Hao Yin
@haoyin.bsky.social
Twitter/X @haoyin20
Vascular biologist
Vascular biologist
Lung morphogenesis🦎 Squamate/Lizards
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
November 17, 2025 at 12:51 PM
Lung morphogenesis🦎 Squamate/Lizards
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
Pressure-driven pushing of 🫁epithelium +
Proliferation-driven expansion of elongating epithelial subbronchi/diverticulae
Smooth muscle mesh provides structural guide for epithelial protrusions
#DevDyn 2025
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
#SmoothMuscleCell m6A Epitranscriptomics
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
November 16, 2025 at 8:34 PM
#SmoothMuscleCell m6A Epitranscriptomics
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
METTL14 ⬆️in 🐭 #ThoracicAorticAneurysm (AngII+HFD) or erastin-treated SMC
Liproxstatin-1 or AAV-shMettl14⏬🐭TAA
METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️
SMC #Ferroptosis
SRAMP➡️m6A site prediction
#AJPCellPhys 2025
journals.physiology.org/doi/full/10....
APOE4 genotype promotes a brain Pericyte-to-Myofibroblast transition
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
November 16, 2025 at 12:20 PM
APOE4 genotype promotes a brain Pericyte-to-Myofibroblast transition
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
November 15, 2025 at 11:20 PM
Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater
#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
November 15, 2025 at 12:17 PM
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Germline Bmp9 KO🐭, Not Bmp10 KO🐭or BMP9-neutralizing Ab
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
November 14, 2025 at 7:59 PM
Germline Bmp9 KO🐭, Not Bmp10 KO🐭or BMP9-neutralizing Ab
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
Normoxia
⏬muscularized pulmonary arterioles
Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ
#Angiogenesis 2025
link.springer.com/article/10.1...
In vivo two-photon microscopy for studies of #NeuroVascularCoupling in rodents
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
November 14, 2025 at 12:13 PM
In vivo two-photon microscopy for studies of #NeuroVascularCoupling in rodents
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
(More than) a beginner’s guide🫡
Likely adaptable for skeletal muscle with second skin window😁
#Neurophotonics 2025
www.spiedigitallibrary.org/journals/neu...
#SmoothMuscleCell Mettl14, ⬆️in injured artery, aggravates #IntimalHyperplasia via ⏫nascent KLF4 & SERPINE1 mRNA synthesis (Not impacting mRNA stability)
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...
November 13, 2025 at 8:02 PM
#SmoothMuscleCell Mettl14, ⬆️in injured artery, aggravates #IntimalHyperplasia via ⏫nascent KLF4 & SERPINE1 mRNA synthesis (Not impacting mRNA stability)
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...
Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role
@insight.jci.org 2025
insight.jci.org/articles/vie...
Do Not miss this great @navbo.bsky.social online event😆
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
November 13, 2025 at 7:51 PM
Do Not miss this great @navbo.bsky.social online event😆
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
Specification of Endothelial Cell Phenotypes
Organized by Dr. Ralf Adams @ralfhadams.bsky.social
& Dr. Vicki Bautch
Abstract deadline November 20
members.navbo.org/calendar-of-...
Zebrafishology, study design guidelines for rigorous & reproducible data using zebrafish
Actually, this is an entertaining reading piece for a non-fishman like me😀
Reminder: Zebrafish is an emerging model of #Aortopathy!
Victoria Bedell lab #CommunBiol 2025
www.nature.com/articles/s42...
Actually, this is an entertaining reading piece for a non-fishman like me😀
Reminder: Zebrafish is an emerging model of #Aortopathy!
Victoria Bedell lab #CommunBiol 2025
www.nature.com/articles/s42...
November 13, 2025 at 11:31 AM
Zebrafishology, study design guidelines for rigorous & reproducible data using zebrafish
Actually, this is an entertaining reading piece for a non-fishman like me😀
Reminder: Zebrafish is an emerging model of #Aortopathy!
Victoria Bedell lab #CommunBiol 2025
www.nature.com/articles/s42...
Actually, this is an entertaining reading piece for a non-fishman like me😀
Reminder: Zebrafish is an emerging model of #Aortopathy!
Victoria Bedell lab #CommunBiol 2025
www.nature.com/articles/s42...
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
November 12, 2025 at 7:59 PM
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
#DiabeticRetinopathy
EC LRG1 ⏫Pericyte TGFβ▶️
Hypercontractile & matrix phenotype
Lrg1 KO in hyperglycemic🐭 rescues
👉Retinal vascular permeability
👉⬇️Density φ Oxygenation in deep vasc plexus
👉⬇️ERG b-wave amp
@giuliaderossi.bsky.social #ScienceTM 2025
www.science.org/doi/10.1126/...
EC LRG1 ⏫Pericyte TGFβ▶️
Hypercontractile & matrix phenotype
Lrg1 KO in hyperglycemic🐭 rescues
👉Retinal vascular permeability
👉⬇️Density φ Oxygenation in deep vasc plexus
👉⬇️ERG b-wave amp
@giuliaderossi.bsky.social #ScienceTM 2025
www.science.org/doi/10.1126/...
November 12, 2025 at 12:32 PM
#DiabeticRetinopathy
EC LRG1 ⏫Pericyte TGFβ▶️
Hypercontractile & matrix phenotype
Lrg1 KO in hyperglycemic🐭 rescues
👉Retinal vascular permeability
👉⬇️Density φ Oxygenation in deep vasc plexus
👉⬇️ERG b-wave amp
@giuliaderossi.bsky.social #ScienceTM 2025
www.science.org/doi/10.1126/...
EC LRG1 ⏫Pericyte TGFβ▶️
Hypercontractile & matrix phenotype
Lrg1 KO in hyperglycemic🐭 rescues
👉Retinal vascular permeability
👉⬇️Density φ Oxygenation in deep vasc plexus
👉⬇️ERG b-wave amp
@giuliaderossi.bsky.social #ScienceTM 2025
www.science.org/doi/10.1126/...
YOLT-101
Another single-infusion #BaseEditor therapy for Heterozygous Familial Hypercholesterolemia
From #YolTech Therapeutics
0.6 mg/kg N=3
Being effective in 1 wk
Sustained 70% ⬇️plasma PCSk9 & 50% ⬇️LDL-C till 16-wk
medRxiv 2025
www.medrxiv.org/content/10.1...
Another single-infusion #BaseEditor therapy for Heterozygous Familial Hypercholesterolemia
From #YolTech Therapeutics
0.6 mg/kg N=3
Being effective in 1 wk
Sustained 70% ⬇️plasma PCSk9 & 50% ⬇️LDL-C till 16-wk
medRxiv 2025
www.medrxiv.org/content/10.1...
November 11, 2025 at 8:04 PM
YOLT-101
Another single-infusion #BaseEditor therapy for Heterozygous Familial Hypercholesterolemia
From #YolTech Therapeutics
0.6 mg/kg N=3
Being effective in 1 wk
Sustained 70% ⬇️plasma PCSk9 & 50% ⬇️LDL-C till 16-wk
medRxiv 2025
www.medrxiv.org/content/10.1...
Another single-infusion #BaseEditor therapy for Heterozygous Familial Hypercholesterolemia
From #YolTech Therapeutics
0.6 mg/kg N=3
Being effective in 1 wk
Sustained 70% ⬇️plasma PCSk9 & 50% ⬇️LDL-C till 16-wk
medRxiv 2025
www.medrxiv.org/content/10.1...
1st single-cell #SpatialTranscriptomics map of human coronary #Atherosclerosis published in peer-reviewed format🤠
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
November 11, 2025 at 12:15 PM
1st single-cell #SpatialTranscriptomics map of human coronary #Atherosclerosis published in peer-reviewed format🤠
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
#Rhabdomyosarcoma
Nanostring multiplex protein + microRNA nCounter (not very spatial omics)
5 Embryonal
7 spindle cell-sclerosing
Poor prognosis
INPP4B
miR-3144-3p
miR-612
miR-302d-3p
miR-421
miR-548ar-5p
miR-548y
Atif Ahmed lab Cancers 2022
www.mdpi.com/2072-6694/14...
Nanostring multiplex protein + microRNA nCounter (not very spatial omics)
5 Embryonal
7 spindle cell-sclerosing
Poor prognosis
INPP4B
miR-3144-3p
miR-612
miR-302d-3p
miR-421
miR-548ar-5p
miR-548y
Atif Ahmed lab Cancers 2022
www.mdpi.com/2072-6694/14...
November 10, 2025 at 7:59 PM
#Rhabdomyosarcoma
Nanostring multiplex protein + microRNA nCounter (not very spatial omics)
5 Embryonal
7 spindle cell-sclerosing
Poor prognosis
INPP4B
miR-3144-3p
miR-612
miR-302d-3p
miR-421
miR-548ar-5p
miR-548y
Atif Ahmed lab Cancers 2022
www.mdpi.com/2072-6694/14...
Nanostring multiplex protein + microRNA nCounter (not very spatial omics)
5 Embryonal
7 spindle cell-sclerosing
Poor prognosis
INPP4B
miR-3144-3p
miR-612
miR-302d-3p
miR-421
miR-548ar-5p
miR-548y
Atif Ahmed lab Cancers 2022
www.mdpi.com/2072-6694/14...
My continued biomedical education
Structural immunity: immune cells as architects of tissue barriers
Beyond destroying, Macrophages & Neutrophils also build - transport/synthesize/deposit matrix components during skin repair or myocardial fibrosis
#NatRevImmun 2025
www.nature.com/articles/s41...
Structural immunity: immune cells as architects of tissue barriers
Beyond destroying, Macrophages & Neutrophils also build - transport/synthesize/deposit matrix components during skin repair or myocardial fibrosis
#NatRevImmun 2025
www.nature.com/articles/s41...
November 10, 2025 at 12:45 PM
My continued biomedical education
Structural immunity: immune cells as architects of tissue barriers
Beyond destroying, Macrophages & Neutrophils also build - transport/synthesize/deposit matrix components during skin repair or myocardial fibrosis
#NatRevImmun 2025
www.nature.com/articles/s41...
Structural immunity: immune cells as architects of tissue barriers
Beyond destroying, Macrophages & Neutrophils also build - transport/synthesize/deposit matrix components during skin repair or myocardial fibrosis
#NatRevImmun 2025
www.nature.com/articles/s41...
Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
November 9, 2025 at 8:29 PM
Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Lipid quality control #Ferroptosis
"Lipid Droplet-localized FSP1/ferroptosis suppressor protein 1 reduces CoQ10 to generate local antioxidants that prevent neutral lipid peroxidation"
Any role of FSP1 in #Atherosclerosis!?😆
@olzmannlab.bsky.social #NatCellBio 2025
www.nature.com/articles/s41...
"Lipid Droplet-localized FSP1/ferroptosis suppressor protein 1 reduces CoQ10 to generate local antioxidants that prevent neutral lipid peroxidation"
Any role of FSP1 in #Atherosclerosis!?😆
@olzmannlab.bsky.social #NatCellBio 2025
www.nature.com/articles/s41...
November 9, 2025 at 1:21 PM
Lipid quality control #Ferroptosis
"Lipid Droplet-localized FSP1/ferroptosis suppressor protein 1 reduces CoQ10 to generate local antioxidants that prevent neutral lipid peroxidation"
Any role of FSP1 in #Atherosclerosis!?😆
@olzmannlab.bsky.social #NatCellBio 2025
www.nature.com/articles/s41...
"Lipid Droplet-localized FSP1/ferroptosis suppressor protein 1 reduces CoQ10 to generate local antioxidants that prevent neutral lipid peroxidation"
Any role of FSP1 in #Atherosclerosis!?😆
@olzmannlab.bsky.social #NatCellBio 2025
www.nature.com/articles/s41...
Multimodal non-invasive imaging of mouse #LimbIschemia
#LaserSpeckleImaging
#NearInfrared2ZoneImaging
#DuplexUltrasound Flow + Muscle elastography
#OpticalCoherenceTomographyAngiography
+Some human data #T2D
#BioengTranslMed 2025
aiche.onlinelibrary.wiley.com/doi/10.1002/...
#LaserSpeckleImaging
#NearInfrared2ZoneImaging
#DuplexUltrasound Flow + Muscle elastography
#OpticalCoherenceTomographyAngiography
+Some human data #T2D
#BioengTranslMed 2025
aiche.onlinelibrary.wiley.com/doi/10.1002/...
November 8, 2025 at 11:15 PM
Multimodal non-invasive imaging of mouse #LimbIschemia
#LaserSpeckleImaging
#NearInfrared2ZoneImaging
#DuplexUltrasound Flow + Muscle elastography
#OpticalCoherenceTomographyAngiography
+Some human data #T2D
#BioengTranslMed 2025
aiche.onlinelibrary.wiley.com/doi/10.1002/...
#LaserSpeckleImaging
#NearInfrared2ZoneImaging
#DuplexUltrasound Flow + Muscle elastography
#OpticalCoherenceTomographyAngiography
+Some human data #T2D
#BioengTranslMed 2025
aiche.onlinelibrary.wiley.com/doi/10.1002/...
"Second Skin"
A flexible PDMS window enables up to 3-week intravital imaging of mouse tissue dynamics of mammary gland, tumor & even skeletal muscle!
Direct visualization of satellite cell division in injured muscle
Enjoyable re-reading!😄
#ScienceAdvances 2021
www.science.org/doi/10.1126/...
A flexible PDMS window enables up to 3-week intravital imaging of mouse tissue dynamics of mammary gland, tumor & even skeletal muscle!
Direct visualization of satellite cell division in injured muscle
Enjoyable re-reading!😄
#ScienceAdvances 2021
www.science.org/doi/10.1126/...
November 8, 2025 at 1:29 PM
"Second Skin"
A flexible PDMS window enables up to 3-week intravital imaging of mouse tissue dynamics of mammary gland, tumor & even skeletal muscle!
Direct visualization of satellite cell division in injured muscle
Enjoyable re-reading!😄
#ScienceAdvances 2021
www.science.org/doi/10.1126/...
A flexible PDMS window enables up to 3-week intravital imaging of mouse tissue dynamics of mammary gland, tumor & even skeletal muscle!
Direct visualization of satellite cell division in injured muscle
Enjoyable re-reading!😄
#ScienceAdvances 2021
www.science.org/doi/10.1126/...
#MetaplasticBreastCancer
Neoadjuvant chemo-immunotherapy response predicts long-term survival
KEYNOTE-522
N=32 stage I-III
high stromal tumor-infiltrating lymphocytes corr. pCR
pCR (n=7)➡️no recurrence
2/3 of residual disease➡️recurrence in 14 mo
#NPJBreastCancer2025
www.nature.com/articles/s41...
Neoadjuvant chemo-immunotherapy response predicts long-term survival
KEYNOTE-522
N=32 stage I-III
high stromal tumor-infiltrating lymphocytes corr. pCR
pCR (n=7)➡️no recurrence
2/3 of residual disease➡️recurrence in 14 mo
#NPJBreastCancer2025
www.nature.com/articles/s41...
November 7, 2025 at 8:04 PM
#MetaplasticBreastCancer
Neoadjuvant chemo-immunotherapy response predicts long-term survival
KEYNOTE-522
N=32 stage I-III
high stromal tumor-infiltrating lymphocytes corr. pCR
pCR (n=7)➡️no recurrence
2/3 of residual disease➡️recurrence in 14 mo
#NPJBreastCancer2025
www.nature.com/articles/s41...
Neoadjuvant chemo-immunotherapy response predicts long-term survival
KEYNOTE-522
N=32 stage I-III
high stromal tumor-infiltrating lymphocytes corr. pCR
pCR (n=7)➡️no recurrence
2/3 of residual disease➡️recurrence in 14 mo
#NPJBreastCancer2025
www.nature.com/articles/s41...
Hao's Preprint Reading List
November 7 2025
EndMT Thermogenesis Brown Adipose Tissue
hiPSC-derived Lymphatic Endothelial Cell
MERFISH+ 3D Spatial Transcriptomics
Atherogenic stress & Neurovascular functions
Smooth muscle lineage in Medial Arterial Calcification
docs.google.com/document/d/e...
November 7 2025
EndMT Thermogenesis Brown Adipose Tissue
hiPSC-derived Lymphatic Endothelial Cell
MERFISH+ 3D Spatial Transcriptomics
Atherogenic stress & Neurovascular functions
Smooth muscle lineage in Medial Arterial Calcification
docs.google.com/document/d/e...
November 7, 2025 at 12:05 PM
Hao's Preprint Reading List
November 7 2025
EndMT Thermogenesis Brown Adipose Tissue
hiPSC-derived Lymphatic Endothelial Cell
MERFISH+ 3D Spatial Transcriptomics
Atherogenic stress & Neurovascular functions
Smooth muscle lineage in Medial Arterial Calcification
docs.google.com/document/d/e...
November 7 2025
EndMT Thermogenesis Brown Adipose Tissue
hiPSC-derived Lymphatic Endothelial Cell
MERFISH+ 3D Spatial Transcriptomics
Atherogenic stress & Neurovascular functions
Smooth muscle lineage in Medial Arterial Calcification
docs.google.com/document/d/e...
#SmoothMuscleCell Epitranscriptomics
METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability)
135 METTL3 target genes by RNAseq+MeRIPseq in rat SMC
SMC Mettl3 KO🐭➡️
⏬carotid #IntimalHyperplasia➡️
⏫by AAV9-SM22a-SGK1
#ATVB 2025 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability)
135 METTL3 target genes by RNAseq+MeRIPseq in rat SMC
SMC Mettl3 KO🐭➡️
⏬carotid #IntimalHyperplasia➡️
⏫by AAV9-SM22a-SGK1
#ATVB 2025 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
November 6, 2025 at 7:52 PM
#SmoothMuscleCell Epitranscriptomics
METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability)
135 METTL3 target genes by RNAseq+MeRIPseq in rat SMC
SMC Mettl3 KO🐭➡️
⏬carotid #IntimalHyperplasia➡️
⏫by AAV9-SM22a-SGK1
#ATVB 2025 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability)
135 METTL3 target genes by RNAseq+MeRIPseq in rat SMC
SMC Mettl3 KO🐭➡️
⏬carotid #IntimalHyperplasia➡️
⏫by AAV9-SM22a-SGK1
#ATVB 2025 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
Bioengineering of the implantable vascularized pancreatic islet constructs for insulin delivery suitable for clinical upscaling
Amniogel (human amniotic membrane-derived)
Blood outgrowth endothelial cell
Isolate islet
s.c. graft in diabetic NSG🐭
bioRxiv 2025
www.biorxiv.org/content/10.1...
Amniogel (human amniotic membrane-derived)
Blood outgrowth endothelial cell
Isolate islet
s.c. graft in diabetic NSG🐭
bioRxiv 2025
www.biorxiv.org/content/10.1...
November 6, 2025 at 11:49 AM
Bioengineering of the implantable vascularized pancreatic islet constructs for insulin delivery suitable for clinical upscaling
Amniogel (human amniotic membrane-derived)
Blood outgrowth endothelial cell
Isolate islet
s.c. graft in diabetic NSG🐭
bioRxiv 2025
www.biorxiv.org/content/10.1...
Amniogel (human amniotic membrane-derived)
Blood outgrowth endothelial cell
Isolate islet
s.c. graft in diabetic NSG🐭
bioRxiv 2025
www.biorxiv.org/content/10.1...
NRIP2+ #SmoothMuscleCell (likely mediating metabolic resilience by Leptin signaling) #AorticDissection
Leptin antagonist R128Q or AAV9-SM22a-NRIP2
⏬🐭AD #AorticRupture (BAPN)
⏫contractile SMC
⏫SMC mitochondrial ultrastructure & OXPHOS
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Leptin antagonist R128Q or AAV9-SM22a-NRIP2
⏬🐭AD #AorticRupture (BAPN)
⏫contractile SMC
⏫SMC mitochondrial ultrastructure & OXPHOS
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
November 5, 2025 at 8:16 PM
NRIP2+ #SmoothMuscleCell (likely mediating metabolic resilience by Leptin signaling) #AorticDissection
Leptin antagonist R128Q or AAV9-SM22a-NRIP2
⏬🐭AD #AorticRupture (BAPN)
⏫contractile SMC
⏫SMC mitochondrial ultrastructure & OXPHOS
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Leptin antagonist R128Q or AAV9-SM22a-NRIP2
⏬🐭AD #AorticRupture (BAPN)
⏫contractile SMC
⏫SMC mitochondrial ultrastructure & OXPHOS
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...