Emmy Li
@emmyli.bsky.social
Postdoctoral Fellow @ Stanley Qi Lab
Extreme dog lover. Fan of both land and marine wildlife.
For dog pictures - @doodlycharlie on instagram
Extreme dog lover. Fan of both land and marine wildlife.
For dog pictures - @doodlycharlie on instagram
Reposted by Emmy Li
Stand up for science - stand up for the NIH!
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
Bethesda Declaration — STAND UP FOR SCIENCE
Support NIH Staff Now!
www.standupforscience.net
June 10, 2025 at 3:23 AM
Stand up for science - stand up for the NIH!
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
I just signed the support letter for the #BethesdaDeclaration.
Please consider signing as well:
www.standupforscience.net/bethesda-dec...
Reposted by Emmy Li
New CRISPR technology developed by @stanleyqilab.bsky.social, Mengting Han & team could pave the way for potential treatments for neurodegenerative diseases like ALS and spinal muscular dystrophy:
New CRISPR technology could help repair damaged neurons
Stanford researchers have developed a technology that delivers RNA to damaged neurons and stimulates regrowth – paving the way for potential treatments targeting neurodegenerative diseases like ALS…
news.stanford.edu
June 10, 2025 at 7:03 PM
New CRISPR technology developed by @stanleyqilab.bsky.social, Mengting Han & team could pave the way for potential treatments for neurodegenerative diseases like ALS and spinal muscular dystrophy:
Reposted by Emmy Li
Reposted by Emmy Li
Thrilled to share our paper in
@nature.com led by @MengtingHan123
on CRISPR-TO technology, which paves the way for treatments for neurodegenerative diseases by precisely delivering therapeutic RNA to the damaged sites. A 🧵@Stanford_ChEMH, @bioe_stanford, @Stanford
@nature.com led by @MengtingHan123
on CRISPR-TO technology, which paves the way for treatments for neurodegenerative diseases by precisely delivering therapeutic RNA to the damaged sites. A 🧵@Stanford_ChEMH, @bioe_stanford, @Stanford
May 26, 2025 at 1:02 AM
Thrilled to share our paper in
@nature.com led by @MengtingHan123
on CRISPR-TO technology, which paves the way for treatments for neurodegenerative diseases by precisely delivering therapeutic RNA to the damaged sites. A 🧵@Stanford_ChEMH, @bioe_stanford, @Stanford
@nature.com led by @MengtingHan123
on CRISPR-TO technology, which paves the way for treatments for neurodegenerative diseases by precisely delivering therapeutic RNA to the damaged sites. A 🧵@Stanford_ChEMH, @bioe_stanford, @Stanford
Reposted by Emmy Li
Institute Scholar Stanley Qi @stanleyqilab.bsky.social discusses the importance of scientific research and his long-term goal of using the genetic engineering technologies developed in his lab to address unmet medical needs in diseases like cancer and Alzheimer’s:
‘For many people, waiting is not an option’
Stanford bioengineer Stanley Qi is developing advanced gene-editing tools to treat life-threatening diseases and slow the onset of neurological aging.
news.stanford.edu
May 23, 2025 at 7:03 PM
Institute Scholar Stanley Qi @stanleyqilab.bsky.social discusses the importance of scientific research and his long-term goal of using the genetic engineering technologies developed in his lab to address unmet medical needs in diseases like cancer and Alzheimer’s:
Reposted by Emmy Li
“Research is like a chemical reaction – it takes time to reach completion. If we ever slow down in training the next generation of scientists, we risk falling behind other competitors in the world – even if we have the better solution.” #ResearchMatters
‘For many people, waiting is not an option’
Stanford bioengineer Stanley Qi is developing advanced gene-editing tools to treat life-threatening diseases and slow the onset of neurological aging.
news.stanford.edu
May 19, 2025 at 11:03 PM
“Research is like a chemical reaction – it takes time to reach completion. If we ever slow down in training the next generation of scientists, we risk falling behind other competitors in the world – even if we have the better solution.” #ResearchMatters
Reposted by Emmy Li
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Modeling tissue-resident macrophage development from mouse pluripotent stem cells
Tissue-resident macrophages (TRMs) are innate immune cells that participate in tissue development, homeostasis, and immune surveillance. Extensive efforts have been made to recapitulate TRM developmen...
www.biorxiv.org
May 13, 2025 at 7:37 PM
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Emmy Li
Reposted by Emmy Li
Grant freezes versus terminations feel different, but they have the same practical effect.
We should start treating freezes as terminations, both of which can be undone by HHS / NIH whenever they want—or by court order if they refuse. They’re all illegal.
We should start treating freezes as terminations, both of which can be undone by HHS / NIH whenever they want—or by court order if they refuse. They’re all illegal.
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
May 19, 2025 at 11:40 AM
Grant freezes versus terminations feel different, but they have the same practical effect.
We should start treating freezes as terminations, both of which can be undone by HHS / NIH whenever they want—or by court order if they refuse. They’re all illegal.
We should start treating freezes as terminations, both of which can be undone by HHS / NIH whenever they want—or by court order if they refuse. They’re all illegal.
Reposted by Emmy Li
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Reposted by Emmy Li
May 2, 2025 at 12:56 AM
Reposted by Emmy Li
LA trash haulers are bringing their loads up to the Antelope Valley and dumping it. I saw a river canyon filled -- 30 feet deep and about 60 acres in area -- of solid trash. www.latimes.com/science/stor...
Antelope Valley residents say they are fed up with rampant dumping, official inaction
Thousands of tons of trash are being dumped at unauthorized waste sites across the Antelope Valley, lawsuits claim. Authorities say they are aware but have done little to stop it.
www.latimes.com
May 11, 2025 at 2:01 PM
LA trash haulers are bringing their loads up to the Antelope Valley and dumping it. I saw a river canyon filled -- 30 feet deep and about 60 acres in area -- of solid trash. www.latimes.com/science/stor...
Reposted by Emmy Li
Reposted by Emmy Li
🎉 Excited to share my postdoc work in the Bernstein lab now online @cp-molcell.bsky.social!
🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬
🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬
The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
By mapping SWI/SNF complex subfamilies in the melanocytic lineage, Grossi and Nguyen
et al. find that PBAF-only sites harbor PRC1/2 modifications and the repressive transcription
factor REST. PBAF is ...
www.cell.com
April 21, 2025 at 12:38 PM
🎉 Excited to share my postdoc work in the Bernstein lab now online @cp-molcell.bsky.social!
🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬
🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬
Reposted by Emmy Li
Game 1, WON.
April 21, 2025 at 4:13 AM
Game 1, WON.
Reposted by Emmy Li
Our latest work now online in Cell:
Rewriting regulatory DNA to dissect and reprogram gene expression
Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression
Thread 👇
Rewriting regulatory DNA to dissect and reprogram gene expression
Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression
Thread 👇
April 17, 2025 at 6:26 PM
Our latest work now online in Cell:
Rewriting regulatory DNA to dissect and reprogram gene expression
Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression
Thread 👇
Rewriting regulatory DNA to dissect and reprogram gene expression
Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression
Thread 👇
Reposted by Emmy Li
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
www.biorxiv.org
April 15, 2025 at 3:37 PM
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Reposted by Emmy Li
Reposted by Emmy Li
Glad to share our paper, in collaboration with Prof W.E. Moerner lab and Prof. Andrew Spakowitz lab on developing a high-resolution DNA imaging technology Oligo-LiveFISH, which is online in Cell this week.
Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵
@stanford-chemh.bsky.social @bioe-stanford.bsky.social
@stanford-chemh.bsky.social @bioe-stanford.bsky.social
April 19, 2025 at 6:18 PM
Glad to share our paper, in collaboration with Prof W.E. Moerner lab and Prof. Andrew Spakowitz lab on developing a high-resolution DNA imaging technology Oligo-LiveFISH, which is online in Cell this week.
Reposted by Emmy Li
Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Same here — too many times😭
So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.
Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...
Supported by @cziscience.bsky.social
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
www.biorxiv.org
April 16, 2025 at 4:39 PM
Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪
Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Reposted by Emmy Li
Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵
@stanford-chemh.bsky.social @bioe-stanford.bsky.social
@stanford-chemh.bsky.social @bioe-stanford.bsky.social
April 16, 2025 at 11:38 PM
Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵
@stanford-chemh.bsky.social @bioe-stanford.bsky.social
@stanford-chemh.bsky.social @bioe-stanford.bsky.social
Reposted by Emmy Li
I'm excited to release what I've been cooking up the past few months at @arcinstitute.org
BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage
BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage
BINSEQ: A Family of High-Performance Binary Formats for Nucleotide Sequences https://www.biorxiv.org/content/10.1101/2025.04.08.647863v1
April 15, 2025 at 2:40 PM
I'm excited to release what I've been cooking up the past few months at @arcinstitute.org
BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage
BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage
Reposted by Emmy Li
They’re destroying federal science capacity & California needs to step up & expand science capacity at the state level.
I introduced SB 829 to create the California Institute for Scientific Research & authorize the State of California to produce vaccines. It just passed the Senate Health Committee.
I introduced SB 829 to create the California Institute for Scientific Research & authorize the State of California to produce vaccines. It just passed the Senate Health Committee.
April 10, 2025 at 1:31 AM
They’re destroying federal science capacity & California needs to step up & expand science capacity at the state level.
I introduced SB 829 to create the California Institute for Scientific Research & authorize the State of California to produce vaccines. It just passed the Senate Health Committee.
I introduced SB 829 to create the California Institute for Scientific Research & authorize the State of California to produce vaccines. It just passed the Senate Health Committee.
Reposted by Emmy Li
As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up.
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
April 1, 2025 at 5:09 PM
As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up.
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵