#SmoothMuscleCell Epitranscriptomics

METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability)

135 METTL3 target genes by RNAseq+MeRIPseq in rat SMC

SMC Mettl3 KO🐭➡️
⏬carotid #IntimalHyperplasia➡️
⏫by AAV9-SM22a-SGK1

#ATVB 2025 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...