Isaac Larkin
@eyesgack.bsky.social
Synthetic biologist. A better world is possible; let’s build it together.
Sunset in the river
November 3, 2025 at 5:32 AM
Sunset in the river
Sunset at the Caldwell Forest Preserve
November 3, 2025 at 5:27 AM
Sunset at the Caldwell Forest Preserve
Reposted by Isaac Larkin
Hope and solidarity won tonight, and will win again in November.
Congratulations, @zohrankmamdani.bsky.social
Congratulations, @zohrankmamdani.bsky.social
June 25, 2025 at 3:07 AM
Hope and solidarity won tonight, and will win again in November.
Congratulations, @zohrankmamdani.bsky.social
Congratulations, @zohrankmamdani.bsky.social
Reposted by Isaac Larkin
"GOOD FUCKING RIDDANCE"
June 25, 2025 at 2:26 AM
"GOOD FUCKING RIDDANCE"
Reposted by Isaac Larkin
🙌🙌
Primary every Democrat who is not meeting this moment. Get rid of them all.
June 25, 2025 at 2:35 AM
🙌🙌
Reposted by Isaac Larkin
Today, the people beat dirty money
June 25, 2025 at 2:37 AM
Today, the people beat dirty money
Reposted by Isaac Larkin
Reposted by Isaac Larkin
May 17, 2025 at 5:12 PM
Well that’s a new one. Very 1930s Kansas coded
May 16, 2025 at 11:31 PM
Well that’s a new one. Very 1930s Kansas coded
Reposted by Isaac Larkin
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Isaac Larkin
This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction.
We all need to speak out to save lives.
We all need to speak out to save lives.
February 8, 2025 at 2:02 AM
This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction.
We all need to speak out to save lives.
We all need to speak out to save lives.
Reposted by Isaac Larkin
Here's the script I wrote for calling my representative about the latest horrors. Would probably benefit from a better breakdown of how indirects work, but I didn't want it to get too long.
Now I just need to decide whether to call now or wait for Monday when I can talk to an actual person.
Now I just need to decide whether to call now or wait for Monday when I can talk to an actual person.
February 8, 2025 at 1:29 AM
Here's the script I wrote for calling my representative about the latest horrors. Would probably benefit from a better breakdown of how indirects work, but I didn't want it to get too long.
Now I just need to decide whether to call now or wait for Monday when I can talk to an actual person.
Now I just need to decide whether to call now or wait for Monday when I can talk to an actual person.
Reposted by Isaac Larkin
Hardly new info, but BSky should know:
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
February 7, 2025 at 12:39 PM
Hardly new info, but BSky should know:
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply.
Thank you, little guardian molluscs.
🧪🌏🚰
Reposted by Isaac Larkin
I went long on the sack creature without an anus whose visage has haunted me since Aug. 2022
Was This Half-Billion-Year-Old Wrinkled Sack With No Anus, Previously Believed To Be Our Earliest Ancestor, Actually A Baby Penis Worm? | Defector
Researchers wondered how a bag with a mouth but no anus could have moved around its environment or managed to eat.
defector.com
December 9, 2024 at 4:54 PM
I went long on the sack creature without an anus whose visage has haunted me since Aug. 2022
Reposted by Isaac Larkin
More of an art project than science project, The Pink Chicken project is thought provoking nonetheless pinkchickenproject.com#what
Pink Chicken Project
Pink Chicken Project suggests changing the colour of the entire species Gallus gallus domesticus to pink - using the recently invented CRISPR gene-drive technique.
pinkchickenproject.com
January 11, 2025 at 10:00 PM
More of an art project than science project, The Pink Chicken project is thought provoking nonetheless pinkchickenproject.com#what
Reposted by Isaac Larkin
This was lots of fun to work on! Beyond what we learned, I think this set of stabilizing indels is a great challenge set for methods that predict stability. Our first paper from a (former) undergrad researcher! @yuliagutierrez.bsky.social is going places!! 🚀💫
I'm super excited to share my recent work with @grocklin.bsky.social “Structural and energetic analysis of stabilizing indel mutations” biorxiv.org/content/10.1.... 1/8
Structural and energetic analysis of stabilizing indel mutations
Amino acid insertions and deletions (indels) are among the most common protein mutations and necessitate changes to a protein’s backbone geometry. Examining how indels affect protein folding stability...
biorxiv.org
January 10, 2025 at 12:56 PM
This was lots of fun to work on! Beyond what we learned, I think this set of stabilizing indels is a great challenge set for methods that predict stability. Our first paper from a (former) undergrad researcher! @yuliagutierrez.bsky.social is going places!! 🚀💫
Reposted by Isaac Larkin
i sometimes forget this "trick" factoid. it's true!
"Human cells are (sometimes) diploid (2n), but MOST human cells are NOT."
"Human cells are (sometimes) diploid (2n), but MOST human cells are NOT."
... but there are variations and nuance that are also easy to miss, and knowing the full story adds to our understanding & represents an opportunity to manage disease and aging.
The more qualified truth:
Human cells are (sometimes) diploid (2n), but MOST human cells are NOT.
The more qualified truth:
Human cells are (sometimes) diploid (2n), but MOST human cells are NOT.
December 30, 2024 at 3:47 PM
i sometimes forget this "trick" factoid. it's true!
"Human cells are (sometimes) diploid (2n), but MOST human cells are NOT."
"Human cells are (sometimes) diploid (2n), but MOST human cells are NOT."
Reposted by Isaac Larkin
Here is a cool example of just how sensitive these skin cells are to touch using GCaMP calcium imaging in a living mouse!
December 11, 2024 at 9:23 PM
Here is a cool example of just how sensitive these skin cells are to touch using GCaMP calcium imaging in a living mouse!
Reposted by Isaac Larkin
Reposted by Isaac Larkin
The PDBs for our TSC structure are now available!
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
December 7, 2024 at 3:33 AM
The PDBs for our TSC structure are now available!
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
Reposted by Isaac Larkin
protease-activated receptors (PARs) are a subfamily of G protein-coupled receptors that are activated by cleavage of their extracellular domain
December 5, 2024 at 3:09 PM
protease-activated receptors (PARs) are a subfamily of G protein-coupled receptors that are activated by cleavage of their extracellular domain