Gesa Freimann
@gfreimann.bsky.social
Doctoral researcher @mpi-bio-fml.bsky.social
The smallest things in life hold so much mystery - I research them 💻, and I love talking about them 💬!
The smallest things in life hold so much mystery - I research them 💻, and I love talking about them 💬!
Reposted by Gesa Freimann
We’re renewing our collaboration with Google DeepMind!
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
October 7, 2025 at 2:03 PM
We’re renewing our collaboration with Google DeepMind!
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
Reposted by Gesa Freimann
Stability vs flexibility: reshaping archaeal membranes in silico
This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model.
buff.ly/jCnRfkO
This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model.
buff.ly/jCnRfkO
September 16, 2025 at 10:02 AM
Stability vs flexibility: reshaping archaeal membranes in silico
This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model.
buff.ly/jCnRfkO
This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model.
buff.ly/jCnRfkO
Reposted by Gesa Freimann
🔔 Don't forget to register for our special edition webinar on 23 September where we will have 3 interesting talks by our BioExcel Summer School 2025 poster prize winners:
Find out more and register here ➡️ bioexcel.eu/ion8
Find out more and register here ➡️ bioexcel.eu/ion8
Webinar Special Edition: Summer School 2025 poster prize winners (2025-09-23)
Date: 23 September 2025
Time: 15:00 CET
Registration
This special edition of the BioExcel webinar series features student speakers who were awarded poster prizes at the BioExcel Summer School 2025. R...
bioexcel.eu
September 9, 2025 at 8:17 AM
🔔 Don't forget to register for our special edition webinar on 23 September where we will have 3 interesting talks by our BioExcel Summer School 2025 poster prize winners:
Find out more and register here ➡️ bioexcel.eu/ion8
Find out more and register here ➡️ bioexcel.eu/ion8
Reposted by Gesa Freimann
There are strong indications that micro- and nanoplastics exposure negatively impacts human health, but a robust evidence base is lacking. A Review in Nature Medicine focuses on the current state of the science. go.nature.com/47H9Q3s #medsky 🧪
September 15, 2025 at 4:39 PM
There are strong indications that micro- and nanoplastics exposure negatively impacts human health, but a robust evidence base is lacking. A Review in Nature Medicine focuses on the current state of the science. go.nature.com/47H9Q3s #medsky 🧪
Reposted by Gesa Freimann
Reminder: We want to hear *your voice* on taboos in women's and gender diverse health! 💬🧠Your perspective will directly inform priorities in research and a women's health resource platform. Find survey link at our website: www.cbs.mpg.de/cbs/en/resea...
August 28, 2025 at 10:21 AM
Reminder: We want to hear *your voice* on taboos in women's and gender diverse health! 💬🧠Your perspective will directly inform priorities in research and a women's health resource platform. Find survey link at our website: www.cbs.mpg.de/cbs/en/resea...
Reposted by Gesa Freimann
📢Our next webinar is a special edition featuring the BioExcel Summer School 2025 poster prize winners
🗓️ Join us on 23 September at 15:00 CET
✍️ Registration and further information ➡️bioexcel.eu/ion8
Find out more about our speakers and their research...
🗓️ Join us on 23 September at 15:00 CET
✍️ Registration and further information ➡️bioexcel.eu/ion8
Find out more about our speakers and their research...
September 2, 2025 at 9:26 AM
📢Our next webinar is a special edition featuring the BioExcel Summer School 2025 poster prize winners
🗓️ Join us on 23 September at 15:00 CET
✍️ Registration and further information ➡️bioexcel.eu/ion8
Find out more about our speakers and their research...
🗓️ Join us on 23 September at 15:00 CET
✍️ Registration and further information ➡️bioexcel.eu/ion8
Find out more about our speakers and their research...
Reposted by Gesa Freimann
Nature research paper: One-shot design of functional protein binders with BindCraft
go.nature.com/46bhOAv
go.nature.com/46bhOAv
One-shot design of functional protein binders with BindCraft - Nature
BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.
go.nature.com
September 1, 2025 at 5:37 PM
Nature research paper: One-shot design of functional protein binders with BindCraft
go.nature.com/46bhOAv
go.nature.com/46bhOAv
Reposted by Gesa Freimann
Was passiert, wenn Hirn, Herz und Hormone aufeinandertreffen? Das zeigt die Ausstellung „LIEBE.“ im Universum Bremen. Die wissenschaftliche Leiterin Dr. Kerstin Haller erläutert, wie die Liebe jenseits gängiger Klischees vermittelt wird. www.wissenschaftskommunikation.de/so-wird-lieb... #Wisskomm
August 13, 2025 at 8:02 AM
Was passiert, wenn Hirn, Herz und Hormone aufeinandertreffen? Das zeigt die Ausstellung „LIEBE.“ im Universum Bremen. Die wissenschaftliche Leiterin Dr. Kerstin Haller erläutert, wie die Liebe jenseits gängiger Klischees vermittelt wird. www.wissenschaftskommunikation.de/so-wird-lieb... #Wisskomm
Reposted by Gesa Freimann
#Pflanzen und #Pilze arbeiten eng zusammen - und sie profitieren beide! 🤗 Wie diese #Symbiose funktioniert, erklärt Caroline Gutjahr in diesem Podcast 🎙️https://detektor.fm/wissen/forschungsquartett-mykorrhiza #Mykorrhiza @detektorfm.bsky.social @mpi-mp-potsdam.bsky.social @carogutj.bsky.social
Mykorrhiza: Wie Pilze und Pflanzen zusammenarbeiten
Pilze und Pflanzenwurzeln verbindet eine enge Gemeinschaft: In ihrer Mykorrhiza-Symbiose tauschen sie lebenswichtige Nährstoffe aus.
detektor.fm
August 7, 2025 at 3:00 PM
#Pflanzen und #Pilze arbeiten eng zusammen - und sie profitieren beide! 🤗 Wie diese #Symbiose funktioniert, erklärt Caroline Gutjahr in diesem Podcast 🎙️https://detektor.fm/wissen/forschungsquartett-mykorrhiza #Mykorrhiza @detektorfm.bsky.social @mpi-mp-potsdam.bsky.social @carogutj.bsky.social
This summer school was so much fun! I feel honored to be selected as a speaker at the BioExcel webinar 🎤🎤☺️
👏 Congratulations to the Summer School 2025 poster prize winners!
🏆 Zuzana Janáčková
🏆 Jan van Elteren
🏆 Gesa Laura Freimann
Join us for a special edition webinar where they will present their work
🗓️ 23 September 2025, 15:00 CET
🏆 Zuzana Janáčková
🏆 Jan van Elteren
🏆 Gesa Laura Freimann
Join us for a special edition webinar where they will present their work
🗓️ 23 September 2025, 15:00 CET
June 17, 2025 at 8:42 AM
This summer school was so much fun! I feel honored to be selected as a speaker at the BioExcel webinar 🎤🎤☺️
Reposted by Gesa Freimann
Day 4 of the Summer School 2025 was about workflows and protein structure prediction
Adam Hospital introduced BioExcel Building Blocks #BioBB and followed up with a hands-on #tutorial on how to perform protein-ligand complex #moleculardynamics in Jupyter notebooks using BioBB
Adam Hospital introduced BioExcel Building Blocks #BioBB and followed up with a hands-on #tutorial on how to perform protein-ligand complex #moleculardynamics in Jupyter notebooks using BioBB
June 12, 2025 at 3:29 PM
Day 4 of the Summer School 2025 was about workflows and protein structure prediction
Adam Hospital introduced BioExcel Building Blocks #BioBB and followed up with a hands-on #tutorial on how to perform protein-ligand complex #moleculardynamics in Jupyter notebooks using BioBB
Adam Hospital introduced BioExcel Building Blocks #BioBB and followed up with a hands-on #tutorial on how to perform protein-ligand complex #moleculardynamics in Jupyter notebooks using BioBB
Reposted by Gesa Freimann
Day 3 of the Summer School is about enhanced sampling and free energy calculations⚡️
Berk Hess introduced the AWH method implemented in #GROMACS and illustrated its application to alchemical transformations where the main challenge is to define a good reaction coordinate
Berk Hess introduced the AWH method implemented in #GROMACS and illustrated its application to alchemical transformations where the main challenge is to define a good reaction coordinate
June 11, 2025 at 12:22 PM
Day 3 of the Summer School is about enhanced sampling and free energy calculations⚡️
Berk Hess introduced the AWH method implemented in #GROMACS and illustrated its application to alchemical transformations where the main challenge is to define a good reaction coordinate
Berk Hess introduced the AWH method implemented in #GROMACS and illustrated its application to alchemical transformations where the main challenge is to define a good reaction coordinate
Reposted by Gesa Freimann
First full day of the Summer School on Biomolecular Simulations 2025 in Sardinia 😎 🏖️
It's mostly about #moleculardynamics and #GROMACS with lectures and hands-on tutorials
Check out these useful MD tricks from Prof. Berk Hess👇
It's mostly about #moleculardynamics and #GROMACS with lectures and hands-on tutorials
Check out these useful MD tricks from Prof. Berk Hess👇
June 9, 2025 at 8:15 PM
First full day of the Summer School on Biomolecular Simulations 2025 in Sardinia 😎 🏖️
It's mostly about #moleculardynamics and #GROMACS with lectures and hands-on tutorials
Check out these useful MD tricks from Prof. Berk Hess👇
It's mostly about #moleculardynamics and #GROMACS with lectures and hands-on tutorials
Check out these useful MD tricks from Prof. Berk Hess👇
Fantastic Proteins, Fantastic Team, Fantastic Diversity Day! 🪄
At this year's diversity day at @mpi-bio-fml.bsky.social , we shared our fascination with proteins with our colleagues.🧪
Huge thanks to my winning team: @hadeerelhabashy.bsky.social , Alex Waldherr, and Claudio Piselli ❤️
At this year's diversity day at @mpi-bio-fml.bsky.social , we shared our fascination with proteins with our colleagues.🧪
Huge thanks to my winning team: @hadeerelhabashy.bsky.social , Alex Waldherr, and Claudio Piselli ❤️
June 2, 2025 at 11:58 AM
Fantastic Proteins, Fantastic Team, Fantastic Diversity Day! 🪄
At this year's diversity day at @mpi-bio-fml.bsky.social , we shared our fascination with proteins with our colleagues.🧪
Huge thanks to my winning team: @hadeerelhabashy.bsky.social , Alex Waldherr, and Claudio Piselli ❤️
At this year's diversity day at @mpi-bio-fml.bsky.social , we shared our fascination with proteins with our colleagues.🧪
Huge thanks to my winning team: @hadeerelhabashy.bsky.social , Alex Waldherr, and Claudio Piselli ❤️
Reposted by Gesa Freimann
Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...
@mpi-bio-fml.bsky.social
@mpi-bio-fml.bsky.social
May 12, 2025 at 9:17 AM
Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...
@mpi-bio-fml.bsky.social
@mpi-bio-fml.bsky.social
Reposted by Gesa Freimann
209 new entries in #PDBrelease (http://PDBe.org/latest)! Here's the cryo-EM derived structure of a photosystem II complex with a Lys317Ala mutation that reveal new insights into proton egress through the conserved chlorine (Cl1) hydrogen-bonding channel (http://PDBe.org/9eh5).
February 19, 2025 at 1:09 PM
209 new entries in #PDBrelease (http://PDBe.org/latest)! Here's the cryo-EM derived structure of a photosystem II complex with a Lys317Ala mutation that reveal new insights into proton egress through the conserved chlorine (Cl1) hydrogen-bonding channel (http://PDBe.org/9eh5).
Reposted by Gesa Freimann
Cook, Chen, Nguyen, Claveras et al. used #CryoEM ❄️& #moleculardynamics 💻 to crack the activation code of this essential complex. Read more here: www.science.org/doi/10.1126/...
Structural pathway for PI3-kinase regulation by VPS15 in autophagy
The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and -C2) have vital roles in macroautophagy and endosomal maturation, respectively. We elucidated a structural pathway of enzy...
www.science.org
February 7, 2025 at 11:22 AM
Cook, Chen, Nguyen, Claveras et al. used #CryoEM ❄️& #moleculardynamics 💻 to crack the activation code of this essential complex. Read more here: www.science.org/doi/10.1126/...
Reposted by Gesa Freimann
January's Molecule of the Month on Assembly Line Polyketide Synthases
Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner. Column by @janetiwasa
pdb101.rcsb.org/motm...
Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner. Column by @janetiwasa
pdb101.rcsb.org/motm...
PDB101: Molecule of the Month: Assembly Line Polyketide Synthases
Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner.
pdb101.rcsb.org
January 9, 2025 at 5:12 PM
January's Molecule of the Month on Assembly Line Polyketide Synthases
Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner. Column by @janetiwasa
pdb101.rcsb.org/motm...
Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner. Column by @janetiwasa
pdb101.rcsb.org/motm...
Reposted by Gesa Freimann
Is your favourite fruit at risk?🍌
Watch & learn from Dr. Honour McCann @honour.bsky.social as she dives into the impact of the pathogen Ralstonia syzygii on banana plantations in our new video.
For more on #PlantPathogen #Evolution, visit: www.bio.mpg.de/48883/plant-pathogen-evolution-honour-mccann
Watch & learn from Dr. Honour McCann @honour.bsky.social as she dives into the impact of the pathogen Ralstonia syzygii on banana plantations in our new video.
For more on #PlantPathogen #Evolution, visit: www.bio.mpg.de/48883/plant-pathogen-evolution-honour-mccann
Plant Pathogen Evolution: Bananas
YouTube video by MPI for Biology & Friedrich Miescher Laboratory
youtu.be
December 19, 2024 at 10:54 AM
Is your favourite fruit at risk?🍌
Watch & learn from Dr. Honour McCann @honour.bsky.social as she dives into the impact of the pathogen Ralstonia syzygii on banana plantations in our new video.
For more on #PlantPathogen #Evolution, visit: www.bio.mpg.de/48883/plant-pathogen-evolution-honour-mccann
Watch & learn from Dr. Honour McCann @honour.bsky.social as she dives into the impact of the pathogen Ralstonia syzygii on banana plantations in our new video.
For more on #PlantPathogen #Evolution, visit: www.bio.mpg.de/48883/plant-pathogen-evolution-honour-mccann
Reposted by Gesa Freimann
📣Please share: we're hiring a 𝗧𝗲𝗰𝗵𝗻𝗶𝗰𝗮𝗹 𝗔𝘀𝘀𝗶𝘀𝘁𝗮𝗻𝘁 (75%-100%) for the Friedrich Miescher Laboratory (FML) of the Max Planck Society. For an overview of the tasks, our requirements for the role and to apply: jobs.tue.mpg.de/jobs/241
Deadline 15 January 2025
Deadline 15 January 2025
December 17, 2024 at 9:26 AM
📣Please share: we're hiring a 𝗧𝗲𝗰𝗵𝗻𝗶𝗰𝗮𝗹 𝗔𝘀𝘀𝗶𝘀𝘁𝗮𝗻𝘁 (75%-100%) for the Friedrich Miescher Laboratory (FML) of the Max Planck Society. For an overview of the tasks, our requirements for the role and to apply: jobs.tue.mpg.de/jobs/241
Deadline 15 January 2025
Deadline 15 January 2025
Reposted by Gesa Freimann
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 8:39 AM
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gesa Freimann
Applications are now open for fully-funded #PhD positions at the Max Planck Institute for Biology and Friedrich Miescher Laboratory. The new cohort starts September 2025.
Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de
#IMPRS
Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de
#IMPRS
December 2, 2024 at 9:03 AM
Applications are now open for fully-funded #PhD positions at the Max Planck Institute for Biology and Friedrich Miescher Laboratory. The new cohort starts September 2025.
Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de
#IMPRS
Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de
#IMPRS
Reposted by Gesa Freimann
If you've ever thought to yourself "self, I wish there was a place that I could share all my molecular dynamics (MD) simulations, to support findability and re-use", I have great news!
I present to you: MDrepo, an open repository of MD simulations for proteins:
academic.oup.com/nar/advance-...
I present to you: MDrepo, an open repository of MD simulations for proteins:
academic.oup.com/nar/advance-...
MDRepo—an open data warehouse for community-contributed molecular dynamics simulations of proteins
Abstract. Molecular Dynamics (MD) simulation of biomolecules provides important insights into conformational changes and dynamic behavior, revealing critic
academic.oup.com
November 14, 2024 at 3:47 AM
If you've ever thought to yourself "self, I wish there was a place that I could share all my molecular dynamics (MD) simulations, to support findability and re-use", I have great news!
I present to you: MDrepo, an open repository of MD simulations for proteins:
academic.oup.com/nar/advance-...
I present to you: MDrepo, an open repository of MD simulations for proteins:
academic.oup.com/nar/advance-...