Rachel Buckley, PhD
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bucklr01.bsky.social
Rachel Buckley, PhD
@bucklr01.bsky.social
1.3K followers 560 following 56 posts
Assoc Prof [Harvard Med School/MGH] - researching sex differences and women's brain health in Alzheimer's disease - twin mum - Aussie + advocate for women in STEM
Chair of Sex and Gender AD PIA for #ISTAART
Posts Replies Media Videos
Reposted by Rachel Buckley, PhD
thetransmitter.bsky.social
Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay,
www.thetransmitter.org/sex-differen...

#neuroskyence
Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research
New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.
www.thetransmitter.org
September 30, 2025 at 9:36 PM
Reposted by Rachel Buckley, PhD
emilysingerneuro.bsky.social
Congrats to @bucklr01.bsky.social on being selected as a finalist in the NASW Science in Society Journalism Awards, for her piece "Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research"! www.nasw.org/article/anno...
Announcing the 2025 NASW Science in Society Journalism Award winners
The National Association of Science Writers and its Awards Committee are pleased to announce the winners of the **2025 NASW Science in Society Journalism Awards.** This year, NASW is awarding prizes i...
www.nasw.org
October 1, 2025 at 2:09 AM
bucklr01.bsky.social
I was fortunate enough to be interviewed by the Karen Toffler Charitable Trust on their Research Renaissance podcast! I talk about sex differences in Alzheimer's disease risk and optimizing women's brain health.

A link for those interested: open.spotify.com/episode/3ou4...
Unlocking Sex-Based Differences in Alzheimer’s Risk with Dr. Rachel Buckley
Research Renaissance: Exploring the Future of Brain Science · Episode
open.spotify.com
July 16, 2025 at 4:25 PM
bucklr01.bsky.social
Final date to get your votes in!!
bucklr01.bsky.social Rachel Buckley, PhD @bucklr01.bsky.social · Jun 19
Don't forget to vote!!! June 25 is the due date. @drjessicacaldwell.bsky.social @shabanashaik.bsky.social @judy-pa.bsky.social
bucklr01.bsky.social Rachel Buckley, PhD @bucklr01.bsky.social · Jun 13
Hey y'all - please vote for your new Sex & Gender Professional Interest Area for the Alzheimer's Association ISTAART!!!!

Voting closes JUNE 25!!!

alz.surveymonkey.com/r/T8GC8J6
June 25, 2025 at 7:35 PM
bucklr01.bsky.social
Don't forget to vote!!! June 25 is the due date. @drjessicacaldwell.bsky.social @shabanashaik.bsky.social @judy-pa.bsky.social
bucklr01.bsky.social Rachel Buckley, PhD @bucklr01.bsky.social · Jun 13
Hey y'all - please vote for your new Sex & Gender Professional Interest Area for the Alzheimer's Association ISTAART!!!!

Voting closes JUNE 25!!!

alz.surveymonkey.com/r/T8GC8J6
2025 PIA Executive Committee Elections
2025 PIA Executive Committee Elections
alz.surveymonkey.com
June 19, 2025 at 12:29 AM
bucklr01.bsky.social
Our new paper is out!

We find that Sex Hormone Binding Globulin (but interestingly not estradiol or testosterone) shows sex specific associations with tau-PET burden in the Framingham Heart Study. In men, it seems to be protective (higher SHBG = lower tau)

onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
June 17, 2025 at 7:52 PM
bucklr01.bsky.social
Hey y'all - please vote for your new Sex & Gender Professional Interest Area for the Alzheimer's Association ISTAART!!!!

Voting closes JUNE 25!!!

alz.surveymonkey.com/r/T8GC8J6
2025 PIA Executive Committee Elections
2025 PIA Executive Committee Elections
alz.surveymonkey.com
June 13, 2025 at 3:27 PM
Reposted by Rachel Buckley, PhD
alzdemjournals.bsky.social
Biomarkers enhance Cerebral Amyloid Angiopathy detection!🩸

Research from Alzheimer’s & Dementia demonstrate lower Aβ42/40 and elevated p-tau-181 effectively differentiate CAA from controls, opening doors for non-invasive diagnostics #AlzResearch

alz-journals.onlinelibrary.wiley.com/doi/full/10....
April 9, 2025 at 3:29 PM
Reposted by Rachel Buckley, PhD
alzdemjournals.bsky.social
AI used for better dementia detection in India

A&D: Diagnosis, Assessment & Disease Monitoring reports cognitive test cutoffs for India’s unique population to improve early diagnosis, a step toward more effective dementia care #DADM #AlzResearch

alz-journals.onlinelibrary.wiley.com/doi/full/10....
April 10, 2025 at 2:33 PM
bucklr01.bsky.social
Loved being at #CCAD2025 this year in Puerto Rico - been an amazing conference!
April 10, 2025 at 1:47 PM
Reposted by Rachel Buckley, PhD
alzdemjournals.bsky.social
What are examples of modifiable risk factors in dementia?

A&D: Diagnosis, Assessment & Disease Monitoring special issue investigates glucose index, sleep variation, vitamin supplements and more as modifiable risk factors #DADM

Read here: alz-journals.onlinelibrary.wiley.com/doi/toc/10.1...
SPECIAL SECTION: Modifiable Risk Factors In Dementia. Edited By Dr. Kaarin Anstey & Dr. Kristine Yaffe: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Click on the title to browse this issue
alz-journals.onlinelibrary.wiley.com
April 1, 2025 at 7:25 PM
Reposted by Rachel Buckley, PhD
suzanneeschindler.bsky.social
We now have a blood biomarker that is even more strongly associated with tau PET and cognitive symptoms than even p-tau217! Plasma eMTBR-tau243 will help us to understand whether cognitive impairment is likely to be related to Alzheimer's pathology. #ENDALZ

www.nature.com/articles/s41...
Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease - Nature Medicine
Plasma eMTBR-tau243 is a specific biomarker of tau tangles in Alzheimer’s disease and enables the detecting and tracking of Alzheimer’s clinical impairment.
www.nature.com
March 31, 2025 at 2:56 PM
bucklr01.bsky.social
A critical area of AD research that is really gaining traction - harmonization across multiple cohorts for big data analysis!
March 31, 2025 at 3:23 PM
Reposted by Rachel Buckley, PhD
carolynfredericks.bsky.social
We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral...

Please share with your circles!
The Fredericks Lab! - with deliberately poor photoshopping of lab members who couldn't be there that day.
March 28, 2025 at 5:26 PM
bucklr01.bsky.social
March 10, 2025 at 6:05 PM
Reposted by Rachel Buckley, PhD
medpagetoday.com
"Women have faster rates of tau accumulation than men in areas of the brain that tend to be most vulnerable to Alzheimer's disease." -- @bucklr01.bsky.social, of Massachusetts General Hospital, discussing women and #Alzheimer'sDisease.
www.medpagetoday.com/neurology/al...
Alzheimer's May Develop Differently in Women
Women show faster tau accumulation than men
www.medpagetoday.com
March 10, 2025 at 1:48 PM
bucklr01.bsky.social
It is an honor to be counted amongst these amazing scientists in this piece, and a privilege to be able to do this incredible work
denadubal.bsky.social Dena Dubal @denadubal.bsky.social · Mar 7
"A little boost went a long way". Increasing an X factor from the silent X improved cognition in aging male and female mice. Privileged to have our discovery reported in @nytimes.com, alongside findings from Kaitlin Casaletto and Rachel Buckley @bucklr01.bsky.social. www.nytimes.com/2025/03/05/h...
Aging Women’s Brain Mysteries Are Tested in Trio of Studies (Gift Article)
Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.
www.nytimes.com
March 7, 2025 at 8:09 PM
Reposted by Rachel Buckley, PhD
bryandjames.bsky.social
Great write up on the latest research on sex differences in brain aging, with quote from Dr. Buckley @bucklr01.bsky.social "talk to your doctor" 😉 Important work--particularly in the context of clamping down on science focused on the health of women and minorities www.nytimes.com/2025/03/05/h...
Aging Women’s Brain Mysteries Are Tested in Trio of Studies
Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.
www.nytimes.com
March 5, 2025 at 8:38 PM
Reposted by Rachel Buckley, PhD
bourzac.bsky.social
Thanks to @denadubal.bsky.social and @bucklr01.bsky.social for talking to me for this story about the fascinating X chromosome!
nature.com Nature @nature.com · Mar 5
“It’s a paradigm shift to know that the silent X doesn’t stay asleep,” says Dena Dubal, a neuroscientist and neurologist at the University of California School of Medicine in San Francisco, who led the study.

https://go.nature.com/4ksThvP
Why women’s brains are more resilient: it could be their ‘silent’ X chromosome
Study in mice and human cadavers hints that a brain-protective gene in the chromosome becomes more active with age.
go.nature.com
March 5, 2025 at 8:57 PM
Reposted by Rachel Buckley, PhD
emilyjacobs.bsky.social
@sheilashanmugan.bsky.social @magdamartinezga.bsky.social @susanacarmona.bsky.social @bucklr01.bsky.social, @denadubal.bsky.social Laura Pritschet, Kaitlin Casaletto, Ina Stelzer, Julia Sacher, Rob Froemke and so many more leading minds.
March 5, 2025 at 9:34 PM
Reposted by Rachel Buckley, PhD
emilyjacobs.bsky.social
More coverage of @denadubal.bsky.social Kaitlin Casaletto, @bucklr01.bsky.social et al: www.nytimes.com/2025/03/05/h...
Aging Women’s Brain Mysteries Are Tested in Trio of Studies
Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.
www.nytimes.com
March 6, 2025 at 1:54 AM
bucklr01.bsky.social
Nominations are still open to become a part of our Sex & Gender PIA Executive Committee for ISTAART!!! Nominations close Mar 10. Please see nomination form: alz.surveymonkey.com/r/RF7JGFF
Information on the positions are here: drive.google.com/file/d/1NKvx...
For any questions, DM me #endAlz
2025 ISTAART PIA Executive Committee Self-Nominations
Take this survey powered by surveymonkey.com. Create your own surveys for free.
alz.surveymonkey.com
March 4, 2025 at 2:51 PM
Reposted by Rachel Buckley, PhD
jeremymberg.bsky.social
UPDATE ON FUNDING

These are data through 2/21/25. The lag in Reporter really does appear to be about a week.

There was a second mini-pause as suspected from internal reports, but grants are being awarded.

About 21% new or competitive renewals (compared to 29% in 2017, and 22% in 2021
February 27, 2025 at 10:14 AM
bucklr01.bsky.social
Hey there, fellow scientists! Interested in reviewing for an Alzheimer's disease journal in future? Us editors are always looking for reviewers, especially those who are earlier career researchers who are looking to test out their reviewing chops.
February 27, 2025 at 2:26 AM
bucklr01.bsky.social
Please consider nominating to join our Sex & Gender PIA Executive Committee for ISTAART!!! We'd love to have you join our amazing team #ADSexGenPIA

alz.surveymonkey.com/r/RF7JGFF
2025 ISTAART PIA Executive Committee Self-Nominations
Take this survey powered by surveymonkey.com. Create your own surveys for free.
alz.surveymonkey.com
February 21, 2025 at 2:02 PM