Janos Groh
@janos-groh.bsky.social
Neurobiologist interested in myelin, inflammation, and degeneration of the diseased and aging nervous system.
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
October 29, 2025 at 3:01 PM
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Reposted by Janos Groh
Join us 10/30 for a Labroots webinar with Dr. Janos Groh: From Myelin Damage to Immune Dysfunction: Unravelling the Aging Brain. Hear how single-cell + spatial transcriptomics reveal glial–immune interactions driving neurodegeneration.
Register: hubs.ly/Q03N0rVJ0
Register: hubs.ly/Q03N0rVJ0
From Myelin Damage to Immune Dysfunction: Unraveling the Aging Brain
Aging is associated with progressive white matter degeneration, which impairs brain structure and function. Defects in myelinating glial cells, combined with chronic neuroinflammation, contr
hubs.ly
October 20, 2025 at 11:31 PM
Join us 10/30 for a Labroots webinar with Dr. Janos Groh: From Myelin Damage to Immune Dysfunction: Unravelling the Aging Brain. Hear how single-cell + spatial transcriptomics reveal glial–immune interactions driving neurodegeneration.
Register: hubs.ly/Q03N0rVJ0
Register: hubs.ly/Q03N0rVJ0
Reposted by Janos Groh
Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging
Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience
How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...
doi.org
August 12, 2025 at 9:12 PM
Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging
Reposted by Janos Groh
Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative
diseases. This study reveals that the interferon-induced immunoproteasome drastically
decreases proteasomal ac...
www.cell.com
June 17, 2025 at 7:18 PM
Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
Reposted by Janos Groh
New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cells drive white matter degeneration in aging brains.
Learn more: vizgen.com/study-publis...
#SpatialBiology
Learn more: vizgen.com/study-publis...
#SpatialBiology
June 17, 2025 at 2:31 PM
New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cells drive white matter degeneration in aging brains.
Learn more: vizgen.com/study-publis...
#SpatialBiology
Learn more: vizgen.com/study-publis...
#SpatialBiology
Reposted by Janos Groh
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 13, 2025 at 1:27 PM
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Now published in the June issue @natneuro.nature.com
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover.
#Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple.
Thanks @elisaflo.bsky.social & team!
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover.
#Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple.
Thanks @elisaflo.bsky.social & team!
June 10, 2025 at 4:23 AM
Now published in the June issue @natneuro.nature.com
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover.
#Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple.
Thanks @elisaflo.bsky.social & team!
I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover.
#Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple.
Thanks @elisaflo.bsky.social & team!
Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience
White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...
www.nature.com
May 22, 2025 at 10:21 AM
Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
Reposted by Janos Groh
Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury: Neuron www.cell.com/neuron/fullt...
Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury
Ge et al. report a maladaptive innate/adaptive immune axis in which CXCR6+CD8+ T cells,
recruited by glycolytically reprogrammed microglia/macrophage-derived CXCL16 chemokines,
play an important role ...
www.cell.com
May 5, 2025 at 2:45 PM
Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury: Neuron www.cell.com/neuron/fullt...
Reposted by Janos Groh
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration
Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...
www.biorxiv.org
April 28, 2025 at 9:09 AM
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
Reposted by Janos Groh
Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
April 23, 2025 at 2:45 PM
Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky
Reposted by Janos Groh
💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
March 6, 2025 at 12:50 PM
💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!
Reposted by Janos Groh
What is the role of oligodendrocytes and myelin in the pathophysiology of Alzheimer's disease? Really excited to see this review published in @natureneuro.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience
Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.
www.nature.com
January 30, 2025 at 3:01 PM
What is the role of oligodendrocytes and myelin in the pathophysiology of Alzheimer's disease? Really excited to see this review published in @natureneuro.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Janos Groh
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying
cerebral plaque burden depending on the parental source of the transgene. Mice inheriting
the transgene paternally...
www.cell.com
January 20, 2025 at 3:49 PM
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging @cp-neuron.bsky.social
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
White matter aging and its impact on brain function
Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.
www.cell.com
January 9, 2025 at 8:09 PM
How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging @cp-neuron.bsky.social
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Janos Groh
To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by Axel Guskjolen.
We hope you enjoy every single piece of it as much as we do!
www.cell.com/neuron/current
We hope you enjoy every single piece of it as much as we do!
www.cell.com/neuron/current
January 8, 2025 at 4:18 PM
To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by Axel Guskjolen.
We hope you enjoy every single piece of it as much as we do!
www.cell.com/neuron/current
We hope you enjoy every single piece of it as much as we do!
www.cell.com/neuron/current
Reposted by Janos Groh
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 18, 2024 at 10:40 PM
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵