Emily Tsao
@emilytsao.bsky.social
PhD candidate in the Hope lab at the University of Toronto | RNA binding protein and hematopoiesis enjoyer | she/her :)
Reposted by Emily Tsao
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 10, 2025 at 11:05 AM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
Excited to be in Kumamoto for #ISEH2025!! 🩸 I get to share my PhD work (so far) at poster #24 tomorrow and poster #3220 on Friday afternoon - please come by to chat about RNA binding proteins, erythropoiesis, and iron metabolism :)
September 23, 2025 at 12:03 PM
Excited to be in Kumamoto for #ISEH2025!! 🩸 I get to share my PhD work (so far) at poster #24 tomorrow and poster #3220 on Friday afternoon - please come by to chat about RNA binding proteins, erythropoiesis, and iron metabolism :)
Reposted by Emily Tsao
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 15, 2025 at 12:45 PM
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
Reposted by Emily Tsao
Iron-loaded Red Blood Cells undergo a lipid peroxidation process akin to ferroptosis during storage in the blood bank. We now show that they also harbor a functional GPX4, and common SNPs, genetic or pharmacological manipulation impact transfusion outcomes www.sciencedirect.com/science/arti...
GPX4 regulates lipid peroxidation and ferroptosis of stored red blood cells
Red blood cell (RBC) membrane lipid peroxidation during blood bank storage profoundly impacts transfusion efficacy; however, the genetic determinants …
www.sciencedirect.com
August 14, 2025 at 6:17 PM
Iron-loaded Red Blood Cells undergo a lipid peroxidation process akin to ferroptosis during storage in the blood bank. We now show that they also harbor a functional GPX4, and common SNPs, genetic or pharmacological manipulation impact transfusion outcomes www.sciencedirect.com/science/arti...
Reposted by Emily Tsao
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
www.nature.com
July 28, 2025 at 3:34 PM
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
Reposted by Emily Tsao
UHN is grateful and honoured to have called Dr. James Till, one of the fathers of stem cell science, a valued member of TeamUHN.
His many colleagues and students continue their work in his legacy, furthering stem cell science and cancer research, and improving patient outcomes.
His many colleagues and students continue their work in his legacy, furthering stem cell science and cancer research, and improving patient outcomes.
May 23, 2025 at 6:26 PM
UHN is grateful and honoured to have called Dr. James Till, one of the fathers of stem cell science, a valued member of TeamUHN.
His many colleagues and students continue their work in his legacy, furthering stem cell science and cancer research, and improving patient outcomes.
His many colleagues and students continue their work in his legacy, furthering stem cell science and cancer research, and improving patient outcomes.
!!!
Excited to share our first study using nanopore direct RNA seq to comprehensively characterize RNA features. We believe that our deep and high coverage datasets should be a nice resource for the field! www.cell.com/cell-genomic...
Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features
Understanding the interactions between various mRNA features—such as RNA modifications,
poly(A) tail length, and splicing—has been highly sought after but remains largely
elusive. Here, Kim and Savill...
www.cell.com
May 13, 2025 at 10:44 PM
!!!
Reposted by Emily Tsao
Reposted by Emily Tsao
What protects individuals from developing blood cancers?
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
March 27, 2025 at 8:31 PM
What protects individuals from developing blood cancers?
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
Thrilled to share my work in @bloodgenes.bsky.social lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇 (1/n)
www.biorxiv.org/content/10.1...
Reposted by Emily Tsao
Congratulations to our Senior Scientists Drs. John Dick and Jean Wang, and Jayne Danska from @sickkidsto.bsky.social
on receiving the Inventor of the Year Award @uhntoronto.bsky.social. Their research has advanced a cancer immunotherapy now in global Phase II trials for hematological malignancies.
on receiving the Inventor of the Year Award @uhntoronto.bsky.social. Their research has advanced a cancer immunotherapy now in global Phase II trials for hematological malignancies.
March 21, 2025 at 3:52 PM
Congratulations to our Senior Scientists Drs. John Dick and Jean Wang, and Jayne Danska from @sickkidsto.bsky.social
on receiving the Inventor of the Year Award @uhntoronto.bsky.social. Their research has advanced a cancer immunotherapy now in global Phase II trials for hematological malignancies.
on receiving the Inventor of the Year Award @uhntoronto.bsky.social. Their research has advanced a cancer immunotherapy now in global Phase II trials for hematological malignancies.
Reposted by Emily Tsao
Well deserved award for Dr. Gordon Keller! Gordon was a member of my thesis committee when I was a PhD student and his helpful suggestions made me a better scientist :)
www.isscr.org/isscr-news/g...
www.isscr.org/isscr-news/g...
Gordon Keller Receives the 2025 ISSCR Achievement Award for his Seminal Work in Regenerative Medicine — International Society for Stem Cell Research
The International Society for Stem Cell Research (ISSCR) is honoring Gordon Keller, Ph.D., with this year’s ISSCR Achievement Award. Dr. Keller is the Director of the McEwen Stem Cell Institute at t...
www.isscr.org
March 18, 2025 at 4:16 PM
Well deserved award for Dr. Gordon Keller! Gordon was a member of my thesis committee when I was a PhD student and his helpful suggestions made me a better scientist :)
www.isscr.org/isscr-news/g...
www.isscr.org/isscr-news/g...
Had the best time in SLC learning lots about iron & heme last week!! So grateful for the fantastic program that the CIHD faculty & staff put together and to have met so many cool people :))
Utah CIHD Rising Stars in Hematology and Iron and Heme 2025
March 17, 2025 at 6:32 PM
Had the best time in SLC learning lots about iron & heme last week!! So grateful for the fantastic program that the CIHD faculty & staff put together and to have met so many cool people :))
Reposted by Emily Tsao
Cristiana O’Brien is our fourth #TeamUHNWomen feature and a doctoral student at @pmresearch-uhn.bsky.social.
Learn about why she is grateful to be in science and what it means to be a woman in her field ➡️ www.uhnresearch.ca/news/shining...
Learn about why she is grateful to be in science and what it means to be a woman in her field ➡️ www.uhnresearch.ca/news/shining...
February 12, 2025 at 9:03 PM
Cristiana O’Brien is our fourth #TeamUHNWomen feature and a doctoral student at @pmresearch-uhn.bsky.social.
Learn about why she is grateful to be in science and what it means to be a woman in her field ➡️ www.uhnresearch.ca/news/shining...
Learn about why she is grateful to be in science and what it means to be a woman in her field ➡️ www.uhnresearch.ca/news/shining...
So excited to visit Utah and listen to all these cool talks in March!!
Watch for the Utah CIHD U54 Rising Stars in Iron, Heme and Hematology Symposium March 10th, 2025!
February 12, 2025 at 2:03 AM
So excited to visit Utah and listen to all these cool talks in March!!
Reposted by Emily Tsao
Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...
January 11, 2025 at 2:03 PM
Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...
Reposted by Emily Tsao
Are you from #HamOnt or surrounding area? Have #asthma or wheezing during exercise? Want to take part in research at @mcmasteruniversity.bsky.social to discover new treatments ? Email asthma@mcmaster.ca to learn more! (Please share with yoru networks) #pulmsky www.linkedin.com/posts/macres...
Respiratory Research Lab @McMaster on LinkedIn: Are you ready to make a difference in asthma research? Your experiences…
Are you ready to make a difference in asthma research? Your experiences could help shape the future of asthma treatments. Participants are financially…
www.linkedin.com
January 1, 2025 at 2:22 PM
Are you from #HamOnt or surrounding area? Have #asthma or wheezing during exercise? Want to take part in research at @mcmasteruniversity.bsky.social to discover new treatments ? Email asthma@mcmaster.ca to learn more! (Please share with yoru networks) #pulmsky www.linkedin.com/posts/macres...
Reposted by Emily Tsao
Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
Single-cell mapping of regulatory DNA:Protein interactions
Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...
biorxiv.org
January 2, 2025 at 9:54 PM
Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon
Reposted by Emily Tsao
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Emily Tsao
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
December 17, 2024 at 1:15 AM
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
Reposted by Emily Tsao
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 22, 2024 at 6:09 PM
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Emily Tsao
🚨 Save the Date!🚨 ISEH is heading to Kumamoto, Japan for #ISEH2025. Check out our confirmed speakers so far and mark your calendars for a great program you won't want to miss ➡️ iseh.org/iseh2025
November 20, 2024 at 10:46 PM
🚨 Save the Date!🚨 ISEH is heading to Kumamoto, Japan for #ISEH2025. Check out our confirmed speakers so far and mark your calendars for a great program you won't want to miss ➡️ iseh.org/iseh2025
Migrating! Happy to see lots of favourite blood folks already here :)
November 19, 2024 at 12:25 AM
Migrating! Happy to see lots of favourite blood folks already here :)