Jim Stewart
@jim-ca.bsky.social
Mitochondrial biologist, expat Canadian, currently in Newcastle Upon Tyne.
https://orcid.org/0000-0002-2902-4968
https://orcid.org/0000-0002-2902-4968
Pinned
Jim Stewart
@jim-ca.bsky.social
· Jan 30
Correcting a pathogenic mitochondrial DNA mutation by base editing in mice
A mitochondrial DNA editor can make compensatory corrections for a pathological mitochondrial DNA mutation in mice.
www.science.org
Another fantastic piece of work from Carlos Moraes' group. Using mitochondrial DdCBE base editors to correct a pathogenic mutation in our heteroplasmic m.5024C>T mice. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jim Stewart
Latest paper in collaboration with the Nicholls lab 🎉 Out in @narjournal.bsky.social
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Proteolytic cleavage activates the mitochondrial isoform of TOP3A
Abstract. The TOP3A gene encodes two isoforms, one targeted to the nucleus and one to mitochondria. Nuclear TOP3A functions as part of the BTRR complex to
academic.oup.com
November 26, 2025 at 9:15 AM
Latest paper in collaboration with the Nicholls lab 🎉 Out in @narjournal.bsky.social
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Jim Stewart
A brilliant explainer from The Lily Foundation on the science behind genetic diagnosis in mitochondrial disease — featuring cake as a metaphor! 🍰
youtu.be/MCx4joZJtFY
#Mito #MitochondrialDisease #GeneticTesting #RareDisease #ClinicalResearch #TheLilyFoundation
youtu.be/MCx4joZJtFY
#Mito #MitochondrialDisease #GeneticTesting #RareDisease #ClinicalResearch #TheLilyFoundation
The recipe for explaining how mitochondrial disease is diagnosed #mito #geneticdisorder #raredisease
YouTube video by The Lily Foundation
youtu.be
November 7, 2025 at 2:23 PM
A brilliant explainer from The Lily Foundation on the science behind genetic diagnosis in mitochondrial disease — featuring cake as a metaphor! 🍰
youtu.be/MCx4joZJtFY
#Mito #MitochondrialDisease #GeneticTesting #RareDisease #ClinicalResearch #TheLilyFoundation
youtu.be/MCx4joZJtFY
#Mito #MitochondrialDisease #GeneticTesting #RareDisease #ClinicalResearch #TheLilyFoundation
A chance to come join Gavin Hudson, Oliver Russell and myself at the Mitochondrial Research Group at Newcastle University.
MRC DiMeN Doctoral Training Partnership: Fuelling the Fight: The role of Innate Immunity in Mitochondrial Disease at Newcastle University.
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Fuelling the Fight: The role of Innate Immunity in Mitochondrial Disease at Newcastle University.
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Fuelling the Fight: The role of Innate Immunity in Mitochondrial Disease at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Fuelling the Fight: The role of Innate Immunity in Mitochondrial Disease at Newcastle University, listed on FindAPhD.com
www.findaphd.com
November 3, 2025 at 12:54 PM
A chance to come join Gavin Hudson, Oliver Russell and myself at the Mitochondrial Research Group at Newcastle University.
MRC DiMeN Doctoral Training Partnership: Fuelling the Fight: The role of Innate Immunity in Mitochondrial Disease at Newcastle University.
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Fuelling the Fight: The role of Innate Immunity in Mitochondrial Disease at Newcastle University.
www.findaphd.com/phds/project...
Reposted by Jim Stewart
Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 9, 2025 at 9:43 PM
Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Reposted by Jim Stewart
Why would anyone want to be a scientist?
"Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection."
journals.biologists.com/jcs/article/...
"Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection."
journals.biologists.com/jcs/article/...
September 7, 2025 at 12:06 PM
Why would anyone want to be a scientist?
"Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection."
journals.biologists.com/jcs/article/...
"Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection."
journals.biologists.com/jcs/article/...
Reposted by Jim Stewart
Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
August 5, 2025 at 10:01 AM
Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
There's a live job ad for a Post-Grad or Post-doc level Bioinformatician position withing the Newcastle Mitohondrial Research Group @mitonewcastle.bsky.social, funded through the LifeArc Centre for Rare Mitochondrial Diseases
www.jobs.ac.uk/job/DNW541/r...
www.jobs.ac.uk/job/DNW541/r...
Research Associate (Bioinformatician) at Newcastle University
Apply for the Research Associate (Bioinformatician) role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
July 23, 2025 at 3:54 PM
There's a live job ad for a Post-Grad or Post-doc level Bioinformatician position withing the Newcastle Mitohondrial Research Group @mitonewcastle.bsky.social, funded through the LifeArc Centre for Rare Mitochondrial Diseases
www.jobs.ac.uk/job/DNW541/r...
www.jobs.ac.uk/job/DNW541/r...
8 healthy babies after Mitochondrial Donation treatment - Press Office - Newcastle University share.google/iaZoEyfgHHd9...
Eight babies born after Mitochondrial donation
The UK’s pioneering licensed IVF technique to reduce the risk of mitochondrial diseases carried out in Newcastle has seen eight babies born, published research shows.
share.google
July 17, 2025 at 7:18 AM
8 healthy babies after Mitochondrial Donation treatment - Press Office - Newcastle University share.google/iaZoEyfgHHd9...
Reposted by Jim Stewart
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
July 17, 2025 at 1:25 AM
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Jim Stewart
Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...
July 2, 2025 at 1:44 PM
Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...
Reposted by Jim Stewart
📢 Exciting 3-year funded PhD opportunity 🧠
Prof Bobby McFarland and Dr Laura Smith are advertising for a PhD student to join their lab at the Newcastle Mitochondrial Research Group.
📅 Closing date: 16th July 2025
⏰ Start date: 15th September 2025
To apply: www.findaphd.com/phds/project...
Prof Bobby McFarland and Dr Laura Smith are advertising for a PhD student to join their lab at the Newcastle Mitochondrial Research Group.
📅 Closing date: 16th July 2025
⏰ Start date: 15th September 2025
To apply: www.findaphd.com/phds/project...
PhD studentship - Understanding the causes and identifying treatments for Alpers’ syndrome at Newcastle University on FindAPhD.com
PhD Project - PhD studentship - Understanding the causes and identifying treatments for Alpers’ syndrome at Newcastle University, listed on FindAPhD.com
www.findaphd.com
June 26, 2025 at 11:39 AM
📢 Exciting 3-year funded PhD opportunity 🧠
Prof Bobby McFarland and Dr Laura Smith are advertising for a PhD student to join their lab at the Newcastle Mitochondrial Research Group.
📅 Closing date: 16th July 2025
⏰ Start date: 15th September 2025
To apply: www.findaphd.com/phds/project...
Prof Bobby McFarland and Dr Laura Smith are advertising for a PhD student to join their lab at the Newcastle Mitochondrial Research Group.
📅 Closing date: 16th July 2025
⏰ Start date: 15th September 2025
To apply: www.findaphd.com/phds/project...
Reposted by Jim Stewart
Yesterday, @carlbergstrom.com presented his course "Modern-day Oracles or BS Machines? How to thrive in a ChatGPT world". Neat way to make students aware of the capacities and limitations of LLMs👇🎰
Recording: www.youtube.com/watch?v=TZC0...
Course: thebullshitmachines.com
@unswbabs.bsky.social
Recording: www.youtube.com/watch?v=TZC0...
Course: thebullshitmachines.com
@unswbabs.bsky.social
Modern Day Oracles or Bullshit Machines? Seminar with Prof. Carl Bergstrom, University of Washington
YouTube video by UNSW eLearning
www.youtube.com
June 26, 2025 at 4:11 AM
Yesterday, @carlbergstrom.com presented his course "Modern-day Oracles or BS Machines? How to thrive in a ChatGPT world". Neat way to make students aware of the capacities and limitations of LLMs👇🎰
Recording: www.youtube.com/watch?v=TZC0...
Course: thebullshitmachines.com
@unswbabs.bsky.social
Recording: www.youtube.com/watch?v=TZC0...
Course: thebullshitmachines.com
@unswbabs.bsky.social
Reposted by Jim Stewart
We are excited to join friends and colleagues from @lilyfoundation.bsky.social , @mdukcharity.bsky.social , @uniofcam.bsky.social and @ucl.ac.uk
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease
May 14, 2025 at 4:07 PM
We are excited to join friends and colleagues from @lilyfoundation.bsky.social , @mdukcharity.bsky.social , @uniofcam.bsky.social and @ucl.ac.uk
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease
Reposted by Jim Stewart
Meet the minds behind the LifeArc Centre for Rare Mitochondrial Diseases
Hear the excitement from the project leads as they hope to transform the mitochondrial research landscape, and meet mito patient Harry, who reminds us why this work matters
www.thelilyfoundation.org.uk/affected-by-...
Hear the excitement from the project leads as they hope to transform the mitochondrial research landscape, and meet mito patient Harry, who reminds us why this work matters
www.thelilyfoundation.org.uk/affected-by-...
May 22, 2025 at 2:15 PM
Meet the minds behind the LifeArc Centre for Rare Mitochondrial Diseases
Hear the excitement from the project leads as they hope to transform the mitochondrial research landscape, and meet mito patient Harry, who reminds us why this work matters
www.thelilyfoundation.org.uk/affected-by-...
Hear the excitement from the project leads as they hope to transform the mitochondrial research landscape, and meet mito patient Harry, who reminds us why this work matters
www.thelilyfoundation.org.uk/affected-by-...
Reposted by Jim Stewart
Perfect title to this article: “When everything is a master regulator, nothing is”
From MBoC
Dr. Robert Krauss, Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, wants to bring clarity to a classic biology term: “master regulator.” What should it really mean? ➡️ www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Dr. Robert Krauss, Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, wants to bring clarity to a classic biology term: “master regulator.” What should it really mean? ➡️ www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
May 15, 2025 at 11:45 AM
Perfect title to this article: “When everything is a master regulator, nothing is”
Reposted by Jim Stewart
I was connected by a writer from The Scientist magazine who was interested in some of my work. Here is what they wrote:
www.the-scientist.com/mitochondria...
www.the-scientist.com/mitochondria...
Mitochondrial DNA: A Maternal Legacy That Helps Trace the Past and Diagnose the Future
The mitochondrial genome can help researchers map ancestry and better understand the inheritance of mitochondrial diseases.
www.the-scientist.com
May 14, 2025 at 3:33 PM
I was connected by a writer from The Scientist magazine who was interested in some of my work. Here is what they wrote:
www.the-scientist.com/mitochondria...
www.the-scientist.com/mitochondria...
Reposted by Jim Stewart
@newcastleuni.bsky.social @nihrnewcastlebrc.bsky.social @medicalsciencesncl.bsky.social @neygenomics.bsky.social
We are excited to join friends and colleagues from @lilyfoundation.bsky.social , @mdukcharity.bsky.social , @uniofcam.bsky.social and @ucl.ac.uk
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease
at the House of Lords to launch the new LifeArc Centre for Rare Mitochondrial Disease
#mitodisease
May 14, 2025 at 4:17 PM
Reposted by Jim Stewart
What to find the Bluesky acount for one of our researchers? Here' a handy-dandy starter pack for you.
go.bsky.app/98NSnmp
go.bsky.app/98NSnmp
May 14, 2025 at 12:21 PM
What to find the Bluesky acount for one of our researchers? Here' a handy-dandy starter pack for you.
go.bsky.app/98NSnmp
go.bsky.app/98NSnmp
Reposted by Jim Stewart
We’re proud that the @lifearc.bsky.social Centre for Rare Mitochondrial Diseases has officially launched at a prestigious House of Lords event – a significant milestone in transforming the UK’s rare disease research landscape
Stay tuned to meet the lead minds behind the centre on our Research Zone!
Stay tuned to meet the lead minds behind the centre on our Research Zone!
May 14, 2025 at 10:31 AM
We’re proud that the @lifearc.bsky.social Centre for Rare Mitochondrial Diseases has officially launched at a prestigious House of Lords event – a significant milestone in transforming the UK’s rare disease research landscape
Stay tuned to meet the lead minds behind the centre on our Research Zone!
Stay tuned to meet the lead minds behind the centre on our Research Zone!
Reposted by Jim Stewart
"I think that the word is being misused. Extinction's forever. It's irreversible...I think it's a really dangerous precedent to claim we can fix some of these irreversible problems," @dieterhochuli.bsky.social says on the podcast.
The U. of Sydney ecologist unpacks what's wrong with 'de-extinction'
The U. of Sydney ecologist unpacks what's wrong with 'de-extinction'
‘De-extinction’ isn’t just misleading — it’s dangerous, ecologist says
A biotech company in the United States made headlines last month by revealing photos of genetically modified gray wolves, calling them “dire wolves,” a species that hasn’t existed for more than 10,000...
news.mongabay.com
May 6, 2025 at 9:48 PM
"I think that the word is being misused. Extinction's forever. It's irreversible...I think it's a really dangerous precedent to claim we can fix some of these irreversible problems," @dieterhochuli.bsky.social says on the podcast.
The U. of Sydney ecologist unpacks what's wrong with 'de-extinction'
The U. of Sydney ecologist unpacks what's wrong with 'de-extinction'
Reposted by Jim Stewart
Latest from Jonas Treebak and team @cbmr.science
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…
www.sciencedirect.com
April 30, 2025 at 3:49 PM
Latest from Jonas Treebak and team @cbmr.science
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
Reposted by Jim Stewart
The de-extinction of the dire wolves?
"Colossal Baloney"— @stemcells.bsky.social
www.latimes.com/business/sto...
@latimes.com by @hiltzikm.bsky.social
"Colossal Baloney"— @stemcells.bsky.social
www.latimes.com/business/sto...
@latimes.com by @hiltzikm.bsky.social
April 27, 2025 at 3:00 PM
The de-extinction of the dire wolves?
"Colossal Baloney"— @stemcells.bsky.social
www.latimes.com/business/sto...
@latimes.com by @hiltzikm.bsky.social
"Colossal Baloney"— @stemcells.bsky.social
www.latimes.com/business/sto...
@latimes.com by @hiltzikm.bsky.social
Reposted by Jim Stewart
Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...
April 25, 2025 at 10:35 AM
Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...
Reposted by Jim Stewart
Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
April 22, 2025 at 6:41 PM
Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...