Emiliano Sotelo
@jemilianosf.bsky.social
PhD student @crg.eu Interested in #bioinformatics #genomics #generegulation #transposons #evolution #popgen
Reposted by Emiliano Sotelo
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Emiliano Sotelo
Applications are open for the @crg_eu PhD Programme! 20 fully funded positions — including one in our group through the Evolutionary Medical Genomics ITN.
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
October 23, 2025 at 11:01 AM
Applications are open for the @crg_eu PhD Programme! 20 fully funded positions — including one in our group through the Evolutionary Medical Genomics ITN.
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics.
www.crg.eu/en/content/t...
Reposted by Emiliano Sotelo
📢 The Call for Symposia for SMBE2026 is now open. We warmly invite you to submit a symposium proposal and help shape the scientific content of our annual meeting.
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
September 9, 2025 at 2:13 PM
📢 The Call for Symposia for SMBE2026 is now open. We warmly invite you to submit a symposium proposal and help shape the scientific content of our annual meeting.
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
🗓️ Key dates
Call for symposia: Sep. 1 - Oct. 15
Announcement of accepted symposia: Nov. 3
More information: smbe2026.org/symposia
Reposted by Emiliano Sotelo
Thrilled to share our study sequencing genetic data from tropical mammoths 🏝️🦣. First DNA recovered from Columbian mammoths southern than USA shorturl.at/xjIvy. Thanks to all collaborators, you were key to this success! See below a fantastic note covering the paper by the great @rpocisv.bsky.social 👇
Columbian mammoth mitogenomes from Mexico uncover the species’ complex evolutionary history
Paleogenomic studies suggest that Mammuthus columbi derives from an ancient hybridization between Mammuthus primigenius and Mammuthus trogontherii. While its habitat spanned from North to Central Amer...
shorturl.at
August 29, 2025 at 2:06 AM
Thrilled to share our study sequencing genetic data from tropical mammoths 🏝️🦣. First DNA recovered from Columbian mammoths southern than USA shorturl.at/xjIvy. Thanks to all collaborators, you were key to this success! See below a fantastic note covering the paper by the great @rpocisv.bsky.social 👇
Reposted by Emiliano Sotelo
Reposted by Emiliano Sotelo
'Here, we show that transcription factor (TF) proteins, key players in gene regulation, can increase mutagenesis from replication errors by directly competing with the recognition of DNA mismatches by MutSα, the primary initiator of eukaryotic mismatch repair'
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized
hypermutation at regulatory elements, with implications for cancer and genome evolution.
www.cell.com
July 30, 2025 at 6:08 AM
'Here, we show that transcription factor (TF) proteins, key players in gene regulation, can increase mutagenesis from replication errors by directly competing with the recognition of DNA mismatches by MutSα, the primary initiator of eukaryotic mismatch repair'
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Emiliano Sotelo
[1/8] *New Open-Access Long Read Resource*. We sequenced 1,019 genomes from the 1000 Genomes Project sample cohort using @nanoporetech.com long-read sequencing (LRS) to median 17x coverage. Publication at go.nature.com/4ffPb8f.
@hhu.de @crg.eu @embl.org @impvienna.bsky.social
@hhu.de @crg.eu @embl.org @impvienna.bsky.social
July 24, 2025 at 9:26 AM
[1/8] *New Open-Access Long Read Resource*. We sequenced 1,019 genomes from the 1000 Genomes Project sample cohort using @nanoporetech.com long-read sequencing (LRS) to median 17x coverage. Publication at go.nature.com/4ffPb8f.
@hhu.de @crg.eu @embl.org @impvienna.bsky.social
@hhu.de @crg.eu @embl.org @impvienna.bsky.social
Reposted by Emiliano Sotelo
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
tinyurl.com
July 23, 2025 at 3:12 PM
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Reposted by Emiliano Sotelo
Researchers have significantly expanded the catalogue of known human genetic variation. Two studies in @nature.com resequenced data from the landmark 1000 Genomes Project with long-read tech, creating what may be the most complete overview of the human genome to date. www.nature.com/articles/s41...
Structural variation in 1,019 diverse humans based on long-read sequencing - Nature
Intermediate-coverage long-read sequencing in 1,019 diverse humans from the 1000 Genomes Project, representing 26 populations, enables the generation of comprehensive population-scale structural varia...
www.nature.com
July 23, 2025 at 3:50 PM
Researchers have significantly expanded the catalogue of known human genetic variation. Two studies in @nature.com resequenced data from the landmark 1000 Genomes Project with long-read tech, creating what may be the most complete overview of the human genome to date. www.nature.com/articles/s41...
Reposted by Emiliano Sotelo
Over 1,000 human genomes sequenced using long-read tech—Siegfried Schloissnig, computer scientist at the IMP, shares how it happened, key findings, and what it means for the future of genomics: www.imp.ac.at/news/article...
➡️Read the paper here: www.nature.com/articles/s41...
➡️Read the paper here: www.nature.com/articles/s41...
July 23, 2025 at 3:11 PM
Over 1,000 human genomes sequenced using long-read tech—Siegfried Schloissnig, computer scientist at the IMP, shares how it happened, key findings, and what it means for the future of genomics: www.imp.ac.at/news/article...
➡️Read the paper here: www.nature.com/articles/s41...
➡️Read the paper here: www.nature.com/articles/s41...
Reposted by Emiliano Sotelo
Listening to former #RegRNALab member (now in the Moreno Lab) Jose Antonio Corona, presenting the #LatinCells project,seeking to characterise the genetic diversity of immune cells. Lots of extreme field work done for sampling indigenous populations across Latin America! 🌎
#SMBE2025
#SMBE2025
July 22, 2025 at 8:55 AM
Listening to former #RegRNALab member (now in the Moreno Lab) Jose Antonio Corona, presenting the #LatinCells project,seeking to characterise the genetic diversity of immune cells. Lots of extreme field work done for sampling indigenous populations across Latin America! 🌎
#SMBE2025
#SMBE2025
Reposted by Emiliano Sotelo
Thanks @lecteroide.bsky.social for the opportunity to share the efforts developed in MexOmics
www.the-scientist.com/mexomics-map...
www.the-scientist.com/mexomics-map...
MexOMICs Maps the Genetic and Social Landscape of Disease in Mexico
By focusing on twins and patients with lupus and Parkinson’s disease, a Mexican consortium is generating critical data to understand health and disease in the country.
www.the-scientist.com
July 2, 2025 at 6:51 PM
Thanks @lecteroide.bsky.social for the opportunity to share the efforts developed in MexOmics
www.the-scientist.com/mexomics-map...
www.the-scientist.com/mexomics-map...
Reposted by Emiliano Sotelo
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Reposted by Emiliano Sotelo
VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.
FlyBase Homepage
FlyBase: a database for drosophila genetics and molecular biology
flybase.org
June 12, 2025 at 1:45 PM
VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.
Reposted by Emiliano Sotelo
Check out our new preprint!
How can we get more out of existing protein/genome language models without retraining them?
How can we get more out of existing protein/genome language models without retraining them?
New preprint in collaboration with @paulinanunezv.bsky.social supervised by @jonnyfrazer.bsky.social and Mafalda Dias – we propose a simple approach to improving zero-shot variant effect prediction in pre-existing protein and genome language models: 🧶 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
From Likelihood to Fitness: Improving Variant Effect Prediction in Protein and Genome Language Models
Generative models trained on natural sequences are increasingly used to predict the effects of genetic variation, enabling progress in therapeutic design, disease risk prediction, and synthetic biolog...
www.biorxiv.org
May 26, 2025 at 8:31 PM
Check out our new preprint!
How can we get more out of existing protein/genome language models without retraining them?
How can we get more out of existing protein/genome language models without retraining them?
Reposted by Emiliano Sotelo
A 🧵 to walk those interested through this paper...
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are
induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
www.cell.com
May 16, 2025 at 4:50 PM
A 🧵 to walk those interested through this paper...
Reposted by Emiliano Sotelo
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...
www.nature.com
May 7, 2025 at 3:23 PM
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Reposted by Emiliano Sotelo
Participate in the Bioconductor community by sharing your work in a meeting designed to maximize interactivity and productivity at the seafront of Barcelona! 👩💻🏖️🧬 #EuroBiocC2025
⏳ Time’s running out! Submit your abstract for #EuroBioC2025 by 24 April.
Join us this Sept in Barcelona to share your research, meet the #Bioconductor community & explore all things #Bioinformatics + #RStats.
👉 eurobioc2025.bioconductor.org/pages/submis...
Join us this Sept in Barcelona to share your research, meet the #Bioconductor community & explore all things #Bioinformatics + #RStats.
👉 eurobioc2025.bioconductor.org/pages/submis...
April 22, 2025 at 4:51 PM
Participate in the Bioconductor community by sharing your work in a meeting designed to maximize interactivity and productivity at the seafront of Barcelona! 👩💻🏖️🧬 #EuroBiocC2025
Reposted by Emiliano Sotelo
🎉 Announcing the EuroBioC2025 Sticker Winner!
🏆 Chaima Hkimi’s design features the Sagrada Família, Park Güell colours, and a nod to Bioconductor in the text. Pick up the sticker at #EuroBioC2025!
#Bioconductor #Bioinformatics #RStats #StickerContest
🏆 Chaima Hkimi’s design features the Sagrada Família, Park Güell colours, and a nod to Bioconductor in the text. Pick up the sticker at #EuroBioC2025!
#Bioconductor #Bioinformatics #RStats #StickerContest
March 31, 2025 at 7:00 PM
🎉 Announcing the EuroBioC2025 Sticker Winner!
🏆 Chaima Hkimi’s design features the Sagrada Família, Park Güell colours, and a nod to Bioconductor in the text. Pick up the sticker at #EuroBioC2025!
#Bioconductor #Bioinformatics #RStats #StickerContest
🏆 Chaima Hkimi’s design features the Sagrada Família, Park Güell colours, and a nod to Bioconductor in the text. Pick up the sticker at #EuroBioC2025!
#Bioconductor #Bioinformatics #RStats #StickerContest
Reposted by Emiliano Sotelo
"We should include eugenics in our undergraduate classes, reminding students that scientists must speak out when others lie about science and use it to further their political views," says professor @peiferlabunc.bsky.social.
www.cell.com/trends/genet...
@cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
@cp-trendsgenetics.bsky.social
March 31, 2025 at 5:04 PM
"We should include eugenics in our undergraduate classes, reminding students that scientists must speak out when others lie about science and use it to further their political views," says professor @peiferlabunc.bsky.social.
www.cell.com/trends/genet...
@cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
@cp-trendsgenetics.bsky.social
Reposted by Emiliano Sotelo
Newly published in Genetics:
academic.oup.com/genetics/adv...
We ask what gene flow & introgression do to gene coexpression networks. The answer is: a lot.
academic.oup.com/genetics/adv...
We ask what gene flow & introgression do to gene coexpression networks. The answer is: a lot.
March 27, 2025 at 6:13 PM
Newly published in Genetics:
academic.oup.com/genetics/adv...
We ask what gene flow & introgression do to gene coexpression networks. The answer is: a lot.
academic.oup.com/genetics/adv...
We ask what gene flow & introgression do to gene coexpression networks. The answer is: a lot.
Reposted by Emiliano Sotelo
Polymorphic transposable elements contribute to variation in recombination landscapes (drosohila 🪰) www.pnas.org/doi/full/10.... #TEsky
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
March 24, 2025 at 9:01 PM
Polymorphic transposable elements contribute to variation in recombination landscapes (drosohila 🪰) www.pnas.org/doi/full/10.... #TEsky
Reposted by Emiliano Sotelo
longcallD is a new variant caller for genomic long reads. It jointly calls phased small and structural variants. Single binary, one command line for the whole process. Comparable accuracy to mainstream callers. Great work by Yan Gao. github.com/yangao07/lon...
GitHub - yangao07/longcallD: A local-haplotagging-based small and structural variant caller
A local-haplotagging-based small and structural variant caller - yangao07/longcallD
github.com
March 24, 2025 at 4:53 PM
longcallD is a new variant caller for genomic long reads. It jointly calls phased small and structural variants. Single binary, one command line for the whole process. Comparable accuracy to mainstream callers. Great work by Yan Gao. github.com/yangao07/lon...
Reposted by Emiliano Sotelo
#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition
DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.
doi.org
March 21, 2025 at 3:14 PM
#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...
Reposted by Emiliano Sotelo
Does the smell and flavor of strawberries depend on variations in gene-associated transposons? It seems so! Check out our new preprint! www.biorxiv.org/content/10.1...
Naturally occurring variation in gene-associated transposable elements impacts gene expression and phenotypic diversity in woodland strawberry
Transposable elements (TEs) constitute a major portion of plant genomes and play key roles in shaping genome architecture, regulating gene expression, and driving genome evolution. In this study, we g...
www.biorxiv.org
March 21, 2025 at 12:57 PM
Does the smell and flavor of strawberries depend on variations in gene-associated transposons? It seems so! Check out our new preprint! www.biorxiv.org/content/10.1...