James Briscoe
@jamesbriscoe.bsky.social
Developmental Biologist working at the Francis Crick Institute. Neural tube, morphogens, and gene regulatory networks. Editor-in-chief, Development.
London · briscoelab.org
London · briscoelab.org
Pinned
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted by James Briscoe
Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.
Congrats to Giulia and co 🍾🥂
Congrats to Giulia and co 🍾🥂
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
November 11, 2025 at 7:36 AM
Lates from the Briscoe lab: Lineage tracing of neural progenitors in 🐤& 👤 - demonstrates sequential binary decisions & persistence of spatial identity despite temporal competence changes.
Congrats to Giulia and co 🍾🥂
Congrats to Giulia and co 🍾🥂
Reposted by James Briscoe
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
BBC News - James Watson: Controversial discoverer of 'the secret of life'
www.bbc.com/news/article...
www.bbc.com/news/article...
Obituary: James Watson
James Watson, the godfather of DNA who discovered the "secrets of life" has died aged 97.
www.bbc.com
November 7, 2025 at 8:43 PM
BBC News - James Watson: Controversial discoverer of 'the secret of life'
www.bbc.com/news/article...
www.bbc.com/news/article...
Working in a biomed institute, its natural to think about health & medical impact of dev bio but there's more to dev bio
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
In preprints: multiomics of low temperature acclimation in the era of intensifying temperature fluctuations
In a warming world, all life forms – endotherms and ectotherms alike – are finding their homeostasis being challenged. The environmental change is challenging at all stages of life. How different orga...
journals.biologists.com
November 5, 2025 at 12:33 PM
Working in a biomed institute, its natural to think about health & medical impact of dev bio but there's more to dev bio
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
Agriculture is dev bio (plant growth, livestock breeding)
And dev bio is important to understand environment & climate impact. See e.g:
journals.biologists.com/dev/article/...
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Volume 152 Issue 20 | Development | The Company of Biologists
journals.biologists.com
November 5, 2025 at 8:54 AM
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Reposted by James Briscoe
November 5, 2025 at 2:01 AM
Looking forward to a day with the developmental biologists at WashU in St Louis.
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
44th Annual Oliver H. Lowry Lecture: 'The Dynamics of Neural Tube Development'
happenings.wustl.edu
October 30, 2025 at 1:07 PM
Looking forward to a day with the developmental biologists at WashU in St Louis.
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
Honoured to be giving the 44th Annual Oliver H. Lowry Lecture
4pm Jeffrey T. Fort NRB Building, Auditorium
happenings.wustl.edu/event/44th-a...
Reposted by James Briscoe
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Evolutionarily conserved transcriptional regulators control monoaminergic neuron development
To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in ...
doi.org
October 30, 2025 at 9:42 AM
New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...
Good to see this study from Ribes & co in print: PAX3/PAX7 transcription factors control neural tube patterning by simultaneously repressing ventral fates via H3K27me3 deposition at silencers & activating dorsal fates as pioneer factors at enhancers
@ribes
journals.plos.org/plosbiology/...
@ribes
journals.plos.org/plosbiology/...
Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks
How do transcription factors, with pleotropic functions, generate organized cellular diversity in developing tissues? This study shows that PAX3 and PAX7 orchestrate spinal cord patterning by acting a...
journals.plos.org
October 29, 2025 at 3:21 PM
Good to see this study from Ribes & co in print: PAX3/PAX7 transcription factors control neural tube patterning by simultaneously repressing ventral fates via H3K27me3 deposition at silencers & activating dorsal fates as pioneer factors at enhancers
@ribes
journals.plos.org/plosbiology/...
@ribes
journals.plos.org/plosbiology/...
Looking forward to a day visiting friends and colleagues at @stowersinstitute.bsky.social
Seminar at noon
www.stowers.org
Seminar at noon
www.stowers.org
Home
Home
www.stowers.org
October 28, 2025 at 1:02 PM
Looking forward to a day visiting friends and colleagues at @stowersinstitute.bsky.social
Seminar at noon
www.stowers.org
Seminar at noon
www.stowers.org
Reposted by James Briscoe
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted by James Briscoe
Beautiful, insightful study from Boezio et al. One of the best clonal analyses I’ve seen so far. We’ll dig in this week! Check it out!
October 26, 2025 at 8:22 PM
Beautiful, insightful study from Boezio et al. One of the best clonal analyses I’ve seen so far. We’ll dig in this week! Check it out!
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted by James Briscoe
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by James Briscoe
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
October 24, 2025 at 5:23 PM
Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
Reposted by James Briscoe
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
October 17, 2025 at 1:11 PM
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
Reposted by James Briscoe
Mansi Srivastava is a Guest Editor for our Special Issue on Lifelong Development #LifelongDevSI. In this interview, Mansi talks about her research path, the links between regeneration and development and the exciting questions her lab is trying to answer.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
October 16, 2025 at 4:45 PM
Mansi Srivastava is a Guest Editor for our Special Issue on Lifelong Development #LifelongDevSI. In this interview, Mansi talks about her research path, the links between regeneration and development and the exciting questions her lab is trying to answer.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by James Briscoe
1953: The Company launches the Journal of Embryology and Experimental Morphology. In 1987, JEEM is renamed Development @dev-journal.bsky.social. Read their 100-year anniversary articles collection: bit.ly/42vDGED
October 15, 2025 at 12:03 PM
1953: The Company launches the Journal of Embryology and Experimental Morphology. In 1987, JEEM is renamed Development @dev-journal.bsky.social. Read their 100-year anniversary articles collection: bit.ly/42vDGED
Looking forward to a day at EMBL Barcelona for Science by the Beach
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
European Molecular Biology Laboratory
With support from more than 30 countries, laboratories at six locations across Europe and thousands of scientists and engineers working together, the European Molecular Biology Laboratory is a powerho...
EMBL.org
October 14, 2025 at 6:38 AM
Looking forward to a day at EMBL Barcelona for Science by the Beach
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by James Briscoe
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted by James Briscoe
It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
October 8, 2025 at 1:15 PM
It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
This year's Crick @crick.ac.uk PhD programme is open for applications
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
Briscoe Lab | Cellular Dynamics and Pattern Formation in Vertebrate Development
www.crick.ac.uk
October 6, 2025 at 11:37 AM
This year's Crick @crick.ac.uk PhD programme is open for applications
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...