Uri Manor
@manorlaboratory.bsky.social
Ass. Prof & Director Goeddel Family Technology Sandbox; CZI Imaging Scientist; Hard-of-hearing; Follows≠endorse; ❤️ organelles/deep-learning/cochlea/neurons
As someone with Connexin-26 (GJB2) mutations, I've managed to so far study most forms of hearing loss that do NOT involve GJB2.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
November 1, 2025 at 6:22 PM
As someone with Connexin-26 (GJB2) mutations, I've managed to so far study most forms of hearing loss that do NOT involve GJB2.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
Looking forward to some "inner ear evangelism" in ~30 minutes (signup link in comments)
October 16, 2025 at 4:32 PM
Looking forward to some "inner ear evangelism" in ~30 minutes (signup link in comments)
Reposted by Uri Manor
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Preparing an RNAseq experiment
I laugh every. single. time. I see this.
Look I respect the hustle.
October 11, 2025 at 4:11 PM
Preparing an RNAseq experiment
Reposted by Uri Manor
Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.
This is a really inspirational way to work with Claude Code
This is a wildly creative set of customizations for Claude Code, using the new plugin system they just released. There are SO many fascinating ideas in this! Strongly recommend reading it and then spending some time exploring the accompanying repo: https://github.com/obra/superpowers […]
October 11, 2025 at 3:46 PM
Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.
Reposted by Uri Manor
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
The things I’ve learned about drug development in the last few weeks are astounding. Our society & economy are centuries behind our science & it is devastating to think about all the parents and children who are held captive.
www.statnews.com/2025/10/09/c...
www.statnews.com/2025/10/09/c...
Parents of children with rare diseases ask: How long until our CRISPR miracle?
How to better manage expectations around gene editing drugs for families of children with rare diseases.
www.statnews.com
October 10, 2025 at 1:34 AM
The things I’ve learned about drug development in the last few weeks are astounding. Our society & economy are centuries behind our science & it is devastating to think about all the parents and children who are held captive.
www.statnews.com/2025/10/09/c...
www.statnews.com/2025/10/09/c...
Reposted by Uri Manor
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
October 8, 2025 at 11:29 PM
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
I've once again found myself in the news for unfortunate reasons. I must be cursed, or perhaps the universe is just balanced and all the positive press I've gotten for our work just needs to counteracted with some negativity
www.youtube.com/shorts/kkmYw...
www.youtube.com/shorts/kkmYw...
Bear Mask donning man arrested for stabbing someone
YouTube video by ABC 10 News
www.youtube.com
October 9, 2025 at 3:53 AM
I've once again found myself in the news for unfortunate reasons. I must be cursed, or perhaps the universe is just balanced and all the positive press I've gotten for our work just needs to counteracted with some negativity
www.youtube.com/shorts/kkmYw...
www.youtube.com/shorts/kkmYw...
Reposted by Uri Manor
Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Structure and Function of the Cytoskeleton
The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …
meetings.embo.org
October 7, 2025 at 3:35 PM
Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Deadline: 20 December 2025
https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Reposted by Uri Manor
For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below:
gbm-online.de/de/tagungska...
gbm-online.de/de/tagungska...
2nd Meeting of the Study Group "Cellular Organelles" - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
organized by Arun Kumar Kondadi and Andreas Reichert
gbm-online.de
October 7, 2025 at 4:20 PM
For the attention of all the Organelle researchers in Germany, the Annual meeting of the @gbmev.bsky.social study section Cellular Organelles will be held in Düsseldorf …. Seats fast filling up … please submit your abstract … information below:
gbm-online.de/de/tagungska...
gbm-online.de/de/tagungska...
Reposted by Uri Manor
For academic purposes, I generated 100 UMAPs from the same tabular raw data, I sorted them and the result looks too funny to not share it with you 😃
haesleinhuepf.github.io/BioImageAnal...
haesleinhuepf.github.io/BioImageAnal...
October 1, 2025 at 2:17 PM
For academic purposes, I generated 100 UMAPs from the same tabular raw data, I sorted them and the result looks too funny to not share it with you 😃
haesleinhuepf.github.io/BioImageAnal...
haesleinhuepf.github.io/BioImageAnal...
The stories in this article are a huge part of what motivated me to start studying rare disease, which is actually one of the most common diseases (~10% of people have a rare disease)
These Patients Got the Cure. Then It Went Away. www.nytimes.com/2025/09/22/h...
These Patients Got the Cure. Then It Went Away. www.nytimes.com/2025/09/22/h...
These Patients Got the Cure. Then It Went Away.
www.nytimes.com
October 1, 2025 at 2:19 PM
The stories in this article are a huge part of what motivated me to start studying rare disease, which is actually one of the most common diseases (~10% of people have a rare disease)
These Patients Got the Cure. Then It Went Away. www.nytimes.com/2025/09/22/h...
These Patients Got the Cure. Then It Went Away. www.nytimes.com/2025/09/22/h...
Soooooo what happens to all the NIH study sections in October if the government shutdown lasts 30+ days like last time? 😬😬😬
October 1, 2025 at 4:31 AM
Soooooo what happens to all the NIH study sections in October if the government shutdown lasts 30+ days like last time? 😬😬😬
Reposted by Uri Manor
#GEF25 the expansion microscopy community would benefit from high NA, long working distance water objectives. Who's working on these? What's out there?
September 28, 2025 at 2:48 PM
#GEF25 the expansion microscopy community would benefit from high NA, long working distance water objectives. Who's working on these? What's out there?
Reposted by Uri Manor
I enjoyed doing this podcast interview which was just released but was actually recorded almost a year ago. A little sad to listen to it now knowing only in retrospect that my funding was about to get demolished 😅😭. But overall I still have the same hope and dreams.
open.spotify.com/episode/1rjG...
open.spotify.com/episode/1rjG...
From Hearing Loss to Superhuman AI: The Inspiring Journey of Dr. Uri Manor
open.spotify.com
September 24, 2025 at 10:02 PM
I enjoyed doing this podcast interview which was just released but was actually recorded almost a year ago. A little sad to listen to it now knowing only in retrospect that my funding was about to get demolished 😅😭. But overall I still have the same hope and dreams.
open.spotify.com/episode/1rjG...
open.spotify.com/episode/1rjG...
I enjoyed doing this podcast interview which was just released but was actually recorded almost a year ago. A little sad to listen to it now knowing only in retrospect that my funding was about to get demolished 😅😭. But overall I still have the same hope and dreams.
open.spotify.com/episode/1rjG...
open.spotify.com/episode/1rjG...
From Hearing Loss to Superhuman AI: The Inspiring Journey of Dr. Uri Manor
open.spotify.com
September 24, 2025 at 10:02 PM
I enjoyed doing this podcast interview which was just released but was actually recorded almost a year ago. A little sad to listen to it now knowing only in retrospect that my funding was about to get demolished 😅😭. But overall I still have the same hope and dreams.
open.spotify.com/episode/1rjG...
open.spotify.com/episode/1rjG...
Reposted by Uri Manor
I have recently used abranalysis (from the GitHub repo) for analysis of a couple of recent datasets and it does a very nice job once I account for the acoustic latency differences. I just had to put our data into the right intermediate format, which was a simple process. Very nice contribution!
September 24, 2025 at 8:22 PM
I have recently used abranalysis (from the GitHub repo) for analysis of a couple of recent datasets and it does a very nice job once I account for the acoustic latency differences. I just had to put our data into the right intermediate format, which was a simple process. Very nice contribution!
Reposted by Uri Manor
2/2: ABRA, which can automatically analyze auditory brainstem response electrophysiology data from a broad range of mice with varying levels of hearing function/loss. New features in the open-source, free-to-use software (hosted on the San Diego Supercomputer Center!) increase usability and control.
September 24, 2025 at 7:59 PM
2/2: ABRA, which can automatically analyze auditory brainstem response electrophysiology data from a broad range of mice with varying levels of hearing function/loss. New features in the open-source, free-to-use software (hosted on the San Diego Supercomputer Center!) increase usability and control.
Reposted by Uri Manor
Pleased to share updates for 2 deep learning papers:
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
September 24, 2025 at 7:59 PM
Pleased to share updates for 2 deep learning papers:
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
Pleased to share updates for 2 deep learning papers:
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
September 24, 2025 at 7:59 PM
Pleased to share updates for 2 deep learning papers:
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
1/2: VASCilia, which can automatically segment and analyze cochlear hair cell stereocilia bundles. We have added more features to the Napari plugin and some new data highlighting the power of our high-throughput automated 3D analysis approach.
Proud to announce that our superstar postdoc Yasmin Kassim was awarded a Schmidt AI in Science fellowship! Check out her recently updated VASCilia paper and then ponder the fact that this barely scratches the surface of what we’ve done and will be doing more of together 🙌🙌🙌
September 24, 2025 at 12:35 AM
Proud to announce that our superstar postdoc Yasmin Kassim was awarded a Schmidt AI in Science fellowship! Check out her recently updated VASCilia paper and then ponder the fact that this barely scratches the surface of what we’ve done and will be doing more of together 🙌🙌🙌
Reposted by Uri Manor
I love SciSky, great term.
SciSky: what’s your favorite software or algorithm for designing siRNA? Bonus points if we can use it to add mismatches to improve allele specificity!
September 13, 2025 at 3:18 PM
I love SciSky, great term.
Reposted by Uri Manor
Flying out of San Jose buzzing after @chanzuckerberg.bsky.social #ImagingTheFuture.
Amazing to shake the hands of long time insprations: @andrewgyork.bsky.social @makertobey.bsky.social @manorlaboratory.bsky.social & new ones like Gustavo Menezes—plus catching up with friends & collaborators!
Amazing to shake the hands of long time insprations: @andrewgyork.bsky.social @makertobey.bsky.social @manorlaboratory.bsky.social & new ones like Gustavo Menezes—plus catching up with friends & collaborators!
September 18, 2025 at 7:46 PM
Flying out of San Jose buzzing after @chanzuckerberg.bsky.social #ImagingTheFuture.
Amazing to shake the hands of long time insprations: @andrewgyork.bsky.social @makertobey.bsky.social @manorlaboratory.bsky.social & new ones like Gustavo Menezes—plus catching up with friends & collaborators!
Amazing to shake the hands of long time insprations: @andrewgyork.bsky.social @makertobey.bsky.social @manorlaboratory.bsky.social & new ones like Gustavo Menezes—plus catching up with friends & collaborators!
Reposted by Uri Manor
SciSky: what’s your favorite software or algorithm for designing siRNA? Bonus points if we can use it to add mismatches to improve allele specificity!
September 13, 2025 at 2:06 AM
SciSky: what’s your favorite software or algorithm for designing siRNA? Bonus points if we can use it to add mismatches to improve allele specificity!