Tommy Vierbuchen
@tvierbuchen.bsky.social
Assistant Professor, Developmental Biology, Center for Stem Cell Biology at Sloan Kettering. Building next generation stem cell models to study genetics of brain development.
https://www.mskcc.org/research/ski/labs/thomas-vierbuchen
https://www.mskcc.org/research/ski/labs/thomas-vierbuchen
Pinned
Tommy Vierbuchen
@tvierbuchen.bsky.social
· Aug 27
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
Reposted by Tommy Vierbuchen
NEXT TUE: DDD seminar, Feb. 17, 2026 @ 1PM Eastern US: Dr. Annerieke Sierksma (in Dr. Bart De Strooper's group at KU Leuven) will share her recent work on "Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo". carlocolantuoni.org/seminar
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
February 11, 2026 at 4:35 AM
NEXT TUE: DDD seminar, Feb. 17, 2026 @ 1PM Eastern US: Dr. Annerieke Sierksma (in Dr. Bart De Strooper's group at KU Leuven) will share her recent work on "Polygenic risk for Alzheimer’s disease shapes microglial inflammatory and antigen-presentation programs in vivo". carlocolantuoni.org/seminar
Reposted by Tommy Vierbuchen
Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1
February 9, 2026 at 3:18 AM
Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1
Reposted by Tommy Vierbuchen
For anyone interested in the history of molecular biology, I cannot recommend Judson's The Eighth Day of Creation highly enough. One of the great book on the history of science.
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
January 31, 2026 at 2:20 PM
For anyone interested in the history of molecular biology, I cannot recommend Judson's The Eighth Day of Creation highly enough. One of the great book on the history of science.
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
I have two copies because a actually wore out the first one (paperback)
www.cshlpress.com/default.tpl?...
Reposted by Tommy Vierbuchen
Today's DDD seminar "A systematic study of morphogen patterning and its reproducibility in human neural organoids" given by Nadezhda Azbukina (from Dr. Barbara Treutlein's group in Basel) is now online at www.youtube.com/playlist?lis...
Developmental Diversity in a Dish Seminar Series - YouTube
A virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. Monthly virtual seminar series, held on one Tuesday o...
www.youtube.com
January 27, 2026 at 8:10 PM
Today's DDD seminar "A systematic study of morphogen patterning and its reproducibility in human neural organoids" given by Nadezhda Azbukina (from Dr. Barbara Treutlein's group in Basel) is now online at www.youtube.com/playlist?lis...
Reposted by Tommy Vierbuchen
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
January 26, 2026 at 7:00 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
Reposted by Tommy Vierbuchen
1/ Our new study, led by Jingwen Ding, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dissecting gene regulatory networks governing human cortical cell fate - Nature
Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissecti...
www.nature.com
January 23, 2026 at 1:16 AM
1/ Our new study, led by Jingwen Ding, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tommy Vierbuchen
B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing https://www.biorxiv.org/content/10.64898/2026.01.16.699998v1
January 18, 2026 at 7:15 PM
B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing https://www.biorxiv.org/content/10.64898/2026.01.16.699998v1
Reposted by Tommy Vierbuchen
Very important research to establish African ancestry cell lines! #Neuroskyence www.thetransmitter.org/cellular-neu...
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
www.thetransmitter.org
January 17, 2026 at 6:33 PM
Very important research to establish African ancestry cell lines! #Neuroskyence www.thetransmitter.org/cellular-neu...
Reposted by Tommy Vierbuchen
Scaling perturbations: beyond genome-scale CRISPR screens https://www.biorxiv.org/content/10.64898/2026.01.16.699948v1
January 17, 2026 at 7:02 PM
Scaling perturbations: beyond genome-scale CRISPR screens https://www.biorxiv.org/content/10.64898/2026.01.16.699948v1
Reposted by Tommy Vierbuchen
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
January 14, 2026 at 9:37 PM
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
Reposted by Tommy Vierbuchen
System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development https://www.biorxiv.org/content/10.64898/2026.01.14.699402v1
January 14, 2026 at 10:47 PM
System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development https://www.biorxiv.org/content/10.64898/2026.01.14.699402v1
Reposted by Tommy Vierbuchen
There's still time to apply to be a 2026 @dev-journal.bsky.social Pathway to Independence fellow
For those about to apply for their first independent academic position, the programme offers
- mentoring
- leadership training
- profile rising
- networking
journals.biologists.com/dev/pages/pi...
For those about to apply for their first independent academic position, the programme offers
- mentoring
- leadership training
- profile rising
- networking
journals.biologists.com/dev/pages/pi...
Pathway to Independence programme | Development | The Company of Biologists
Pathway to Independence programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Launched in 2022, Development’s Pathway Independence programm...
journals.biologists.com
January 13, 2026 at 5:29 PM
There's still time to apply to be a 2026 @dev-journal.bsky.social Pathway to Independence fellow
For those about to apply for their first independent academic position, the programme offers
- mentoring
- leadership training
- profile rising
- networking
journals.biologists.com/dev/pages/pi...
For those about to apply for their first independent academic position, the programme offers
- mentoring
- leadership training
- profile rising
- networking
journals.biologists.com/dev/pages/pi...
Reposted by Tommy Vierbuchen
Machine Learning enables efficient and effective affinity maturation of nanobodies https://www.biorxiv.org/content/10.64898/2026.01.11.698911v1
January 13, 2026 at 2:48 AM
Machine Learning enables efficient and effective affinity maturation of nanobodies https://www.biorxiv.org/content/10.64898/2026.01.11.698911v1
Reposted by Tommy Vierbuchen
Why do some individuals defy their polygenic score?
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
January 6, 2026 at 6:31 PM
Why do some individuals defy their polygenic score?
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference?
www.medrxiv.org/content/10.6...
We had a great experience publishing in Development (doi.org/10.1242/dev....). High-quality reviews, quick turnaround, and our editor (Jim Wells) was very helpful and provided feedback about the reviewers comments.
January 7, 2026 at 4:42 AM
We had a great experience publishing in Development (doi.org/10.1242/dev....). High-quality reviews, quick turnaround, and our editor (Jim Wells) was very helpful and provided feedback about the reviewers comments.
Reposted by Tommy Vierbuchen
Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg
Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex
Nature Neuroscience - Distinct neuron subtypes compartmentalize specific functions by differentially localizing and translating specific RNAs. This work identifies dynamic subtype- and...
rdcu.be
January 4, 2026 at 9:27 AM
Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg
Reposted by Tommy Vierbuchen
NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2025.12.30.686824v1
https://www.biorxiv.org/content/10.64898/2025.12.30.686824v1
December 31, 2025 at 5:00 PM
NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2025.12.30.686824v1
https://www.biorxiv.org/content/10.64898/2025.12.30.686824v1
Reposted by Tommy Vierbuchen
As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below
Know of a relevant event that’s missing? Please reply below
Conferences & Schools – 2026 – Gene Regulation – Teif Lab
generegulation.org
December 29, 2025 at 3:29 PM
As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below
Know of a relevant event that’s missing? Please reply below
Reposted by Tommy Vierbuchen
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1
December 24, 2025 at 5:31 PM
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1
Reposted by Tommy Vierbuchen
Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...
Trans-regulation of heterochromatin underlies genetic variation in 3D genome contacts
Genetic variation drives phenotypic diversity and disease susceptibility. Trans -acting genetic variation coordinates genome-wide chromatin changes, yet the molecular mechanisms underlying this regula...
www.biorxiv.org
December 24, 2025 at 10:12 PM
Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...
Reposted by Tommy Vierbuchen
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
www.biorxiv.org
December 24, 2025 at 3:06 PM
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
One of the best reviews I read this year...
I have a chapter in there on Variability in Neural Circuit Formation pubmed.ncbi.nlm.nih.gov/38253418/
Variability in Neural Circuit Formation - PubMed
The study of neural development is usually concerned with the question of how nervous systems get put together. Variation in these processes is usually of interest as a means of revealing these normative mechanisms. However, variation itself can be an object of study and is of interest from multiple …
pubmed.ncbi.nlm.nih.gov
December 20, 2025 at 6:09 PM
One of the best reviews I read this year...
Reposted by Tommy Vierbuchen
Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
CAD-C reveals centromere pairing and near-perfect alignment of sister chromatids
Three-dimensional (3D) genome organization plays a central role in gene regulation, chromatin folding, and genome stability. Although chromosome-conformation capture (3C)-derived methods have revoluti...
www.biorxiv.org
December 20, 2025 at 4:43 PM
Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.
www.biorxiv.org/content/10.6...
#3DGenome #chromatin #Cohesin #centromere
Reposted by Tommy Vierbuchen
Tommy Vierbuchen @tvierbuchen.bsky.social shared his work with us today: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". see the recording at: www.youtube.com/playlist?lis... (more info at www.carlocolantuoni.org/seminar)
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
December 16, 2025 at 9:14 PM
Tommy Vierbuchen @tvierbuchen.bsky.social shared his work with us today: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". see the recording at: www.youtube.com/playlist?lis... (more info at www.carlocolantuoni.org/seminar)
Nice preview of our paper by Hanwen Yu and Yan Liu.
Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...
Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...
Generating 3D mouse organoids for cortex development and evo-devo
How do cis-regulatory differences, across mouse subspecies over timescales, shape
cell-type specification and maturation during corticogenesis? In this issue of Developmental
Cell, Medina-Cano et al. ...
www.cell.com
December 15, 2025 at 10:12 PM
Nice preview of our paper by Hanwen Yu and Yan Liu.
Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...
Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...