Hart Jackson
@hartjackson.bsky.social
Investigator at LTRI, Uni Toronto. Spatial bio & methods.
Reposted by Hart Jackson
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
www.nature.com
November 19, 2025 at 5:51 PM
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
Reposted by Hart Jackson
Great collaboration with @gingraslab.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
October 23, 2025 at 1:40 PM
Great collaboration with @gingraslab.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
& congrats to lead author Vesal.
Paper: www.nature.com/articles/s41...
Thanks to @sinaihealth.bsky.social
Reposted by Hart Jackson
New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force.
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations
Distinctively, pancreatic ductal adenocarcinoma (PDAC) consists of sparse tumour lesions intertwined with extensive desmoplastic stroma. The complexity of tumour–microenvironment interactions within t...
biorxiv.org
August 23, 2025 at 12:00 PM
New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force.
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
Reposted by Hart Jackson
🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦
Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area.
👉 apply.interfolio.com/168307
Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area.
👉 apply.interfolio.com/168307
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
May 27, 2025 at 3:42 PM
🧬 We're hiring - join our lab in Toronto, Canada! 🇨🇦
Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area.
👉 apply.interfolio.com/168307
Exciting postdoc joint with @hartjackson.bsky.social developing machine learning methods for the next generation of spatial histopathology technologies joint with industry partners in the Bay Area.
👉 apply.interfolio.com/168307
Reposted by Hart Jackson
Cells differ in their cell-division cycle pace. But only now has it been shown that those types with faster cycles are more susceptible to cancer.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The cell-division cycle is faster in cell types prone to forming cancer
Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.
www.nature.com
April 30, 2025 at 7:16 PM
Cells differ in their cell-division cycle pace. But only now has it been shown that those types with faster cycles are more susceptible to cancer.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Hart Jackson
🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with @durocher1.bsky.social at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation.
Apply ➡️ apply.interfolio.com/162929
or DM with questions!
Apply ➡️ apply.interfolio.com/162929
or DM with questions!
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
February 11, 2025 at 3:08 PM
🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with @durocher1.bsky.social at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation.
Apply ➡️ apply.interfolio.com/162929
or DM with questions!
Apply ➡️ apply.interfolio.com/162929
or DM with questions!
Reposted by Hart Jackson
Canada at this point needs to double research money to become a true powerhouse. In terms of dollars, it’s not a lot to get there. A visionary government would leap at the chance. Alas no party in Canada has that vision. Most institutions are freezing hiring (in ON anyways).
February 8, 2025 at 4:36 PM
Canada at this point needs to double research money to become a true powerhouse. In terms of dollars, it’s not a lot to get there. A visionary government would leap at the chance. Alas no party in Canada has that vision. Most institutions are freezing hiring (in ON anyways).
Reposted by Hart Jackson
So excited to see our paper describing the class of ARGOS genes in cancer out in @naturecomms.bsky.social! 🤩
www.nature.com/articles/s41...
A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social
🧵👇:
www.nature.com/articles/s41...
A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social
🧵👇:
A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer - Nature Communications
In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tum...
nature.com
January 27, 2025 at 10:07 PM
So excited to see our paper describing the class of ARGOS genes in cancer out in @naturecomms.bsky.social! 🤩
www.nature.com/articles/s41...
A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social
🧵👇:
www.nature.com/articles/s41...
A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social
🧵👇:
Need better clusters from your segmented single cell data?
Check out our new method with @kieranrcampbell.bsky.social for unsupervised correction of imperfectly segmented cells.
Great and highly useful work by Jett Lee!
Check out our new method with @kieranrcampbell.bsky.social for unsupervised correction of imperfectly segmented cells.
Great and highly useful work by Jett Lee!
How can we quantify single cell expression from multiplexed imaging datasets given segmentation errors?
To help tackle this, we introduce evaluation metrics, a gold-standard dataset, and STARLING—a new probabilistic machine learning method (1/4)
www.nature.com/articles/s41...
To help tackle this, we introduce evaluation metrics, a gold-standard dataset, and STARLING—a new probabilistic machine learning method (1/4)
www.nature.com/articles/s41...
Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data - Nature Communications
Spatial expression assays are affected by segmentation errors leading to difficulty interpreting cell types. Here, the authors introduce a machine learning model to infer cell types accounting for suc...
www.nature.com
January 8, 2025 at 1:36 AM
Need better clusters from your segmented single cell data?
Check out our new method with @kieranrcampbell.bsky.social for unsupervised correction of imperfectly segmented cells.
Great and highly useful work by Jett Lee!
Check out our new method with @kieranrcampbell.bsky.social for unsupervised correction of imperfectly segmented cells.
Great and highly useful work by Jett Lee!
Reposted by Hart Jackson
in the coffee shop listening to a dad explain photosynthesis to a kid (3-4yrs). I can tell he’s a scientist because when the kid said “really?” He then hedged for a full minute like he was responding to reviewer #2
December 27, 2024 at 8:29 PM
in the coffee shop listening to a dad explain photosynthesis to a kid (3-4yrs). I can tell he’s a scientist because when the kid said “really?” He then hedged for a full minute like he was responding to reviewer #2
Reposted by Hart Jackson
Each of us contributes incrementally to a future we may never see. If it is in our lifetime, if our science, or our contribution, is part of a practical solution, it will likely be one sentence in a vast tome with contributions from thousands of authors across dozens of (not just science) fields.
December 22, 2024 at 3:10 PM
Each of us contributes incrementally to a future we may never see. If it is in our lifetime, if our science, or our contribution, is part of a practical solution, it will likely be one sentence in a vast tome with contributions from thousands of authors across dozens of (not just science) fields.
Reposted by Hart Jackson
Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
December 19, 2024 at 9:30 PM
Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...
Reposted by Hart Jackson
Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
1/
www.nature.com/articles/s41...
1/
www.nature.com/articles/s41...
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology
Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.
www.nature.com
December 16, 2024 at 12:02 PM
Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
1/
www.nature.com/articles/s41...
1/
www.nature.com/articles/s41...
Reposted by Hart Jackson
Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1
Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1
The tumor microenvironment (TME) is a complex network of interactions between malignant and host cel
www.biorxiv.org
December 4, 2024 at 12:50 AM
Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes https://www.biorxiv.org/content/10.1101/2024.11.29.626039v1
Reposted by Hart Jackson
One amazing aspect of cryo-EM revolution is there are a bunch of giant E3 Ubiquitin ligase complexes that are mechanistically accessible- this seems cool from the Rapé lab
The molecular basis of integrated stress response silencing https://www.biorxiv.org/content/10.1101/2024.12.02.626349v1
The molecular basis of integrated stress response silencing https://www.biorxiv.org/content/10.1101/2024.12.02.626349v1
Chronic stress response activation impairs cell survival and causes devastating degenerative disease
www.biorxiv.org
December 3, 2024 at 4:28 AM
One amazing aspect of cryo-EM revolution is there are a bunch of giant E3 Ubiquitin ligase complexes that are mechanistically accessible- this seems cool from the Rapé lab
Reposted by Hart Jackson
Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs. bit.ly/3O4bOjq
December 2, 2024 at 4:03 PM
Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs. bit.ly/3O4bOjq
Reposted by Hart Jackson
#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
November 23, 2024 at 9:52 PM
#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
Reposted by Hart Jackson
Save the date... our 3rd edition, 2nd hybrid, of this course tailored to bio image analysts. Further info to come soon.
November 14, 2024 at 9:22 PM
Save the date... our 3rd edition, 2nd hybrid, of this course tailored to bio image analysts. Further info to come soon.
Hot off the CyTOF - one tumour contains multitudes - how do you treat that?!!
November 14, 2024 at 12:55 PM
Hot off the CyTOF - one tumour contains multitudes - how do you treat that?!!
Reposted by Hart Jackson
First post here!
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
Profound synthetic lethality between SMARCAL1 and FANCM
Feng et al. uncover a critical genetic interaction between the DNA translocases SMARCAL1
and FANCM. Their combined loss leads to catastrophic genome instability, particularly
at simple-repeat sequence...
www.cell.com
November 10, 2024 at 11:46 AM
First post here!
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
Reposted by Hart Jackson
I don't think I saw this on social media at all: a bunch of very clever people (including our team) has put together a federated bioimage repository based on OME-Zarr with 500TB of data in 4 months! ome.github.io/ome2024-ngff...
November 10, 2024 at 6:38 PM
I don't think I saw this on social media at all: a bunch of very clever people (including our team) has put together a federated bioimage repository based on OME-Zarr with 500TB of data in 4 months! ome.github.io/ome2024-ngff...
Reposted by Hart Jackson
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬
🦠🧪🧫🧬
November 10, 2024 at 1:13 PM
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬
🦠🧪🧫🧬
Reposted by Hart Jackson
Surreal thread that culminates with an official list of a burgeoning journal's sworn enemies.
Is this... a fringe science journal?
Its banner endorsement is from Kary Mullis, most famous in recent years for climate change denialism, AIDS denialism, and belief in the paranormal.
Its banner endorsement is from Kary Mullis, most famous in recent years for climate change denialism, AIDS denialism, and belief in the paranormal.
January 8, 2024 at 8:58 PM
Surreal thread that culminates with an official list of a burgeoning journal's sworn enemies.
Reposted by Hart Jackson
