Lionel Le Bourhis
@lionellb.bsky.social
Assistant Professor (CRCN) Immunologist at the institut de Recherche Saint-Louis, INSERM, in Paris.
Working on immune responses in the human intestinal mucosa.
Working on immune responses in the human intestinal mucosa.
Today was the annual Remind Getaid meeting of French clinical and translational research on Inflammatory Bowel Diseases.
There were great discussion and a vibrant hommage to Nicolas Barnich.
There were great discussion and a vibrant hommage to Nicolas Barnich.
December 6, 2024 at 6:15 PM
Today was the annual Remind Getaid meeting of French clinical and translational research on Inflammatory Bowel Diseases.
There were great discussion and a vibrant hommage to Nicolas Barnich.
There were great discussion and a vibrant hommage to Nicolas Barnich.
Reposted by Lionel Le Bourhis
New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA
shorturl.at/EImjA
Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia
Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While representing interesting targets for immunomodulatory therapies in inflamma...
shorturl.at
December 1, 2024 at 8:45 PM
New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA
shorturl.at/EImjA
Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
T cell mediated impairment of epithelial integrity in Crohn's disease
T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance between self-renewal and differentiation of intestinal epithelial cells (IECs). In Crohn's disease (C...
www.biorxiv.org
November 16, 2024 at 4:50 PM
Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lionel Le Bourhis
T cell mediated impairment of epithelial integrity in Crohn's disease https://www.biorxiv.org/content/10.1101/2024.11.12.621219v1
T cell mediated impairment of epithelial integrity in Crohn's disease https://www.biorxiv.org/content/10.1101/2024.11.12.621219v1
T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance b
www.biorxiv.org
November 15, 2024 at 9:15 PM
T cell mediated impairment of epithelial integrity in Crohn's disease https://www.biorxiv.org/content/10.1101/2024.11.12.621219v1