Angelo D’Alessandro
@dalessandrolab.bsky.social
Small molecules, big data and something (often red blood cells) in between…
Reposted by Angelo D’Alessandro
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Angelo D’Alessandro
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
Reposted by Angelo D’Alessandro
The October 2025 issue of Transfusion Today is out now!
Discover how developments in Big Data are progressing the field of transfusion medicine by diving into the latest issue of Transfusion Today!
🔗 Read the full issue here: isbtweb.foleon.com/transfusion-...
#TransfusionToday
Discover how developments in Big Data are progressing the field of transfusion medicine by diving into the latest issue of Transfusion Today!
🔗 Read the full issue here: isbtweb.foleon.com/transfusion-...
#TransfusionToday
Cover - Transfusion Today - October 2025
isbtweb.foleon.com
October 31, 2025 at 3:44 PM
The October 2025 issue of Transfusion Today is out now!
Discover how developments in Big Data are progressing the field of transfusion medicine by diving into the latest issue of Transfusion Today!
🔗 Read the full issue here: isbtweb.foleon.com/transfusion-...
#TransfusionToday
Discover how developments in Big Data are progressing the field of transfusion medicine by diving into the latest issue of Transfusion Today!
🔗 Read the full issue here: isbtweb.foleon.com/transfusion-...
#TransfusionToday
Reposted by Angelo D’Alessandro
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 10, 2025 at 11:05 AM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
Reposted by Angelo D’Alessandro
Elegant work from Kirk Hansen’s lab @cuanschutz.bsky.social Transglutaminase 2 (likely from RBCs) contributes to forming fibrin beta cross-links, even in the absence of FXIII. TG2 increases in plasma in trauma patients with higher injury severity score.
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in trauma patients
Key Points. Trauma patient plasma clots feature entirely novel fibrin β-chain crosslinking not evident in healthy controlsFibrin β-chain crosslinks evident
ashpublications.org
September 22, 2025 at 11:51 PM
Elegant work from Kirk Hansen’s lab @cuanschutz.bsky.social Transglutaminase 2 (likely from RBCs) contributes to forming fibrin beta cross-links, even in the absence of FXIII. TG2 increases in plasma in trauma patients with higher injury severity score.
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Reposted by Angelo D’Alessandro
BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states
doi.org/10.1038/s422...
doi.org/10.1038/s422...
BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states - Nature Metabolism
Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell phenotypes, ultimately a...
doi.org
September 20, 2025 at 6:48 AM
BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states
doi.org/10.1038/s422...
doi.org/10.1038/s422...
Patients with SCD transfused with blood stored >30 days have higher iron, cytokines, hemolysis, hypoxia and inflammation markers compared to recipients of RBCs stored <10 days. Metabolites in the bag impact in vivo metabolism (hypoxanthine —> urate). Kudos to Matt Karafin for this clinical trial
RBC units can be stored in the refrigerator for up to 42 days, but it’s unclear how extended storage affects recipients.
@dalessandrolab.bsky.social & team compare short- and long-stored RBC transfusions in patients with sickle cell disease 👇
buff.ly/CWjcWGc
@dalessandrolab.bsky.social & team compare short- and long-stored RBC transfusions in patients with sickle cell disease 👇
buff.ly/CWjcWGc
September 14, 2025 at 12:37 PM
Patients with SCD transfused with blood stored >30 days have higher iron, cytokines, hemolysis, hypoxia and inflammation markers compared to recipients of RBCs stored <10 days. Metabolites in the bag impact in vivo metabolism (hypoxanthine —> urate). Kudos to Matt Karafin for this clinical trial
Another great one from the @cjoneslab.bsky.social !
Excited to share a new publications led by Dr. Cristiana O'Brien showing that circulating lipids levels can be used to predict chemotherapy response in AML patients.
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
September 5, 2025 at 1:26 AM
Another great one from the @cjoneslab.bsky.social !
Blood donors, like 67% of adult Americans, drink a lot of coffee. However, caffeine may reduce quality of stored RBCs by (i) inhibiting G6PD (~40%); (ii) antagonizing ADORA2b. Likely relevant beyond blood transfusion!
Paper: haematologica.org/haematologic...
news.cuanschutz.edu/news-stories...
Paper: haematologica.org/haematologic...
news.cuanschutz.edu/news-stories...
Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness
Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness
news.cuanschutz.edu
September 4, 2025 at 7:26 PM
Blood donors, like 67% of adult Americans, drink a lot of coffee. However, caffeine may reduce quality of stored RBCs by (i) inhibiting G6PD (~40%); (ii) antagonizing ADORA2b. Likely relevant beyond blood transfusion!
Paper: haematologica.org/haematologic...
news.cuanschutz.edu/news-stories...
Paper: haematologica.org/haematologic...
news.cuanschutz.edu/news-stories...
Reposted by Angelo D’Alessandro
Evidence that mitochondria in macrophages are destroyed by microautophagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Evidence that mitochondria in macrophages are destroyed by microautophagy - Nature Communications
Mitophagy, the selective degradation of mitochondria, has been thought to occur via macroautophagy. Here, the authors present data indicating that microautophagy also mediates mitophagy in macrophages...
www.nature.com
September 1, 2025 at 4:59 AM
Evidence that mitochondria in macrophages are destroyed by microautophagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Angelo D’Alessandro
Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️
August 30, 2025 at 2:11 PM
Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️
Great job Pavel and team! Thanks for the inclusion
Behind the scenes: first author Guadalupe Roja-Sanchez pipetting away!
August 14, 2025 at 10:07 PM
Great job Pavel and team! Thanks for the inclusion
Iron-loaded Red Blood Cells undergo a lipid peroxidation process akin to ferroptosis during storage in the blood bank. We now show that they also harbor a functional GPX4, and common SNPs, genetic or pharmacological manipulation impact transfusion outcomes www.sciencedirect.com/science/arti...
GPX4 regulates lipid peroxidation and ferroptosis of stored red blood cells
Red blood cell (RBC) membrane lipid peroxidation during blood bank storage profoundly impacts transfusion efficacy; however, the genetic determinants …
www.sciencedirect.com
August 14, 2025 at 6:17 PM
Iron-loaded Red Blood Cells undergo a lipid peroxidation process akin to ferroptosis during storage in the blood bank. We now show that they also harbor a functional GPX4, and common SNPs, genetic or pharmacological manipulation impact transfusion outcomes www.sciencedirect.com/science/arti...
Reposted by Angelo D’Alessandro
Stop 👏 building 👏 python/R👏 packages!
we show that well described methods in academic papers can serve as the specification for an LLM to create methods on demand. This can serve to reduce package maintenance while ensuring accessibility in any programming language
arxiv.org/abs/2507.22324
we show that well described methods in academic papers can serve as the specification for an LLM to create methods on demand. This can serve to reduce package maintenance while ensuring accessibility in any programming language
arxiv.org/abs/2507.22324
From Articles to Code: On-Demand Generation of Core Algorithms from Scientific Publications
Maintaining software packages imposes significant costs due to dependency management, bug fixes, and versioning. We show that rich method descriptions in scientific publications can serve as standalon...
arxiv.org
August 2, 2025 at 5:15 PM
Stop 👏 building 👏 python/R👏 packages!
we show that well described methods in academic papers can serve as the specification for an LLM to create methods on demand. This can serve to reduce package maintenance while ensuring accessibility in any programming language
arxiv.org/abs/2507.22324
we show that well described methods in academic papers can serve as the specification for an LLM to create methods on demand. This can serve to reduce package maintenance while ensuring accessibility in any programming language
arxiv.org/abs/2507.22324
Great work James, Mercedes and teams!
Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades — until they one day trigger a relapse
go.nature.com/41iIdJR
go.nature.com/41iIdJR
‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu
Inflammation from the respiratory infections seems to be the culprit, study in mice finds.
go.nature.com
July 30, 2025 at 9:49 PM
Great work James, Mercedes and teams!
Reposted by Angelo D’Alessandro
Researchers at #CUAnschutz, @einsteinmededu.bsky.social and @utrechtuniversity.bsky.social have found the first direct evidence that common respiratory infections, including #COVID-19, can awaken dormant #breastcancer cells that have spread to the lungs, setting the stage for new metastatic tumors.
Respiratory Viruses Can Wake Up Breast Cancer Cells in Lungs
Respiratory Viruses Can Wake Up Breast Cancer Cells in Lungs
news.cuanschutz.edu
July 30, 2025 at 6:41 PM
Researchers at #CUAnschutz, @einsteinmededu.bsky.social and @utrechtuniversity.bsky.social have found the first direct evidence that common respiratory infections, including #COVID-19, can awaken dormant #breastcancer cells that have spread to the lungs, setting the stage for new metastatic tumors.
Reposted by Angelo D’Alessandro
A free version just posted—courtesy of #Nature.
Lipidomics (via #XCMS / #METLIN) reveals α-tocopherol (vitamin E) as a key player in ferroptosis resistance in cancer.
t.co/HMJSLuTAnM
#Lipidomics #CancerResearch #Ferroptosis #VitaminE
Lipidomics (via #XCMS / #METLIN) reveals α-tocopherol (vitamin E) as a key player in ferroptosis resistance in cancer.
t.co/HMJSLuTAnM
#Lipidomics #CancerResearch #Ferroptosis #VitaminE
June 17, 2025 at 9:36 PM
A free version just posted—courtesy of #Nature.
Lipidomics (via #XCMS / #METLIN) reveals α-tocopherol (vitamin E) as a key player in ferroptosis resistance in cancer.
t.co/HMJSLuTAnM
#Lipidomics #CancerResearch #Ferroptosis #VitaminE
Lipidomics (via #XCMS / #METLIN) reveals α-tocopherol (vitamin E) as a key player in ferroptosis resistance in cancer.
t.co/HMJSLuTAnM
#Lipidomics #CancerResearch #Ferroptosis #VitaminE
Reposted by Angelo D’Alessandro
Single-cell RNA sequencing data are often used as indirect estimates of protein abundance in single cells.
Instead, I think the goal should be to use the consistent discrepancies to understand regulatory mechanisms.
www.biorxiv.org/content/10.1...
Instead, I think the goal should be to use the consistent discrepancies to understand regulatory mechanisms.
www.biorxiv.org/content/10.1...
June 7, 2025 at 4:53 PM
Single-cell RNA sequencing data are often used as indirect estimates of protein abundance in single cells.
Instead, I think the goal should be to use the consistent discrepancies to understand regulatory mechanisms.
www.biorxiv.org/content/10.1...
Instead, I think the goal should be to use the consistent discrepancies to understand regulatory mechanisms.
www.biorxiv.org/content/10.1...
Always great to catch up with friends and colleagues around the world, while sharing the latest stories with the transfusion medicine community at #ISBTMILAN!
June 4, 2025 at 10:36 AM
Always great to catch up with friends and colleagues around the world, while sharing the latest stories with the transfusion medicine community at #ISBTMILAN!
Reposted by Angelo D’Alessandro
Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...
June 4, 2025 at 1:59 AM
Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...
Reposted by Angelo D’Alessandro
Very excited that our work describing hu.MAP3.0 is published in @molsystbiol.org. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
hu.MAP3.0: atlas of human protein complexes by integration of >25,000 proteomic experiments | Molecular Systems Biology
imageimagehu.MAP3.0 integrates mass spectrometry experiments to identify human protein complexes.
Using this resource, this study characterizes covariation of complexes, identifies
mutually exclusive ...
www.embopress.org
May 29, 2025 at 11:24 PM
Very excited that our work describing hu.MAP3.0 is published in @molsystbiol.org. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Love it!
Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
May 15, 2025 at 7:00 PM
Love it!
Reposted by Angelo D’Alessandro
Taurine from tumour niche drives glycolysis to promote leukaemogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Taurine from tumour niche drives glycolysis to promote leukaemogenesis - Nature
The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.
www.nature.com
May 14, 2025 at 4:50 PM
Taurine from tumour niche drives glycolysis to promote leukaemogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Angelo D’Alessandro
I'd like to share this short piece on a topic I hope you will find useful. It is the result of a personl journey and many discussions with friends and peers. Let me know your thoughts.
network.febs.org/posts/the-pr...
network.febs.org/posts/the-pr...
The Professional Self: The Enemy Inside
network.febs.org
May 9, 2025 at 6:05 PM
I'd like to share this short piece on a topic I hope you will find useful. It is the result of a personl journey and many discussions with friends and peers. Let me know your thoughts.
network.febs.org/posts/the-pr...
network.febs.org/posts/the-pr...