Uri Manor
@manorlaboratory.bsky.social
Ass. Prof & Director Goeddel Family Technology Sandbox; CZI Imaging Scientist; Hard-of-hearing; Follows≠endorse; ❤️ organelles/deep-learning/cochlea/neurons
🚀 Registration is NOW OPEN for AIMS 2026!
Join us at UC San Diego for the premier workshop on AI for Multimodal Science.
Secure your spot (Deadline March 7):
👉 Register: tinyurl.com/AIMS2026
🔗 Website: aims-2026.vercel.app
Join us at UC San Diego for the premier workshop on AI for Multimodal Science.
Secure your spot (Deadline March 7):
👉 Register: tinyurl.com/AIMS2026
🔗 Website: aims-2026.vercel.app
AIMS 2026: AI for Multimodal Science Registration
Register for the AIMS 2026 workshop, sponsored by Schmidt Sciences, exploring the latest advancements in Artificial Intelligence for Multimodal Science.
Time: June 23–25, 2026
Location: Seventh Colle...
tinyurl.com
January 30, 2026 at 7:01 PM
🚀 Registration is NOW OPEN for AIMS 2026!
Join us at UC San Diego for the premier workshop on AI for Multimodal Science.
Secure your spot (Deadline March 7):
👉 Register: tinyurl.com/AIMS2026
🔗 Website: aims-2026.vercel.app
Join us at UC San Diego for the premier workshop on AI for Multimodal Science.
Secure your spot (Deadline March 7):
👉 Register: tinyurl.com/AIMS2026
🔗 Website: aims-2026.vercel.app
Press release on our paper: today.ucsd.edu/story/new-ai...
January 27, 2026 at 8:11 PM
Press release on our paper: today.ucsd.edu/story/new-ai...
Does anyone understand how the AC meeting is literally the day after Study Section? Don't they need summary statements for this? I have been refreshing my commons page every minute to see if there is a score/summary statement, but in reality this would be unprecedented speed? What am I missing?
January 23, 2026 at 8:08 PM
Does anyone understand how the AC meeting is literally the day after Study Section? Don't they need summary statements for this? I have been refreshing my commons page every minute to see if there is a score/summary statement, but in reality this would be unprecedented speed? What am I missing?
So excited to see Yasmin’s beautiful paper is finally out! We hope this tool will be useful for everyone studying stereocilia bundles (including companies developing gene therapies). I fantasized about having an AI tool like this when I was a grad student.
All the code and data is open source.
All the code and data is open source.
January 21, 2026 at 3:25 PM
So excited to see Yasmin’s beautiful paper is finally out! We hope this tool will be useful for everyone studying stereocilia bundles (including companies developing gene therapies). I fantasized about having an AI tool like this when I was a grad student.
All the code and data is open source.
All the code and data is open source.
Reposted by Uri Manor
Cochlear hair cell #stereocilia bundles are vital for hearing, but what is their 3D morphology? @manorlaboratory.bsky.social present VASCilia, a tool that automates analysis of 3D #ConfocalMicroscopy datasets of phalloidin-stained #CochlearHairCell bundles @plosbiology.org 🧪 plos.io/3NSHdYW
January 21, 2026 at 1:55 PM
Cochlear hair cell #stereocilia bundles are vital for hearing, but what is their 3D morphology? @manorlaboratory.bsky.social present VASCilia, a tool that automates analysis of 3D #ConfocalMicroscopy datasets of phalloidin-stained #CochlearHairCell bundles @plosbiology.org 🧪 plos.io/3NSHdYW
It took me >3 hours to update my @NIH ScienCV biosketch to meet new formatting requirements. These formats are often updated, forcing every one of ~45,000 NIH PI's to spend time on this. Assuming *minimum wage* ~$20/hour and my experience was average, this amounts to $3M/update.
a poster that says ' your tax dollars hard at work '
ALT: a poster that says ' your tax dollars hard at work '
media.tenor.com
January 16, 2026 at 6:00 PM
It took me >3 hours to update my @NIH ScienCV biosketch to meet new formatting requirements. These formats are often updated, forcing every one of ~45,000 NIH PI's to spend time on this. Assuming *minimum wage* ~$20/hour and my experience was average, this amounts to $3M/update.
Reposted by Uri Manor
I'm so happy to have gotten the opportunity to work on this project and I'm SO excited that they selected our image for the cover!
This one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell!
This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍
[Maybe long thread ahead]
This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍
[Maybe long thread ahead]
January 9, 2026 at 7:20 PM
I'm so happy to have gotten the opportunity to work on this project and I'm SO excited that they selected our image for the cover!
The original proposal's critique scores.
I don't know how we are supposed to succeed in such a capricious system.
I don't know how we are supposed to succeed in such a capricious system.
January 9, 2026 at 9:31 PM
The original proposal's critique scores.
I don't know how we are supposed to succeed in such a capricious system.
I don't know how we are supposed to succeed in such a capricious system.
Reposted by Uri Manor
Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
The Microscopists | Uri Manor (UC San Diego School of Biological Sciences)
In this episode of The Microscopists, Uri Manor, Assistant Professor of UCSD, opens up about growing up with profound hearing loss and how, despite wanting nothing to do with becoming a scientist, ...
bit.ly
January 9, 2026 at 11:42 AM
Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
Initial submission of a grant received a 15%-ile score. But we had to submit as new since the PAR expired. We submitted an even stronger, but just slightly modified version to address any/all weaknesses in the prior summary statement.
Just found out it was "Not Discussed"😱
Just found out it was "Not Discussed"😱
January 9, 2026 at 8:27 PM
Initial submission of a grant received a 15%-ile score. But we had to submit as new since the PAR expired. We submitted an even stronger, but just slightly modified version to address any/all weaknesses in the prior summary statement.
Just found out it was "Not Discussed"😱
Just found out it was "Not Discussed"😱
Can someone please connect me with someone at FDA CDER (or with expertise thereof) to discuss the pathway to approval for n-of-1 & n-of-many ASOs? I've got some pretty technical questions too involved to describe here.
December 9, 2025 at 9:36 PM
Can someone please connect me with someone at FDA CDER (or with expertise thereof) to discuss the pathway to approval for n-of-1 & n-of-many ASOs? I've got some pretty technical questions too involved to describe here.
Reposted by Uri Manor
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 163 at CellBio2025 Sunday Dec 7, I present work by Hiro Ishikawa using a synthetic biology approach to test a length-sensing model based on diffusion of kinesin in flagella
December 7, 2025 at 3:44 AM
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 163 at CellBio2025 Sunday Dec 7, I present work by Hiro Ishikawa using a synthetic biology approach to test a length-sensing model based on diffusion of kinesin in flagella
Reposted by Uri Manor
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 155 at the CellBio2025 meeting Sunday Dec 7, Ximena Garcia Arceo uses Lithium, which increases intraflagellar transport, as a tool to probe how length-altering mutants work.
December 7, 2025 at 3:43 AM
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 155 at the CellBio2025 meeting Sunday Dec 7, Ximena Garcia Arceo uses Lithium, which increases intraflagellar transport, as a tool to probe how length-altering mutants work.
Best email I ever got after a talk 🥹🥹🥹
December 2, 2025 at 9:16 PM
Best email I ever got after a talk 🥹🥹🥹
Off to a great start!
December 2, 2025 at 2:31 PM
Off to a great start!
My tenure talk is tomorrow 😅😅😅😅😅
December 1, 2025 at 2:59 PM
My tenure talk is tomorrow 😅😅😅😅😅
Omg this is amazing. Fun fact: my original PhD goal was to study magnetoreception but no PIs were interested and someone suggested I study hair cells as an analogous system. Turns out they were even more analogous than we imagined!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
www.science.org
November 24, 2025 at 6:01 AM
Omg this is amazing. Fun fact: my original PhD goal was to study magnetoreception but no PIs were interested and someone suggested I study hair cells as an analogous system. Turns out they were even more analogous than we imagined!!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Uri Manor
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
November 21, 2025 at 3:54 AM
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
Reposted by Uri Manor
Important for reviewers and people interpreting reviews of their grants
"Nice" NIH study sections screw their applicants because of the way NIH calculates percentile. drugmonkey.wordpress.com/2025/11/20/n...
“Nice” NIH study sections screw their applicants because of the way NIH calculates percentile.
I often write blog comments about NIH grant review matters that exist in an uncomfortable tension between what NIH wants us to do on study section and what I see as our professional obligation to t…
drugmonkey.wordpress.com
November 21, 2025 at 2:10 PM
Important for reviewers and people interpreting reviews of their grants
As someone with Connexin-26 (GJB2) mutations, I've managed to so far study most forms of hearing loss that do NOT involve GJB2.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
November 1, 2025 at 6:22 PM
As someone with Connexin-26 (GJB2) mutations, I've managed to so far study most forms of hearing loss that do NOT involve GJB2.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss.
Now this paper drops.
Looking forward to some "inner ear evangelism" in ~30 minutes (signup link in comments)
October 16, 2025 at 4:32 PM
Looking forward to some "inner ear evangelism" in ~30 minutes (signup link in comments)
Reposted by Uri Manor
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Preparing an RNAseq experiment
I laugh every. single. time. I see this.
Look I respect the hustle.
October 11, 2025 at 4:11 PM
Preparing an RNAseq experiment
Reposted by Uri Manor
Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.
This is a really inspirational way to work with Claude Code
This is a wildly creative set of customizations for Claude Code, using the new plugin system they just released. There are SO many fascinating ideas in this! Strongly recommend reading it and then spending some time exploring the accompanying repo: https://github.com/obra/superpowers […]
October 11, 2025 at 3:46 PM
Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.