Giammarco Di Gregorio
@gdigregorio.bsky.social
Early-life Stress | Serotonin | Psychedelics
PhD candidate studying neuroplasticity in corticolimbic circuits @DurhamUniversity
PhD candidate studying neuroplasticity in corticolimbic circuits @DurhamUniversity
Reposted by Giammarco Di Gregorio
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience
The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...
www.nature.com
July 30, 2025 at 4:39 PM
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
www.nature.com/articles/s41...
www.nature.com/articles/s41...
LSD’s rapid antidepressant effects are modulated by 5-HT2B receptors.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
LSD's rapid antidepressant effects are modulated by 5-HT2B receptors
Recent clinical trials show that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), possess a great …
www.sciencedirect.com
July 21, 2025 at 10:30 AM
LSD’s rapid antidepressant effects are modulated by 5-HT2B receptors.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
New Faraday cage set up!
Almost ready to roll 💪🏼⚡
🔬 @marcobocchio.bsky.social
🏫 @durhampsych.bsky.social
Almost ready to roll 💪🏼⚡
🔬 @marcobocchio.bsky.social
🏫 @durhampsych.bsky.social
July 15, 2025 at 8:10 AM
New Faraday cage set up!
Almost ready to roll 💪🏼⚡
🔬 @marcobocchio.bsky.social
🏫 @durhampsych.bsky.social
Almost ready to roll 💪🏼⚡
🔬 @marcobocchio.bsky.social
🏫 @durhampsych.bsky.social
Reposted by Giammarco Di Gregorio
Intracranial directed connectivity links subregions of the prefrontal cortex to major depression
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intracranial directed connectivity links subregions of the prefrontal cortex to major depression - Nature Communications
Low frequency brain waves convey information between regions. Here, the authors demonstrate that for patients with major depression, mood becomes more negative as low frequency waves increase intensit...
www.nature.com
July 9, 2025 at 1:47 PM
Intracranial directed connectivity links subregions of the prefrontal cortex to major depression
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Giammarco Di Gregorio
Stress-responsive neuronal ensembles and β-adrenergic signaling in the basolateral amygdala modulate the infra-limbic cortical activity and govern the delayed stress-induced fear extinction deficit
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Stress-responsive neuronal ensembles and β-adrenergic signaling in the basolateral amygdala modulate the infra-limbic cortical activity and govern the delayed stress-induced fear extinction deficit.
Stress is a critical risk factor for the development of psychological disorders, including anxiety and post-traumatic stress disorder (PTSD). Key brain regions, including the basolateral amygdala (BLA...
www.jneurosci.org
July 7, 2025 at 4:54 PM
Stress-responsive neuronal ensembles and β-adrenergic signaling in the basolateral amygdala modulate the infra-limbic cortical activity and govern the delayed stress-induced fear extinction deficit
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Yesterday I got the chance to share a bit more about my PhD research at the BNA #NeuroNE2025 meeting (@britishneuro.bsky.social). I’m over the moon for receiving the prize for best poster! Thanks so much to my supervisor @marcobocchio.bsky.social for being a great mentor!
June 19, 2025 at 9:15 AM
Yesterday I got the chance to share a bit more about my PhD research at the BNA #NeuroNE2025 meeting (@britishneuro.bsky.social). I’m over the moon for receiving the prize for best poster! Thanks so much to my supervisor @marcobocchio.bsky.social for being a great mentor!
Reposted by Giammarco Di Gregorio
Scholarship for Durham University Students
£15,000 for a full-time student from the North East of England and from a lower income household to study full-time for a STEM taught Masters degree for the year 2025-26.
Durham people please spread the word!
Application form 👇
£15,000 for a full-time student from the North East of England and from a lower income household to study full-time for a STEM taught Masters degree for the year 2025-26.
Durham people please spread the word!
Application form 👇
Microsoft Forms
forms.office.com
June 12, 2025 at 10:13 AM
Scholarship for Durham University Students
£15,000 for a full-time student from the North East of England and from a lower income household to study full-time for a STEM taught Masters degree for the year 2025-26.
Durham people please spread the word!
Application form 👇
£15,000 for a full-time student from the North East of England and from a lower income household to study full-time for a STEM taught Masters degree for the year 2025-26.
Durham people please spread the word!
Application form 👇
Reposted by Giammarco Di Gregorio
Stress-induced anxiety is associated with increased activity of the protein Rap1 in the ventral hippocampus and can be prevented by injecting a Rap1 inhibitor, a new #ScienceAdvances study shows. scim.ag/3HQyymQ
Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety
Chronic stress activates Rap1 in vHPC PNs to promote anxiety-like behaviors by increasing their intrinsic excitability.
scim.ag
June 11, 2025 at 8:14 PM
Stress-induced anxiety is associated with increased activity of the protein Rap1 in the ventral hippocampus and can be prevented by injecting a Rap1 inhibitor, a new #ScienceAdvances study shows. scim.ag/3HQyymQ
Reposted by Giammarco Di Gregorio
Exciting new work from colleagues at @umich.edu ... "Structural Brain Correlates of Multi-Domain Resilience Among Youth Exposed to Neighborhood Disadvantage" sciencedirect.com/science/arti...
June 12, 2025 at 1:33 AM
Exciting new work from colleagues at @umich.edu ... "Structural Brain Correlates of Multi-Domain Resilience Among Youth Exposed to Neighborhood Disadvantage" sciencedirect.com/science/arti...
Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood m...
Studies of psychedelic use in naturalistic and clinical settings have suggested safety and mental health benefits for adults with histories of childho…
www.sciencedirect.com
June 4, 2025 at 10:53 AM
Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Neuroplasticity and psychedelics: A comprehensive examination of classic
and non-classic compounds in pre and clinical models
www.sciencedirect.com/science/arti...
and non-classic compounds in pre and clinical models
www.sciencedirect.com/science/arti...
May 5, 2025 at 8:05 AM
Neuroplasticity and psychedelics: A comprehensive examination of classic
and non-classic compounds in pre and clinical models
www.sciencedirect.com/science/arti...
and non-classic compounds in pre and clinical models
www.sciencedirect.com/science/arti...
Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model
Major depressive disorder (MDD) remains a leading cause of disability worldwide, with current treatments limited by delayed onset and low efficacy. The serotonergic psychedelic N,N-dimethyltryptamine ...
www.biorxiv.org
May 5, 2025 at 7:42 AM
Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Giammarco Di Gregorio
🧠 🧪I am still awed by this live imaging of microglia (green) surveying #stress-sensitive CRH cells (red) in #hypothalamus and lopping off extraneous synapses. By the amazing @jessicalbolton.bsky.social #FluorescentFriday
May 2, 2025 at 5:04 PM
🧠 🧪I am still awed by this live imaging of microglia (green) surveying #stress-sensitive CRH cells (red) in #hypothalamus and lopping off extraneous synapses. By the amazing @jessicalbolton.bsky.social #FluorescentFriday
Reposted by Giammarco Di Gregorio
Stellar new paper from Tochukwu Nweze
"Developmental trajectories of externalizing and internalizing linked to harsh parenting: The role of ethnicity and socioeconomic status" now out in Development and Psychopathology www.cambridge.org/core/journal...
"Developmental trajectories of externalizing and internalizing linked to harsh parenting: The role of ethnicity and socioeconomic status" now out in Development and Psychopathology www.cambridge.org/core/journal...
May 2, 2025 at 6:23 PM
Stellar new paper from Tochukwu Nweze
"Developmental trajectories of externalizing and internalizing linked to harsh parenting: The role of ethnicity and socioeconomic status" now out in Development and Psychopathology www.cambridge.org/core/journal...
"Developmental trajectories of externalizing and internalizing linked to harsh parenting: The role of ethnicity and socioeconomic status" now out in Development and Psychopathology www.cambridge.org/core/journal...
Reposted by Giammarco Di Gregorio
Neuromodulatory signaling contributing to the encoding of aversion
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
Neuromodulatory signaling contributing to the encoding of aversion
The appropriate and rapid encoding of stimuli bearing a negative valence enables behaviors
that are essential for survival. Recent advances in neuroscience using rodents as
a model system highlight th...
www.cell.com
May 3, 2025 at 11:23 AM
Neuromodulatory signaling contributing to the encoding of aversion
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
Reposted by Giammarco Di Gregorio
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice
Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and aut...
www.biorxiv.org
March 11, 2025 at 7:00 AM
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
Reposted by Giammarco Di Gregorio
So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience
The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...
www.nature.com
February 27, 2025 at 11:52 AM
So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Reposted by Giammarco Di Gregorio
Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults with Remitted Depression www.sciencedirect.com/science/arti...
February 27, 2025 at 4:23 AM
Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults with Remitted Depression www.sciencedirect.com/science/arti...
Reposted by Giammarco Di Gregorio
Cortical representations of affective pain shape empathic fear in male mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cortical representations of affective pain shape empathic fear in male mice - Nature Communications
The neural basis of affect sharing is not fully understood. Here, the authors show that the anterior cingulate cortex (ACC) stably recruits neural ensembles encoding observational fear, specifically r...
www.nature.com
February 25, 2025 at 9:54 AM
Cortical representations of affective pain shape empathic fear in male mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Giammarco Di Gregorio
The authors of a Comment article in Nature Human Behaviour propose six actionable steps of allyship that researchers, faculty members and educators can engage in to foster a diverse, equitable and inclusive academia. #Academicsky 🧪
Cultivating allyship for a diverse, equitable and inclusive academia - Nature Human Behaviour
We propose six actionable steps of allyship that researchers, faculty members and educators can engage in to foster a diverse, equitable and inclusive academia: listening to marginalized voices, challenging one's own biases, speaking up to include disadvantaged groups, speaking out to confront bias, advocating for inclusive policies and dismantling institutional biases.
go.nature.com
February 21, 2025 at 2:36 AM
The authors of a Comment article in Nature Human Behaviour propose six actionable steps of allyship that researchers, faculty members and educators can engage in to foster a diverse, equitable and inclusive academia. #Academicsky 🧪
Reposted by Giammarco Di Gregorio
This review has turned into my go-to paper for rodent PFC circuit. Useful in the lab and for teaching. Thanks @panastasiades.bsky.social and @carterlab.bsky.social for writing this. www.cell.com/trends/neuro...
Circuit organization of the rodent medial prefrontal cortex
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted
in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous
variety of projection neurons a...
www.cell.com
February 18, 2025 at 9:21 AM
This review has turned into my go-to paper for rodent PFC circuit. Useful in the lab and for teaching. Thanks @panastasiades.bsky.social and @carterlab.bsky.social for writing this. www.cell.com/trends/neuro...
Reposted by Giammarco Di Gregorio
It turns out that the environment & exposone and how you live as well as #genetics influence health #lifespan and #Aging #genetics @naturemedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...
www.nature.com
February 19, 2025 at 11:13 AM
It turns out that the environment & exposone and how you live as well as #genetics influence health #lifespan and #Aging #genetics @naturemedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Giammarco Di Gregorio
Multiple developmental switches in mPFC-NAc and mPFC-BLA pathways that underlie developmental transitions in threat avoidance behavior revealed by circuit dissection in juvenile, adolescent and adult mice mice 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Developmentally distinct architectures in top–down pathways controlling threat avoidance - Nature Neuroscience
Through circuit dissection in juvenile, adolescent and adult mice, Klune, Goodpaster and colleagues reveal multiple developmental switches in mPFC–NAc and mPFC–BLA pathways that underlie developmental...
www.nature.com
February 20, 2025 at 4:10 PM
Multiple developmental switches in mPFC-NAc and mPFC-BLA pathways that underlie developmental transitions in threat avoidance behavior revealed by circuit dissection in juvenile, adolescent and adult mice mice 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...