Hao Yin
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haoyin.bsky.social
Hao Yin
@haoyin.bsky.social
Twitter/X @haoyin20
Vascular biologist
Pinned
Hao's Preprint Reading List
Oct 29th, 2025

Akt1 Nitration, EndMT & Pulmonary hypertension

Alternative splicing in cerebrovascular & cardiac development

Self-organization of vascularized liver organoids

TurboID compartmentalized proteome of sensory neuron

docs.google.com/document/d/e...
Reposted by Hao Yin
Friendly reminder that this seminar is taking place this Thursday, 12pm EST on Zoom, see you all there!
We are excited for our next talk in the Forces at Play: Molecular Mechanobiology Seminar Series with Dr. Bianxiao Cui from Stanford University on Thursday, November 13th at 12pm EST on Zoom. Please see the flyer for more information. We hope to see you all virtually!
November 10, 2025 at 1:44 PM
#Rhabdomyosarcoma
Nanostring multiplex protein + microRNA nCounter (not very spatial omics)
5 Embryonal
7 spindle cell-sclerosing

Poor prognosis
INPP4B
miR-3144-3p
miR-612
miR-302d-3p
miR-421
miR-548ar-5p
miR-548y

Atif Ahmed lab Cancers 2022
www.mdpi.com/2072-6694/14...
November 10, 2025 at 7:59 PM
Reposted by Hao Yin
How does the tumor microenvironment change as cancer progresses - & which cells appear, persist, or disappear along the way?

Excited to share our new study on the #TME answering this question!

Great collaboration with the Hausser lab 🧪🧬🔬

Open access link: www.cell.com/iscience/ful...

Read more ⏬
Study reveals dynamics of breast tumor microenvironment over time | Johanna Joyce posted on the topic | LinkedIn
How does the tumor microenvironment change as cancer progresses — and which cells appear, persist, or disappear along the way? In this new study, a wonderful collaboration with Jean Hausser and his l...
www.linkedin.com
November 10, 2025 at 3:06 PM
Reposted by Hao Yin
#DBfeature

Fritz Müller’s "Für Darwin" (1864) bridged evolution and development, anticipating evo-devo and warning to the dangers of scientific dogma

By Scott Gilbert and Beatrice Steinert
tinyurl.com/3sccvcr5

#SpecialIssue on Research that transformed #DevBio
November 10, 2025 at 12:35 PM
My continued biomedical education

Structural immunity: immune cells as architects of tissue barriers

Beyond destroying, Macrophages & Neutrophils also build - transport/synthesize/deposit matrix components during skin repair or myocardial fibrosis

#NatRevImmun 2025
www.nature.com/articles/s41...
November 10, 2025 at 12:45 PM
Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth

Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types

#PNAS 2025
www.pnas.org/doi/10.1073/...
November 9, 2025 at 8:29 PM
Reposted by Hao Yin
What a privilege to be in the audience for the #AHA25 Nobel Laureate address by @ardemp.bskyverified.social

Inspiring story describing his Piezo journey, complete with sage advice & encouragement for researchers, as well as demonstration of his dermatological commitment to his discovery (video) 💪🏼
November 9, 2025 at 6:12 PM
Reposted by Hao Yin
A non biologic PCSK9 inhibitor could be a game changer! www.nytimes.com/2025/11/08/h...
New Pill From Merck Could Slash Cholesterol Levels, Trials Show
www.nytimes.com
November 9, 2025 at 1:54 PM
Reposted by Hao Yin
Works for grants too
Note from my notebook (2018). Still relevant.
November 9, 2025 at 4:04 PM
Reposted by Hao Yin
Interesting organoid work on an often overlooked lineage emerging from the Lateral Plate Mesoderm: ventral dermis!
#devbio #evodevo #MesodermIsStillCool 🧬🎈⚾
The latest story from my group. Working toward build regionally distinct skin and amnion piece by piece.
Lateral plate mesoderm directs human amnion and ventral skin organoid formation https://www.biorxiv.org/content/10.1101/2025.11.05.685987v1
November 9, 2025 at 4:51 PM
Lipid quality control #Ferroptosis

"Lipid Droplet-localized FSP1/ferroptosis suppressor protein 1 reduces CoQ10 to generate local antioxidants that prevent neutral lipid peroxidation"

Any role of FSP1 in #Atherosclerosis!?😆

@olzmannlab.bsky.social #NatCellBio 2025
www.nature.com/articles/s41...
November 9, 2025 at 1:21 PM
November 8, 2025 at 11:15 PM
"Second Skin"
A flexible PDMS window enables up to 3-week intravital imaging of mouse tissue dynamics of mammary gland, tumor & even skeletal muscle!

Direct visualization of satellite cell division in injured muscle

Enjoyable re-reading!😄

#ScienceAdvances 2021
www.science.org/doi/10.1126/...
November 8, 2025 at 1:29 PM
Reposted by Hao Yin
New in @natureportfolio.nature.com on microglial regulation in Alzheimer’s disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!
November 7, 2025 at 10:13 PM
Reposted by Hao Yin
#DBfeature

Developmental life history transitions can be shaped by structural inequities: Insights from the sociology of race

by Sarah McMenamin, Latrica Best

sciencedirect.com/science/arti...
November 7, 2025 at 10:25 PM
Reposted by Hao Yin
Great opportunity for musculoskeletal researchers!! Help us grow more inclusive research across regenerative medicine, prosthetics, epidemiology, preclinical research, clinical trials & global health 🦴🏃‍♂️🌎 Grow your profile, networks & have real impact! Apply now 👇 #Dsxhe #datascience #FortisNet
Help Shape Inclusive Musculoskeletal (MSK) Research: Volunteer Resource Curator Wanted
Bring data scientists and interdisciplinary musculoskeletal experts together to tackle health inequity for the benefit of the wider community.As people live longer, musculoskeletal (MSK) disease and i...
www.datascienceforhealthequity.com
November 7, 2025 at 10:16 PM
#MetaplasticBreastCancer

Neoadjuvant chemo-immunotherapy response predicts long-term survival

KEYNOTE-522
N=32 stage I-III

high stromal tumor-infiltrating lymphocytes corr. pCR
pCR (n=7)➡️no recurrence
2/3 of residual disease➡️recurrence in 14 mo

#NPJBreastCancer2025
www.nature.com/articles/s41...
November 7, 2025 at 8:04 PM
Reposted by Hao Yin
Good morning from #AHA25!

First up for your #sportscardio itinerary:

“Competitive Sports Participation for Athletes with Heart Disease”

Join us @ 12:30pm CT in Rm 275 for discussions on the new guidelines, SDM, PPE, CMY, ORCCA registry, and more

Submit your ?’s via the AHA conference app 📱
November 7, 2025 at 2:26 PM
Hao's Preprint Reading List
November 7 2025

EndMT Thermogenesis Brown Adipose Tissue

hiPSC-derived Lymphatic Endothelial Cell

MERFISH+ 3D Spatial Transcriptomics

Atherogenic stress & Neurovascular functions

Smooth muscle lineage in Medial Arterial Calcification

docs.google.com/document/d/e...
November 7, 2025 at 12:05 PM
#SmoothMuscleCell Epitranscriptomics

METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability)

135 METTL3 target genes by RNAseq+MeRIPseq in rat SMC

SMC Mettl3 KO🐭➡️
⏬carotid #IntimalHyperplasia➡️
⏫by AAV9-SM22a-SGK1

#ATVB 2025 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
November 6, 2025 at 7:52 PM
Reposted by Hao Yin
📅 Save the Date!
The 4th Canadian Zebrafish Research Conference will take place on Friday, May 15, 2026, at CHU Sainte-Justine, Montreal (just before the Canadian Neuroscience Conference!)
Multiple travel awards available with 2 Postdoctoral Rising Stars Awards! #izfs
November 6, 2025 at 3:31 PM
Reposted by Hao Yin
Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com

The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s.

Makes me also wonder how many could be druggable targets.
November 6, 2025 at 6:50 PM
Reposted by Hao Yin
The next Ethel Browne Harvey Postdoc Seminar will be Friday, November 14 at 3 pm Eastern Time with Olya Yarychkivska from @rockefeller.edu and Anthony Galenza from Stanford University. Register today and join us. bit.ly/4gvaHqd #SDBPostdocSeminar #Celegans #drosophila
November 6, 2025 at 6:32 PM