Ellen Weinzapfel, PhD
@ellen-epi.bsky.social
Senior Product Manager at EpiCypher, where I write all the things about CUT&RUN, CUT&Tag, and chromatin biology. Avid distance runner.
🧬🧪So I got really inspired by the amazing scientists writing op-eds, so I wrote one for my hometown newspaper in Evansville, IN.
I wrote it a week ago, it went online yesterday, and now I'm wishing I had been harsher about the realities. What 5 days can do...😭
www.courierpress.com/story/opinio...
I wrote it a week ago, it went online yesterday, and now I'm wishing I had been harsher about the realities. What 5 days can do...😭
www.courierpress.com/story/opinio...
OPINION | Op-Ed: Funding cuts will slow medical research, lead to deaths
Cuts to National Institutes of Health and National Science Foundation research funding aren’t just numbers on a budget spreadsheet.
www.courierpress.com
March 13, 2025 at 1:18 AM
🧬🧪So I got really inspired by the amazing scientists writing op-eds, so I wrote one for my hometown newspaper in Evansville, IN.
I wrote it a week ago, it went online yesterday, and now I'm wishing I had been harsher about the realities. What 5 days can do...😭
www.courierpress.com/story/opinio...
I wrote it a week ago, it went online yesterday, and now I'm wishing I had been harsher about the realities. What 5 days can do...😭
www.courierpress.com/story/opinio...
This man is a national treasure, and this is not hyperbole. Thank you @jeremymberg.bsky.social for your updates, advocacy, and so much more that we probably don't know about.
Also I guess I need to contact my reps/senators again...
Also I guess I need to contact my reps/senators again...
I have spent many hours over the past two days speaking with reporters from major outlets, linking them to public and not-so-public documents, and connecting them with other folks. I hope there will be lots coming out soon.
Yes thanks! How can we get this into bigger news outlets?
February 21, 2025 at 2:05 AM
This man is a national treasure, and this is not hyperbole. Thank you @jeremymberg.bsky.social for your updates, advocacy, and so much more that we probably don't know about.
Also I guess I need to contact my reps/senators again...
Also I guess I need to contact my reps/senators again...
Reposted by Ellen Weinzapfel, PhD
The thing about destroying NIH is NIH’s scale in medical research just dwarfs everyone else.
For ex, in 2023 the American Cancer Society gave out $64.5 million worth of grants. Sounds big, right?
But NIH’s budget was $49 billion. With a B.
Kill NIH and the floor drops out of US science.
For ex, in 2023 the American Cancer Society gave out $64.5 million worth of grants. Sounds big, right?
But NIH’s budget was $49 billion. With a B.
Kill NIH and the floor drops out of US science.
HHS might as well be wrapping a wire around a piece of metal and running a current through it and see what happens.
February 20, 2025 at 3:06 AM
The thing about destroying NIH is NIH’s scale in medical research just dwarfs everyone else.
For ex, in 2023 the American Cancer Society gave out $64.5 million worth of grants. Sounds big, right?
But NIH’s budget was $49 billion. With a B.
Kill NIH and the floor drops out of US science.
For ex, in 2023 the American Cancer Society gave out $64.5 million worth of grants. Sounds big, right?
But NIH’s budget was $49 billion. With a B.
Kill NIH and the floor drops out of US science.
Reposted by Ellen Weinzapfel, PhD
So I did this today: banged out a couple hundred words of a pitch while managing lab, sent it to the opinion page editor at the newspaper my parents still somehow get in print, and got back a "yes" in, I absolutely kid you not, under 15 minutes
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
February 20, 2025 at 2:12 AM
So I did this today: banged out a couple hundred words of a pitch while managing lab, sent it to the opinion page editor at the newspaper my parents still somehow get in print, and got back a "yes" in, I absolutely kid you not, under 15 minutes
THIS.
I work for a company that supports and collaborates with NIH funded labs, and our R&D is partially funded by the NIH. So many labs, start-ups, and companies rely on this funding for life-saving research.
You are seen and you matter ❤️
I work for a company that supports and collaborates with NIH funded labs, and our R&D is partially funded by the NIH. So many labs, start-ups, and companies rely on this funding for life-saving research.
You are seen and you matter ❤️
Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.
January 30, 2025 at 2:46 AM
THIS.
I work for a company that supports and collaborates with NIH funded labs, and our R&D is partially funded by the NIH. So many labs, start-ups, and companies rely on this funding for life-saving research.
You are seen and you matter ❤️
I work for a company that supports and collaborates with NIH funded labs, and our R&D is partially funded by the NIH. So many labs, start-ups, and companies rely on this funding for life-saving research.
You are seen and you matter ❤️
Reposted by Ellen Weinzapfel, PhD
The administration took down the reproductive rights website that women need access to. So The Skimm bought a url and brought the content back. Pass this on!
Go to reproductiverightsdotgov.com
Go to reproductiverightsdotgov.com
ReproductiveRights.Gov Vanished, So We Brought It Back
theSkimm makes it easier to live smarter. You're welcome. Get all the info you need from AM to PM, wherever you are.
buff.ly
January 25, 2025 at 11:44 AM
The administration took down the reproductive rights website that women need access to. So The Skimm bought a url and brought the content back. Pass this on!
Go to reproductiverightsdotgov.com
Go to reproductiverightsdotgov.com
Reposted by Ellen Weinzapfel, PhD
I am not cowed, but I am very sad.
I am sad for so many, people facing upheaval in their lives, with their families, at work, and in their communities. I am sad because it is being done out of hate, and also out of spite. I am sad because it is going to get much worse.
I am sad for so many, people facing upheaval in their lives, with their families, at work, and in their communities. I am sad because it is being done out of hate, and also out of spite. I am sad because it is going to get much worse.
January 23, 2025 at 7:01 AM
I am not cowed, but I am very sad.
I am sad for so many, people facing upheaval in their lives, with their families, at work, and in their communities. I am sad because it is being done out of hate, and also out of spite. I am sad because it is going to get much worse.
I am sad for so many, people facing upheaval in their lives, with their families, at work, and in their communities. I am sad because it is being done out of hate, and also out of spite. I am sad because it is going to get much worse.
Reposted by Ellen Weinzapfel, PhD
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
January 22, 2025 at 11:04 PM
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Devastating seems like an understatement. Especially with no timeline or future plans laid out. This impacts researchers, students, patients, physicians, and anyone related to this work.
Is Terrifying a better word? Despicable? I don't know. The last few days have been all these words combined.
Is Terrifying a better word? Despicable? I don't know. The last few days have been all these words combined.
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
scim.ag
January 23, 2025 at 12:11 AM
Devastating seems like an understatement. Especially with no timeline or future plans laid out. This impacts researchers, students, patients, physicians, and anyone related to this work.
Is Terrifying a better word? Despicable? I don't know. The last few days have been all these words combined.
Is Terrifying a better word? Despicable? I don't know. The last few days have been all these words combined.
Reposted by Ellen Weinzapfel, PhD
Transcription dynamics and genome organization in the mammalian nucleus: Recent advances [perspective by Kaustubh Wagh, Diana Stavreva and Gordon Hager] www.cell.com/molecular-ce...
January 16, 2025 at 4:22 PM
Transcription dynamics and genome organization in the mammalian nucleus: Recent advances [perspective by Kaustubh Wagh, Diana Stavreva and Gordon Hager] www.cell.com/molecular-ce...
🧪🧬Extensive chromatin mapping, including Hi-C, Capture-C, ATAC-seq, and RNA-seq help link GWAS variants to gene regulatory mechanisms in Type I Diabetes.
Great work by some fantastic scientists at UPenn, congrats to all!
Great work by some fantastic scientists at UPenn, congrats to all!
Khanh Trang in our @elife.bsky.social paper integrates 3D genomic maps for >50 diverse cell types with pediatric obesity GWAS. Findings implicate a role for pancreatic islet cell types. Our #V2G mapping nominates effector genes. @penngenetics.bsky.social
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
January 16, 2025 at 3:32 PM
🧪🧬Extensive chromatin mapping, including Hi-C, Capture-C, ATAC-seq, and RNA-seq help link GWAS variants to gene regulatory mechanisms in Type I Diabetes.
Great work by some fantastic scientists at UPenn, congrats to all!
Great work by some fantastic scientists at UPenn, congrats to all!
🧬🧪#PAG33 Learning about the economics, genomics, and genetic diversity of blueberries. Posting because...I LOVE blueberries 🫐
Fun talk by Kendall Lee at HudsonAlpha Institute for Biotechnology!
Fun talk by Kendall Lee at HudsonAlpha Institute for Biotechnology!
January 13, 2025 at 12:49 AM
🧬🧪#PAG33 Learning about the economics, genomics, and genetic diversity of blueberries. Posting because...I LOVE blueberries 🫐
Fun talk by Kendall Lee at HudsonAlpha Institute for Biotechnology!
Fun talk by Kendall Lee at HudsonAlpha Institute for Biotechnology!
🧪🧬Don't miss out on Andrea's poster - you'll want to download this!!
Why?
If you are doing whole genome bisulfite or EM-seq, we are working on some new, low cost DNA methylation profiling options for you.
With MORE coverage than arrays.
See you at #PAG32!! I'm en route ☺️
Why?
If you are doing whole genome bisulfite or EM-seq, we are working on some new, low cost DNA methylation profiling options for you.
With MORE coverage than arrays.
See you at #PAG32!! I'm en route ☺️
🧪🧬 Calling all #PAG32 attendees!
Are you studying #DNAmethylation using bisulfite seq, arrays, or EM-seq? We have some innovations that might help your research!
Learn more at Andrea Johnstone's poster:
Mon Jan 13, 10-11:30 AM
Or download her poster here! explore.epicypher.com/pag-conferen...
Are you studying #DNAmethylation using bisulfite seq, arrays, or EM-seq? We have some innovations that might help your research!
Learn more at Andrea Johnstone's poster:
Mon Jan 13, 10-11:30 AM
Or download her poster here! explore.epicypher.com/pag-conferen...
January 11, 2025 at 9:56 PM
🧪🧬Don't miss out on Andrea's poster - you'll want to download this!!
Why?
If you are doing whole genome bisulfite or EM-seq, we are working on some new, low cost DNA methylation profiling options for you.
With MORE coverage than arrays.
See you at #PAG32!! I'm en route ☺️
Why?
If you are doing whole genome bisulfite or EM-seq, we are working on some new, low cost DNA methylation profiling options for you.
With MORE coverage than arrays.
See you at #PAG32!! I'm en route ☺️
🧪SUPER excited for @emadden.bsky.social talk about EpiCypher's latest work developing chromatin mapping assays for #FFPE tissues. These strategies will open the door to thousands of samples that were inaccessible by other methods. Stay tuned!!
🧪🧬 Biobanked FFPE tissues are a massive resource in biomedical research, but are incompatible with most chromatin profiling assays.
Can newer strategies - like CUT&Tag - help solve this problem?
See @emadden.bsky.social talk about our progress at Keystone Precision Oncology, Jan 15, to learn more!
Can newer strategies - like CUT&Tag - help solve this problem?
See @emadden.bsky.social talk about our progress at Keystone Precision Oncology, Jan 15, to learn more!
January 10, 2025 at 5:38 PM
🧪SUPER excited for @emadden.bsky.social talk about EpiCypher's latest work developing chromatin mapping assays for #FFPE tissues. These strategies will open the door to thousands of samples that were inaccessible by other methods. Stay tuned!!
🧬🧪 I'm flying out to San Diego tomorrow for #PAG32 and I can't wait!
My poster on CUT&RUN and CUT&Tag is Monday evening. We also have a poster (P052) in the Monday morning session on DNA methylation, from Andrea Johnstone.
How can we help you apply #epigenomics in plants? Let us know!
My poster on CUT&RUN and CUT&Tag is Monday evening. We also have a poster (P052) in the Monday morning session on DNA methylation, from Andrea Johnstone.
How can we help you apply #epigenomics in plants? Let us know!
🧪🧬EpiCypher is headed to #PAG32!
Our team wants to learn about your research. Are you using ChIP? Bisulfite seq? We can help!
Connect with us at Booth #533 all week or at Poster #043 on Monday from 3-4:30 PM, presented by @ellen-epi.bsky.social
Download her poster here: lnkd.in/emFwekkS
Our team wants to learn about your research. Are you using ChIP? Bisulfite seq? We can help!
Connect with us at Booth #533 all week or at Poster #043 on Monday from 3-4:30 PM, presented by @ellen-epi.bsky.social
Download her poster here: lnkd.in/emFwekkS
January 10, 2025 at 5:36 PM
🧬🧪 I'm flying out to San Diego tomorrow for #PAG32 and I can't wait!
My poster on CUT&RUN and CUT&Tag is Monday evening. We also have a poster (P052) in the Monday morning session on DNA methylation, from Andrea Johnstone.
How can we help you apply #epigenomics in plants? Let us know!
My poster on CUT&RUN and CUT&Tag is Monday evening. We also have a poster (P052) in the Monday morning session on DNA methylation, from Andrea Johnstone.
How can we help you apply #epigenomics in plants? Let us know!
🧪🧬We are SUPER excited about the launch of our 24 reaction CUT&RUN Kit.
It has all the controls and reagents from the larger CUT&RUN kit, but in a kit size that is more accessible to a lot of researchers.
It has all the controls and reagents from the larger CUT&RUN kit, but in a kit size that is more accessible to a lot of researchers.
🧪🧬Our 24-reaction CUT&RUN Kit is here!
Everything you love about our 48 reaction CUT&RUN kit in an affordable and convenient kit size.
Perfect for:
✔️First-time CUT&RUN users
✔️Running small experiments
✔️Testing new cells or targets
Check it out now:
www.epicypher.com/products/epi...
Everything you love about our 48 reaction CUT&RUN kit in an affordable and convenient kit size.
Perfect for:
✔️First-time CUT&RUN users
✔️Running small experiments
✔️Testing new cells or targets
Check it out now:
www.epicypher.com/products/epi...
December 17, 2024 at 8:05 PM
🧪🧬We are SUPER excited about the launch of our 24 reaction CUT&RUN Kit.
It has all the controls and reagents from the larger CUT&RUN kit, but in a kit size that is more accessible to a lot of researchers.
It has all the controls and reagents from the larger CUT&RUN kit, but in a kit size that is more accessible to a lot of researchers.
Reposted by Ellen Weinzapfel, PhD
🎄🔔Ho Ho ho!😆 Our final
#FragileNucleosome
seminar of the year! We are excited to host Julia and Nithya, two amazing ECR scientists!
🗓️Don't forget to register: us06web.zoom.us/webinar/regi...
#FragileNucleosome
seminar of the year! We are excited to host Julia and Nithya, two amazing ECR scientists!
🗓️Don't forget to register: us06web.zoom.us/webinar/regi...
December 11, 2024 at 7:41 AM
🎄🔔Ho Ho ho!😆 Our final
#FragileNucleosome
seminar of the year! We are excited to host Julia and Nithya, two amazing ECR scientists!
🗓️Don't forget to register: us06web.zoom.us/webinar/regi...
#FragileNucleosome
seminar of the year! We are excited to host Julia and Nithya, two amazing ECR scientists!
🗓️Don't forget to register: us06web.zoom.us/webinar/regi...
🧪🧬Very exited to see this out on bioRxiv! I helped develop and edit this manuscript, but so much time and effort was put in by the lead author, Tessa Firestone, and senior author Lu Sun, PhD.
We hope it helps boost the efforts of new and expert CUT&RUN users alike!
We hope it helps boost the efforts of new and expert CUT&RUN users alike!
🧪🧬 Pre-print of our CUT&RUN protocol is out NOW!
This comprehensive #protocol includes all the tips and tricks for assay optimization used by our scientists, making it a key read for kit users and home-brew #CUT&RUN users alike.
What makes it special? (1/n)
www.biorxiv.org/content/10.1...
This comprehensive #protocol includes all the tips and tricks for assay optimization used by our scientists, making it a key read for kit users and home-brew #CUT&RUN users alike.
What makes it special? (1/n)
www.biorxiv.org/content/10.1...
High-efficiency genomic mapping of chromatin-associated targets with CUT&RUN
The precise regulation of chromatin composition is critical to gene expression and cellular identity, and thus a key component in development and disease. Robust assays to study chromatin features, in...
www.biorxiv.org
December 11, 2024 at 9:32 PM
🧪🧬Very exited to see this out on bioRxiv! I helped develop and edit this manuscript, but so much time and effort was put in by the lead author, Tessa Firestone, and senior author Lu Sun, PhD.
We hope it helps boost the efforts of new and expert CUT&RUN users alike!
We hope it helps boost the efforts of new and expert CUT&RUN users alike!
Reposted by Ellen Weinzapfel, PhD
Immunologists, time to embrace your inner neuroscientist 🧠🧪
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
www.nature.com
December 11, 2024 at 12:00 PM
Immunologists, time to embrace your inner neuroscientist 🧠🧪
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology
www.nature.com/articles/s41...
🧪 Great resource - and a great reminder that how we present data is important to proper interpretation and discussion.
Bar plot is a case of length based visualization, rather than position based visualization. Confusing these could lead to misleading graphics.
See my repository about “bad graphs” for more information: github.com/cxli233/Frie...
See my repository about “bad graphs” for more information: github.com/cxli233/Frie...
December 10, 2024 at 1:56 PM
🧪 Great resource - and a great reminder that how we present data is important to proper interpretation and discussion.
🧪🧬A new review on epigenetic-targeted drugs - with a big focus on how epigenetic drugs are being explored for combination therapies across multiple types of cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Getting the right combination to break the epigenetic code - Nature Reviews Clinical Oncology
Increased recognition of the roles of epigenetic reprogramming in cancer has spurred the development of epigenetic therapies, although these drugs have meaningful efficacy as single agents in only a n...
www.nature.com
December 5, 2024 at 1:45 PM
🧪🧬A new review on epigenetic-targeted drugs - with a big focus on how epigenetic drugs are being explored for combination therapies across multiple types of cancer.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ellen Weinzapfel, PhD
Overwhelmed by all of the exciting new research on chromatin modifiers in AML? Find it hard to keep track of all the new menin inhibitors? Well good news, we’ve just published the perfect review for you in SCTM!
@alexkschurer.bsky.social
@gritsmanlab.bsky.social
academic.oup.com/stcltm/advan...
@alexkschurer.bsky.social
@gritsmanlab.bsky.social
academic.oup.com/stcltm/advan...
Targeting chromatin modifying complexes in acute myeloid leukemia
Abstract. Acute myeloid leukemia (AML) is a devastating hematologic malignancy with high rates of relapse, which can, in part, be attributed to the dysregu
academic.oup.com
December 4, 2024 at 3:20 AM
Overwhelmed by all of the exciting new research on chromatin modifiers in AML? Find it hard to keep track of all the new menin inhibitors? Well good news, we’ve just published the perfect review for you in SCTM!
@alexkschurer.bsky.social
@gritsmanlab.bsky.social
academic.oup.com/stcltm/advan...
@alexkschurer.bsky.social
@gritsmanlab.bsky.social
academic.oup.com/stcltm/advan...