being the most prevalent and important risk factor for #VTE in women <50, there is huge underrepresentation of risk models and funding.

Food for thought and action 💪🏼

#ISTH2025
June 23, 2025 at 1:07 PM
There is still taboo about discussing menstruation 🩸

There are differences between assessment of abnormal uterine bleeding between professional societies.
This is important to realisme and underscores the need to collaborate multidisciplinary.
Dr Roseline d’Oiron
#ISTH2025
June 23, 2025 at 12:52 PM
Even if you are not a pediatrician, you can learn so much. Beautiful slides on thrombolysis 🤩

Dr Irene Klaassen #ISTH2025
June 23, 2025 at 12:09 PM
Good morning everyone! Another exciting day ahead #ISTH2025.

Thirty years ago I visited my first @isth.org Congress.
📣 This morning, I can switch sessions to see two of my former PhD students shine in State-of-the-Art sessions.
We take good care of the next generation @isth.org!
June 23, 2025 at 11:32 AM
Interesting data on influence of race from the RIETE registry. After correction for treatment etc, these differences did not show in multi-variate analysis.

#ISTH2025
June 22, 2025 at 7:13 PM
Dragons’s Den of the highly fruitful www.invent-vte.com netwerk. Collaboration leads to practice-changing trials!!

#ISTH2025
June 22, 2025 at 4:26 PM
This is what we were waiting for. A direct comparison between apixaban and rivaroxaban for the treatment of acute VTE. Apixaban reduces bleeding risk in the first 3 months by >50%!

Practice changing investigator-initiated RCT.

#ISTH2025
June 22, 2025 at 1:49 PM
What a fantastic plenary lecture by Prof Jennifer Curnow - in loving and admiring memory of my dear friend Dr Claire McLintock.

#ISTH2025
June 21, 2025 at 10:43 PM
Intriguing findings from a high-quality prospective study on SVT in #pregnancy and #postpartum. Incident higher, heterogeneous treatment, but low rate of #DVT and #PE. I was surprised and so were the authors. Would love to see the full results.

#ISTH2025
June 21, 2025 at 6:13 PM
Having fun and enjoying excellent science #ISTH2025 now on to my favourite topic #pregnancy and #thrombosis. Interesting cohort study on #LMWH - with therapeutic dose postpartum - still VTE. I think it could be a problem with adherence even though this was assessed by self-reporting
June 21, 2025 at 5:32 PM
Great to be here! #ISTH2025. Looking forward to hearing and supporting all excellent science and scientists from all over the world. #thrombosis
June 20, 2025 at 5:34 PM
I have been quiet on the socials for a while, but very excited to be on my way to @isth.org #ISTH2025 ✈️. Let's hope that Bluesky gets to fly too!
And I also just realized that it has been 30 years since my first @isth.org meeting in 1995. I haven't missed one single congress. #thrombosis
June 19, 2025 at 8:52 AM
Large international multicenter cohort study showing that DOACs are a good option to treat cerebral venous thrombosis. Kudos to @jonathancoutinho20.bsky.social and team for pulling this off!
authors.elsevier.com/c/1ke765FFzL...
February 20, 2025 at 7:14 AM