Zachary Sanchez
@ento-sanchez.bsky.social
Entomology enthusiast and microscopist interested in all the ways microscopy enables incredible research
Ph.D. candidate in the Burnette Lab at Vanderbilt
Ph.D. candidate in the Burnette Lab at Vanderbilt
Reposted by Zachary Sanchez
1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1...
Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.
Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.
Cytokines control the physical state of immune tissue
Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional ...
www.biorxiv.org
November 18, 2025 at 9:31 PM
1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1...
Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.
Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.
Reposted by Zachary Sanchez
A story about our blebbisome paper, "Exploring a New Frontier in Cell Communication: A Q&A with the Burnette Lab on Blebbisomes" has now been posted by @vubasicsciences.bsky.social!
medschool.vanderbilt.edu/basic-scienc...
medschool.vanderbilt.edu/basic-scienc...
Exploring a New Frontier in Cell Communication: A Q&A with the Burnette Lab on Blebbisomes
Since its February 2025 publication in Nature Cell Biology, a groundbreaking study from the Burnette Lab has drawn more than 44,000 Article Accesses—amplified by Vanderbilt’s new open access agreement...
medschool.vanderbilt.edu
April 7, 2025 at 11:59 PM
A story about our blebbisome paper, "Exploring a New Frontier in Cell Communication: A Q&A with the Burnette Lab on Blebbisomes" has now been posted by @vubasicsciences.bsky.social!
medschool.vanderbilt.edu/basic-scienc...
medschool.vanderbilt.edu/basic-scienc...
It’s a little late, but as of last Monday, I am now officially Dr. Sanchez. So incredibly grateful for the training and mentorship that I received in the Burnette lab under @mag2art.bsky.social ! Can’t wait to change research paths a little bit and start studying Toxoplasma with the Lourido Lab!
March 26, 2025 at 4:21 PM
It’s a little late, but as of last Monday, I am now officially Dr. Sanchez. So incredibly grateful for the training and mentorship that I received in the Burnette lab under @mag2art.bsky.social ! Can’t wait to change research paths a little bit and start studying Toxoplasma with the Lourido Lab!
Reposted by Zachary Sanchez
March 17, 2025 at 7:03 PM
Happy #FluorescenceFriday ! Today is an exciting day because I can finally share data from my thesis work. Below is a gif of a blebbisome, a new large extracellular vesicle that I describe and characterize in the article below. www.nature.com/articles/s41...
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology
Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.
www.nature.com
February 21, 2025 at 4:38 PM
Happy #FluorescenceFriday ! Today is an exciting day because I can finally share data from my thesis work. Below is a gif of a blebbisome, a new large extracellular vesicle that I describe and characterize in the article below. www.nature.com/articles/s41...
Reposted by Zachary Sanchez
I’ll write more about this pre-print in the next few days, but please do take a look at this piece of work by Clément Dégut. It’s a 3D-printed open-source microscope that can image microtitre plates. Ideal for anyone looking for a new #DIY #science project
#OpenSource #3Dprinting #microscope
#OpenSource #3Dprinting #microscope
January 2, 2025 at 7:07 PM
I’ll write more about this pre-print in the next few days, but please do take a look at this piece of work by Clément Dégut. It’s a 3D-printed open-source microscope that can image microtitre plates. Ideal for anyone looking for a new #DIY #science project
#OpenSource #3Dprinting #microscope
#OpenSource #3Dprinting #microscope
So happy to have had the opportunity to present my research at #ASCB this year. Can’t wait to soon share the published research with everyone! Be on the look out for a paper talking about blebbisomes!
December 16, 2024 at 10:27 PM
So happy to have had the opportunity to present my research at #ASCB this year. Can’t wait to soon share the published research with everyone! Be on the look out for a paper talking about blebbisomes!
Reposted by Zachary Sanchez
Tau is one of the most captivating cytoskeletal accessory proteins, shown here in hippocampal neurons for #FluorescenceFriday 🔬
December 6, 2024 at 10:15 AM
Tau is one of the most captivating cytoskeletal accessory proteins, shown here in hippocampal neurons for #FluorescenceFriday 🔬
Reposted by Zachary Sanchez
Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reactive oxygen species control protein degradation at the mitochondrial import gate
This work identifies reactive oxygen species released by the electron transport chain as sentinel molecules that regulate localized protein degradation at mitochondrial TOM complexes, a mechanism that controls mitochondrial protein import and adjusts the abundance of the electron transport chain to cellular needs.
www.cell.com
December 6, 2024 at 7:07 AM
Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Zachary Sanchez
Vimentin DNA-PAINT 🌞 in COS-7 cells #FluorescenceFriday
December 6, 2024 at 12:40 PM
Vimentin DNA-PAINT 🌞 in COS-7 cells #FluorescenceFriday
Reposted by Zachary Sanchez
Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature
Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...
www.nature.com
December 5, 2024 at 2:02 PM
Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Zachary Sanchez
Great thread full of #bioimageanalysis goodies
November 27, 2024 at 3:25 PM
Great thread full of #bioimageanalysis goodies
Reposted by Zachary Sanchez
Nothing like the confocal room to boost your melatonin levels and have you ITCHING for a nap at 3pm
November 25, 2024 at 3:44 PM
Nothing like the confocal room to boost your melatonin levels and have you ITCHING for a nap at 3pm
Reposted by Zachary Sanchez
Inaugural post 🦋 The apical microvilli of intestinal epithelial cells create dazzling displays as they assemble the #brushborder! This image was acquired on the remarkable #Nikon NSPARC in @tyskalabactual.bsky.social
November 20, 2024 at 11:14 PM
Inaugural post 🦋 The apical microvilli of intestinal epithelial cells create dazzling displays as they assemble the #brushborder! This image was acquired on the remarkable #Nikon NSPARC in @tyskalabactual.bsky.social
Reposted by Zachary Sanchez
I'm excited to rebuild this #science community over here on Bluesky! In honor of this clean slate, here's a repost of my favorite #epithelial cell building its brush border. @tyskalabactual.bsky.social
November 21, 2024 at 6:49 PM
I'm excited to rebuild this #science community over here on Bluesky! In honor of this clean slate, here's a repost of my favorite #epithelial cell building its brush border. @tyskalabactual.bsky.social
Reposted by Zachary Sanchez
First #FluorescenceFriday here on 🦋 Hope you enjoy this cross-section of the intestinal epithelium, highlighting the actin within the #brushborder @tyskalabactual.bsky.social
November 22, 2024 at 9:09 PM
First #FluorescenceFriday here on 🦋 Hope you enjoy this cross-section of the intestinal epithelium, highlighting the actin within the #brushborder @tyskalabactual.bsky.social
Reposted by Zachary Sanchez
Admittedly, this is a reversed movie of #microvilli collapsing, but how cool would it be if growth were synchronized like this? #FluorescenceFriday
@tyskalabactual.bsky.social
@tyskalabactual.bsky.social
November 22, 2024 at 9:08 PM
Admittedly, this is a reversed movie of #microvilli collapsing, but how cool would it be if growth were synchronized like this? #FluorescenceFriday
@tyskalabactual.bsky.social
@tyskalabactual.bsky.social
Reposted by Zachary Sanchez
It's #FluorescenceFriday fresh off the press is this depth coded image of #Microtubules. @tyskalabactual.bsky.social
November 22, 2024 at 9:09 PM
It's #FluorescenceFriday fresh off the press is this depth coded image of #Microtubules. @tyskalabactual.bsky.social
Reposted by Zachary Sanchez
A cardiac myocyte (heart muscle cell) going through cell division surrounded by cardiac myocytes not going through cell division. DNA (yellow), myosin II (cyan) and actin filaments (magenta) are shown. #FluorescenceFriday #Science #Biology #CellBiology #microscopy
November 22, 2024 at 3:16 PM
A cardiac myocyte (heart muscle cell) going through cell division surrounded by cardiac myocytes not going through cell division. DNA (yellow), myosin II (cyan) and actin filaments (magenta) are shown. #FluorescenceFriday #Science #Biology #CellBiology #microscopy
Reposted by Zachary Sanchez
Hello BlueSky! Here's my inaugral post for #FluorescenceFriday: microtubules lead the way! #microtubules #microscopy #migration
November 22, 2024 at 2:39 PM
Hello BlueSky! Here's my inaugral post for #FluorescenceFriday: microtubules lead the way! #microtubules #microscopy #migration
Happy #FluorescenceFriday! For my first one on this app, I’m showing a movie I got while taking the MBL physiology course. Using the NSPARC, I imaged Trichoplax stained with a membrane dye.
November 22, 2024 at 3:21 PM
Happy #FluorescenceFriday! For my first one on this app, I’m showing a movie I got while taking the MBL physiology course. Using the NSPARC, I imaged Trichoplax stained with a membrane dye.