Jean-Charles Lambert
@jclambert.bsky.social
Team leader, neuroscientist specialized in genetics and post-genomics of Alzheimer’s disease. in EN or/ou en FR 🇫🇷🇪🇺🏳️🌈
In this preprint, the main consortia working on Alzheimer GWAS combined their efforts to validate an detect new loci associated with AD risk.
We observed 91 genome-wide significant signals (16 nove) . Among these 91 loci, 56 of them are specifically detected in clinically diagnosed AD cases.
We observed 91 genome-wide significant signals (16 nove) . Among these 91 loci, 56 of them are specifically detected in clinically diagnosed AD cases.
Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia https://www.medrxiv.org/content/10.1101/2025.10.20.25338060v1
October 24, 2025 at 12:30 AM
In this preprint, the main consortia working on Alzheimer GWAS combined their efforts to validate an detect new loci associated with AD risk.
We observed 91 genome-wide significant signals (16 nove) . Among these 91 loci, 56 of them are specifically detected in clinically diagnosed AD cases.
We observed 91 genome-wide significant signals (16 nove) . Among these 91 loci, 56 of them are specifically detected in clinically diagnosed AD cases.
Reposted by Jean-Charles Lambert
🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease”
Join the network or DM for more info
Join the network or DM for more info
August 27, 2025 at 8:09 AM
🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease”
Join the network or DM for more info
Join the network or DM for more info
In this preprint led by Devrim Kilinc and Pierre Dourlen, we observed that differential expression of BIN1 isoforms in the presynaptic part leads to differential synaptotoxicity. BIN1 isoforms could contribute to the synaptic loss observed in Alzheimer's disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity
Alzheimer’s disease (AD) is characterized by a strong genetic predisposition and by an early loss of synaptic connectivity that strongly correlates with cognitive deficit. Some genetic determinants co...
www.biorxiv.org
August 24, 2025 at 8:05 AM
In this preprint led by Devrim Kilinc and Pierre Dourlen, we observed that differential expression of BIN1 isoforms in the presynaptic part leads to differential synaptotoxicity. BIN1 isoforms could contribute to the synaptic loss observed in Alzheimer's disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
In this preprint, primarily conducted by Dolores Siedlecki, we established a neuron-microglia co-culture model within the synaptic chamber of a microfluidic device. This compartmented approach enables us to study synapse phagocytosis in close proximity to microglia.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture model
Microglia play a critical role in synapse remodeling and neuroinflammation, both of which are dysregulated in Alzheimer′s disease (AD). However, most in vitro models rely on neonatal or immortalized m...
www.biorxiv.org
August 24, 2025 at 7:48 AM
In this preprint, primarily conducted by Dolores Siedlecki, we established a neuron-microglia co-culture model within the synaptic chamber of a microfluidic device. This compartmented approach enables us to study synapse phagocytosis in close proximity to microglia.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jean-Charles Lambert
Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community.
reeserichardson.blog/2025/08/04/a...
reeserichardson.blog/2025/08/04/a...
A do-or-die moment for the scientific enterprise
Reflecting on our paper “The entities enabling scientific fraud at scale are large, resilient, and growing rapidly”
reeserichardson.blog
August 4, 2025 at 8:47 PM
Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community.
reeserichardson.blog/2025/08/04/a...
reeserichardson.blog/2025/08/04/a...
In this new EADB preprint led by Ole Andreassen, we present an improved polygenic hazard score model for AD that demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation
Objectives Polygenic hazard score (PHS) models can be used to predict the age-associated risk for complex diseases, including Alzheimer’s disease (AD). In this study, we present an improved PHS model ...
www.medrxiv.org
August 2, 2025 at 9:28 AM
In this new EADB preprint led by Ole Andreassen, we present an improved polygenic hazard score model for AD that demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Happy cat on my belly
July 30, 2025 at 7:08 PM
Happy cat on my belly
A new EADB paper published in Nature Communications and led by Kristel Van Steen, Cornelia Van Duijn and Valentina Escott-Price.
We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer.
www.nature.com/articles/s41...
We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer.
www.nature.com/articles/s41...
Machine learning in Alzheimer’s disease genetics - Nature Communications
Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional...
www.nature.com
July 23, 2025 at 1:29 PM
A new EADB paper published in Nature Communications and led by Kristel Van Steen, Cornelia Van Duijn and Valentina Escott-Price.
We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer.
www.nature.com/articles/s41...
We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer.
www.nature.com/articles/s41...
Reposted by Jean-Charles Lambert
Finally out in Nature genetics !
A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries.
www.nature.com/articles/s41...
A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries.
www.nature.com/articles/s41...
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations - Nature Genetics
Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary ...
www.nature.com
June 18, 2025 at 10:33 AM
Finally out in Nature genetics !
A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries.
www.nature.com/articles/s41...
A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries.
www.nature.com/articles/s41...
Reposted by Jean-Charles Lambert
Trump’s cuts to more than 1700 #NIH grants get court hearing www.science.org/content/arti... by @sarareardon.bsky.social @science.org
#Alzheimers #dementia #neuroscience #science
#Alzheimers #dementia #neuroscience #science
Trump’s cuts to more than 1700 NIH grants get court hearing
District judge could declare terminations unlawful—or toss suit based on technicalities
www.science.org
June 15, 2025 at 1:21 PM
Trump’s cuts to more than 1700 #NIH grants get court hearing www.science.org/content/arti... by @sarareardon.bsky.social @science.org
#Alzheimers #dementia #neuroscience #science
#Alzheimers #dementia #neuroscience #science
Reposted by Jean-Charles Lambert
This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.
June 11, 2025 at 12:55 AM
This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.
Reposted by Jean-Charles Lambert
Announcing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9
June 10, 2025 at 4:28 PM
Announcing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9
Reposted by Jean-Charles Lambert
Here is a direct link to the open access article @amit-das.bsky.social mentions. alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Tempting to say it feels like a miracle, but this progress always comes down to dedicated study participants, brilliant scientists, and reliably funded science.
June 6, 2025 at 9:09 PM
Here is a direct link to the open access article @amit-das.bsky.social mentions. alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Tempting to say it feels like a miracle, but this progress always comes down to dedicated study participants, brilliant scientists, and reliably funded science.
Reposted by Jean-Charles Lambert
I went in search of cygnets. Still not hatched so had to make do with a heron fishing instead. Look at those feet!
#UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha
#UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha
May 24, 2025 at 4:10 PM
I went in search of cygnets. Still not hatched so had to make do with a heron fishing instead. Look at those feet!
#UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha
#UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha
Currently visiting the Medieval Museum in Barcelona. This was painted in 1210…
May 22, 2025 at 6:26 PM
Currently visiting the Medieval Museum in Barcelona. This was painted in 1210…
In this report, to improve our understanding of the genetic architecture of AD in the context of its main genetic driver, the EADB consortium and collaborators performed the largest global genome-wide association studies stratified by ε4 and ε2 carrier status.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers’s disease
Among the more than 90 identified genetic risk loci for late-onset Alzheimer’s disease (AD) and related dementias, the apolipoprotein E gene ( APOE ) ɛ2/ɛ3/ɛ4 polymorphism remains the longstanding ben...
www.medrxiv.org
May 12, 2025 at 5:38 PM
In this report, to improve our understanding of the genetic architecture of AD in the context of its main genetic driver, the EADB consortium and collaborators performed the largest global genome-wide association studies stratified by ε4 and ε2 carrier status.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
And definitively accepted after more than a month of editing to meet all the publisher's requirements.
Finally accepted “in principle”
In Nature Genetics … 18 months of hard works because of massive revisions (that strongly improved the manuscript to be honest). A long journey finally successful. What a relief …
In Nature Genetics … 18 months of hard works because of massive revisions (that strongly improved the manuscript to be honest). A long journey finally successful. What a relief …
Revision submitted last Friday and sent back for review 😔
I was really hoping for a quick and positive answer from the editor … Clearly less confident at present
I was really hoping for a quick and positive answer from the editor … Clearly less confident at present
April 29, 2025 at 5:47 PM
And definitively accepted after more than a month of editing to meet all the publisher's requirements.
Reposted by Jean-Charles Lambert
'BIN1 and Alzheimer’s disease: the tau connection'
by Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis & Jean-Charles Lambert @jclambert.bsky.social
www.cell.com/trends/neuro...
by Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis & Jean-Charles Lambert @jclambert.bsky.social
www.cell.com/trends/neuro...
April 29, 2025 at 12:25 PM
'BIN1 and Alzheimer’s disease: the tau connection'
by Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis & Jean-Charles Lambert @jclambert.bsky.social
www.cell.com/trends/neuro...
by Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis & Jean-Charles Lambert @jclambert.bsky.social
www.cell.com/trends/neuro...
When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
BIN1 and Alzheimer’s disease: the tau connection
Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In …
www.sciencedirect.com
April 22, 2025 at 5:15 AM
When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jean-Charles Lambert
Quick guide to understand your cat
April 18, 2025 at 12:54 PM
Quick guide to understand your cat
Reposted by Jean-Charles Lambert
am pleased to share our letter, highlighting that the science does not yet support regulatory approval of amyloid-targeting therapies for AD based solely on biomarker evidence.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
alz-journals.onlinelibrary.wiley.com/doi/full/10....
The science does not yet support regulatory approval of amyloid‐targeting therapies for Alzheimer's disease based solely on biomarker evidence
Click on the article title to read more.
alz-journals.onlinelibrary.wiley.com
April 17, 2025 at 6:58 PM
am pleased to share our letter, highlighting that the science does not yet support regulatory approval of amyloid-targeting therapies for AD based solely on biomarker evidence.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
alz-journals.onlinelibrary.wiley.com/doi/full/10....
She's 8 years old and it sometimes seems like she still looks like a teenage cat. Admittedly, she's a very small size
April 15, 2025 at 5:38 AM
She's 8 years old and it sometimes seems like she still looks like a teenage cat. Admittedly, she's a very small size
Reposted by Jean-Charles Lambert
Join us at @pasteurlille.bsky.social ! We're hiring a Facility Manager specializing in human iPSCs, organoids, and organ-on-chip technologies. Drive innovation in cutting-edge biomedical research. Apply now!
Contact Dr Alexandre Grassart
#CDP @univlille.bsky.social @cnrs-hautsdefrance.bsky.social
Contact Dr Alexandre Grassart
#CDP @univlille.bsky.social @cnrs-hautsdefrance.bsky.social
March 14, 2025 at 8:30 AM
Join us at @pasteurlille.bsky.social ! We're hiring a Facility Manager specializing in human iPSCs, organoids, and organ-on-chip technologies. Drive innovation in cutting-edge biomedical research. Apply now!
Contact Dr Alexandre Grassart
#CDP @univlille.bsky.social @cnrs-hautsdefrance.bsky.social
Contact Dr Alexandre Grassart
#CDP @univlille.bsky.social @cnrs-hautsdefrance.bsky.social
Reposted by Jean-Charles Lambert
📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣
Plus d'infos sur le mouvement 👉 standupforscience.fr
#pasteurlille
Plus d'infos sur le mouvement 👉 standupforscience.fr
#pasteurlille
March 7, 2025 at 3:28 PM
📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣
Plus d'infos sur le mouvement 👉 standupforscience.fr
#pasteurlille
Plus d'infos sur le mouvement 👉 standupforscience.fr
#pasteurlille