Christy Niemeyer, PhD
@csniemeyerphd.bsky.social
Assistant Professor and Principal Investigator @ CU Anschutz, Dept. of Neurology. Neuroscientist, Neurovirologist, Science Advocate
My new article on @sciencerabbit.bsky.social discussing why women make up 2/3 of all Alzheimer’s disease patients.
Fantastic new article by Dr. Christy Niemeyer on the disproportionate burden of Alzheimer's disease on women. @csniemeyerphd.bsky.social
sciencerabbit.org/2025/04/04/w...
sciencerabbit.org/2025/04/04/w...
Why are women twice as likely to get Alzheimer’s disease?
Explore the complexities of Alzheimer's disease and its disproportionate impact on women, influenced by hormonal and societal factors.
sciencerabbit.org
May 1, 2025 at 11:35 PM
My new article on @sciencerabbit.bsky.social discussing why women make up 2/3 of all Alzheimer’s disease patients.
Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing! @projbridgeco.bsky.social @cuanschutz.bsky.social
March 11, 2025 at 6:20 PM
Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing! @projbridgeco.bsky.social @cuanschutz.bsky.social
Check out this article on @sciencerabbit.bsky.social giving a deep dive into The Link Between Shingles and Stroke sciencerabbit.org/2025/02/20/s...
The Link Between Shingles and Stroke Explained
Prof. Andrew Bubak (PhD, MS) - The varicella zoster virus (VZV), primarily known for causing chickenpox and shingles, can reactivate and significantly increase stroke risk. Studies indicate a heighten...
sciencerabbit.org
March 8, 2025 at 12:57 AM
Check out this article on @sciencerabbit.bsky.social giving a deep dive into The Link Between Shingles and Stroke sciencerabbit.org/2025/02/20/s...
Reposted by Christy Niemeyer, PhD
OUT NOW: Human enteric α-defensin 5 interacts with colonic epithelial receptor P2Y11 to induce filopodia and promote Shigella infection
by Kai Ye & co
www.nature.com/articles/s41...
by Kai Ye & co
www.nature.com/articles/s41...
Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11 - Nature Microbiology
HD5 induces filopodial extensions in epithelial cells that the pathogen Shigella exploits to facilitate invasion and infection.
www.nature.com
February 3, 2025 at 6:22 PM
OUT NOW: Human enteric α-defensin 5 interacts with colonic epithelial receptor P2Y11 to induce filopodia and promote Shigella infection
by Kai Ye & co
www.nature.com/articles/s41...
by Kai Ye & co
www.nature.com/articles/s41...
Reposted by Christy Niemeyer, PhD
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service.
“Pausing” grants means people don’t eat.
“Pausing” grants means people don’t eat.
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
www.washingtonpost.com
January 28, 2025 at 3:03 AM
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service.
“Pausing” grants means people don’t eat.
“Pausing” grants means people don’t eat.
Reposted by Christy Niemeyer, PhD
“Shock and awe” at NIH returns to a new version of routine existential terror…
www.science.org/content/arti...
www.science.org/content/arti...
NIH memo addresses ‘confusion’ about restrictions imposed by Trump, easing some concerns
Memo from acting director to staff allows some purchasing, and suggests travel and study sections could soon resume
www.science.org
January 28, 2025 at 12:34 AM
“Shock and awe” at NIH returns to a new version of routine existential terror…
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Christy Niemeyer, PhD
Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art.
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
December 4, 2024 at 8:55 PM
Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art.
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
Reposted by Christy Niemeyer, PhD
How much of age associated #microglia dysfunction in #Alzheimers disease is due to activation of LINE retrotransposons? Fun #openaccess study exploring this hypothesis - worth a read.
#neuroinflammation #neurosky
#neuroinflammation #neurosky
Super excited to be here and to start using this platform with a great news - check out the latest study from the Sher lab published in Acta Neuropathologica reporting on the effect of LINE-1 retrotransposons on microglial function in Alzheimer’s disease 🙂
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction - Acta Neuropathologica
Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to contribute to cellular dysfunction in age-related disorders, including late-ons...
link.springer.com
December 1, 2024 at 9:39 PM
How much of age associated #microglia dysfunction in #Alzheimers disease is due to activation of LINE retrotransposons? Fun #openaccess study exploring this hypothesis - worth a read.
#neuroinflammation #neurosky
#neuroinflammation #neurosky
Reposted by Christy Niemeyer, PhD
In #neuroinflammation, lineage matters….check out this preprint of long term engraftment of blood derived- #macrophages vs brain resident #microglia in #TBI
# neuroskyence
# neuroskyence
Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain Injury https://www.biorxiv.org/content/10.1101/2024.11.18.624186v1
Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain Injury https://www.biorxiv.org/content/10.1101/2024.11.18.624186v1
Traumatic Brain Injury (TBI) is one of the most established environmental risk factors for the devel
www.biorxiv.org
November 21, 2024 at 4:34 AM
In #neuroinflammation, lineage matters….check out this preprint of long term engraftment of blood derived- #macrophages vs brain resident #microglia in #TBI
# neuroskyence
# neuroskyence
Reposted by Christy Niemeyer, PhD
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion https://www.biorxiv.org/content/10.1101/2024.11.18.624173v1
Abnormal lipid metabolism in Alzheimer's disease (AD) was first documented by Alois Alzheimer in his
www.biorxiv.org
November 19, 2024 at 12:08 PM
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
Reposted by Christy Niemeyer, PhD
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 26, 2024 at 5:31 PM
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Christy Niemeyer, PhD
👏 to Tetsuo Hasegawa & others of Clatworthy lab
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology
Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...
www.nature.com
November 26, 2024 at 1:19 PM
👏 to Tetsuo Hasegawa & others of Clatworthy lab
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
Reposted by Christy Niemeyer, PhD
Fluorescent Friday brought to you by microglia (🟢) surrounding HSV-1 infection (🟣) and counterstained with DAPI (🔵). Taken from our recently published paper. journals.asm.org/doi/10.1128/...
November 21, 2024 at 7:04 PM
Fluorescent Friday brought to you by microglia (🟢) surrounding HSV-1 infection (🟣) and counterstained with DAPI (🔵). Taken from our recently published paper. journals.asm.org/doi/10.1128/...
Reposted by Christy Niemeyer, PhD
This threaded discussion on sex differences in mechanisms leading to Alzheimer’s disease and neurodegeneration is worth a read. #microglia, #neuroinflammation
You hit the NAIL ON THE HEAD, Simon. While women and men might 'get there' together, the biological pathways are sometimes (not always) vastly different. There is increasing evidence of immune pathways being implicated (doi.org/10.1093/brai... as one ex). So much more that needs to be discovered.
Sex-specific effects of microglial activation on Alzheimer’s disease proteinopathy in older adults
Using counterfactual causal inference models with human neuropathological data, Casaletto and Nichols et al. find that microglial activation mediates the r
doi.org
November 20, 2024 at 9:50 PM
This threaded discussion on sex differences in mechanisms leading to Alzheimer’s disease and neurodegeneration is worth a read. #microglia, #neuroinflammation
Reposted by Christy Niemeyer, PhD
I love how kind everyone is on Bluesky! X is giving #reviewer2 vibes and Bluesky is like a kind reviewer 1! #Academia #endFTD
November 20, 2024 at 12:44 PM
I love how kind everyone is on Bluesky! X is giving #reviewer2 vibes and Bluesky is like a kind reviewer 1! #Academia #endFTD
Reposted by Christy Niemeyer, PhD
I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.
November 20, 2024 at 5:28 PM
I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.
Reposted by Christy Niemeyer, PhD
I like microglia and I like electron microscopy. Today my new review on microglia ultrastructure came out on Open Biology.
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
November 20, 2024 at 5:38 PM
I like microglia and I like electron microscopy. Today my new review on microglia ultrastructure came out on Open Biology.
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
Reposted by Christy Niemeyer, PhD
Just joined and happy to see our recent work highlighted here!
Virologists identify a key protein behind spread of shingles virus. A Univ of Colorado team discovered a new evasion strategy of varicella zoster virus, the cause of chickenpox & shingles, that may allow it to affect tissues far from the original site of infection medicalxpress.com/news/2024-07...
Scientists identify key protein behind spread of shingles virus
Scientists at the University of Colorado Anschutz Medical Campus have discovered a new evasion strategy used by the varicella zoster virus, which causes chickenpox and shingles, that may allow it to a...
medicalxpress.com
November 18, 2024 at 10:47 PM
Just joined and happy to see our recent work highlighted here!
Reposted by Christy Niemeyer, PhD
Persistently primed microglia restrict the reactivation of latent cytomegalovirus at the expense of neuronal synaptic connectivity #singlecell
https://www.researchsquare.com/article/rs-5144336/latest
https://www.researchsquare.com/article/rs-5144336/latest
October 6, 2024 at 7:40 AM
Persistently primed microglia restrict the reactivation of latent cytomegalovirus at the expense of neuronal synaptic connectivity #singlecell
https://www.researchsquare.com/article/rs-5144336/latest
https://www.researchsquare.com/article/rs-5144336/latest
I’ll start off strong by highlighting the wonderful work we are doing over here!
#CUAnschutz researchers are among the first to recognize how Herpes simplex virus type 1 infiltrates the brain, leading to a better understanding of how it may trigger neurological diseases. The study was recently published in the Journal of Virology. ⬇️🧠
Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain
Silent Intruder: How the Cold Sore Virus Maps its Way Through the Brain
news.cuanschutz.edu
November 18, 2024 at 8:33 PM
I’ll start off strong by highlighting the wonderful work we are doing over here!