Johannes Bohacek
@bohaceklab.bsky.social
Dad. Associate Professor @ ETH Zurich. We study stress, behavior, hippocampus, noradrenaline and the mighty locus coeruleus. We work with mice and focus a lot on 3Rs.
Here to learn, share, laugh and rant.
Here to learn, share, laugh and rant.
Pinned
Distinct molecular mechanisms of stress habituation in the mouse hippocampus https://www.biorxiv.org/content/10.1101/2025.03.04.641433v1
I’m trilled to release the largest amount of stress profiling data from our (I think any) lab so far. We asked how the molecular response to acute stress adapts as the stressor becomes chronic. Multiomic profiling in the mouse hippocampus, led by Rebecca Waag and co-last author Pierre-Luc Germain 💪
Day 4 of sharing my favorite cartoons. I forget who, but someone showed this at a talk on startle behavior in mice and for some weird reason I have to laugh every time I see it.
December 26, 2025 at 12:09 PM
Day 4 of sharing my favorite cartoons. I forget who, but someone showed this at a talk on startle behavior in mice and for some weird reason I have to laugh every time I see it.
uff...
Psychedelic research must be grounded in pharmacology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psychedelic research must be grounded in pharmacology - Nature Neuroscience
Psychedelic science is growing rapidly and offers great promise for exciting new therapies, but this rapid growth has brought growing pains. These include a lack of appreciation of the history of the ...
www.nature.com
December 25, 2025 at 10:43 PM
uff...
Day 3 - the best science cartoon. If you have a better one, please share.
December 25, 2025 at 10:32 PM
Day 3 - the best science cartoon. If you have a better one, please share.
Day 2 from my cartoon collection. I don't know what it says about me that I find this so funny.
December 24, 2025 at 7:50 AM
Day 2 from my cartoon collection. I don't know what it says about me that I find this so funny.
The world can feel heavy these days, and holidays aren’t easy for everyone.
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
December 23, 2025 at 8:16 AM
The world can feel heavy these days, and holidays aren’t easy for everyone.
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
@bejalab.bsky.social I watched spinal tap 1+2 back-to-back the last two days. I was laughing so much. Thanks for having this image as your icon 😍
a man with long hair and a beard is saying it 's a morale builder isn 't it
ALT: a man with long hair and a beard is saying it 's a morale builder isn 't it
media.tenor.com
December 23, 2025 at 8:01 AM
@bejalab.bsky.social I watched spinal tap 1+2 back-to-back the last two days. I was laughing so much. Thanks for having this image as your icon 😍
After an intense journal-club class, I've decided that this is my favorite neuroscience paper of 2025: www.cell.com/cell/fulltex...
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors
Stress-induced depression-like behaviors are driven by a dynamic recurrent network
involving neurons and astrocytes in the lateral habenula and norepinephrine release
from neurons in the locus coerule...
www.cell.com
December 22, 2025 at 3:13 PM
After an intense journal-club class, I've decided that this is my favorite neuroscience paper of 2025: www.cell.com/cell/fulltex...
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
I'm back from social media DETOX.
5 months... what did I miss?
5 months... what did I miss?
a man wearing a gas mask and a leather jacket is standing in front of a wooden building
ALT: a man wearing a gas mask and a leather jacket is standing in front of a wooden building
media.tenor.com
December 15, 2025 at 3:13 PM
I'm back from social media DETOX.
5 months... what did I miss?
5 months... what did I miss?
🔵 I'm interrupting my social media hiatus to flag this important preprint from the Bruchas lab (is he not on Bluesky!?) together with @davidweinshenker.bsky.social. Very difficult experiments to show that dopamine release from LC terminals is independent of VTA 🔥
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 17, 2025 at 5:44 AM
🔵 I'm interrupting my social media hiatus to flag this important preprint from the Bruchas lab (is he not on Bluesky!?) together with @davidweinshenker.bsky.social. Very difficult experiments to show that dopamine release from LC terminals is independent of VTA 🔥
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This preprint has been under review >110 days... I think they can't find reviewers.
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice
Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and aut...
www.biorxiv.org
June 27, 2025 at 11:43 AM
This preprint has been under review >110 days... I think they can't find reviewers.
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
I'd have so much to complain about these days. But given the state of affairs in the world, it feels inappropriate to whine about daily hassles. So let me just say this on behalf of everyone who is struggling but otherwise safe: fucking hell.
June 18, 2025 at 4:35 PM
I'd have so much to complain about these days. But given the state of affairs in the world, it feels inappropriate to whine about daily hassles. So let me just say this on behalf of everyone who is struggling but otherwise safe: fucking hell.
🔵 Interesting new work from @davidweinshenker.bsky.social on why locus coeruleus neurons might be vulnerable to degeneration in humans (Alzheimer's) but not in mice. And a new approach on how this could be modelled in mice through human tyrosinase overexpression: www.biorxiv.org/content/10.1...
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
The locus coeruleus (LC), the major source of norepinephrine (NE) in the brain, is among the earliest site of pathology in both Alzheimers disease (AD) and Parkinsons disease (PD), and it undergoes ca...
www.biorxiv.org
April 9, 2025 at 7:25 PM
🔵 Interesting new work from @davidweinshenker.bsky.social on why locus coeruleus neurons might be vulnerable to degeneration in humans (Alzheimer's) but not in mice. And a new approach on how this could be modelled in mice through human tyrosinase overexpression: www.biorxiv.org/content/10.1...
Impression from the evening panel discussion at #ESC2025. Amazing talks today, wonderfully open and fun atmosphere. After all these years, still my favorite meeting in the conference cycle ❤️
March 17, 2025 at 6:44 PM
Impression from the evening panel discussion at #ESC2025. Amazing talks today, wonderfully open and fun atmosphere. After all these years, still my favorite meeting in the conference cycle ❤️
Reposted by Johannes Bohacek
Dopamine and acetylcholine interactions - so hot right now! Tour de force work from Steph Cragg's group out in NN (lead Yan-Feng Zhang). They find Cholinergic Interneurons (ChIs) largely suppress DA release, distinct from what we just reported in songbirds (1/x)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 17, 2025 at 1:24 PM
Dopamine and acetylcholine interactions - so hot right now! Tour de force work from Steph Cragg's group out in NN (lead Yan-Feng Zhang). They find Cholinergic Interneurons (ChIs) largely suppress DA release, distinct from what we just reported in songbirds (1/x)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stellar women-only (💪) panel on stress and development, loaded with cutting-edge multiomic data kicking off the European Stress Conference #ESC2025 in Innsbruck, Austria
March 16, 2025 at 9:53 AM
Stellar women-only (💪) panel on stress and development, loaded with cutting-edge multiomic data kicking off the European Stress Conference #ESC2025 in Innsbruck, Austria
Reposted by Johannes Bohacek
My lab is hiring 2 postdocs on an NIH-funded grant characterizing molecular & cellular changes in the human brain across menopausal transition. Other neuroepigenomics projects are also available. We plan to hire a wet lab scientist and a bioinformatician. Please RT!
kundakoviclab.com
More info 👇
kundakoviclab.com
More info 👇
March 11, 2025 at 6:32 AM
My lab is hiring 2 postdocs on an NIH-funded grant characterizing molecular & cellular changes in the human brain across menopausal transition. Other neuroepigenomics projects are also available. We plan to hire a wet lab scientist and a bioinformatician. Please RT!
kundakoviclab.com
More info 👇
kundakoviclab.com
More info 👇
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice
Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and aut...
www.biorxiv.org
March 11, 2025 at 7:00 AM
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
I’m trilled to release the largest amount of stress profiling data from our (I think any) lab so far. We asked how the molecular response to acute stress adapts as the stressor becomes chronic. Multiomic profiling in the mouse hippocampus, led by Rebecca Waag and co-last author Pierre-Luc Germain 💪
Distinct molecular mechanisms of stress habituation in the mouse hippocampus https://www.biorxiv.org/content/10.1101/2025.03.04.641433v1
March 6, 2025 at 9:12 PM
I’m trilled to release the largest amount of stress profiling data from our (I think any) lab so far. We asked how the molecular response to acute stress adapts as the stressor becomes chronic. Multiomic profiling in the mouse hippocampus, led by Rebecca Waag and co-last author Pierre-Luc Germain 💪
Uuuhh... DANNCE is back! Now social-DANNCE. Looks very cool, taking multi-animal tracking and analysis of social behavior to a whole new level. Just the green-room multiple-camera setup looks quite complex, I wonder how easy this can be replicated in other labs. Will certainly spark excitement!
Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8
March 4, 2025 at 6:15 PM
Uuuhh... DANNCE is back! Now social-DANNCE. Looks very cool, taking multi-animal tracking and analysis of social behavior to a whole new level. Just the green-room multiple-camera setup looks quite complex, I wonder how easy this can be replicated in other labs. Will certainly spark excitement!
Reposted by Johannes Bohacek
SAVE THE DATE: #resilience2025 - the 11th International Symposium on Resilience Research - Mainz, Germany - September 24-26, 2025
Satellite methods workshop: September 23 & many opportunities for early-career researchers
Meet the stress resilience research community, get latest insights, spur you
Satellite methods workshop: September 23 & many opportunities for early-career researchers
Meet the stress resilience research community, get latest insights, spur you
December 4, 2024 at 12:52 PM
SAVE THE DATE: #resilience2025 - the 11th International Symposium on Resilience Research - Mainz, Germany - September 24-26, 2025
Satellite methods workshop: September 23 & many opportunities for early-career researchers
Meet the stress resilience research community, get latest insights, spur you
Satellite methods workshop: September 23 & many opportunities for early-career researchers
Meet the stress resilience research community, get latest insights, spur you
Is this still the place to post scientific updates about papers, preprints and cool new data? Asking for a friend.
March 4, 2025 at 3:32 PM
Is this still the place to post scientific updates about papers, preprints and cool new data? Asking for a friend.
Reposted by Johannes Bohacek
Amazing work from our colleagues at ETH/UZH answering many unknowns about arousal during sleep. And congrats to their participants for being able to sleep with their eyes taped open!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pupil size reveals arousal level fluctuations in human sleep - Nature Communications
Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...
www.nature.com
March 2, 2025 at 11:52 AM
Amazing work from our colleagues at ETH/UZH answering many unknowns about arousal during sleep. And congrats to their participants for being able to sleep with their eyes taped open!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
First day of the new semester. 5th time I'm teaching this class. Got tenured along the way. And still, I'm nervous before going in... 😅🤷♂️
February 17, 2025 at 8:52 AM
First day of the new semester. 5th time I'm teaching this class. Got tenured along the way. And still, I'm nervous before going in... 😅🤷♂️
Reposted by Johannes Bohacek
delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Atypical hippocampal excitatory neurons express and govern object memory - Nature Communications
Pyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene ex...
www.nature.com
February 13, 2025 at 6:38 PM
delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...