@jasonsims89.bsky.social
Italian - American scientist interested in DNA repair, repetitive DNA and Ribosome Heterogeneity. Microscopy and Imaging enthusiasts. Nanopore aficionado.
Reposted
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
November 23, 2025 at 3:47 PM
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
Reposted
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
November 21, 2025 at 8:20 AM
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
Reposted
We've teamed up with Axion BioSystems to bring you the Maestro Pro™ MEA system and neural media for both functional cultures and publication-ready data. 🤝
📍 Learn more at booth #1521! #SfN25
📍 Learn more at booth #1521! #SfN25
November 18, 2025 at 7:55 PM
We've teamed up with Axion BioSystems to bring you the Maestro Pro™ MEA system and neural media for both functional cultures and publication-ready data. 🤝
📍 Learn more at booth #1521! #SfN25
📍 Learn more at booth #1521! #SfN25
Reposted
Register for the next EuSARC conference in Oslo, Norway, in June 2026
oslocancercluster.no/events/8th-e...
oslocancercluster.no/events/8th-e...
November 15, 2025 at 8:26 PM
Register for the next EuSARC conference in Oslo, Norway, in June 2026
oslocancercluster.no/events/8th-e...
oslocancercluster.no/events/8th-e...
Reposted
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted
Multilingualism is associated with a reduced risk of accelerated ageing, according to data from more than 86,000 people across 27 European countries published in Nature Aging. go.nature.com/4hWRpLh #medsky 🧪
November 11, 2025 at 2:36 PM
Multilingualism is associated with a reduced risk of accelerated ageing, according to data from more than 86,000 people across 27 European countries published in Nature Aging. go.nature.com/4hWRpLh #medsky 🧪
Reposted
We are proud to see Peter Peneder, formerly with the Tomazou group, contributing to such an impressive project!
🗨️Chat with your cells, explore #CellWhisperer!
CeMM PI Christoph Bock (@bocklab.bsky.social) together with @meduniwien.ac.at & @stanna-ccri.bsky.social have developed a new #AI tool that lets scientists explore single-cell data using plain English.
➡️ https://bit.ly/3JQqe87
📄 https://bit.ly/3WJCxGi
CeMM PI Christoph Bock (@bocklab.bsky.social) together with @meduniwien.ac.at & @stanna-ccri.bsky.social have developed a new #AI tool that lets scientists explore single-cell data using plain English.
➡️ https://bit.ly/3JQqe87
📄 https://bit.ly/3WJCxGi
November 11, 2025 at 10:29 AM
We are proud to see Peter Peneder, formerly with the Tomazou group, contributing to such an impressive project!
Reposted
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 5, 2025 at 10:59 AM
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
Reposted
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
Reposted
Another opportunity to join @maxperutzlabs.ac.at !
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
Tenure-Track Professorship in Genome Biology - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12848567
Launch your lab at the Max Perutz Labs and join us in our mission to analyze and reconstitute complex biological systems across scales.
www.nature.com
November 4, 2025 at 2:43 PM
Another opportunity to join @maxperutzlabs.ac.at !
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
Reposted
Reposted
Check out our new paper @jci.org
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
JCI -
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org
October 17, 2025 at 6:31 PM
Check out our new paper @jci.org
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
Reposted
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 15, 2025 at 2:08 PM
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Reposted
RNA biology is a major research focus at the Perutz - and the new @fwf-at.bsky.social grants strengthen it even further 🙌 Elif Karagöz and Pavel Kovarik will investigate how RNA-binding proteins regulate cellular stress and immune responses ➡️ tinyurl.com/2s3f3mu8
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
October 16, 2025 at 2:09 PM
RNA biology is a major research focus at the Perutz - and the new @fwf-at.bsky.social grants strengthen it even further 🙌 Elif Karagöz and Pavel Kovarik will investigate how RNA-binding proteins regulate cellular stress and immune responses ➡️ tinyurl.com/2s3f3mu8
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
Reposted
A new method called VIPS enables organ-wide nanoscale reconstruction for quantitative mapping of connectivity and molecular landscape in intact tissue.
Learn more this week in Science: https://scim.ag/4n4GKPm
Learn more this week in Science: https://scim.ag/4n4GKPm
October 16, 2025 at 6:05 PM
A new method called VIPS enables organ-wide nanoscale reconstruction for quantitative mapping of connectivity and molecular landscape in intact tissue.
Learn more this week in Science: https://scim.ag/4n4GKPm
Learn more this week in Science: https://scim.ag/4n4GKPm
Reposted
❓Why does a fusion oncogene cause Ewing sarcoma only in certain cells?
Hana Bernhardova from the Tomazou Lab at St. Anna CCRI, who recently received the BIF PhD Fellowship, is building a new model from pluripotent stem cells.
Details: 🔗 ccri.at/bif-fellowsh...
Hana Bernhardova from the Tomazou Lab at St. Anna CCRI, who recently received the BIF PhD Fellowship, is building a new model from pluripotent stem cells.
Details: 🔗 ccri.at/bif-fellowsh...
BIF Fellowship: Building Ewing Sarcoma Models from Scratch - St. Anna CCRI
BIF Fellowship: Building Ewing Sarcoma Models from Scratch Due to a lack of good models and an unknown cell of origin, Ewing sarcoma still poses a great puzzle in childhood cancer research. Hana Bernh...
ccri.at
October 13, 2025 at 8:41 AM
❓Why does a fusion oncogene cause Ewing sarcoma only in certain cells?
Hana Bernhardova from the Tomazou Lab at St. Anna CCRI, who recently received the BIF PhD Fellowship, is building a new model from pluripotent stem cells.
Details: 🔗 ccri.at/bif-fellowsh...
Hana Bernhardova from the Tomazou Lab at St. Anna CCRI, who recently received the BIF PhD Fellowship, is building a new model from pluripotent stem cells.
Details: 🔗 ccri.at/bif-fellowsh...
Reposted
Acidosis is not just a byproduct of an altere Metabolism - it drives cancer cells‘ stress resilience mechanisms. Big congratulations to our friends from the @johanneszuber.bsky.social lab as well as the team around @wilhelmpalm.bsky.social on this wonderful story now out in Science.
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 13, 2025 at 8:09 PM
Acidosis is not just a byproduct of an altere Metabolism - it drives cancer cells‘ stress resilience mechanisms. Big congratulations to our friends from the @johanneszuber.bsky.social lab as well as the team around @wilhelmpalm.bsky.social on this wonderful story now out in Science.
Reposted
Off he is ...
Ulrich is one of the most remarkable scientists I had the pleasure to work with. I learned so much from him about biochemistry, proteins, structural biology, and so much more.
Great people make great things happen.
The really great people are rare.
Ulrich is one of them ...
Ulrich is one of the most remarkable scientists I had the pleasure to work with. I learned so much from him about biochemistry, proteins, structural biology, and so much more.
Great people make great things happen.
The really great people are rare.
Ulrich is one of them ...
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology.
PhD positions available!
October 12, 2025 at 9:15 PM
Off he is ...
Ulrich is one of the most remarkable scientists I had the pleasure to work with. I learned so much from him about biochemistry, proteins, structural biology, and so much more.
Great people make great things happen.
The really great people are rare.
Ulrich is one of them ...
Ulrich is one of the most remarkable scientists I had the pleasure to work with. I learned so much from him about biochemistry, proteins, structural biology, and so much more.
Great people make great things happen.
The really great people are rare.
Ulrich is one of them ...
Reposted
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.
www.nature.com
October 6, 2025 at 6:57 AM
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Reposted
Nature research paper: Holliday junction–ZMM protein feedback enables meiotic crossover assurance
go.nature.com/42JHXnV
go.nature.com/42JHXnV
Holliday junction–ZMM protein feedback enables meiotic crossover assurance - Nature
Holliday junctions maintain chromosome synapsis to enable crossover assurance in budding yeast.
go.nature.com
September 30, 2025 at 7:47 AM
Nature research paper: Holliday junction–ZMM protein feedback enables meiotic crossover assurance
go.nature.com/42JHXnV
go.nature.com/42JHXnV
Reposted
✨New paper from the lab! ✨
We present a fun study aimed at characterizing the interaction between the H3K4me3 reader Spp1 and the meiotic double-strand break protein Mer2, and their relationship with DNA binding. We got some new insights and a few surprises.🧵
www.biorxiv.org/content/10.1...
We present a fun study aimed at characterizing the interaction between the H3K4me3 reader Spp1 and the meiotic double-strand break protein Mer2, and their relationship with DNA binding. We got some new insights and a few surprises.🧵
www.biorxiv.org/content/10.1...
Insights into the recruitment of the H3K4me3 reader Spp1 by the meiotic double-strand break protein Mer2
The formation of DNA double-strand breaks (DSBs) by Spo11 is tied to the loop-axis organization of meiotic chromosomes. Prior to DSB formation, chromatin loops marked by histone H3K4 trimethylation be...
www.biorxiv.org
September 28, 2025 at 6:15 PM
✨New paper from the lab! ✨
We present a fun study aimed at characterizing the interaction between the H3K4me3 reader Spp1 and the meiotic double-strand break protein Mer2, and their relationship with DNA binding. We got some new insights and a few surprises.🧵
www.biorxiv.org/content/10.1...
We present a fun study aimed at characterizing the interaction between the H3K4me3 reader Spp1 and the meiotic double-strand break protein Mer2, and their relationship with DNA binding. We got some new insights and a few surprises.🧵
www.biorxiv.org/content/10.1...
Reposted
Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
September 25, 2025 at 7:04 AM
Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
Reposted
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 24, 2025 at 9:45 PM
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇