Greg Sebepos-Rogers
@gseberog.bsky.social
Gastroenterologist @Imperial, organoid dabbler, interested in Inflammatory Bowel Disease.
Reposted by Greg Sebepos-Rogers
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
www.nature.com
November 7, 2025 at 12:30 PM
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
Reposted by Greg Sebepos-Rogers
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
October 14, 2025 at 5:07 PM
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Reposted by Greg Sebepos-Rogers
Do you have:
📌 Blood in your poo?
📌 Abdominal pain that won’t go away?
📌 Diarrhoea that can’t wait?
If you have experienced any of these symptoms, you may have a problem with your bowel health.
FREE testing kits are available for EX postcode residents aged 16–49 ➡️ bit.ly/IBDKit
📌 Blood in your poo?
📌 Abdominal pain that won’t go away?
📌 Diarrhoea that can’t wait?
If you have experienced any of these symptoms, you may have a problem with your bowel health.
FREE testing kits are available for EX postcode residents aged 16–49 ➡️ bit.ly/IBDKit
October 6, 2025 at 9:07 AM
Do you have:
📌 Blood in your poo?
📌 Abdominal pain that won’t go away?
📌 Diarrhoea that can’t wait?
If you have experienced any of these symptoms, you may have a problem with your bowel health.
FREE testing kits are available for EX postcode residents aged 16–49 ➡️ bit.ly/IBDKit
📌 Blood in your poo?
📌 Abdominal pain that won’t go away?
📌 Diarrhoea that can’t wait?
If you have experienced any of these symptoms, you may have a problem with your bowel health.
FREE testing kits are available for EX postcode residents aged 16–49 ➡️ bit.ly/IBDKit
Reposted by Greg Sebepos-Rogers
Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
September 27, 2025 at 2:40 PM
Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Greg Sebepos-Rogers
Reposted by Greg Sebepos-Rogers
Honoured to to be part of this Future of Hepatology session at @easlnews.bsky.social #EASL2025, discussing the promise of #microbiome related therapies in #PSC #cholestatic liver disease - where have we come since the original #FMT #PSC pilot study by @DrAllegrettiIBD? doi.org/10.14309/ajg...
May 10, 2025 at 6:33 AM
Honoured to to be part of this Future of Hepatology session at @easlnews.bsky.social #EASL2025, discussing the promise of #microbiome related therapies in #PSC #cholestatic liver disease - where have we come since the original #FMT #PSC pilot study by @DrAllegrettiIBD? doi.org/10.14309/ajg...
Reposted by Greg Sebepos-Rogers
📘 What could nephrology look like in 2050?
This article for the Future Healthcare Journal was fun to write! — here’s a 🧵 of what might be coming next in kidney care:
shorturl.at/A18zK
This article for the Future Healthcare Journal was fun to write! — here’s a 🧵 of what might be coming next in kidney care:
shorturl.at/A18zK
The future of nephrology in 2050
As medicine advances at an unprecedented pace, the field of nephrology is poised for transformative change. By 2050, breakthroughs in kidney disease p…
shorturl.at
April 2, 2025 at 1:43 PM
📘 What could nephrology look like in 2050?
This article for the Future Healthcare Journal was fun to write! — here’s a 🧵 of what might be coming next in kidney care:
shorturl.at/A18zK
This article for the Future Healthcare Journal was fun to write! — here’s a 🧵 of what might be coming next in kidney care:
shorturl.at/A18zK
Reposted by Greg Sebepos-Rogers
The National Genomics Education Programme have launched #GeNotes collection specifically for #Genomics cases in your practice @britsocgastro.bsky.social www.bsg.org.uk/news/new-nat...
New national genomics resources in Gastroenterology and Hepatology
The National Genomics Education Programme have launched #GeNotes collection specifically for #Genomics cases in your practice. It is packed with educational scenarios written by experts in your field,...
www.bsg.org.uk
March 19, 2025 at 12:35 PM
The National Genomics Education Programme have launched #GeNotes collection specifically for #Genomics cases in your practice @britsocgastro.bsky.social www.bsg.org.uk/news/new-nat...
Reposted by Greg Sebepos-Rogers
1. You feel powerless? Don’t know what you can do to resist the rise of fascism?
Here is an answer: Good Things.
Fascism inflicts pain and harm as a matter of doctrine.
Kindness, care and conviviality defend us from it.
The more we build community, the less it can take root.
🧵
Here is an answer: Good Things.
Fascism inflicts pain and harm as a matter of doctrine.
Kindness, care and conviviality defend us from it.
The more we build community, the less it can take root.
🧵
March 10, 2025 at 1:12 PM
1. You feel powerless? Don’t know what you can do to resist the rise of fascism?
Here is an answer: Good Things.
Fascism inflicts pain and harm as a matter of doctrine.
Kindness, care and conviviality defend us from it.
The more we build community, the less it can take root.
🧵
Here is an answer: Good Things.
Fascism inflicts pain and harm as a matter of doctrine.
Kindness, care and conviviality defend us from it.
The more we build community, the less it can take root.
🧵
Reposted by Greg Sebepos-Rogers
A great first day at the #BSG #GutMicrobiome event, covering everything from early life @halllab.bsky.social, to #liver @debbieshawcross.bsky.social, to #cancer @jameskinross.bsky.social, and culminating in a tour de force on #IBD and the #microbiome in clinical practice from Prof Harry Sokol
March 6, 2025 at 9:46 PM
A great first day at the #BSG #GutMicrobiome event, covering everything from early life @halllab.bsky.social, to #liver @debbieshawcross.bsky.social, to #cancer @jameskinross.bsky.social, and culminating in a tour de force on #IBD and the #microbiome in clinical practice from Prof Harry Sokol
Reposted by Greg Sebepos-Rogers
🚨 We're hiring! 🚨
The Chain Florey Transition-To-Independence Fellowship Scheme is open for applications! We have 3 positions available: 2 generic and 1 cardiology specific.
If you're a clinician scientist this is your chance to join the Chain Florey program!
Don't miss out—apply now! 💼👇
The Chain Florey Transition-To-Independence Fellowship Scheme is open for applications! We have 3 positions available: 2 generic and 1 cardiology specific.
If you're a clinician scientist this is your chance to join the Chain Florey program!
Don't miss out—apply now! 💼👇
Vacancies at the LMS
View all the current vacancies at the MRC Laboratory of Medical Sciences, including research, technician, and support roles and jobs.
lms.mrc.ac.uk
February 12, 2025 at 1:13 PM
🚨 We're hiring! 🚨
The Chain Florey Transition-To-Independence Fellowship Scheme is open for applications! We have 3 positions available: 2 generic and 1 cardiology specific.
If you're a clinician scientist this is your chance to join the Chain Florey program!
Don't miss out—apply now! 💼👇
The Chain Florey Transition-To-Independence Fellowship Scheme is open for applications! We have 3 positions available: 2 generic and 1 cardiology specific.
If you're a clinician scientist this is your chance to join the Chain Florey program!
Don't miss out—apply now! 💼👇
Reposted by Greg Sebepos-Rogers
Wondering if your patient with small bowel inflammation has Crohn's vs intestinal TB?
Summarize all of your data with this website to get a probability. Add new (projected) test results to see how new results would change the estimate. #IBD
www.pathology.med.umich.edu/shiny/tbcroh...
Summarize all of your data with this website to get a probability. Add new (projected) test results to see how new results would change the estimate. #IBD
www.pathology.med.umich.edu/shiny/tbcroh...
Model to differentiate intestinal TB from Crohn's disease
www.pathology.med.umich.edu
January 25, 2025 at 1:03 AM
Wondering if your patient with small bowel inflammation has Crohn's vs intestinal TB?
Summarize all of your data with this website to get a probability. Add new (projected) test results to see how new results would change the estimate. #IBD
www.pathology.med.umich.edu/shiny/tbcroh...
Summarize all of your data with this website to get a probability. Add new (projected) test results to see how new results would change the estimate. #IBD
www.pathology.med.umich.edu/shiny/tbcroh...
Reposted by Greg Sebepos-Rogers
Really enjoyed working on this review for Frontline Gastroenterology. How do anti-IL23 therapies work? What’s the evidence for their use in IBD? And is there any guidance on how we should position them in the treatment landscape?
fg.bmj.com/content/earl...
fg.bmj.com/content/earl...
January 17, 2025 at 11:15 AM
Really enjoyed working on this review for Frontline Gastroenterology. How do anti-IL23 therapies work? What’s the evidence for their use in IBD? And is there any guidance on how we should position them in the treatment landscape?
fg.bmj.com/content/earl...
fg.bmj.com/content/earl...
Reposted by Greg Sebepos-Rogers
Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social
FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial
Introduction Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven...
doi.org
January 7, 2025 at 7:30 AM
Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social
Reposted by Greg Sebepos-Rogers
Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
December 18, 2024 at 8:15 PM
Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Greg Sebepos-Rogers
Check out the @mrc-lms.bsky.social Chain Florey clinician scientist programme for those interested in mechanistic discovery science and experimental medicine - 12-month predoctoral fellowships currently up for grabs!
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
December 10, 2024 at 4:53 PM
Check out the @mrc-lms.bsky.social Chain Florey clinician scientist programme for those interested in mechanistic discovery science and experimental medicine - 12-month predoctoral fellowships currently up for grabs!
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
Reposted by Greg Sebepos-Rogers
What is inflammatory bowel disease (IBD) and how can a gene desert help us to understand its causes and potential future treatments? 🧬🧪
Hear the Crick's James Lee sharing his insights in the first in our series of Crick Crash Courses. www.youtube.com/watch?v=bcc8...
Hear the Crick's James Lee sharing his insights in the first in our series of Crick Crash Courses. www.youtube.com/watch?v=bcc8...
IBD and Gene Deserts - with James Lee
YouTube video by Francis Crick Institute
www.youtube.com
December 4, 2024 at 4:53 PM
What is inflammatory bowel disease (IBD) and how can a gene desert help us to understand its causes and potential future treatments? 🧬🧪
Hear the Crick's James Lee sharing his insights in the first in our series of Crick Crash Courses. www.youtube.com/watch?v=bcc8...
Hear the Crick's James Lee sharing his insights in the first in our series of Crick Crash Courses. www.youtube.com/watch?v=bcc8...
Reposted by Greg Sebepos-Rogers
New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA
shorturl.at/EImjA
Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia
Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While representing interesting targets for immunomodulatory therapies in inflamma...
shorturl.at
December 1, 2024 at 8:45 PM
New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA
shorturl.at/EImjA
Reposted by Greg Sebepos-Rogers
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
December 1, 2024 at 11:12 PM
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
Reposted by Greg Sebepos-Rogers
#LocationLocationLocation! Baghdadi, Kim &co show @science.org that intestinal stem cells #ISCs located at the bottom of the crypts sense a more rigid environment & activate PIEZO to tune their proliferation/differentiation maintaining gut physiology! doi.org/10.1126/scie...
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...
doi.org
November 29, 2024 at 5:21 PM
#LocationLocationLocation! Baghdadi, Kim &co show @science.org that intestinal stem cells #ISCs located at the bottom of the crypts sense a more rigid environment & activate PIEZO to tune their proliferation/differentiation maintaining gut physiology! doi.org/10.1126/scie...
Reposted by Greg Sebepos-Rogers
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
https://www.nature.com/articles/s41586-024-08216-z
t.co
November 23, 2024 at 8:37 PM
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
Reposted by Greg Sebepos-Rogers
👨🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5
November 13, 2024 at 9:14 PM
👨🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5
Reposted by Greg Sebepos-Rogers
Happy to share the work from my residency at #Charite available as pre-proof version in #Gastroenterology.
We identify Ki67+ memory CD4+ T cells as robust blood-based predictor for non-response to #vedolizumab (anti-integrin a4b7) in #IBD patients before therapy.
doi.org/10.1053/j.ga...
We identify Ki67+ memory CD4+ T cells as robust blood-based predictor for non-response to #vedolizumab (anti-integrin a4b7) in #IBD patients before therapy.
doi.org/10.1053/j.ga...
Redirecting
doi.org
November 21, 2024 at 3:32 PM
Happy to share the work from my residency at #Charite available as pre-proof version in #Gastroenterology.
We identify Ki67+ memory CD4+ T cells as robust blood-based predictor for non-response to #vedolizumab (anti-integrin a4b7) in #IBD patients before therapy.
doi.org/10.1053/j.ga...
We identify Ki67+ memory CD4+ T cells as robust blood-based predictor for non-response to #vedolizumab (anti-integrin a4b7) in #IBD patients before therapy.
doi.org/10.1053/j.ga...
Reposted by Greg Sebepos-Rogers
Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
T cell mediated impairment of epithelial integrity in Crohn's disease
T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance between self-renewal and differentiation of intestinal epithelial cells (IECs). In Crohn's disease (C...
www.biorxiv.org
November 16, 2024 at 4:50 PM
Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...