Sylvia Erhardt
@erhardtlab.bsky.social
Centromeres, Repetitive RNAs, Epigenetic inheritance and everything chromatin-related. Professor @ kit.edu/. Love my girls and running hills. She/Her. Personal account (views are mine).
Reposted by Sylvia Erhardt
Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. We also find that cancer cells with low levels of CENP-E are sensitive for KIF18A inhibition. Congrats Jiahang Miao!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
Miao et al. demonstrate that KIF18A depletion causes synthetic defects with CENP-C
hypomorphic mutant and KIF18A functions for chromosome congression in cooperation
with CENP-E. CENP-E levels at kinet...
www.cell.com
November 10, 2025 at 10:05 PM
Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. We also find that cancer cells with low levels of CENP-E are sensitive for KIF18A inhibition. Congrats Jiahang Miao!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Sylvia Erhardt
🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.
👉 www.molgen.mpg.de/5099133/schu...
👉 www.molgen.mpg.de/5099133/schu...
November 4, 2025 at 11:19 AM
🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.
👉 www.molgen.mpg.de/5099133/schu...
👉 www.molgen.mpg.de/5099133/schu...
Reposted by Sylvia Erhardt
Special issue: The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
October 27, 2025 at 11:35 AM
Special issue: The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
Sam Corless @scorless.bsky.social and Goks Thangaval @gokilavani.bsky.social are Revisiting the question: When is a centromere not a kinetochore? Check it out. rdcu.be/eMJkd
Left work and 30 sec later it came down hard…but got to see a nice rainbow. Karlsruhe Schlosspark.
October 24, 2025 at 2:56 PM
Left work and 30 sec later it came down hard…but got to see a nice rainbow. Karlsruhe Schlosspark.
Reposted by Sylvia Erhardt
Next Tuesday Oct 28, great talks of invited and local speakers of our Synthetic Genomics Center, in Heidelberg and on Zoom!
October 24, 2025 at 1:57 PM
Next Tuesday Oct 28, great talks of invited and local speakers of our Synthetic Genomics Center, in Heidelberg and on Zoom!
Reposted by Sylvia Erhardt
As promised, a recent painting!
“Roja”
Oils 16x9
You can still view this one in person (always looks so much better in person!) at @spoke-art.com NY!
spoke-art.com/blogs/news/1...
“Roja”
Oils 16x9
You can still view this one in person (always looks so much better in person!) at @spoke-art.com NY!
spoke-art.com/blogs/news/1...
October 24, 2025 at 1:16 AM
As promised, a recent painting!
“Roja”
Oils 16x9
You can still view this one in person (always looks so much better in person!) at @spoke-art.com NY!
spoke-art.com/blogs/news/1...
“Roja”
Oils 16x9
You can still view this one in person (always looks so much better in person!) at @spoke-art.com NY!
spoke-art.com/blogs/news/1...
New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off
Center Kick-Off Event | Center SynGen
www.syn-gen.de
October 24, 2025 at 11:19 AM
New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off
Reposted by Sylvia Erhardt
My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls
Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨
🔗 www.nikonsmallworld.com/galleries/20...
#NikonSmallWorld #Microscopy #ScienceArt
🔵 lifeact &
🔴 RFP-nls
Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨
🔗 www.nikonsmallworld.com/galleries/20...
#NikonSmallWorld #Microscopy #ScienceArt
October 3, 2025 at 9:06 AM
My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls
Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨
🔗 www.nikonsmallworld.com/galleries/20...
#NikonSmallWorld #Microscopy #ScienceArt
🔵 lifeact &
🔴 RFP-nls
Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨
🔗 www.nikonsmallworld.com/galleries/20...
#NikonSmallWorld #Microscopy #ScienceArt
Reposted by Sylvia Erhardt
Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
www.keystonesymposia.org
October 17, 2025 at 2:36 PM
Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Reposted by Sylvia Erhardt
This is 'Rakotzbrücke Devil’s Bridge', commissioned in 1860 in the German village of Kromlau in Gablenz on the estate of Friedrich Herrmann Rötschke, now a public park.
Its purpose is ornamental: to form a perfect circle with its own reflection when light & wind permit.
(📷: Dirk Förster, Flickr)
Its purpose is ornamental: to form a perfect circle with its own reflection when light & wind permit.
(📷: Dirk Förster, Flickr)
October 15, 2025 at 12:45 PM
This is 'Rakotzbrücke Devil’s Bridge', commissioned in 1860 in the German village of Kromlau in Gablenz on the estate of Friedrich Herrmann Rötschke, now a public park.
Its purpose is ornamental: to form a perfect circle with its own reflection when light & wind permit.
(📷: Dirk Förster, Flickr)
Its purpose is ornamental: to form a perfect circle with its own reflection when light & wind permit.
(📷: Dirk Förster, Flickr)
Reposted by Sylvia Erhardt
An Interview with Azim Surani
Ashley Moffett and @geraldinejowett.bsky.social spoke to Azim, recipient of both the 2025 Kyoto Prize and 2026 Paul Ehrlich and Ludwig Darmstaedter Prize, about his non-traditional and inspirational route into academia:
journals.biologists.com/dev/article/...
Ashley Moffett and @geraldinejowett.bsky.social spoke to Azim, recipient of both the 2025 Kyoto Prize and 2026 Paul Ehrlich and Ludwig Darmstaedter Prize, about his non-traditional and inspirational route into academia:
journals.biologists.com/dev/article/...
October 9, 2025 at 5:05 PM
An Interview with Azim Surani
Ashley Moffett and @geraldinejowett.bsky.social spoke to Azim, recipient of both the 2025 Kyoto Prize and 2026 Paul Ehrlich and Ludwig Darmstaedter Prize, about his non-traditional and inspirational route into academia:
journals.biologists.com/dev/article/...
Ashley Moffett and @geraldinejowett.bsky.social spoke to Azim, recipient of both the 2025 Kyoto Prize and 2026 Paul Ehrlich and Ludwig Darmstaedter Prize, about his non-traditional and inspirational route into academia:
journals.biologists.com/dev/article/...
Reposted by Sylvia Erhardt
A gallery of fireflies.
Phenomenal Fireflies - Alex Wild
Fireflies are a family (Lampyridae) of about 2,000 beetle species known for their ability to produce light through chemical reactions.
www.alexanderwild.com
October 9, 2025 at 8:08 PM
A gallery of fireflies.
Reposted by Sylvia Erhardt
Last week we were in the Washington Post for our characterization of Robertsonian chromosomes. This week we are entering our 10th day of being shut down and all of our research is on hold. To help me feel not-so-bad, here is a thread of some studies we released right before the shutdown 🧵 [1/n]...
October 10, 2025 at 3:24 PM
Last week we were in the Washington Post for our characterization of Robertsonian chromosomes. This week we are entering our 10th day of being shut down and all of our research is on hold. To help me feel not-so-bad, here is a thread of some studies we released right before the shutdown 🧵 [1/n]...
Reposted by Sylvia Erhardt
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
September 24, 2025 at 6:48 PM
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
Reposted by Sylvia Erhardt
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
October 7, 2025 at 5:49 PM
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Reposted by Sylvia Erhardt
Thanks to @erhardtlab.bsky.social for the news and views on our paper on DNA methylation¢romere www.nature.com/articles/s41....
Dipping into the function of DNA methylation at centromeres - Nature Genetics
Human centromeres contain a small chromatin region with low levels of DNA cytosine methylation that resides with CENP-A. Salinas-Luypaert et al. find a role of DNA methylation in maintaining the size and function of centromeres by controlling the binding affinity of key centromere components.
www.nature.com
October 6, 2025 at 6:58 AM
Thanks to @erhardtlab.bsky.social for the news and views on our paper on DNA methylation¢romere www.nature.com/articles/s41....
Reposted by Sylvia Erhardt
I am leaving Rochester NY after attending the retirement fest of four giants in the field of evolutionary biology including my PhD advisor. This visit gave me a chance to revisit old haunts and reflect on my own somewhat unlikely origin story. 1/n
October 5, 2025 at 4:26 PM
I am leaving Rochester NY after attending the retirement fest of four giants in the field of evolutionary biology including my PhD advisor. This visit gave me a chance to revisit old haunts and reflect on my own somewhat unlikely origin story. 1/n
Reposted by Sylvia Erhardt
🧪
On October 6, please join me, @richardsever.bsky.social, @rachelzamzow.bsky.social, and @gabestein.com for a virtual panel: how can we make sure open science advances not just science itself, but society’s understanding of, trust in, and willingness to invest in research? Register here:
How Can Open Science Practices Increase Trust In Research? | Shorenstein Center
Join representatives from each stage of open science for a frank discussion of how each part of the publishing process must adapt to make sure open science advances not just science itself, but societ...
shorensteincenter.org
September 24, 2025 at 6:10 PM
🧪
Reposted by Sylvia Erhardt
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
October 2, 2025 at 2:56 AM
“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.”
― Jane Goodall
💙 RIP to a real one. My childhood hero
― Jane Goodall
💙 RIP to a real one. My childhood hero
Reposted by Sylvia Erhardt
🧬🌉Online @science.org Megabase-scale human #genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 29, 2025 at 10:01 PM
🧬🌉Online @science.org Megabase-scale human #genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Reposted by Sylvia Erhardt
Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
Job Details
my.corehr.com
September 29, 2025 at 9:25 AM
Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism
my.corehr.com/pls/uoxrecru...
Reposted by Sylvia Erhardt
Embryonic signatures of intergenerational epigenetic inheritance across paternal environment & genetic background
@jamiehackett.bsky.social et al @embl.org see transcriptome changes in offspring after fertilisation by fathers exposed to gut dysbiosis or western diet
www.embopress.org/doi/full/10....
@jamiehackett.bsky.social et al @embl.org see transcriptome changes in offspring after fertilisation by fathers exposed to gut dysbiosis or western diet
www.embopress.org/doi/full/10....
September 29, 2025 at 10:25 AM
Embryonic signatures of intergenerational epigenetic inheritance across paternal environment & genetic background
@jamiehackett.bsky.social et al @embl.org see transcriptome changes in offspring after fertilisation by fathers exposed to gut dysbiosis or western diet
www.embopress.org/doi/full/10....
@jamiehackett.bsky.social et al @embl.org see transcriptome changes in offspring after fertilisation by fathers exposed to gut dysbiosis or western diet
www.embopress.org/doi/full/10....
Reposted by Sylvia Erhardt
Reposted by Sylvia Erhardt
Wut
September 27, 2025 at 1:02 PM
Wut