Laurence Ettwiller
@ettwiller.bsky.social
Scientist working at New England Biolabs. Tweets and comments represent my personal opinion and do not necessarily reflect the opinions of New England Biolabs.
Pinned
Laurence Ettwiller
@ettwiller.bsky.social
· Oct 13
So happy to share our new study
“A Bait-and-Switch strategy links phenotypes to genes coding for Polymer-Degrading Enzymes in Intact Microbiomes.”
In this work, we discovered novel chitinases directly on microbiome; a study brilliantly led by Dr. Colleen Yancey
www.biorxiv.org/content/10.1...
“A Bait-and-Switch strategy links phenotypes to genes coding for Polymer-Degrading Enzymes in Intact Microbiomes.”
In this work, we discovered novel chitinases directly on microbiome; a study brilliantly led by Dr. Colleen Yancey
www.biorxiv.org/content/10.1...
Excited to share our new study using metagenomes to reveal key players in 2,6-Diaminopurine (dZ) Biosynthesis : We explore how some bacteriophages swap dA for 2-aminoadenine (dZ) in their genomes to evade bacterial defenses. #PhageBiology #Metagenomics #bacteriophage www.biorxiv.org/content/10.1...
October 24, 2025 at 12:56 PM
Excited to share our new study using metagenomes to reveal key players in 2,6-Diaminopurine (dZ) Biosynthesis : We explore how some bacteriophages swap dA for 2-aminoadenine (dZ) in their genomes to evade bacterial defenses. #PhageBiology #Metagenomics #bacteriophage www.biorxiv.org/content/10.1...
So happy to share our new study
“A Bait-and-Switch strategy links phenotypes to genes coding for Polymer-Degrading Enzymes in Intact Microbiomes.”
In this work, we discovered novel chitinases directly on microbiome; a study brilliantly led by Dr. Colleen Yancey
www.biorxiv.org/content/10.1...
“A Bait-and-Switch strategy links phenotypes to genes coding for Polymer-Degrading Enzymes in Intact Microbiomes.”
In this work, we discovered novel chitinases directly on microbiome; a study brilliantly led by Dr. Colleen Yancey
www.biorxiv.org/content/10.1...
October 13, 2025 at 10:50 PM
So happy to share our new study
“A Bait-and-Switch strategy links phenotypes to genes coding for Polymer-Degrading Enzymes in Intact Microbiomes.”
In this work, we discovered novel chitinases directly on microbiome; a study brilliantly led by Dr. Colleen Yancey
www.biorxiv.org/content/10.1...
“A Bait-and-Switch strategy links phenotypes to genes coding for Polymer-Degrading Enzymes in Intact Microbiomes.”
In this work, we discovered novel chitinases directly on microbiome; a study brilliantly led by Dr. Colleen Yancey
www.biorxiv.org/content/10.1...
Reposted by Laurence Ettwiller
🧪⚒️Just released an episode on the dynamics of subduction zones with Claudio Faccenna. Not only do trenches roll back and move laterally, they also advance and flip polarity. But when they penetrate the viscous lower mantle they get locked in place. Enjoy listening!
September 17, 2025 at 4:25 PM
🧪⚒️Just released an episode on the dynamics of subduction zones with Claudio Faccenna. Not only do trenches roll back and move laterally, they also advance and flip polarity. But when they penetrate the viscous lower mantle they get locked in place. Enjoy listening!
Reposted by Laurence Ettwiller
A novel NGS-compatible Enzymatic Strategy Enables Carryover Contamination Removal and Enhances Sequencing Performance. https://www.biorxiv.org/content/10.1101/2025.08.01.668201v1
August 3, 2025 at 3:33 AM
A novel NGS-compatible Enzymatic Strategy Enables Carryover Contamination Removal and Enhances Sequencing Performance. https://www.biorxiv.org/content/10.1101/2025.08.01.668201v1
Dream of avoiding carryover contamination in your NGS experiment?
Check out our latest preprint:
🧬 “A Novel NGS-Compatible Enzymatic Strategy Enables Carryover Contamination Removal and Enhances Sequencing Performance” www.biorxiv.org/content/10.1...
Check out our latest preprint:
🧬 “A Novel NGS-Compatible Enzymatic Strategy Enables Carryover Contamination Removal and Enhances Sequencing Performance” www.biorxiv.org/content/10.1...
August 3, 2025 at 6:07 PM
Dream of avoiding carryover contamination in your NGS experiment?
Check out our latest preprint:
🧬 “A Novel NGS-Compatible Enzymatic Strategy Enables Carryover Contamination Removal and Enhances Sequencing Performance” www.biorxiv.org/content/10.1...
Check out our latest preprint:
🧬 “A Novel NGS-Compatible Enzymatic Strategy Enables Carryover Contamination Removal and Enhances Sequencing Performance” www.biorxiv.org/content/10.1...
Reposted by Laurence Ettwiller
This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 23, 2025 at 6:55 PM
This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Laurence Ettwiller
🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9
May 2, 2025 at 9:02 PM
🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9
Reposted by Laurence Ettwiller
The BASEL collection of E. coli #phages is limited by its host strain. @humollidorentina.bsky.social @damienpiel.bsky.social @aharms485.bsky.social &co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity @plosbiology.org 🧪 plos.io/4jirGvX
April 8, 2025 at 4:55 PM
The BASEL collection of E. coli #phages is limited by its host strain. @humollidorentina.bsky.social @damienpiel.bsky.social @aharms485.bsky.social &co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity @plosbiology.org 🧪 plos.io/4jirGvX
Proxi-RIMS-seq now enables direct study of epigenetic modifications in microbiomes using Illumina sequencing on genome-resolved microbiomes ! Learn more in our latest work with @phasegenomics:
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
pendingpublications
Pending Publication
doi.org
March 31, 2025 at 3:05 PM
Proxi-RIMS-seq now enables direct study of epigenetic modifications in microbiomes using Illumina sequencing on genome-resolved microbiomes ! Learn more in our latest work with @phasegenomics:
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Reposted by Laurence Ettwiller
#StandUpForScience
#Toulouse @sufs-paris-rp.bsky.social
@emmanuelleperez.bsky.social
"C'est très important d'avoir un lien très fort entre la recherche et la formation, de former à l'esprit scientifique pour se confronter à la complexité du monde d'aujourd'hui"
www.francetvinfo.fr/replay-jt/fr...
#Toulouse @sufs-paris-rp.bsky.social
@emmanuelleperez.bsky.social
"C'est très important d'avoir un lien très fort entre la recherche et la formation, de former à l'esprit scientifique pour se confronter à la complexité du monde d'aujourd'hui"
www.francetvinfo.fr/replay-jt/fr...
Le 14h/16h du vendredi 7 mars 2025
Le 14h/16h du vendredi 7 mars 2025. JT franceinfo consultable en ligne en replay pour voir et revoir ce journal télé qui décrypte l'actualité.
www.francetvinfo.fr
March 7, 2025 at 9:34 PM
#StandUpForScience
#Toulouse @sufs-paris-rp.bsky.social
@emmanuelleperez.bsky.social
"C'est très important d'avoir un lien très fort entre la recherche et la formation, de former à l'esprit scientifique pour se confronter à la complexité du monde d'aujourd'hui"
www.francetvinfo.fr/replay-jt/fr...
#Toulouse @sufs-paris-rp.bsky.social
@emmanuelleperez.bsky.social
"C'est très important d'avoir un lien très fort entre la recherche et la formation, de former à l'esprit scientifique pour se confronter à la complexité du monde d'aujourd'hui"
www.francetvinfo.fr/replay-jt/fr...
Reposted by Laurence Ettwiller
Hair ice!! This is caused by a fungus in the wood. I'm always excited to find it when it gets cold.
January 20, 2025 at 4:59 PM
Hair ice!! This is caused by a fungus in the wood. I'm always excited to find it when it gets cold.
Reposted by Laurence Ettwiller
Genomes assembled from #metagenomes (a.k.a. MAGs) are awesome and have revolutionized our ability to study uncultivated microbes
...BUT: they still don't capture a lot of the 🦠 species that are out there
New @jgi.doe.gov paper led by Dongying Wu and Natalia Ivanova: www.science.org/doi/10.1126/...
...BUT: they still don't capture a lot of the 🦠 species that are out there
New @jgi.doe.gov paper led by Dongying Wu and Natalia Ivanova: www.science.org/doi/10.1126/...
January 17, 2025 at 9:53 PM
Genomes assembled from #metagenomes (a.k.a. MAGs) are awesome and have revolutionized our ability to study uncultivated microbes
...BUT: they still don't capture a lot of the 🦠 species that are out there
New @jgi.doe.gov paper led by Dongying Wu and Natalia Ivanova: www.science.org/doi/10.1126/...
...BUT: they still don't capture a lot of the 🦠 species that are out there
New @jgi.doe.gov paper led by Dongying Wu and Natalia Ivanova: www.science.org/doi/10.1126/...
Reposted by Laurence Ettwiller
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...
Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...
www.biorxiv.org
January 16, 2025 at 2:26 AM
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...
Reposted by Laurence Ettwiller
Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in @eLife ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317
Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification
tRNA Q34 modification impacts tyrosine codon decoding and leads to proteome reprogramming in response to antibiotic stress in Vibrio cholerae.
elifesciences.org
January 12, 2025 at 11:07 AM
Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in @eLife ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317
Reposted by Laurence Ettwiller
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
January 9, 2025 at 1:18 PM
What is the diversity of antiphage systems out there ?
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families.
Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
Reposted by Laurence Ettwiller
Methyl-CODEC enables simultaneous methylation and duplex sequencing https://www.biorxiv.org/content/10.1101/2024.12.23.630102v1
December 23, 2024 at 7:33 PM
Methyl-CODEC enables simultaneous methylation and duplex sequencing https://www.biorxiv.org/content/10.1101/2024.12.23.630102v1
Reposted by Laurence Ettwiller
Tracking bacterial ‘seeds’ in new soil reveals how they grow, adapt, and pave the way for next-gen microbiome therapies.
@gangfang.bsky.social @biorxivpreprint.bsky.social
t.co/QisGjqmInv
#ImmunoSky 🧪
@gangfang.bsky.social @biorxivpreprint.bsky.social
t.co/QisGjqmInv
#ImmunoSky 🧪
December 19, 2024 at 7:54 AM
Tracking bacterial ‘seeds’ in new soil reveals how they grow, adapt, and pave the way for next-gen microbiome therapies.
@gangfang.bsky.social @biorxivpreprint.bsky.social
t.co/QisGjqmInv
#ImmunoSky 🧪
@gangfang.bsky.social @biorxivpreprint.bsky.social
t.co/QisGjqmInv
#ImmunoSky 🧪
Transposable element exonization generates a reservoir of evolving and functional protein isoforms: Cell www.cell.com/cell/fulltex...
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
www.cell.com
December 12, 2024 at 2:02 PM
Transposable element exonization generates a reservoir of evolving and functional protein isoforms: Cell www.cell.com/cell/fulltex...
Reposted by Laurence Ettwiller
Stunning free #science vector art for your next poster, paper or talk 🤩
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
December 10, 2024 at 7:52 AM
Stunning free #science vector art for your next poster, paper or talk 🤩
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
Reposted by Laurence Ettwiller
Glad to share our preprint 🏃 **LongTrack**: long read metagenomics-based precise tracking of bacterial strains (and their genomic changes!) after 💩 fecal microbiota transplantation. A 4+ years journey and tour de force by ** @yufan01.bsky.social ** & team. A long 🧵 www.biorxiv.org/content/10.1...
December 11, 2024 at 1:51 PM
Glad to share our preprint 🏃 **LongTrack**: long read metagenomics-based precise tracking of bacterial strains (and their genomic changes!) after 💩 fecal microbiota transplantation. A 4+ years journey and tour de force by ** @yufan01.bsky.social ** & team. A long 🧵 www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
December 9, 2024 at 2:12 PM
www.biorxiv.org/content/10.1...
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.