Anna Kuchina
@annabiosys.bsky.social
Assistant Professor at @isbscience.org studying single-cell lifestyles of bacteria.
Pinned
Anna Kuchina
@annabiosys.bsky.social
· Jan 16
Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...
www.biorxiv.org
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...
Reposted by Anna Kuchina
Rubbing shoulders with a @nobelprize.bsky.social laureate! 🤩What a week!
Couldn’t have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
Couldn’t have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
October 8, 2025 at 12:19 AM
Rubbing shoulders with a @nobelprize.bsky.social laureate! 🤩What a week!
Couldn’t have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
Couldn’t have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
Dmitry explains how surprisingly universal functional patterns emerge once you look closer into a bacterial community. @isbscience.org
It’s #PostdocAppreciation Week!
@isbscience.org Postdoc Dr. Dmitry Sutormin found gut bacteria form 3 guilds:
Stressors
Metabolizers
Growers
A survival “bet-hedging” strategy that helps them adapt.
🎥 Watch Dmitry explain: youtu.be/5LG_Ae0SiFg
@isbscience.org Postdoc Dr. Dmitry Sutormin found gut bacteria form 3 guilds:
Stressors
Metabolizers
Growers
A survival “bet-hedging” strategy that helps them adapt.
🎥 Watch Dmitry explain: youtu.be/5LG_Ae0SiFg
Inside the Hidden Lives of Bacteria
YouTube video by Institute for Systems Biology
youtu.be
October 7, 2025 at 6:18 PM
Dmitry explains how surprisingly universal functional patterns emerge once you look closer into a bacterial community. @isbscience.org
What an astonishing achievement, congratulations Mary! @isbscience.org
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....
What a tremendous honor! Congratulations!
What a tremendous honor! Congratulations!
October 7, 2025 at 6:15 PM
What an astonishing achievement, congratulations Mary! @isbscience.org
Reposted by Anna Kuchina
Check out our latest preprint on the development of clocks to predict PhenoAge in mice! www.biorxiv.org/content/10.1...
Multiomic clocks to predict phenotypic age in mice
Biological age refers to a person's overall health in aging, as distinct from their chronological age. Diverse measures of biological age, referred to as clocks, have been developed in recent years an...
www.biorxiv.org
May 6, 2025 at 4:34 PM
Check out our latest preprint on the development of clocks to predict PhenoAge in mice! www.biorxiv.org/content/10.1...
Reposted by Anna Kuchina
Huge work from @benadler.bsky.social et al @cresslab.bsky.social; Glad to be part of this super cool work.
Dive into our lab’s first peer-reviewed publication—co-led with our friends @benadler.bsky.social and Muntathar Al-Shimary from the @doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s415... @naturemicrobiol.bsky.social
CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d - Nature Microbiology
Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.
doi.org
February 27, 2025 at 10:13 PM
Huge work from @benadler.bsky.social et al @cresslab.bsky.social; Glad to be part of this super cool work.
Reposted by Anna Kuchina
I sat down with @isbscience.org president Jim Heath, to chat about our work, which you can watch here: youtu.be/ZwMDqp5n1S4?...
Scientists Develop First Stool-Based Test for Tracking Diet and Disease Risk
YouTube video by Institute for Systems Biology
youtu.be
February 18, 2025 at 1:48 PM
I sat down with @isbscience.org president Jim Heath, to chat about our work, which you can watch here: youtu.be/ZwMDqp5n1S4?...
Estimation of diet from the metagenomics data is now possible! Curious to see how this can be applied for reanalyzing existing datasets to link the diet information with the data
Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42...
#metagenomics #microbiome #microbiomesky
So what is MEDI? A combination of two things:
#metagenomics #microbiome #microbiomesky
So what is MEDI? A combination of two things:
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
www.nature.com
February 18, 2025 at 8:10 PM
Estimation of diet from the metagenomics data is now possible! Curious to see how this can be applied for reanalyzing existing datasets to link the diet information with the data
Reposted by Anna Kuchina
What a stupid, petty move (rising to the top of the many many stupid, petty moves by this administration so far).
Dispersing free HIV medication is one of the greatest unequivocally 'good' things the US does for the world. This program has saved 25 million lives. Why the fuck would you cut it?!
Dispersing free HIV medication is one of the greatest unequivocally 'good' things the US does for the world. This program has saved 25 million lives. Why the fuck would you cut it?!
BREAKING: The Trump administration has instructed organizations in other countries to stop disbursing HIV medications purchased with U.S. aid, even if the drugs have already been obtained and are sitting in local clinics.
www.nytimes.com/2025/01/27/h...
www.nytimes.com/2025/01/27/h...
Trump Administration Halts H.I.V. Drug Distribution in Poor Countries (Gift Article)
PEPFAR’s computer systems also are being taken offline, a sign that the program may not return, as Republican critics had hoped.
www.nytimes.com
January 28, 2025 at 2:49 AM
What a stupid, petty move (rising to the top of the many many stupid, petty moves by this administration so far).
Dispersing free HIV medication is one of the greatest unequivocally 'good' things the US does for the world. This program has saved 25 million lives. Why the fuck would you cut it?!
Dispersing free HIV medication is one of the greatest unequivocally 'good' things the US does for the world. This program has saved 25 million lives. Why the fuck would you cut it?!
Reposted by Anna Kuchina
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service.
“Pausing” grants means people don’t eat.
“Pausing” grants means people don’t eat.
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
www.washingtonpost.com
January 28, 2025 at 3:03 AM
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service.
“Pausing” grants means people don’t eat.
“Pausing” grants means people don’t eat.
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...
Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...
www.biorxiv.org
January 16, 2025 at 2:26 AM
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...
Reposted by Anna Kuchina
ISB Associate Professor Dr. Wei Wei has developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient. Learn more: isbscience.org/news/2024/11...
ISB-Developed MetaboCore Offers Precision Cancer Care Faster Than Ever
ISB's MetaboCore is a diagnostic tool that can help physicians quickly select the most effective systemic therapy for each cancer patient.
isbscience.org
December 2, 2024 at 3:13 PM
ISB Associate Professor Dr. Wei Wei has developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient. Learn more: isbscience.org/news/2024/11...
Reposted by Anna Kuchina
Warm congratulations to my @isbscience.org colleagues @gibbological.bsky.social, Andrew Magis, and team for winning a 2024 Amazon Web Services IMAGINE grant for developing "My Digital Gut", an online platform for personalized, predictive, and preventive healthcare!
isbscience.org/news/2024/12...
isbscience.org/news/2024/12...
ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits
ISB was selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant, which will support continued development of My Digital Gut.
isbscience.org
December 12, 2024 at 5:08 PM
Warm congratulations to my @isbscience.org colleagues @gibbological.bsky.social, Andrew Magis, and team for winning a 2024 Amazon Web Services IMAGINE grant for developing "My Digital Gut", an online platform for personalized, predictive, and preventive healthcare!
isbscience.org/news/2024/12...
isbscience.org/news/2024/12...
Reposted by Anna Kuchina
Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Diverse viral cas genes antagonize CRISPR immunity - Nature
We demonstrate that phages have co-opted cas genes from CRISPR defence systems, which subsequently evolved anti-defence functions.
www.nature.com
December 17, 2024 at 10:22 PM
Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anna Kuchina
Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org
doi.org/10.1016/j.ch...
doi.org/10.1016/j.ch...
Redirecting
doi.org
January 3, 2025 at 5:44 PM
Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org
doi.org/10.1016/j.ch...
doi.org/10.1016/j.ch...