New Year, new paper from our lab. Emily Kramer used 3D light-sheet imaging and tissue clearing to examine the spatial architecture of mouse amygdala engram ensembles.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Examining the Three‐Dimensional Spatial Architecture of Mouse Amygdala Engram Ensembles
Memories are stored in a sparse population of neurons active at the time of an event, an engram ensemble, and reactivation of the engram ensemble drives memory recall. Although the amygdala is essent...
onlinelibrary.wiley.com
January 1, 2026 at 2:43 PM
New Year, new paper from our lab. Emily Kramer used 3D light-sheet imaging and tissue clearing to examine the spatial architecture of mouse amygdala engram ensembles.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by SJo
New paper from @ykneurores.bsky.social in our lab 📢
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
Body size predicts the selection of defensive behavioral strategies
Survival depends on the ability to respond appropriately to threats, yet the selection of defensive behaviors varies among individuals with distinct b…
www.sciencedirect.com
December 24, 2025 at 12:32 AM
New paper from @ykneurores.bsky.social in our lab 📢
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
We show body size predicts defensive behavioral strategy; smaller animals adopt active avoidance, larger ones favor freezing, while sex and age don’t drive the effect. A clear demonstration that traits matter.
www.sciencedirect.com/science/arti...
Will find way to incorporate this into next talk! 🫶
Frontiers | Taylor Swift versus Mozart: music preferences of C57BL/6J mice
IntroductionMusic has become an established complementary element of modern medicine, demonstrating beneficial effects towards various diseases such as demen...
www.frontiersin.org
December 3, 2025 at 12:46 AM
Will find way to incorporate this into next talk! 🫶
Reposted by SJo
Join us for Fall 2026. In our group, you can run studies from human behavior and neuroimaging, to large-scale NHP ephys, and join them up with a robust computational foundation. Bonus: you can help build the reading list.
The Sensorimotor Superlab with @gribblelab.org and @andpru.bsky.social is a unique place to work and learn. We are now accepting MSc and PhD applications for Fall 2026. Join our awesome team at Western University... For application instructions see diedrichsenlab.org and gribblelab.org/join.html!
Diedrichsenlab
diedrichsenlab.org
December 2, 2025 at 1:23 PM
Join us for Fall 2026. In our group, you can run studies from human behavior and neuroimaging, to large-scale NHP ephys, and join them up with a robust computational foundation. Bonus: you can help build the reading list.
Reposted by SJo
@okaysteve.bsky.social's How to Change a Memory is out now!
In this book, Ramirez draws on his own memories to reveal how memory can be turned on & off like a switch, edited, & even constructed from nothing.
Explore a free sample: press.princeton.edu/books/hardco...
#Neuroscience #Memory
In this book, Ramirez draws on his own memories to reveal how memory can be turned on & off like a switch, edited, & even constructed from nothing.
Explore a free sample: press.princeton.edu/books/hardco...
#Neuroscience #Memory
December 1, 2025 at 7:03 PM
@okaysteve.bsky.social's How to Change a Memory is out now!
In this book, Ramirez draws on his own memories to reveal how memory can be turned on & off like a switch, edited, & even constructed from nothing.
Explore a free sample: press.princeton.edu/books/hardco...
#Neuroscience #Memory
In this book, Ramirez draws on his own memories to reveal how memory can be turned on & off like a switch, edited, & even constructed from nothing.
Explore a free sample: press.princeton.edu/books/hardco...
#Neuroscience #Memory
Reposted by SJo
Exciting collab with Paul Palme, Peter Imming, & Adrian Richter!
Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f
#MedChem #TB #NTM
pubs.acs.org/doi/full/10....
Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f
#MedChem #TB #NTM
pubs.acs.org/doi/full/10....
Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase
Amides of squaric acid are new drug candidates with activity against mycobacteria. Like the approved drug bedaquiline, these compounds achieve efficacy by inhibiting mycobacterial ATP synthase. Howeve...
pubs.acs.org
November 27, 2025 at 11:53 PM
Exciting collab with Paul Palme, Peter Imming, & Adrian Richter!
Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f
#MedChem #TB #NTM
pubs.acs.org/doi/full/10....
Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f
#MedChem #TB #NTM
pubs.acs.org/doi/full/10....
Reposted by SJo
Brenda Milner showed the world that memory isn’t one thing — the hippocampus supports our life stories, while other circuits let us keep learning skills.
Her research on patient H.M. built the foundation of cognitive neuroscience.
#WomenInScience #MemoryResearch #NeuroHistory
Her research on patient H.M. built the foundation of cognitive neuroscience.
#WomenInScience #MemoryResearch #NeuroHistory
November 25, 2025 at 10:05 PM
Brenda Milner showed the world that memory isn’t one thing — the hippocampus supports our life stories, while other circuits let us keep learning skills.
Her research on patient H.M. built the foundation of cognitive neuroscience.
#WomenInScience #MemoryResearch #NeuroHistory
Her research on patient H.M. built the foundation of cognitive neuroscience.
#WomenInScience #MemoryResearch #NeuroHistory
Reposted by SJo
Love this💕 Thanks @bsneuroendo.bsky.social for giving me the platform to share my story. Everyone should join this amazing society! @infneuroendo.bsky.social
"People who have told me that I can't do things have inspired me to prove them wrong." - @denisebelsham.bsky.social
Watch Denise's full Alison Douglas Lecture on hypothalamic neurons for free as a BSN member (login to mySociety): my.neuroendo.org.uk/...
Watch Denise's full Alison Douglas Lecture on hypothalamic neurons for free as a BSN member (login to mySociety): my.neuroendo.org.uk/...
November 23, 2025 at 4:26 PM
Love this💕 Thanks @bsneuroendo.bsky.social for giving me the platform to share my story. Everyone should join this amazing society! @infneuroendo.bsky.social
Reposted by SJo
📣 #MCCS25 starts TOMORROW! Check out our poster session tomorrow & our symposium on Friday to hear from the best and brightest in molecular and cellular cognition.
More information here: event.fourwaves.com/MCCS25/pages
More information here: event.fourwaves.com/MCCS25/pages
November 12, 2025 at 6:41 PM
📣 #MCCS25 starts TOMORROW! Check out our poster session tomorrow & our symposium on Friday to hear from the best and brightest in molecular and cellular cognition.
More information here: event.fourwaves.com/MCCS25/pages
More information here: event.fourwaves.com/MCCS25/pages
Reposted by SJo
.@andpru.bsky.social CRC in Sensorimotor Neuroscience and @schulichmeddent.bsky.social professor and his collaborators recently published in Nature on how our brains not only plan out our actions, but they actually anticipate unexpected disturbances.
Learn more: news.westernu.ca/2025/10/sens...
Learn more: news.westernu.ca/2025/10/sens...
October 30, 2025 at 2:35 PM
.@andpru.bsky.social CRC in Sensorimotor Neuroscience and @schulichmeddent.bsky.social professor and his collaborators recently published in Nature on how our brains not only plan out our actions, but they actually anticipate unexpected disturbances.
Learn more: news.westernu.ca/2025/10/sens...
Learn more: news.westernu.ca/2025/10/sens...
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
Molecular mechanisms mediating engram ensemble retrievability state in mice
Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…
www.sciencedirect.com
October 30, 2025 at 3:32 PM
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
(1/2)
www.sciencedirect.com/science/arti...
Reposted by SJo
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200
Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.
www.nature.com
October 28, 2025 at 10:06 PM
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
Reposted by SJo
@senapati.bsky.social latest and greatest! Charly Treiber on board too. Over and out.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Visceral signaling of post-ingestive malaise directs memory updating in Drosophila
Consolidation is a time when labile memories transition to a stable form. Malaise learning in Drosophila reveals consolidation to also permit memory updating. Flies taught to associate one of two odor...
www.biorxiv.org
October 23, 2025 at 8:32 PM
@senapati.bsky.social latest and greatest! Charly Treiber on board too. Over and out.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by SJo
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
authors.elsevier.com
October 22, 2025 at 6:50 PM
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
A great read!!!!
@okaysteve.bsky.social's How to Change a Memory is a disarmingly personal account of the new science of memory manipulation.
The #audiobook, read by the author himself, arrives 4 November.
Preorder it today: press.princeton.edu/books/audio/...
#Neuroscience #Science #Memory
The #audiobook, read by the author himself, arrives 4 November.
Preorder it today: press.princeton.edu/books/audio/...
#Neuroscience #Science #Memory
October 22, 2025 at 8:20 AM
A great read!!!!
Reposted by SJo
Enormous thanks to the Chica and Heinz Schaller Foundation for this award!
I am thrilled and truly humbled, & I share it with my lab over the years and our wonderful collaborators!
A timely boost to keep our science moving!
Thanks to everyone for your kind messages!
Looking forward to #FENS2026!
I am thrilled and truly humbled, & I share it with my lab over the years and our wonderful collaborators!
A timely boost to keep our science moving!
Thanks to everyone for your kind messages!
Looking forward to #FENS2026!
The Chica and Heinz Schaller Foundation and #FENS are thrilled to announce the winner of the Chica and Heinz Schaller Foundation Award in Translational Neuroscience 2026: Prof. Carmen Sandi (@carmensandi10.bsky.social)! 🧠
👉 https://loom.ly/Uh0TghU
👉 https://loom.ly/Uh0TghU
October 20, 2025 at 7:11 PM
Enormous thanks to the Chica and Heinz Schaller Foundation for this award!
I am thrilled and truly humbled, & I share it with my lab over the years and our wonderful collaborators!
A timely boost to keep our science moving!
Thanks to everyone for your kind messages!
Looking forward to #FENS2026!
I am thrilled and truly humbled, & I share it with my lab over the years and our wonderful collaborators!
A timely boost to keep our science moving!
Thanks to everyone for your kind messages!
Looking forward to #FENS2026!
Reposted by SJo
Stoked to see this paper finally out!
It answers two big questions: where visual objects are encoded in the brain, and how head-direction cells get oriented using visual landmarks.
Super fun collaboration with @mace-lab.bsky.social and Stuart Trenholm.
www.science.org/doi/10.1126/...
It answers two big questions: where visual objects are encoded in the brain, and how head-direction cells get oriented using visual landmarks.
Super fun collaboration with @mace-lab.bsky.social and Stuart Trenholm.
www.science.org/doi/10.1126/...
September 11, 2025 at 9:13 PM
Stoked to see this paper finally out!
It answers two big questions: where visual objects are encoded in the brain, and how head-direction cells get oriented using visual landmarks.
Super fun collaboration with @mace-lab.bsky.social and Stuart Trenholm.
www.science.org/doi/10.1126/...
It answers two big questions: where visual objects are encoded in the brain, and how head-direction cells get oriented using visual landmarks.
Super fun collaboration with @mace-lab.bsky.social and Stuart Trenholm.
www.science.org/doi/10.1126/...
Reposted by SJo
Good morning everyone!
So, I wrote a book (!!) and it’s coming out November 4th in physical and audiobook form. It’s called *How to Change a Memory*
www.amazon.com/How-Change-M...
So, I wrote a book (!!) and it’s coming out November 4th in physical and audiobook form. It’s called *How to Change a Memory*
www.amazon.com/How-Change-M...
How to Change a Memory: One Neuroscientist’s Quest to Alter the Past
Buy How to Change a Memory: One Neuroscientist’s Quest to Alter the Past on Amazon.com ✓ FREE SHIPPING on qualified orders
www.amazon.com
September 8, 2025 at 1:41 PM
Good morning everyone!
So, I wrote a book (!!) and it’s coming out November 4th in physical and audiobook form. It’s called *How to Change a Memory*
www.amazon.com/How-Change-M...
So, I wrote a book (!!) and it’s coming out November 4th in physical and audiobook form. It’s called *How to Change a Memory*
www.amazon.com/How-Change-M...
Reposted by SJo
After your SfN in San Diego, drift 130 km up the coast to Irvine for a bit more: cncm.medschool.uci.edu/2025-special... Go ahead and register now.
September 7, 2025 at 7:11 PM
After your SfN in San Diego, drift 130 km up the coast to Irvine for a bit more: cncm.medschool.uci.edu/2025-special... Go ahead and register now.
Reposted by SJo
Check out the meeting lineup for #MCCS25! It's going to be an incredible day.
Don't miss out, register now: event.fourwaves.com/MCCS25/pages
Don't miss out, register now: event.fourwaves.com/MCCS25/pages
September 5, 2025 at 2:39 PM
Check out the meeting lineup for #MCCS25! It's going to be an incredible day.
Don't miss out, register now: event.fourwaves.com/MCCS25/pages
Don't miss out, register now: event.fourwaves.com/MCCS25/pages
Reposted by SJo
Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience.
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
Professor - Computational Cognitive Neuroscience
Professor - Computational Cognitive Neuroscience
jobs.utoronto.ca
September 5, 2025 at 8:22 AM
Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience.
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
Reposted by SJo
This is an exquisite demonstration of using intracranial recordings in humans to validate our findings that amygdala neurons encode the value of exploring in NHPs.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rate and noise in human amygdala drive increased exploration in aversive learning - Nature
Human exploration is driven by two distinct neural mechanisms, a valence-independent rate signal and a valence-dependent global noise signal.
www.nature.com
August 31, 2025 at 2:29 PM
This is an exquisite demonstration of using intracranial recordings in humans to validate our findings that amygdala neurons encode the value of exploring in NHPs.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by SJo
News from Canada: The Toronto Blue Jays have broken their single-game dollar hot-dog sales record.
August 27, 2025 at 1:06 AM
News from Canada: The Toronto Blue Jays have broken their single-game dollar hot-dog sales record.
Reposted by SJo
🚨Another PI job opening in the Neuroscience dept. at @umontreal.ca ! 🚨
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Professor at the rank of Assistant or Associate Professor, in the field of neurocircuitry - Montréal, Quebec (CA) job with Université de Montréal | 12843808
Professor at the rank of Assistant or Associate Professor, in the field of neurocircuitry involved in the production of complex behaviors
www.nature.com
August 21, 2025 at 11:57 PM
🚨Another PI job opening in the Neuroscience dept. at @umontreal.ca ! 🚨
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Such a cool technique! Activity history tracing!
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
August 16, 2025 at 10:41 AM
Such a cool technique! Activity history tracing!