Sid Venkatesh
@flash-point.bsky.social
Assistant Professor at ISB and UW Microbiology in Seattle, WA | Lover of collaboration, generosity and trust in science | Opinions are my own | https://venkatesh.isbscience.org/
Reposted by Sid Venkatesh
Painted stork carefully selecting a stick for its nest. Taken at Sultanpur National Park, India. #birds #wildlife #photography #pnw #india
December 23, 2025 at 4:35 AM
Painted stork carefully selecting a stick for its nest. Taken at Sultanpur National Park, India. #birds #wildlife #photography #pnw #india
Reposted by Sid Venkatesh
My dissertation work was finally published! Check it out below!
Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease: Cell Reports www.cell.com/cell-reports...
#microsky #science #microbiology #pathology #pathobiology
Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease: Cell Reports www.cell.com/cell-reports...
#microsky #science #microbiology #pathology #pathobiology
Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease
Luck et al. identify the bacterial protein ZmpB as a key factor in heart damage during
severe Streptococcus pneumoniae infections. Variants of ZmpB with FIVAR domains enable
cardiac cell invasion, whi...
www.cell.com
December 4, 2025 at 11:03 PM
My dissertation work was finally published! Check it out below!
Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease: Cell Reports www.cell.com/cell-reports...
#microsky #science #microbiology #pathology #pathobiology
Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease: Cell Reports www.cell.com/cell-reports...
#microsky #science #microbiology #pathology #pathobiology
Reposted by Sid Venkatesh
@isbscience.org postdoc @n8ritz.bsky.social (Venkatesh Lab) was selected as a 2026 WRF Postdoc Fellow. The fellowship supports early-career researchers pursuing high-impact science. Congrats Nate! π
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
December 17, 2025 at 7:55 PM
@isbscience.org postdoc @n8ritz.bsky.social (Venkatesh Lab) was selected as a 2026 WRF Postdoc Fellow. The fellowship supports early-career researchers pursuing high-impact science. Congrats Nate! π
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
Reposted by Sid Venkatesh
The imminent rise in healthcare insurance costs could not have been better timed with the imminent rise of infectious diseases over the winter holidays. Yay us!
December 17, 2025 at 3:12 AM
The imminent rise in healthcare insurance costs could not have been better timed with the imminent rise of infectious diseases over the winter holidays. Yay us!
Reposted by Sid Venkatesh
See you in less than 1 hour for the kickoff to the 2025 @isbscience.org Virtual Microbiome Symposium!
This year, we will explore microbial metabolites and their impacts on the host.
@flash-point.bsky.social will start things off at 9AM Pacific Time.
#ISBmicro2025
isbscience.org/events/2025-...
This year, we will explore microbial metabolites and their impacts on the host.
@flash-point.bsky.social will start things off at 9AM Pacific Time.
#ISBmicro2025
isbscience.org/events/2025-...
isbscience.org
December 12, 2025 at 4:10 PM
See you in less than 1 hour for the kickoff to the 2025 @isbscience.org Virtual Microbiome Symposium!
This year, we will explore microbial metabolites and their impacts on the host.
@flash-point.bsky.social will start things off at 9AM Pacific Time.
#ISBmicro2025
isbscience.org/events/2025-...
This year, we will explore microbial metabolites and their impacts on the host.
@flash-point.bsky.social will start things off at 9AM Pacific Time.
#ISBmicro2025
isbscience.org/events/2025-...
@isbscience.org's Dr. Mary Brunkow gave a "practice talk" for her Nobel Lecture, and it was riveting! Mapping the Foxp3 locus was an arduous task in the late 90s, and this recognition is a fitting tribute. Thrilled for you, Mary! Your humility and grace are a wonderful example for all of us.
December 3, 2025 at 4:54 AM
@isbscience.org's Dr. Mary Brunkow gave a "practice talk" for her Nobel Lecture, and it was riveting! Mapping the Foxp3 locus was an arduous task in the late 90s, and this recognition is a fitting tribute. Thrilled for you, Mary! Your humility and grace are a wonderful example for all of us.
Please join us on Dec 12th for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems".
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
The gutβs microbial ecosystem produces diverse metabolites that actively shape neural, immune, and endocrine function. Join leading researchers on December 12 as they share new discoveries into these ...
isbscience.org
December 2, 2025 at 5:05 PM
Please join us on Dec 12th for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems".
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
Reposted by Sid Venkatesh
π£ Join us for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems".
co-director - @flash-point.bsky.social π¦ π₯
It's free, & we have an amazing line-up of speakers!
Dec. 12th. Please share!
isbscience.org/2025-isb-vir...
co-director - @flash-point.bsky.social π¦ π₯
It's free, & we have an amazing line-up of speakers!
Dec. 12th. Please share!
isbscience.org/2025-isb-vir...
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
Symposium Schedule All presentation times are shown in Pacific Daylight Time (GMT -07:00 / UTC -07:00) Time Talk / Session 9:00 Welcoming remarks by Sid Venkatesh Session One: Neural Effects
isbscience.org
November 13, 2025 at 7:13 AM
π£ Join us for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems".
co-director - @flash-point.bsky.social π¦ π₯
It's free, & we have an amazing line-up of speakers!
Dec. 12th. Please share!
isbscience.org/2025-isb-vir...
co-director - @flash-point.bsky.social π¦ π₯
It's free, & we have an amazing line-up of speakers!
Dec. 12th. Please share!
isbscience.org/2025-isb-vir...
Reposted by Sid Venkatesh
Reposted by Sid Venkatesh
Dr. Meghan Koch from @fredhutch.org has discovered a biological mechanism sprung in the first week of life that trains a mouse pupβs #ImmuneSystem to tolerate harmless gut bugs and new foods.
βοΈ Abstract: https://bit.ly/4nt6qGh
π° Press release: https://bit.ly/46N7vBY
βοΈ Abstract: https://bit.ly/4nt6qGh
π° Press release: https://bit.ly/46N7vBY
October 1, 2025 at 8:15 PM
Dr. Meghan Koch from @fredhutch.org has discovered a biological mechanism sprung in the first week of life that trains a mouse pupβs #ImmuneSystem to tolerate harmless gut bugs and new foods.
βοΈ Abstract: https://bit.ly/4nt6qGh
π° Press release: https://bit.ly/46N7vBY
βοΈ Abstract: https://bit.ly/4nt6qGh
π° Press release: https://bit.ly/46N7vBY
Reposted by Sid Venkatesh
Rubbing shoulders with a @nobelprize.bsky.social laureate! π€©What a week!
Couldnβt have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
Couldnβt have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
October 8, 2025 at 12:19 AM
Rubbing shoulders with a @nobelprize.bsky.social laureate! π€©What a week!
Couldnβt have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
Couldnβt have happened to a nicer person: isbscience.org/news/press-r...
@isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social
Reposted by Sid Venkatesh
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....
What a tremendous honor! Congratulations!
What a tremendous honor! Congratulations!
October 6, 2025 at 4:19 PM
This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine....
What a tremendous honor! Congratulations!
What a tremendous honor! Congratulations!
Reposted by Sid Venkatesh
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi βfor their discoveries concerning peripheral immune tolerance.β
October 6, 2025 at 9:51 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi βfor their discoveries concerning peripheral immune tolerance.β
Inspirational stuff from a scientific pioneer who also happens to be incredibly modest. β₯οΈ
October 6, 2025 at 12:02 PM
Inspirational stuff from a scientific pioneer who also happens to be incredibly modest. β₯οΈ
Many congratulations, Mary Brunkow! Couldnβt be happier for you and @isbscience.org ! β₯οΈ
www.nobelprize.org
www.nobelprize.org
The official website of the Nobel Prize - NobelPrize.org
The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...
www.nobelprize.org
October 6, 2025 at 11:46 AM
Many congratulations, Mary Brunkow! Couldnβt be happier for you and @isbscience.org ! β₯οΈ
www.nobelprize.org
www.nobelprize.org
Reposted by Sid Venkatesh
It was an honor to highlight this fantastic work by Cheng and Venkatesh et al of the Gordon lab. Many thanks to them, and to Francis Chandra for doing all the heavy lifting on this Spotlight! @cp-cellchembiol.bsky.social
Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org
doi.org/10.1016/j.ch...
doi.org/10.1016/j.ch...
Redirecting
doi.org
January 4, 2025 at 9:40 AM
It was an honor to highlight this fantastic work by Cheng and Venkatesh et al of the Gordon lab. Many thanks to them, and to Francis Chandra for doing all the heavy lifting on this Spotlight! @cp-cellchembiol.bsky.social
Reposted by Sid Venkatesh
Happy to kick off 2025 with this new review on gut microbiota-neuroepithelial signaling by the very talented Taka Ohara!
January 4, 2025 at 9:50 AM
Happy to kick off 2025 with this new review on gut microbiota-neuroepithelial signaling by the very talented Taka Ohara!
Reposted by Sid Venkatesh
Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org
doi.org/10.1016/j.ch...
doi.org/10.1016/j.ch...
Redirecting
doi.org
January 3, 2025 at 5:44 PM
Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org
doi.org/10.1016/j.ch...
doi.org/10.1016/j.ch...
Reposted by Sid Venkatesh
Happy to see this paper, led by former grad student Cassie Chartier, out in its final form at Protein Science! We characterized the interaction between PTP1B and the ubiquitous signaling adaptor Grb2 and identified new PTP1B interactors along the way!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Allosteric regulation of the tyrosine phosphatase PTP1B by a proteinβprotein interaction
The rapid identification of proteinβprotein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and pr...
onlinelibrary.wiley.com
December 26, 2024 at 3:49 PM
Happy to see this paper, led by former grad student Cassie Chartier, out in its final form at Protein Science! We characterized the interaction between PTP1B and the ubiquitous signaling adaptor Grb2 and identified new PTP1B interactors along the way!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Sid Venkatesh
Excited to share a new preprint from our lab, joint with the Bussemaker group, where we combined peptide display and selection with biophysically interpretable machine learning to build affinity models for SH2-phosphopeptide recognition.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression
Short linear peptide motifs play important roles in cell signaling. They can act as modification sites for enzymes and as recognition sites for peptide binding domains. SH2 domains bind specifically t...
www.biorxiv.org
December 24, 2024 at 6:00 PM
Excited to share a new preprint from our lab, joint with the Bussemaker group, where we combined peptide display and selection with biophysically interpretable machine learning to build affinity models for SH2-phosphopeptide recognition.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sid Venkatesh
Fantastic work! Congrats @nandangokhale.bsky.social, @ramlabuw.bsky.social and team.
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
@ramlabuw.bsky.social
www.science.org/doi/10.1126/...
Cellular RNA interacts with MAVS to promote antiviral signaling
Antiviral signaling downstream of RIG-Iβlike receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...
www.science.org
December 20, 2024 at 5:02 PM
Fantastic work! Congrats @nandangokhale.bsky.social, @ramlabuw.bsky.social and team.
Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Diverse viral cas genes antagonize CRISPR immunity - Nature
We demonstrate that phages have co-opted cas genes from CRISPR defence systems, which subsequently evolved anti-defence functions.
www.nature.com
December 17, 2024 at 10:22 PM
Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Warm congratulations to my @isbscience.org colleagues @gibbological.bsky.social, Andrew Magis, and team for winning a 2024 Amazon Web Services IMAGINE grant for developing "My Digital Gut", an online platform for personalized, predictive, and preventive healthcare!
isbscience.org/news/2024/12...
isbscience.org/news/2024/12...
ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits
ISB was selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant, which will support continued development of My Digital Gut.
isbscience.org
December 12, 2024 at 5:08 PM
Warm congratulations to my @isbscience.org colleagues @gibbological.bsky.social, Andrew Magis, and team for winning a 2024 Amazon Web Services IMAGINE grant for developing "My Digital Gut", an online platform for personalized, predictive, and preventive healthcare!
isbscience.org/news/2024/12...
isbscience.org/news/2024/12...
Reposted by Sid Venkatesh
Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
Nature Communications - The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal...
rdcu.be
December 2, 2024 at 2:17 PM
Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk