Andrew Mendiola
@andrewmendiola.bsky.social
Assistant Professor, UCSD School of Medicine
We study brain Immunology and how innate immunity drives inflammation in multiple sclerosis and Alzheimer’s.
Mendiolalab.com
We study brain Immunology and how innate immunity drives inflammation in multiple sclerosis and Alzheimer’s.
Mendiolalab.com
Pinned
Thrilled to share that I received the NoA for my first R01 “Mechanisms of pathogenic microglial populations in CNS inflammation”. Major milestone for the Lab. Extremely grateful for SS/SRO, PO and everyone else at NINDS for their continued support. Photo of my lab, wife and son, celebrating!
Reposted by Andrew Mendiola
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
November 8, 2025 at 1:58 PM
Bluetorial-Jim Watson
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions.
What follows is my personal perspective.
1/41
Reposted by Andrew Mendiola
Applications are open for the 2026 Zara Weinberg cohort of Leading Edge, named in honor of the incredible, brilliant, fearless @weinberz.witchlab.org.
The LE community has been truly transformative for my scientific journey and my happiness. Please apply!! www.leadingedgesymposium.org/apply/
The LE community has been truly transformative for my scientific journey and my happiness. Please apply!! www.leadingedgesymposium.org/apply/
Apply | leadingedgesymposium
Apply. The 2026 Leading Edge cohort application is now open! This cohort is named the Zara Weinberg Cohort, in honor of 2021 Leading Edge Fellow, Zara Weinberg. Applications are due February 2, 2026.
www.leadingedgesymposium.org
November 6, 2025 at 3:23 AM
Applications are open for the 2026 Zara Weinberg cohort of Leading Edge, named in honor of the incredible, brilliant, fearless @weinberz.witchlab.org.
The LE community has been truly transformative for my scientific journey and my happiness. Please apply!! www.leadingedgesymposium.org/apply/
The LE community has been truly transformative for my scientific journey and my happiness. Please apply!! www.leadingedgesymposium.org/apply/
Reposted by Andrew Mendiola
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 1:18 PM
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
Excited to share some research highlights today during the neuroimmune sessions at KAI2025, beautiful day in Incheon, Korea
October 30, 2025 at 10:38 PM
Excited to share some research highlights today during the neuroimmune sessions at KAI2025, beautiful day in Incheon, Korea
Reposted by Andrew Mendiola
Very pleased to publish this new review with Farah Wahbeh on the role of #EBV in #Multiplesclerosis. I learned a lot writing this, I hope others find it useful too
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Epstein-Barr Virus in Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation
Epstein-Barr virus (EBV) is a very common herpesvirus that infects more than 90% of
the general population. Epidemiologic data indicate that EBV is a requisite risk factor
for the development of multi...
www.neurology.org
September 16, 2025 at 1:51 PM
Very pleased to publish this new review with Farah Wahbeh on the role of #EBV in #Multiplesclerosis. I learned a lot writing this, I hope others find it useful too
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Reposted by Andrew Mendiola
A show of bipartisan support for NIH. Basically flat except for ARPA-H.
The President’s budget proposal basically ignored (as it should have been).
The President’s budget proposal basically ignored (as it should have been).
House LHHC bill is out. Lots of hits to HHS, but the top line number for NIH is 1% decrease, mostly due to cuts ARPA-H. This seems like a huge rejection of the president's budget request.
democrats-appropriations.house.gov
September 2, 2025 at 12:37 AM
A show of bipartisan support for NIH. Basically flat except for ARPA-H.
The President’s budget proposal basically ignored (as it should have been).
The President’s budget proposal basically ignored (as it should have been).
Honored to receive an @alzassociation.bsky.social Research Grant for my project “Role of APOE4-driven microglial mitochondrial dysfunction”. Excited to advance our research on APOE4, neurovascular inflammation, and microglial metabolism in Alzheimer’s disease. Grateful to be #ALZFunded !!
August 21, 2025 at 7:58 PM
Honored to receive an @alzassociation.bsky.social Research Grant for my project “Role of APOE4-driven microglial mitochondrial dysfunction”. Excited to advance our research on APOE4, neurovascular inflammation, and microglial metabolism in Alzheimer’s disease. Grateful to be #ALZFunded !!
Reposted by Andrew Mendiola
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Andrew Mendiola
This is so frustrating. In 2018 I remember thinking how this paper would transform my work since we were already looking at mitophagy. I have cited this paper in 3 of my papers between 2018-2020 and probably every grant application. This guy won a 2021 breakthrough prize in part because of this work
August 21, 2025 at 1:55 PM
This is so frustrating. In 2018 I remember thinking how this paper would transform my work since we were already looking at mitophagy. I have cited this paper in 3 of my papers between 2018-2020 and probably every grant application. This guy won a 2021 breakthrough prize in part because of this work
Reposted by Andrew Mendiola
I have
NIGMS R35, impact score 12
NIHGRI R21, 4th percentile
NHGRI R01, 7th percentile (co-I)
and it seems like none will be funded. 0/3.
PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25."
😭
NIGMS R35, impact score 12
NIHGRI R21, 4th percentile
NHGRI R01, 7th percentile (co-I)
and it seems like none will be funded. 0/3.
PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25."
😭
August 19, 2025 at 11:29 PM
I have
NIGMS R35, impact score 12
NIHGRI R21, 4th percentile
NHGRI R01, 7th percentile (co-I)
and it seems like none will be funded. 0/3.
PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25."
😭
NIGMS R35, impact score 12
NIHGRI R21, 4th percentile
NHGRI R01, 7th percentile (co-I)
and it seems like none will be funded. 0/3.
PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25."
😭
one of the best!
Here you go..." Why strong mentorship was essential for my career success in science" JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors. www.nature.com/articles/d41...
Why strong mentorship was essential for my career success in science
JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors.
www.nature.com
August 20, 2025 at 5:00 AM
one of the best!
Reposted by Andrew Mendiola
Delighted to share this perspective piece by Lewis Yu on microbial regulation of serotonin and neuroimmune interactions. Looking forward to sharing more on this topic soon 🤞 www.sciencedirect.com/science/arti...
Microbial regulation of serotonin and neuroimmune interactions
Bidirectional communication between the gut microbiota and neuroimmune system is essential during host–microbiome interactions. Recent research has be…
www.sciencedirect.com
August 20, 2025 at 2:21 AM
Delighted to share this perspective piece by Lewis Yu on microbial regulation of serotonin and neuroimmune interactions. Looking forward to sharing more on this topic soon 🤞 www.sciencedirect.com/science/arti...
Managed to track down some texas-style bbq in san diego. Gathered the lab to celebrate their accomplishments and keep building our amazing community!
August 14, 2025 at 2:40 PM
Managed to track down some texas-style bbq in san diego. Gathered the lab to celebrate their accomplishments and keep building our amazing community!
Reposted by Andrew Mendiola
The numbers of women in science falls substantially at the transition from postdoc to independent investigator/ PI
So what can we do to prevent this?
One initiative we now organise annually at #EACR is the highly successful 'Women in Leadership' workshop ⏬
#WomenInScience 🧪
@helloeacr.bsky.social
So what can we do to prevent this?
One initiative we now organise annually at #EACR is the highly successful 'Women in Leadership' workshop ⏬
#WomenInScience 🧪
@helloeacr.bsky.social
The EACR’s Women in Leadership workshop returns for 2025 - The Cancer Researcher
Ahead of the EACR 2025 Congress in Lisbon, Portugal, the EACR once again hosted its popular Women in Leadership Workshop on 16 June 2025. The event brought together 26 early-career female cancer resea...
magazine.eacr.org
August 13, 2025 at 1:03 PM
The numbers of women in science falls substantially at the transition from postdoc to independent investigator/ PI
So what can we do to prevent this?
One initiative we now organise annually at #EACR is the highly successful 'Women in Leadership' workshop ⏬
#WomenInScience 🧪
@helloeacr.bsky.social
So what can we do to prevent this?
One initiative we now organise annually at #EACR is the highly successful 'Women in Leadership' workshop ⏬
#WomenInScience 🧪
@helloeacr.bsky.social
Reposted by Andrew Mendiola
200 days in, checking in on HHMI funding opportunities:
Freeman Hrabowski Scholars Program - not accepting applications
Gilliam Fellows Program - not accepting applications
Hanna H. Gray Fellows Program - not accepting applications
Investigator Program - not accepting applications
Freeman Hrabowski Scholars Program - not accepting applications
Gilliam Fellows Program - not accepting applications
Hanna H. Gray Fellows Program - not accepting applications
Investigator Program - not accepting applications
This is not some small foundation -- HHMI has a $24 billion endowment. It is the world's 2nd richest biomedical research foundation.
If any funder can double down on their support for science right now, it's HHMI. But they are doing the opposite.
If any funder can double down on their support for science right now, it's HHMI. But they are doing the opposite.
August 9, 2025 at 4:42 PM
200 days in, checking in on HHMI funding opportunities:
Freeman Hrabowski Scholars Program - not accepting applications
Gilliam Fellows Program - not accepting applications
Hanna H. Gray Fellows Program - not accepting applications
Investigator Program - not accepting applications
Freeman Hrabowski Scholars Program - not accepting applications
Gilliam Fellows Program - not accepting applications
Hanna H. Gray Fellows Program - not accepting applications
Investigator Program - not accepting applications
Reposted by Andrew Mendiola
Just to give the TL;DR on this one:
*The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.
*The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.
This is literally some of the craziest shit I have ever read.
And that's saying a lot.
www.whitehouse.gov/presidential...
And that's saying a lot.
www.whitehouse.gov/presidential...
Improving Oversight of Federal Grantmaking
By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal
www.whitehouse.gov
August 7, 2025 at 10:55 PM
Just to give the TL;DR on this one:
*The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.
*The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.
Thrilled to share that I received the NoA for my first R01 “Mechanisms of pathogenic microglial populations in CNS inflammation”. Major milestone for the Lab. Extremely grateful for SS/SRO, PO and everyone else at NINDS for their continued support. Photo of my lab, wife and son, celebrating!
August 6, 2025 at 11:17 PM
Thrilled to share that I received the NoA for my first R01 “Mechanisms of pathogenic microglial populations in CNS inflammation”. Major milestone for the Lab. Extremely grateful for SS/SRO, PO and everyone else at NINDS for their continued support. Photo of my lab, wife and son, celebrating!
Reposted by Andrew Mendiola
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Reposted by Andrew Mendiola
We need a new microscope objective. A $1.6k tariff for something that you can hold in your hand and that is only manufactured in Germany
August 1, 2025 at 8:50 PM
We need a new microscope objective. A $1.6k tariff for something that you can hold in your hand and that is only manufactured in Germany
www.sciencedirect.com/science/arti... Great review on "Alzheimer’s disease and vascular biology – A focus on the procoagulant state"
August 1, 2025 at 6:56 PM
www.sciencedirect.com/science/arti... Great review on "Alzheimer’s disease and vascular biology – A focus on the procoagulant state"
Surreal…
This is moving.
Kamala Harris feels the pain we feel. Not just from her loss, but from the trauma and abuse our country is living through.
What could have been…
Kamala Harris feels the pain we feel. Not just from her loss, but from the trauma and abuse our country is living through.
What could have been…
August 1, 2025 at 2:15 PM
Surreal…
Reposted by Andrew Mendiola
🔥New preprint from the lab! Led by @rileyirmen.bsky.social
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
Alzheimer's disease (AD) is not only characterized by amyloid-beta (Aβ) and tau pathology, but also by early and progressive disruptions in metabolism. Neuronal excitability is tightly coupled with me...
biorxiv.org
July 31, 2025 at 3:49 PM
🔥New preprint from the lab! Led by @rileyirmen.bsky.social
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
📍 biorxiv.org/content/10.1101/2025.07.25.666872v1
🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease
Reposted by Andrew Mendiola
Happening Now!
Mark-up of Labor, Health, and Human Services
www.appropriations.senate.gov/hearings/ful...
Mark-up of Labor, Health, and Human Services
www.appropriations.senate.gov/hearings/ful...
Full Committee Markup of Defense and Labor, Health and Human Services, and Education Appropriations Acts | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
July 31, 2025 at 3:52 PM
Happening Now!
Mark-up of Labor, Health, and Human Services
www.appropriations.senate.gov/hearings/ful...
Mark-up of Labor, Health, and Human Services
www.appropriations.senate.gov/hearings/ful...
Reposted by Andrew Mendiola
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
July 31, 2025 at 1:53 PM
The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.
"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.