Andrew Newman
@epinewman.bsky.social
Investigating the Neuronal Epigenome in Development, Evolution, & Aging.
Junior Group Leader @ Charité Universitätsmedizin Berlin
Junior Group Leader @ Charité Universitätsmedizin Berlin
Pinned
Andrew Newman
@epinewman.bsky.social
· Sep 1
Our study on chronic de-repression of ERVs in the brain is finally out in
@natcomms.nature.com
We dove deep into the molecular mechanisms controlling their repression as well as the physiological consequences of their extended expression in the cortex over the lifespan of a mouse.
a 🧵 👇
@natcomms.nature.com
We dove deep into the molecular mechanisms controlling their repression as well as the physiological consequences of their extended expression in the cortex over the lifespan of a mouse.
a 🧵 👇
Reposted by Andrew Newman
The problem with every post-Millennial generation is they got to go straight to high speed internet. Of course you'll get computer madness that way. Make them start with those old screeching modems and work their way up
November 10, 2024 at 12:14 AM
The problem with every post-Millennial generation is they got to go straight to high speed internet. Of course you'll get computer madness that way. Make them start with those old screeching modems and work their way up
Reposted by Andrew Newman
I wrote about this problem in The Death of Expertise. (My solution, despite years of good evals, was to have other faculty observe my class and give me feedback, even when I was senior and tenured.)
by @rosehorowitch.bsky.social
www.theatlantic.com/ideas/archiv...
by @rosehorowitch.bsky.social
www.theatlantic.com/ideas/archiv...
September 13, 2025 at 6:42 PM
I wrote about this problem in The Death of Expertise. (My solution, despite years of good evals, was to have other faculty observe my class and give me feedback, even when I was senior and tenured.)
by @rosehorowitch.bsky.social
www.theatlantic.com/ideas/archiv...
by @rosehorowitch.bsky.social
www.theatlantic.com/ideas/archiv...
Reposted by Andrew Newman
One week left to register for the 1st conference on assembloids at @cshlnews.bsky.social this December. Spectacular list of speakers (see below) tackling cell-cell interactions across tissues and organs
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
September 12, 2025 at 6:28 PM
One week left to register for the 1st conference on assembloids at @cshlnews.bsky.social this December. Spectacular list of speakers (see below) tackling cell-cell interactions across tissues and organs
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
Reposted by Andrew Newman
scAgeClock: a single-cell transcriptome based human aging clock model using gated multi-head attention neural networks https://www.biorxiv.org/content/10.1101/2025.08.29.673183v1
September 3, 2025 at 12:47 PM
scAgeClock: a single-cell transcriptome based human aging clock model using gated multi-head attention neural networks https://www.biorxiv.org/content/10.1101/2025.08.29.673183v1
Our study on chronic de-repression of ERVs in the brain is finally out in
@natcomms.nature.com
We dove deep into the molecular mechanisms controlling their repression as well as the physiological consequences of their extended expression in the cortex over the lifespan of a mouse.
a 🧵 👇
@natcomms.nature.com
We dove deep into the molecular mechanisms controlling their repression as well as the physiological consequences of their extended expression in the cortex over the lifespan of a mouse.
a 🧵 👇
September 1, 2025 at 12:42 PM
Our study on chronic de-repression of ERVs in the brain is finally out in
@natcomms.nature.com
We dove deep into the molecular mechanisms controlling their repression as well as the physiological consequences of their extended expression in the cortex over the lifespan of a mouse.
a 🧵 👇
@natcomms.nature.com
We dove deep into the molecular mechanisms controlling their repression as well as the physiological consequences of their extended expression in the cortex over the lifespan of a mouse.
a 🧵 👇
Reposted by Andrew Newman
Reposted by Andrew Newman
Happy to have this published …https://www.science.org/doi/10.1126/sciadv.adr6698
A detailed theory of thalamic and cortical microcircuits for predictive visual inference
A generative vision model offers a detailed theory for cortical columns, thalamus, and computations in cortical circuits.
www.science.org
February 5, 2025 at 9:38 PM
Happy to have this published …https://www.science.org/doi/10.1126/sciadv.adr6698
Reposted by Andrew Newman
Oooh, Senseory Plants has a new website! I love how this startup is forming and the vision these very talented ladies running this operation have. Sincerely delighted to be part of their story. Also very cool to be bioengineering scent in plants!
Senseoryplants.com
Senseoryplants.com
SENSEORY PLANTS
Senseoryplants.com
November 19, 2024 at 4:57 AM
Oooh, Senseory Plants has a new website! I love how this startup is forming and the vision these very talented ladies running this operation have. Sincerely delighted to be part of their story. Also very cool to be bioengineering scent in plants!
Senseoryplants.com
Senseoryplants.com
Reposted by Andrew Newman
Quick visit to X, looking at the crossposts
November 16, 2024 at 9:49 AM
Quick visit to X, looking at the crossposts
What about a Bluenote?
So, we used to call them Tweetorials.
But, uh, when we now outline a paper on here - do we call it a Skeetorial? Bskytorial? Blutorial? Paperskeet?
#AskingForAFriend #PILife #AlwaysBeWriting #NewDigs
But, uh, when we now outline a paper on here - do we call it a Skeetorial? Bskytorial? Blutorial? Paperskeet?
#AskingForAFriend #PILife #AlwaysBeWriting #NewDigs
November 15, 2024 at 12:07 PM
What about a Bluenote?
Reposted by Andrew Newman
Looks like the ChatGPT desktop app can now watch what you're doing in VS Code or Terminal and talk to you about the code.
November 14, 2024 at 9:41 PM
Looks like the ChatGPT desktop app can now watch what you're doing in VS Code or Terminal and talk to you about the code.
Reposted by Andrew Newman
Thrilled to announce that the EMBO workshop «Mobile Genome» will be back in Heidelberg, Nov 4-7th 2025 @EMBLEvents @EMBO. Registration open soon but you can already register interest. Organized with fantastic colleagues @juliusbrennecke @GonzalezLab_BCN @JoePetersLab
www.embl.org/about/info/c...
www.embl.org/about/info/c...
The mobile genome: genetic and physiological impacts of transposable elements
www.embl.org
November 14, 2024 at 11:27 AM
Thrilled to announce that the EMBO workshop «Mobile Genome» will be back in Heidelberg, Nov 4-7th 2025 @EMBLEvents @EMBO. Registration open soon but you can already register interest. Organized with fantastic colleagues @juliusbrennecke @GonzalezLab_BCN @JoePetersLab
www.embl.org/about/info/c...
www.embl.org/about/info/c...
Unmethylated cytosine in your backyard
November 14, 2024 at 8:51 AM
Unmethylated cytosine in your backyard
So there's no bookmarking function here? How am I supposed to collect a large amount of tweets that I will never revisit?
November 13, 2024 at 9:01 PM
So there's no bookmarking function here? How am I supposed to collect a large amount of tweets that I will never revisit?
Reposted by Andrew Newman
Our latest Preprint is now on BioRXiv: www.biorxiv.org/content/10.1...
It explains how heterochromatin-dependent epimutations mediate resistance to caffeine & antifungals by imposing mitochondrial dysfunction.
Thanks to all authors for their efforts especially Andreas Fellas & Alison Pidoux. Enjoy!
It explains how heterochromatin-dependent epimutations mediate resistance to caffeine & antifungals by imposing mitochondrial dysfunction.
Thanks to all authors for their efforts especially Andreas Fellas & Alison Pidoux. Enjoy!
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
Global health and food supply are endangered by an increasing frequency of antifungal resistance in pathogenic fungi. Wild-type fission yeast, Schizosaccharomyces pombe, can gain resistance to insults...
www.biorxiv.org
November 13, 2024 at 4:10 PM
Our latest Preprint is now on BioRXiv: www.biorxiv.org/content/10.1...
It explains how heterochromatin-dependent epimutations mediate resistance to caffeine & antifungals by imposing mitochondrial dysfunction.
Thanks to all authors for their efforts especially Andreas Fellas & Alison Pidoux. Enjoy!
It explains how heterochromatin-dependent epimutations mediate resistance to caffeine & antifungals by imposing mitochondrial dysfunction.
Thanks to all authors for their efforts especially Andreas Fellas & Alison Pidoux. Enjoy!
Reposted by Andrew Newman
Hey #cutandrun #epigenomics folks, has anyone tried this normalisation method? academic.oup.com/bib/article/...
The CUT&RUN greenlist: genomic regions of consistent noise are effective normalizing factors for quantitative epigenome mapping
Abstract. Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is a recent development for epigenome mapping, but its unique methodology can ham
academic.oup.com
July 3, 2024 at 2:09 AM
Hey #cutandrun #epigenomics folks, has anyone tried this normalisation method? academic.oup.com/bib/article/...
Reposted by Andrew Newman
behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩🔬 🧵.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 23, 2024 at 6:19 PM
behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩🔬 🧵.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hello bluesky. It's time to start again.
November 11, 2024 at 9:58 PM
Hello bluesky. It's time to start again.