Martina Foglizzo
@foglizzomartina.bsky.social
BBSRC Discovery Fellow @AstburyCentre @UniversityLeeds | PhD and Postdoc @OtagoBiochemist | #ubiquitin and #chromatin enthusiast | Views my own.
Reposted by Martina Foglizzo
📣 Fully funded PhD opportunity - CryoEM, Phage Biology & Structural Mechanisms
University of Sheffield, UK | Start Oct 2026
We’re looking for a motivated student to uncover how bacteriophage proteins shut down drug-resistant Enterococcus bacteria.
University of Sheffield, UK | Start Oct 2026
We’re looking for a motivated student to uncover how bacteriophage proteins shut down drug-resistant Enterococcus bacteria.
YBDTP – BBSRC Yorkshire Bioscience Doctoral Training Partnership
yorkshirebiosciencedtp.ac.uk
November 21, 2025 at 9:34 AM
📣 Fully funded PhD opportunity - CryoEM, Phage Biology & Structural Mechanisms
University of Sheffield, UK | Start Oct 2026
We’re looking for a motivated student to uncover how bacteriophage proteins shut down drug-resistant Enterococcus bacteria.
University of Sheffield, UK | Start Oct 2026
We’re looking for a motivated student to uncover how bacteriophage proteins shut down drug-resistant Enterococcus bacteria.
Reposted by Martina Foglizzo
Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!
Fully-funded 4-years competitive PhD project in our lab (MIBTP-doctoral-training-programme. p97 unfoldase functions during DNA replication. Open to UK/international candidates. Please get in touch for informal enquiries. Deadline 27th of November. Please share.
warwick.ac.uk/fac/cross_fa...
warwick.ac.uk/fac/cross_fa...
Professor Aga Gambus
Professor Aga Gambus
warwick.ac.uk
November 22, 2025 at 8:44 AM
Last few days to apply for this PhD project in our lab. Mix of biochemistry and structural biology, DNA replication and ubiquitin signalling. Get in touch if interested. Full application through official university portal. Deadline on 27th of November!
Reposted by Martina Foglizzo
📆Save the date: 20-21 April 2026
#AstburyConvo26 is back with a bold new theme: Designing Biology.
Expect cutting-edge talks and the chance to shape the future of molecular science.
Register now: astburyconversation.leeds.ac.uk
@astburycentre.bsky.social @universityofleeds.bsky.social
#AstburyConvo26 is back with a bold new theme: Designing Biology.
Expect cutting-edge talks and the chance to shape the future of molecular science.
Register now: astburyconversation.leeds.ac.uk
@astburycentre.bsky.social @universityofleeds.bsky.social
November 11, 2025 at 4:14 PM
📆Save the date: 20-21 April 2026
#AstburyConvo26 is back with a bold new theme: Designing Biology.
Expect cutting-edge talks and the chance to shape the future of molecular science.
Register now: astburyconversation.leeds.ac.uk
@astburycentre.bsky.social @universityofleeds.bsky.social
#AstburyConvo26 is back with a bold new theme: Designing Biology.
Expect cutting-edge talks and the chance to shape the future of molecular science.
Register now: astburyconversation.leeds.ac.uk
@astburycentre.bsky.social @universityofleeds.bsky.social
Reposted by Martina Foglizzo
We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!
Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds on FindAPhD.com
PhD Project - Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 10, 2025 at 10:11 AM
We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!
Reposted by Martina Foglizzo
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Martina Foglizzo
We're looking for a new lecturer, here at the Department of Biochemistry in Dunedin, New Zealand. "Applications are invited in all areas of biochemistry, molecular genetics, and bioinformatics." otago.taleo.net/careersectio...
September 15, 2025 at 1:09 AM
We're looking for a new lecturer, here at the Department of Biochemistry in Dunedin, New Zealand. "Applications are invited in all areas of biochemistry, molecular genetics, and bioinformatics." otago.taleo.net/careersectio...
Reposted by Martina Foglizzo
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.
www.science.org
September 9, 2025 at 3:17 PM
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Martina Foglizzo
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...
rdcu.be
September 2, 2025 at 11:55 AM
Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk
rdcu.be/eDzPk
Reposted by Martina Foglizzo
Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!
August 30, 2025 at 12:15 PM
Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!
Reposted by Martina Foglizzo
Happy to share that my first-author paper from my postdoc at Imperial @imperialcollegeldn.bsky.social and The Francis Crick Institute @crick.ac.uk is now published in Cell Reports!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition
Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic ra…
www.sciencedirect.com
August 28, 2025 at 1:16 PM
Happy to share that my first-author paper from my postdoc at Imperial @imperialcollegeldn.bsky.social and The Francis Crick Institute @crick.ac.uk is now published in Cell Reports!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Martina Foglizzo
Exciting work led by @nano-chalmers.bsky.social delivered in collaboration with @georgerheath.bsky.social introducing a rationally designed DNA origami system for the multiplexed detection of miRNA in crude RNA extracts via nanopore sensing.
August 19, 2025 at 2:24 PM
Exciting work led by @nano-chalmers.bsky.social delivered in collaboration with @georgerheath.bsky.social introducing a rationally designed DNA origami system for the multiplexed detection of miRNA in crude RNA extracts via nanopore sensing.
Reposted by Martina Foglizzo
💫NEW: @buszczaklab.bsky.social @jun-wu-lab.bsky.social & co use human #brain #organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired #ribosome production and protein synthesis, and delayed radial glial cell specification.
bit.ly/4lvVBBP
bit.ly/4lvVBBP
A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology
Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...
bit.ly
August 19, 2025 at 11:01 AM
💫NEW: @buszczaklab.bsky.social @jun-wu-lab.bsky.social & co use human #brain #organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired #ribosome production and protein synthesis, and delayed radial glial cell specification.
bit.ly/4lvVBBP
bit.ly/4lvVBBP
Reposted by Martina Foglizzo
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of
the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone
mH2A1.2 ubiquitination in p...
www.cell.com
August 13, 2025 at 3:20 PM
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Martina Foglizzo
A rare job opportunity for a biochemist who wants to work in beautiful Dunedin.
Will suit someone who enjoys lab-based work.
otago.taleo.net/careersectio...
Will suit someone who enjoys lab-based work.
otago.taleo.net/careersectio...
August 17, 2025 at 9:28 PM
A rare job opportunity for a biochemist who wants to work in beautiful Dunedin.
Will suit someone who enjoys lab-based work.
otago.taleo.net/careersectio...
Will suit someone who enjoys lab-based work.
otago.taleo.net/careersectio...
Reposted by Martina Foglizzo
Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.
A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology
Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...
www.nature.com
August 4, 2025 at 4:33 PM
Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.
Reposted by Martina Foglizzo
It’s too late on a Friday night for me to post sensibly about this work! But I’m super proud of Joanna’s determination to validate Parkin substrates and I love working with her robust and creative science!
The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...
June 27, 2025 at 10:52 PM
It’s too late on a Friday night for me to post sensibly about this work! But I’m super proud of Joanna’s determination to validate Parkin substrates and I love working with her robust and creative science!
Reposted by Martina Foglizzo
The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...
June 27, 2025 at 8:10 PM
The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...
Reposted by Martina Foglizzo
3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...
Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com
www.findaphd.com
June 16, 2025 at 6:54 PM
3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...
Reposted by Martina Foglizzo
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
doi.org
May 4, 2025 at 7:39 AM
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Reposted by Martina Foglizzo
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴
www.biochemistry.org/events-and-t...
www.biochemistry.org/events-and-t...
UK DNA Replication Meeting 2026
Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...
www.biochemistry.org
April 15, 2025 at 10:30 AM
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴
www.biochemistry.org/events-and-t...
www.biochemistry.org/events-and-t...
Reposted by Martina Foglizzo
After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
Identification of RING E3 pseudoligases in the TRIM protein family
Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...
rdcu.be
April 11, 2025 at 12:55 PM
After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
Reposted by Martina Foglizzo
#TeamTomo is going to be all over chromatin structure and organization in the next years. Beautiful efforts like this are only the beginning! 🧪🧶🧬🔬
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
April 12, 2025 at 4:30 AM
#TeamTomo is going to be all over chromatin structure and organization in the next years. Beautiful efforts like this are only the beginning! 🧪🧶🧬🔬
Reposted by Martina Foglizzo
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
www.nature.com
April 9, 2025 at 5:19 PM
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Reposted by Martina Foglizzo
New paper alert 🚨
We determined the structure of phiCD508, a 225 nm tailed myovirus #phage infecting clinical strains of C. difficile, using #cryoEM.
Thrilled to see this finally out at @lsajournal.org .
www.life-science-alliance.org/content/8/6/...
We determined the structure of phiCD508, a 225 nm tailed myovirus #phage infecting clinical strains of C. difficile, using #cryoEM.
Thrilled to see this finally out at @lsajournal.org .
www.life-science-alliance.org/content/8/6/...
March 27, 2025 at 10:54 AM
New paper alert 🚨
We determined the structure of phiCD508, a 225 nm tailed myovirus #phage infecting clinical strains of C. difficile, using #cryoEM.
Thrilled to see this finally out at @lsajournal.org .
www.life-science-alliance.org/content/8/6/...
We determined the structure of phiCD508, a 225 nm tailed myovirus #phage infecting clinical strains of C. difficile, using #cryoEM.
Thrilled to see this finally out at @lsajournal.org .
www.life-science-alliance.org/content/8/6/...
Reposted by Martina Foglizzo
First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....
Structural characterization and inhibition of the interaction between ch-TOG and TACC3 | Journal of Cell Biology | Rockefeller University Press
Shelford, Burgess, and colleagues present a structural model of the interaction between TACC3 and ch-TOG. They discover Affimers that can inhibit this inte
doi.org
March 21, 2025 at 9:27 AM
First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....