@hasselljames.bsky.social
Neuro/metabolism post doc @ CU Anschutz | Learning & Memory | 🐀🧠
Reposted
🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!
Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
Molecular Psychiatry - Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
urldefense.com
May 24, 2025 at 6:35 PM
🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!
Reposted
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Reposted
Fantastic new article by Dr. Christy Niemeyer on the disproportionate burden of Alzheimer's disease on women. @csniemeyerphd.bsky.social
sciencerabbit.org/2025/04/04/w...
sciencerabbit.org/2025/04/04/w...
Why are women twice as likely to get Alzheimer’s disease?
Explore the complexities of Alzheimer's disease and its disproportionate impact on women, influenced by hormonal and societal factors.
sciencerabbit.org
May 1, 2025 at 4:02 PM
Fantastic new article by Dr. Christy Niemeyer on the disproportionate burden of Alzheimer's disease on women. @csniemeyerphd.bsky.social
sciencerabbit.org/2025/04/04/w...
sciencerabbit.org/2025/04/04/w...
Reposted
This piece from @tressiemcphd.bsky.social starts with a bang and just gets better and better. Gift link.
Opinion | The Tech Fantasy That Powers A.I. Is Running on Fumes (Gift Article)
A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.
www.nytimes.com
March 29, 2025 at 6:48 PM
This piece from @tressiemcphd.bsky.social starts with a bang and just gets better and better. Gift link.
Reposted
I wrote a piece for @thetransmitter.bsky.social www.thetransmitter.org/sex-differen... With the fate of NIH-funded research uncertain, it is extra important that the work we do now is most likely to benefit everyone. Adhering to SABV in the lab and in grant & paper review is the right thing to do.
Amid NIH upheaval, how to keep sex as a biological variable
Even in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices.
www.thetransmitter.org
March 25, 2025 at 1:43 PM
I wrote a piece for @thetransmitter.bsky.social www.thetransmitter.org/sex-differen... With the fate of NIH-funded research uncertain, it is extra important that the work we do now is most likely to benefit everyone. Adhering to SABV in the lab and in grant & paper review is the right thing to do.
@aoc.bsky.social and @sanders.senate.gov anti-oligarchy rally in Denver, CO!
March 22, 2025 at 11:54 AM
@aoc.bsky.social and @sanders.senate.gov anti-oligarchy rally in Denver, CO!
Reposted
Thank you @sanders.senate.gov and @aoc.bsky.social for rallying us together, and not dividing us apart! #denver #fightoligarchy
March 22, 2025 at 4:45 AM
Thank you @sanders.senate.gov and @aoc.bsky.social for rallying us together, and not dividing us apart! #denver #fightoligarchy
Reposted
New review from the lab!
Do #microglia metabolize #fructose in #Alzheimers Disease?
rdcu.be/edIRM
Big congrats to the first author @AnnaliseSturno for all her hard work 💪🏻👩🏻🔬💪🏻
Do #microglia metabolize #fructose in #Alzheimers Disease?
rdcu.be/edIRM
Big congrats to the first author @AnnaliseSturno for all her hard work 💪🏻👩🏻🔬💪🏻
March 16, 2025 at 1:35 PM
New review from the lab!
Do #microglia metabolize #fructose in #Alzheimers Disease?
rdcu.be/edIRM
Big congrats to the first author @AnnaliseSturno for all her hard work 💪🏻👩🏻🔬💪🏻
Do #microglia metabolize #fructose in #Alzheimers Disease?
rdcu.be/edIRM
Big congrats to the first author @AnnaliseSturno for all her hard work 💪🏻👩🏻🔬💪🏻
Why would a commercial software use 0's for missing values????
March 15, 2025 at 2:16 AM
Why would a commercial software use 0's for missing values????
Reposted
More than ever we need to talk about the importance of our "basic research" in public and political forums. Kudos to #AnnaliseSturno and @neurohassell.bsky.social for getting out there and sharing their work on fructose metabolism and Alzheimers Disease at #Denver #Capitol
March 12, 2025 at 3:38 PM
More than ever we need to talk about the importance of our "basic research" in public and political forums. Kudos to #AnnaliseSturno and @neurohassell.bsky.social for getting out there and sharing their work on fructose metabolism and Alzheimers Disease at #Denver #Capitol
Reposted
Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing! @projbridgeco.bsky.social @cuanschutz.bsky.social
March 11, 2025 at 6:20 PM
Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing! @projbridgeco.bsky.social @cuanschutz.bsky.social
@lindseyforco.bsky.social & @shannonbird4co.bsky.social I live in y'alls district and will be talking about the link between sugar on the 🧠 and Alzheimer's in @drkimberleybruce.bsky.social 's lab at @cuanschutz.bsky.social with @projbridgeco.bsky.social. Hope to see y'all there!
March 11, 2025 at 12:01 AM
@lindseyforco.bsky.social & @shannonbird4co.bsky.social I live in y'alls district and will be talking about the link between sugar on the 🧠 and Alzheimer's in @drkimberleybruce.bsky.social 's lab at @cuanschutz.bsky.social with @projbridgeco.bsky.social. Hope to see y'all there!
Reposted
I continue to be blown away by the sub-cellular resolution that our new #Nanolive 3D explorer allows. Look at these #microglia go!
March 10, 2025 at 8:45 PM
I continue to be blown away by the sub-cellular resolution that our new #Nanolive 3D explorer allows. Look at these #microglia go!
Reposted
TODAY IS THE DAY! 🧪☀️⬇️
Join us at the Lincoln Memorial or your local site to Stand Up for Science!
Join us at the Lincoln Memorial or your local site to Stand Up for Science!
March 7, 2025 at 11:44 AM
TODAY IS THE DAY! 🧪☀️⬇️
Join us at the Lincoln Memorial or your local site to Stand Up for Science!
Join us at the Lincoln Memorial or your local site to Stand Up for Science!
Reposted
Your lab scissors are actually a parafilmase - a highly specialized enzyme that catalyzes the precise cutting of parafilm through a metal-dependent mechanism
February 16, 2025 at 8:22 PM
Your lab scissors are actually a parafilmase - a highly specialized enzyme that catalyzes the precise cutting of parafilm through a metal-dependent mechanism
Reposted
Join our monthly Getting Started on the OSF webinar every 2nd Monday at 11 AM ET!
Learn how OSF supports open science and streamlines research workflows
🌟 Highlights:
✔ Guided feature tour
✔ Use case exploration
✔ Live Q&A
🔗 Register: cos-io.zoom.us/webin...
Learn how OSF supports open science and streamlines research workflows
🌟 Highlights:
✔ Guided feature tour
✔ Use case exploration
✔ Live Q&A
🔗 Register: cos-io.zoom.us/webin...
January 9, 2025 at 1:00 PM
Join our monthly Getting Started on the OSF webinar every 2nd Monday at 11 AM ET!
Learn how OSF supports open science and streamlines research workflows
🌟 Highlights:
✔ Guided feature tour
✔ Use case exploration
✔ Live Q&A
🔗 Register: cos-io.zoom.us/webin...
Learn how OSF supports open science and streamlines research workflows
🌟 Highlights:
✔ Guided feature tour
✔ Use case exploration
✔ Live Q&A
🔗 Register: cos-io.zoom.us/webin...
Reposted
A Black woman named Aliyah was struggling to find work. So, she catfished herself and made a fake profile on LinkedIn named "Emily." Emily had the same qualifications as Aliyah but received 57.9% of interview invites while Aliyah received 8.9%
This is what we mean when we say racism is systemic.
This is what we mean when we say racism is systemic.
January 26, 2025 at 4:37 AM
A Black woman named Aliyah was struggling to find work. So, she catfished herself and made a fake profile on LinkedIn named "Emily." Emily had the same qualifications as Aliyah but received 57.9% of interview invites while Aliyah received 8.9%
This is what we mean when we say racism is systemic.
This is what we mean when we say racism is systemic.
I think I finally got the hang of surface mount resistors. Version 7.1 is a different piecing together project for sure.
January 24, 2025 at 6:11 PM
I think I finally got the hang of surface mount resistors. Version 7.1 is a different piecing together project for sure.
Back at it again! @csniemeyerphd.bsky.social @kravitzlab.com
January 17, 2025 at 7:25 PM
Back at it again! @csniemeyerphd.bsky.social @kravitzlab.com
Reposted
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 26, 2024 at 5:31 PM
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Question for science Bluesky. Does 4% PFA during cell fixation permeabilize cell membranes?
November 20, 2024 at 12:13 AM
Question for science Bluesky. Does 4% PFA during cell fixation permeabilize cell membranes?
Reposted
🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)
Read it here: www.nature.com/articles/s41...
Read it here: www.nature.com/articles/s41...
November 19, 2024 at 4:50 PM
🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)
Read it here: www.nature.com/articles/s41...
Read it here: www.nature.com/articles/s41...
Reposted
#CUAnschutz researchers are among the first to recognize how Herpes simplex virus type 1 infiltrates the brain, leading to a better understanding of how it may trigger neurological diseases. The study was recently published in the Journal of Virology. ⬇️🧠
Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain
Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain
news.cuanschutz.edu
November 13, 2024 at 5:26 PM
#CUAnschutz researchers are among the first to recognize how Herpes simplex virus type 1 infiltrates the brain, leading to a better understanding of how it may trigger neurological diseases. The study was recently published in the Journal of Virology. ⬇️🧠
Reposted
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…
www.sciencedirect.com
November 15, 2024 at 4:37 PM
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted
A quick note to all the NewSkys: there really isn’t algorithm here. We depend on each other to spread the word. So if you want others to see something, repost it. Liking something adds it to your feed but doesn’t surface it for others.
November 8, 2024 at 4:18 PM
A quick note to all the NewSkys: there really isn’t algorithm here. We depend on each other to spread the word. So if you want others to see something, repost it. Liking something adds it to your feed but doesn’t surface it for others.