dysmetric
@dysmetric.bsky.social
Translational neuroscience; non-motor functions of the cerebellum; psychopharmacology
Eukaryotic/eukaryote
Eukaryotic/eukaryote
A beautiful loop: An active inference theory of consciousness (2025)
New theory proposes active inference can ground 3 conditions for consciousness: An epistemic field (world model), Bayesian binding, and epistemic depth.
Discusses implications for silicon.
www.sciencedirect.com/science/arti...
New theory proposes active inference can ground 3 conditions for consciousness: An epistemic field (world model), Bayesian binding, and epistemic depth.
Discusses implications for silicon.
www.sciencedirect.com/science/arti...
https://sciencedirect.com/science/articl…
August 31, 2025 at 6:45 PM
A beautiful loop: An active inference theory of consciousness (2025)
New theory proposes active inference can ground 3 conditions for consciousness: An epistemic field (world model), Bayesian binding, and epistemic depth.
Discusses implications for silicon.
www.sciencedirect.com/science/arti...
New theory proposes active inference can ground 3 conditions for consciousness: An epistemic field (world model), Bayesian binding, and epistemic depth.
Discusses implications for silicon.
www.sciencedirect.com/science/arti...
Preprint reviews evidence for the Allostatic Theory of Oxytocin, suggesting it isn't a love-hormone/social-salience-modulator.
Instead, it increases plasticity, and flexibility, while reducing anxiety, and the effects of stress, to create a 'window of adaptation' to change.
osf.io/preprints/os...
Instead, it increases plasticity, and flexibility, while reducing anxiety, and the effects of stress, to create a 'window of adaptation' to change.
osf.io/preprints/os...
OSF
osf.io
August 26, 2025 at 2:41 PM
Preprint reviews evidence for the Allostatic Theory of Oxytocin, suggesting it isn't a love-hormone/social-salience-modulator.
Instead, it increases plasticity, and flexibility, while reducing anxiety, and the effects of stress, to create a 'window of adaptation' to change.
osf.io/preprints/os...
Instead, it increases plasticity, and flexibility, while reducing anxiety, and the effects of stress, to create a 'window of adaptation' to change.
osf.io/preprints/os...
Reposted by dysmetric
struggling with an analogy here but imagine NASA posting a meme about how excited they are to return aviation to the pre-jet age
![u.s. department of energy post on x praising coal:
"She's an icon
She's a legend
And she is the moment
[sparkly picture of coal]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:fwks525g7gw5wc7ul2wg4wj5/bafkreiemlnocjpmihyy2yegdsvokmpk3vdrwkvaqbgpopxqbb4bgiebtqm@jpeg)
July 31, 2025 at 9:48 PM
struggling with an analogy here but imagine NASA posting a meme about how excited they are to return aviation to the pre-jet age
Reposted by dysmetric
So cool, a novel archaeon with a super small genome and no metabolic genes!
"An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses."
www.biorxiv.org/content/10.1...
"An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses."
www.biorxiv.org/content/10.1...
A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome
Defining the minimal genetic requirements for cellular life remains a fundamental question in biology. Genomic exploration continually reveals novel microbial lineages, often exhibiting extreme genome...
www.biorxiv.org
June 27, 2025 at 4:29 AM
So cool, a novel archaeon with a super small genome and no metabolic genes!
"An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses."
www.biorxiv.org/content/10.1...
"An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses."
www.biorxiv.org/content/10.1...
Reposted by dysmetric
Inferring context-dependent computations through linear approximations of prefrontal cortex dynamics
www.science.org/doi/10.1126/...
#neuroscience
www.science.org/doi/10.1126/...
#neuroscience
Inferring context-dependent computations through linear approximations of prefrontal cortex dynamics
PFC neural responses during contextual decision-making are consistent with both recurrent and input-driven flexible computations.
www.science.org
January 3, 2025 at 7:00 PM
Inferring context-dependent computations through linear approximations of prefrontal cortex dynamics
www.science.org/doi/10.1126/...
#neuroscience
www.science.org/doi/10.1126/...
#neuroscience
Reposted by dysmetric
Three distinct gamma oscillatory networks within cortical columns in macaque monkeys’ area V1
www.frontiersin.org/journals/neu...
#neuroscience
www.frontiersin.org/journals/neu...
#neuroscience
Frontiers | Three distinct gamma oscillatory networks within cortical columns in macaque monkeys’ area V1
IntroductionA fundamental property of the neocortex is its columnar organization in many species. Generally, neurons of the same column share stimulus prefer...
www.frontiersin.org
January 3, 2025 at 7:05 PM
Three distinct gamma oscillatory networks within cortical columns in macaque monkeys’ area V1
www.frontiersin.org/journals/neu...
#neuroscience
www.frontiersin.org/journals/neu...
#neuroscience
Reposted by dysmetric
New work from the lab of Chengtian Zhao at Ocean University of China 🇨🇳 🐟
Technically superb, live imaging experiments visualise intraflagellar transport in zebrafish ciliated tissues, unveil the surprising breadth of intraflagellar transport speed.
https://buff.ly/41UJjMS
https://buff.ly/41UJjMS
January 2, 2025 at 2:07 PM
New work from the lab of Chengtian Zhao at Ocean University of China 🇨🇳 🐟
Reposted by dysmetric
I just found one! go.bsky.app/QPFZpj9
November 25, 2024 at 10:17 PM
I just found one! go.bsky.app/QPFZpj9
Reposted by dysmetric
Setting a good rhythm for my Sunday with this new eLife review from Ichim…Muresan on gamma oscillations - from neural processing to brain maintenance. Brain rhythms for breakfast. 1/10 #neuroscience 🧪🧠
The gamma rhythm as a guardian of brain health
Fast oscillations (30-150Hz), generated by internal brain mechanisms may be essential for the maintenance of healthy brain function.
elifesciences.org
November 24, 2024 at 4:13 PM
Setting a good rhythm for my Sunday with this new eLife review from Ichim…Muresan on gamma oscillations - from neural processing to brain maintenance. Brain rhythms for breakfast. 1/10 #neuroscience 🧪🧠
Reposted by dysmetric
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…
www.sciencedirect.com
November 15, 2024 at 4:37 PM
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by dysmetric
🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)
Read it here: www.nature.com/articles/s41...
Read it here: www.nature.com/articles/s41...
November 19, 2024 at 4:50 PM
🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)
Read it here: www.nature.com/articles/s41...
Read it here: www.nature.com/articles/s41...
Reposted by dysmetric
Our paper is published in the latest issue of NEURON. We examined the neural mechanisms involved in learning from the gains and losses of symbolic reinforcers in the ventral frontostriatal circuitry. 🧠
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses
Tang et al. show that OFC plays a more important role in learning from symbolic reinforcers
than subcortical structures. OFC computes reinforcement signals and sends the information
to the VS through ...
www.cell.com
November 21, 2024 at 1:27 PM
Our paper is published in the latest issue of NEURON. We examined the neural mechanisms involved in learning from the gains and losses of symbolic reinforcers in the ventral frontostriatal circuitry. 🧠
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Reposted by dysmetric
Nature
Stress can disrupt memory and lead to needless anxiety — here’s how
In mice, stress altered the way that the brain formed memories, resulting in an unnecessary fear response.
www.nature.com/articles/d41...
Stress can disrupt memory and lead to needless anxiety — here’s how
In mice, stress altered the way that the brain formed memories, resulting in an unnecessary fear response.
www.nature.com/articles/d41...
Stress can disrupt memory and lead to needless anxiety — here’s how
In mice, stress altered the way that the brain formed memories, resulting in an unnecessary fear response.
www.nature.com
November 23, 2024 at 12:04 PM
Nature
Stress can disrupt memory and lead to needless anxiety — here’s how
In mice, stress altered the way that the brain formed memories, resulting in an unnecessary fear response.
www.nature.com/articles/d41...
Stress can disrupt memory and lead to needless anxiety — here’s how
In mice, stress altered the way that the brain formed memories, resulting in an unnecessary fear response.
www.nature.com/articles/d41...
Reposted by dysmetric
A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps
www.cell.com/neuron/fullt...
#Neuroscience
www.cell.com/neuron/fullt...
#Neuroscience
A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps
The algorithm of the prefrontal working memory system on sequence memory tasks is
not well understood, whereas it is well understood for the hippocampal episodic memory
system. This work shows a mathe...
www.cell.com
November 25, 2024 at 2:36 AM
A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps
www.cell.com/neuron/fullt...
#Neuroscience
www.cell.com/neuron/fullt...
#Neuroscience