Guy Leonard
@guyleonard.bsky.social
Bioinformatician w/ Tom Richards & Team at @oxfordbiology.bsky.social
Homebrewer. WSET Beer Level 2.
Rejoiner 🇪🇺🤝🇬🇧
AI is not 'inevitable', resist its uncritical adoption.
Constant politics-doom ruined the other place.
Homebrewer. WSET Beer Level 2.
Rejoiner 🇪🇺🤝🇬🇧
AI is not 'inevitable', resist its uncritical adoption.
Constant politics-doom ruined the other place.
Pinned
Guy Leonard
@guyleonard.bsky.social
· Jul 1
Applications are now open for the Workshop on Genomics 2026 (11-24 Jan) in Cesky Krumlov, Czechia. For the first time, we are offering Early Bird Registration discounts! 🐣 Do not miss the chance! 🤩 Help us spread the word among friends and colleagues! 🙆🏽♀️ #evomics2026
evomics.org/apply-worksh...
evomics.org/apply-worksh...
Early bird applications are now open! Go go go genomics!
Reposted by Guy Leonard
since chatgpt has coached another young person in a mental health crisis to their death, I am yet again tapping the sign
November 7, 2025 at 10:59 AM
since chatgpt has coached another young person in a mental health crisis to their death, I am yet again tapping the sign
Nothing irks me more from a pub when you're sat at a table and a staff member comes over and reserves the table for later. I am here now, I might have stayed later. I am not coming back.
The Pellicle Essential Guide to Pub Ettiquette!
Already noted as curmudgeonly by @boakandbailey.bsky.social, we prefer "righteously bothered."
Table rezzies, bogey-filled tissues in empty glasses, rounds and more, all documented for posterity.
www.pelliclemag.com/home/2025/10...
Already noted as curmudgeonly by @boakandbailey.bsky.social, we prefer "righteously bothered."
Table rezzies, bogey-filled tissues in empty glasses, rounds and more, all documented for posterity.
www.pelliclemag.com/home/2025/10...
The Essential Guide to Pub Etiquette — Pellicle
It was the writer and politician Hilaire Belloc (1870–1953) who famously said, “ Change your hearts or you will lose your inns and you will deserve to have lost them. But when you have lost your inns ...
www.pelliclemag.com
November 5, 2025 at 9:49 AM
Nothing irks me more from a pub when you're sat at a table and a staff member comes over and reserves the table for later. I am here now, I might have stayed later. I am not coming back.
Reposted by Guy Leonard
Arthur took a deep breath without much enthusiasm.
November 4, 2025 at 10:45 AM
Arthur took a deep breath without much enthusiasm.
Reposted by Guy Leonard
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
Attention Authors: Updated Practice for Review Articles and Position Papers in arXiv CS Category – arXiv blog
blog.arxiv.org
November 1, 2025 at 5:28 PM
arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
This is due to being overwhelmed by a hundreds of AI generated papers a month.
Yet another open submission process killed by LLMs.
Reposted by Guy Leonard
Enshittification is a term coined by Cory Doctorow in 2022. In his new book, Doctorow lays out how tech companies have made our lives progressively worse, finds Matthew Sparkes
Has life today been enshittified? Cory Doctorow's new book explores
Enshittification is a term coined by Cory Doctorow in 2022. In his new book, Doctorow lays out how tech companies have made our lives progressively worse, finds Matthew Sparkes
www.newscientist.com
November 2, 2025 at 9:17 AM
Enshittification is a term coined by Cory Doctorow in 2022. In his new book, Doctorow lays out how tech companies have made our lives progressively worse, finds Matthew Sparkes
Reposted by Guy Leonard
"The new Luddites aren’t afraid of AI. They’re afraid of the people who profit from pretending it’s intelligent." Erik J. Larson reviews "The AI Con" by Emily M. Bender and Alex Hanna: https://lareviewofbooks.org/article/the-return-of-the-luddites/
October 31, 2025 at 3:31 PM
"The new Luddites aren’t afraid of AI. They’re afraid of the people who profit from pretending it’s intelligent." Erik J. Larson reviews "The AI Con" by Emily M. Bender and Alex Hanna: https://lareviewofbooks.org/article/the-return-of-the-luddites/
Reposted by Guy Leonard
@guyleonard.bsky.social et al. report a near-complete genome and transcriptome sequence dataset for green algae host Paramecium bursaria, an endosymbiotic model system.
🔗 doi.org/10.1093/gbe/evaf183
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf183
#genome #evolution
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
Abstract. How two species engage in stable endosymbiosis is a biological quandary. The study of facultative endosymbiotic interactions has emerged as a use
doi.org
October 31, 2025 at 10:54 AM
@guyleonard.bsky.social et al. report a near-complete genome and transcriptome sequence dataset for green algae host Paramecium bursaria, an endosymbiotic model system.
🔗 doi.org/10.1093/gbe/evaf183
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf183
#genome #evolution
Reposted by Guy Leonard
There's so much being researched and published about GenAI that I update the 'Against Generative AI' resource list almost every day. Check it out catherinedenial.org/blog/uncateg...
Against Generative AI – Cate Denial
catherinedenial.org
October 30, 2025 at 10:52 AM
There's so much being researched and published about GenAI that I update the 'Against Generative AI' resource list almost every day. Check it out catherinedenial.org/blog/uncateg...
Apply to our sister workshop now!
It's a great follow on from the Workshop on Genomics, and in the same great town with even more great people!
It's a great follow on from the Workshop on Genomics, and in the same great town with even more great people!
Come join the Workshop on Phylogenomics in Cesky Krumlov, Czechia, from January 25 through February 7, 2026!
Applications close November 15!
#phylogenetics #evolution #genomics #ai
evomics.org/apply-worksh...
Applications close November 15!
#phylogenetics #evolution #genomics #ai
evomics.org/apply-worksh...
Apply: Workshop on Phylogenomics 2026 - Evolution and Genomics
Application for the 2026 Workshop on Phylogenomics Use this form to apply for the 2026 Workshop on Phylogenomics being held in Cesky Krumlov, Czechia from 25th January through 7th February, ...
evomics.org
October 30, 2025 at 9:55 AM
Apply to our sister workshop now!
It's a great follow on from the Workshop on Genomics, and in the same great town with even more great people!
It's a great follow on from the Workshop on Genomics, and in the same great town with even more great people!
Reposted by Guy Leonard
Online today!
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
October 29, 2025 at 2:29 PM
Online today!
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
Online today!
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
October 29, 2025 at 2:29 PM
Online today!
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System
academic.oup.com/gbe/article/...
Reposted by Guy Leonard
Merce Montoliu brings us a presentation about wonderful #lichens at the #biodiversity25. Lichens are associations between mycobionts (fungi), photobionts (green algae or cianobacteria) and microbiomes. 38 different lichens were sequenced in DToL & ASH. Results show complex multiorganismal scenarios
October 28, 2025 at 12:21 PM
Merce Montoliu brings us a presentation about wonderful #lichens at the #biodiversity25. Lichens are associations between mycobionts (fungi), photobionts (green algae or cianobacteria) and microbiomes. 38 different lichens were sequenced in DToL & ASH. Results show complex multiorganismal scenarios
“My life mission has been [to] work on a piece of technology that would improve the quality of life of every human on the planet and hasten the coming of Christ’s return,” he said.
Utterly deranged.
Utterly deranged.
An ex-Intel CEO’s mission to build a Christian AI: ‘hasten the coming of Christ’s return’
An ex-Intel CEO’s mission to build a Christian AI: ‘hasten the coming of Christ’s return’
Patrick Gelsinger, executive chairman of Gloo, has made it his mission to advance Christian principles in Silicon Valley
www.theguardian.com
October 28, 2025 at 1:32 PM
“My life mission has been [to] work on a piece of technology that would improve the quality of life of every human on the planet and hasten the coming of Christ’s return,” he said.
Utterly deranged.
Utterly deranged.
Reposted by Guy Leonard
AI in education is the answer to a critical question: how do we provide bullshit education that will prepare students for the bullshit jobs they will do when they graduate?
May 7, 2025 at 1:01 PM
AI in education is the answer to a critical question: how do we provide bullshit education that will prepare students for the bullshit jobs they will do when they graduate?
Finally! About time.
October 27, 2025 at 9:14 PM
Finally! About time.
Reposted by Guy Leonard
The Renters’ Rights Act is NOW LAW!
Soon S21 evictions, which have forced millions of people out of their homes for no reason & with just 2 months notice, will be a thing of the past.
This is what our movement can achieve when we stand together.
Soon S21 evictions, which have forced millions of people out of their homes for no reason & with just 2 months notice, will be a thing of the past.
This is what our movement can achieve when we stand together.
October 27, 2025 at 8:13 PM
The Renters’ Rights Act is NOW LAW!
Soon S21 evictions, which have forced millions of people out of their homes for no reason & with just 2 months notice, will be a thing of the past.
This is what our movement can achieve when we stand together.
Soon S21 evictions, which have forced millions of people out of their homes for no reason & with just 2 months notice, will be a thing of the past.
This is what our movement can achieve when we stand together.
Reposted by Guy Leonard
Katrien Beuls: "When ChatGPT launched at the end of 2022, the then rector, Rik Van de Walle, swiftly announced that students could use the chatbot for their master's thesis. A bad move. Or at least the beginning of a lot of trouble.”
apache.be/2025/10/24/b...
apache.be/2025/10/24/b...
Belgian AI scientists resist the use of AI in academia
Several AI scientists have published an open letter calling for a ban on AI use by students.
apache.be
October 24, 2025 at 10:18 AM
Katrien Beuls: "When ChatGPT launched at the end of 2022, the then rector, Rik Van de Walle, swiftly announced that students could use the chatbot for their master's thesis. A bad move. Or at least the beginning of a lot of trouble.”
apache.be/2025/10/24/b...
apache.be/2025/10/24/b...
Reposted by Guy Leonard
Just nuked my Spotify account. If they're going to invest in AI to kill people, donate money to Trump and run ICE adverts then I want nothing to do with them!
October 23, 2025 at 9:05 PM
Just nuked my Spotify account. If they're going to invest in AI to kill people, donate money to Trump and run ICE adverts then I want nothing to do with them!
"provokes strong responses in people"
an interesting way to write "lactose intolerance" :p
an interesting way to write "lactose intolerance" :p
'Milk is never just milk. It’s saturated with meaning, emotion and contradiction, and provokes strong responses in people.'
Read more ⬇️
Read more ⬇️
The politics of milk: how a simple drink got caught up in power, culture and identity
Milk is never just milk. It’s saturated with meaning, emotion and contradiction, and provokes strong responses in people.
theconversation.com
October 22, 2025 at 1:12 PM
"provokes strong responses in people"
an interesting way to write "lactose intolerance" :p
an interesting way to write "lactose intolerance" :p
Reposted by Guy Leonard
Reposted by Guy Leonard
🧬 Now published in Bioinformatics Advances: “Advances and challenges in understanding evolution through genome comparison.”
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf223
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf223
October 20, 2025 at 10:01 AM
🧬 Now published in Bioinformatics Advances: “Advances and challenges in understanding evolution through genome comparison.”
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf223
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf223
Reposted by Guy Leonard
Every AWS outage makes it extremely, painfully clear that consolidating the entire Internet in the hands of one fucked up billionaire is not a good idea.
And then it's resolved and everyone kind of forgets about it til the next time.
And the next time, their fridge stops working because of it.
And then it's resolved and everyone kind of forgets about it til the next time.
And the next time, their fridge stops working because of it.
October 20, 2025 at 10:13 AM
Every AWS outage makes it extremely, painfully clear that consolidating the entire Internet in the hands of one fucked up billionaire is not a good idea.
And then it's resolved and everyone kind of forgets about it til the next time.
And the next time, their fridge stops working because of it.
And then it's resolved and everyone kind of forgets about it til the next time.
And the next time, their fridge stops working because of it.
Reposted by Guy Leonard
I'm advertising a PhD project on the evolution of horizontal transfer. Interested in this or other topics in evolution and species diversity, please get in touch. www.findaphd.com/phds/project...
The evolutionary costs and benefits of horizontal gene transfer in eukaryotes (TB01) at University of Oxford on FindAPhD.com
PhD Project - The evolutionary costs and benefits of horizontal gene transfer in eukaryotes (TB01) at University of Oxford, listed on FindAPhD.com
www.findaphd.com
October 20, 2025 at 10:41 AM
I'm advertising a PhD project on the evolution of horizontal transfer. Interested in this or other topics in evolution and species diversity, please get in touch. www.findaphd.com/phds/project...
Reposted by Guy Leonard
tl;dr
1. Studies of genAI in the classroom show that it harms learning
2. The quality of AI-generated text is irrelevant to its most negative effects on teaching
3. The way AI has entered the classroom is as a money-making project extracting new labour, not a “tool” serving teachers’ actual needs
1. Studies of genAI in the classroom show that it harms learning
2. The quality of AI-generated text is irrelevant to its most negative effects on teaching
3. The way AI has entered the classroom is as a money-making project extracting new labour, not a “tool” serving teachers’ actual needs
Why I am not using AI in the classroom
Last week I spoke with some of my colleagues about the “challenges” posed by generative AI to our teaching. As anyone who follows me on Bluesky — or followed me on Twitter, prior …
memoriousblog.com
October 19, 2025 at 4:32 PM
tl;dr
1. Studies of genAI in the classroom show that it harms learning
2. The quality of AI-generated text is irrelevant to its most negative effects on teaching
3. The way AI has entered the classroom is as a money-making project extracting new labour, not a “tool” serving teachers’ actual needs
1. Studies of genAI in the classroom show that it harms learning
2. The quality of AI-generated text is irrelevant to its most negative effects on teaching
3. The way AI has entered the classroom is as a money-making project extracting new labour, not a “tool” serving teachers’ actual needs