Cress Lab
@cresslab.bsky.social
The Cress Lab | Innovative Genomics Institute @ UC Berkeley | Microbiome Editing | Microbiome Delivery Technologies | Phage and MGE Functional Genomics | Hiring!
https://www.cresslab.bio/
https://www.cresslab.bio/
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Cress Lab
@cresslab.bsky.social
· Feb 26
CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d - Nature Microbiology
Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.
doi.org
Dive into our lab’s first peer-reviewed publication—co-led with our friends @benadler.bsky.social and Muntathar Al-Shimary from the @doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s415... @naturemicrobiol.bsky.social
Reposted by Cress Lab
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
A phage protein screen identifies triggers of the bacterial innate immune system - Nature Microbiology
A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
www.nature.com
January 18, 2026 at 10:45 PM
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
Reposted by Cress Lab
Also a big thanks to @cresslab.bsky.social and @therubinlab.bsky.social who came up with the idea to start this meeting and were instrumental in making it happen! And congratulations to @therubinlab.bsky.social and @paulwilmes.bsky.social for their elections as vice-chairs for the next one!
January 19, 2026 at 1:58 PM
Also a big thanks to @cresslab.bsky.social and @therubinlab.bsky.social who came up with the idea to start this meeting and were instrumental in making it happen! And congratulations to @therubinlab.bsky.social and @paulwilmes.bsky.social for their elections as vice-chairs for the next one!
Reposted by Cress Lab
It was a true privilege to co-chair the inaugural GRC meeting on Microbiome Editing together with @jenniferdoudna.bsky.social . The positive energy and quality of the Science presented were truly inspiring. I look forward to the next one chaired by KC Huang and @omalleylab.bsky.social !!!
January 19, 2026 at 1:53 PM
It was a true privilege to co-chair the inaugural GRC meeting on Microbiome Editing together with @jenniferdoudna.bsky.social . The positive energy and quality of the Science presented were truly inspiring. I look forward to the next one chaired by KC Huang and @omalleylab.bsky.social !!!
Reposted by Cress Lab
Out Now! A phage protein screen identifies triggers of the bacterial innate immune system #MicroSky
A phage protein screen identifies triggers of the bacterial innate immune system
Nature Microbiology, Published online: 16 January 2026; doi:10.1038/s41564-025-02239-6A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
go.nature.com
January 16, 2026 at 4:53 PM
Out Now! A phage protein screen identifies triggers of the bacterial innate immune system #MicroSky
Reposted by Cress Lab
We're excited to help launch the inaugural Gordon research conference on #microbiome editing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/a6Am50X9XkE
October 27, 2025 at 3:05 PM
We're excited to help launch the inaugural Gordon research conference on #microbiome editing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/a6Am50X9XkE
Reposted by Cress Lab
This is shaping up to be one of the top conferences on microbiome editing!!
We're excited to help launch the inaugural Gordon research conference on #microbiome editing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/a6Am50X9XkE
January 13, 2026 at 11:45 PM
This is shaping up to be one of the top conferences on microbiome editing!!
Reposted by Cress Lab
Such a privilege to share the Phage Foundry (phagefoundry.org) team’s work at the inaugural GRC meeting on Microbiome Editing 🎉🎊.
January 13, 2026 at 11:56 PM
Such a privilege to share the Phage Foundry (phagefoundry.org) team’s work at the inaugural GRC meeting on Microbiome Editing 🎉🎊.
Reposted by Cress Lab
On my way to two *awesome* back-to-back conferences:
First, GRC on Microbiome Editing in Pomona, CA
www.grc.org/microbiome-e...
Then, Keystone Conference on Human Microbiomes in Banff (co-organizing)
www.keystonesymposia.org/conferences/...
First, GRC on Microbiome Editing in Pomona, CA
www.grc.org/microbiome-e...
Then, Keystone Conference on Human Microbiomes in Banff (co-organizing)
www.keystonesymposia.org/conferences/...
2026 Microbiome Editing Conference GRC
The 2026 Gordon Research Conference on Microbiome Editing will be held in Pomona, California. Apply today to reserve your spot.
www.grc.org
January 11, 2026 at 7:26 PM
On my way to two *awesome* back-to-back conferences:
First, GRC on Microbiome Editing in Pomona, CA
www.grc.org/microbiome-e...
Then, Keystone Conference on Human Microbiomes in Banff (co-organizing)
www.keystonesymposia.org/conferences/...
First, GRC on Microbiome Editing in Pomona, CA
www.grc.org/microbiome-e...
Then, Keystone Conference on Human Microbiomes in Banff (co-organizing)
www.keystonesymposia.org/conferences/...
Reposted by Cress Lab
I get ~100 emails a day, but such an email is rare:
"Dr. Moon,
On behalf of Chairs Jennifer Doudna and David Bikard..."
So excited to see the Nobel laureate again, chair a session & give a talk at #microbiome editing GRC! See you all!
@dbikard.bsky.social
www.grc.org/microbiome-e...
"Dr. Moon,
On behalf of Chairs Jennifer Doudna and David Bikard..."
So excited to see the Nobel laureate again, chair a session & give a talk at #microbiome editing GRC! See you all!
@dbikard.bsky.social
www.grc.org/microbiome-e...
January 9, 2026 at 8:28 PM
I get ~100 emails a day, but such an email is rare:
"Dr. Moon,
On behalf of Chairs Jennifer Doudna and David Bikard..."
So excited to see the Nobel laureate again, chair a session & give a talk at #microbiome editing GRC! See you all!
@dbikard.bsky.social
www.grc.org/microbiome-e...
"Dr. Moon,
On behalf of Chairs Jennifer Doudna and David Bikard..."
So excited to see the Nobel laureate again, chair a session & give a talk at #microbiome editing GRC! See you all!
@dbikard.bsky.social
www.grc.org/microbiome-e...
Reposted by Cress Lab
Feeling grateful to end this year by contributing to a commentary on bioengineering the coral holobiont. This is my first manuscript as a professor and a dream come true to team up with leaders in coral probiotics, Raquel Peixoto and @reefgenomics.bsky.social. 🪸🧪🧬🦠
www.cell.com/one-earth/ab...
www.cell.com/one-earth/ab...
Bioengineering the coral holobiont: Evidence, hurdles, and pathways for rebuilding reefs
At the frontline of climate impacts, coral reef ecosystems now increasingly depend
on active intervention for their functional survival. Bioengineering the coral holobiont,
comprising the host, algal ...
www.cell.com
December 20, 2025 at 8:59 PM
Feeling grateful to end this year by contributing to a commentary on bioengineering the coral holobiont. This is my first manuscript as a professor and a dream come true to team up with leaders in coral probiotics, Raquel Peixoto and @reefgenomics.bsky.social. 🪸🧪🧬🦠
www.cell.com/one-earth/ab...
www.cell.com/one-earth/ab...
Reposted by Cress Lab
Stepwise DNA unwinding gates TnpB genome-editing activity https://www.biorxiv.org/content/10.64898/2026.01.09.698545v1
January 10, 2026 at 2:45 AM
Stepwise DNA unwinding gates TnpB genome-editing activity https://www.biorxiv.org/content/10.64898/2026.01.09.698545v1
Reposted by Cress Lab
I’m looking to host a postdoc in our lab to use proteomics to discover and characterize phage receptors.
Strong fit if you have experience in MS based proteomics and an interest in infection biology.
Call info: www.scilifelab.se/data-driven/...
#postdoc #proteomics #phage #infectionbiology
Strong fit if you have experience in MS based proteomics and an interest in infection biology.
Call info: www.scilifelab.se/data-driven/...
#postdoc #proteomics #phage #infectionbiology
DDLS Research School Postdoc call 2026
Call for Academic and Industrial Postdoctoral Fellowships in Data-Driven Life Science 2026 Generic Description of the DDLS Postdoc Program The SciLifeLab and Wallenberg National Program for Data-Drive...
www.scilifelab.se
January 9, 2026 at 8:18 AM
I’m looking to host a postdoc in our lab to use proteomics to discover and characterize phage receptors.
Strong fit if you have experience in MS based proteomics and an interest in infection biology.
Call info: www.scilifelab.se/data-driven/...
#postdoc #proteomics #phage #infectionbiology
Strong fit if you have experience in MS based proteomics and an interest in infection biology.
Call info: www.scilifelab.se/data-driven/...
#postdoc #proteomics #phage #infectionbiology
Reposted by Cress Lab
Last call to secure your spot at Microbes in Wastewater Symposium!
Connect with experts across wastewater research, environmental microbiology, and public health. Plus, enjoy an exclusive dinner cruise on the beautiful Newport Beach Harbor!
Register now: www.wastewateramr.com
Connect with experts across wastewater research, environmental microbiology, and public health. Plus, enjoy an exclusive dinner cruise on the beautiful Newport Beach Harbor!
Register now: www.wastewateramr.com
January 6, 2026 at 5:21 PM
Last call to secure your spot at Microbes in Wastewater Symposium!
Connect with experts across wastewater research, environmental microbiology, and public health. Plus, enjoy an exclusive dinner cruise on the beautiful Newport Beach Harbor!
Register now: www.wastewateramr.com
Connect with experts across wastewater research, environmental microbiology, and public health. Plus, enjoy an exclusive dinner cruise on the beautiful Newport Beach Harbor!
Register now: www.wastewateramr.com
Reposted by Cress Lab
New preprint from my lab (with Arya Kaul, @fernpizza.bsky.social, and @brinda.eu), in which we explore new genes hitchhiking on the beneficial deletion that fused them together, and find them in the LTEE, M. Tb/bovis, and across the bacterial tree of life
Novel genes arise from genomic deletions across the bacterial tree of life https://www.biorxiv.org/content/10.64898/2026.01.05.697752v1
January 6, 2026 at 4:12 PM
New preprint from my lab (with Arya Kaul, @fernpizza.bsky.social, and @brinda.eu), in which we explore new genes hitchhiking on the beneficial deletion that fused them together, and find them in the LTEE, M. Tb/bovis, and across the bacterial tree of life
Reposted by Cress Lab
If you are looking to integrate your latest genetic creation into the genome of your favourite bug, you might find our latest review now out in OUP Synthetic Biology useful. 🧬⚒️ Work led by Riesa Rohmat with input from Thea Irvine and Shivang Joshi. #genome #synbio doi.org/10.1093/synb...
January 6, 2026 at 10:58 AM
If you are looking to integrate your latest genetic creation into the genome of your favourite bug, you might find our latest review now out in OUP Synthetic Biology useful. 🧬⚒️ Work led by Riesa Rohmat with input from Thea Irvine and Shivang Joshi. #genome #synbio doi.org/10.1093/synb...
Reposted by Cress Lab
🧫 🧪 We’re so excited to share our new preprint, where we tackle the wealth of structural and functional diversity across antiviral STAND NTPases in bacteria.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Diverse bacterial pattern recognition receptors sense the conserved phage proteome
Recognition of foreign molecules inside cells is critical for immunity in all domains of life. Proteins of the STAND NTPase superfamily, including eukaryotic nucleotide-binding oligomerization domain ...
www.biorxiv.org
January 6, 2026 at 1:19 AM
🧫 🧪 We’re so excited to share our new preprint, where we tackle the wealth of structural and functional diversity across antiviral STAND NTPases in bacteria.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Cress Lab
During my postdoc in @therubinlab.bsky.social, @leosong.bsky.social and I aimed to make CRISPR-associated transposons more efficient for editing bacteria.
Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social
Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social
Happy New Year from the Rubin Lab! 🎇
We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)
We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)
Identification of proteins influencing CRISPR-associated transposases for enhanced genome editing
Whole-genome screening reveals strategies to boost CRISPR-associated transposase genome editing efficiency.
www.science.org
January 5, 2026 at 9:39 PM
During my postdoc in @therubinlab.bsky.social, @leosong.bsky.social and I aimed to make CRISPR-associated transposons more efficient for editing bacteria.
Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social
Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social
Reposted by Cress Lab
New in Science Magazine Science Advances from the Doudna Lab, Rubin Lab and Cress Lab —Identification of proteins influencing #CRISPR-associated #transposases for enhanced #GenomeEditing. Read here: https://ow.ly/U0s450XS82n
January 5, 2026 at 7:23 PM
New in Science Magazine Science Advances from the Doudna Lab, Rubin Lab and Cress Lab —Identification of proteins influencing #CRISPR-associated #transposases for enhanced #GenomeEditing. Read here: https://ow.ly/U0s450XS82n
Reposted by Cress Lab
Happy New Year from the Rubin Lab! 🎇
We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)
We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)
Identification of proteins influencing CRISPR-associated transposases for enhanced genome editing
Whole-genome screening reveals strategies to boost CRISPR-associated transposase genome editing efficiency.
www.science.org
January 5, 2026 at 6:45 PM
Happy New Year from the Rubin Lab! 🎇
We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)
We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)
Reposted by Cress Lab
BiomeGPT: A foundation model for the human gut microbiome https://www.biorxiv.org/content/10.64898/2026.01.05.697599v1
January 5, 2026 at 5:46 PM
BiomeGPT: A foundation model for the human gut microbiome https://www.biorxiv.org/content/10.64898/2026.01.05.697599v1
Reposted by Cress Lab
The distinction between virulent & temperate phages gets fuzzier if one can find so many virulent phages in the sequences of bacterial genomes coming from standard lab "pure" cultures. Check Peter's thread on our work and the N&V by Carson & Hynes: doi.org/10.1038/s415...
#phagesky #microsky
#phagesky #microsky
January 5, 2026 at 4:41 PM
The distinction between virulent & temperate phages gets fuzzier if one can find so many virulent phages in the sequences of bacterial genomes coming from standard lab "pure" cultures. Check Peter's thread on our work and the N&V by Carson & Hynes: doi.org/10.1038/s415...
#phagesky #microsky
#phagesky #microsky
Reposted by Cress Lab
Decoding E. coli's Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and Strains https://www.biorxiv.org/content/10.64898/2026.01.05.697630v1
January 5, 2026 at 6:17 PM
Decoding E. coli's Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and Strains https://www.biorxiv.org/content/10.64898/2026.01.05.697630v1
Reposted by Cress Lab
Decoding E. coli's Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and Strains https://www.biorxiv.org/content/10.64898/2026.01.05.697630v1
January 5, 2026 at 6:18 PM
Decoding E. coli's Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and Strains https://www.biorxiv.org/content/10.64898/2026.01.05.697630v1
Reposted by Cress Lab
🚨 Our Lab is HIRING! If you are interested in characterizing model microbiomes using genome-resolved methods, statistical/metabolic modeling, and/or machine learning please submit an application here: aprecruit.berkeley.edu/JPF05234
#postdoc #sciencejobs #biology #microbiome
#postdoc #sciencejobs #biology #microbiome
Postdoc - Microbiome - Innovative Genomics Institute
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
January 5, 2026 at 6:19 PM
🚨 Our Lab is HIRING! If you are interested in characterizing model microbiomes using genome-resolved methods, statistical/metabolic modeling, and/or machine learning please submit an application here: aprecruit.berkeley.edu/JPF05234
#postdoc #sciencejobs #biology #microbiome
#postdoc #sciencejobs #biology #microbiome
Reposted by Cress Lab
🚨 New paper from our lab in Cell Reports @cp-cellreports.bsky.social, led by Clara Douadi!
We show that bacteriophages can cross the intestinal barrier, with increased translocation in Crohn's disease.
🔗 www.cell.com/cell-reports...
Many thanks to all the authors!
We show that bacteriophages can cross the intestinal barrier, with increased translocation in Crohn's disease.
🔗 www.cell.com/cell-reports...
Many thanks to all the authors!
Differential translocation of bacteriophages across the intestinal barrier in health and Crohn’s disease
Intestinal barrier integrity is crucial for gut homeostasis. Douadi et al. show that
bacteriophages can cross this barrier without causing damage and that translocation
rates depend on the barrier sta...
www.cell.com
January 5, 2026 at 1:40 PM