Marta Olszewska, PhD
@drmaolsz.bsky.social
Research Team of Sperm Genetics (Head), Institute of Human Genetics PAS (Assoc. Prof.); cytogenetics, genetics, epigenetics of male infertility 🧬🔬
Pinned
If you are an enthusiast of molecular biology and want to reveal the secrets of infertility - join our team!🐭 🔬 🧬 🧫
Open positions for two PhD students.
We guarantee a lot of fun and satisfaction 😁 🎉 💻 🧬 🧪 🧫
More details:
Open positions for two PhD students.
We guarantee a lot of fun and satisfaction 😁 🎉 💻 🧬 🧪 🧫
More details:
Reposted by Marta Olszewska, PhD
⏰ Last week to apply!
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
🚀 We’re hiring a Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
October 25, 2025 at 5:48 AM
⏰ Last week to apply!
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
Reposted by Marta Olszewska, PhD
Impact of Sperm Fractionation on Chromosome Positioning, Chromatin Integrity, DNA Methylation and Hydroxymethylation Level https://www.biorxiv.org/content/10.1101/2025.06.07.658443v1
June 9, 2025 at 8:35 AM
Impact of Sperm Fractionation on Chromosome Positioning, Chromatin Integrity, DNA Methylation and Hydroxymethylation Level https://www.biorxiv.org/content/10.1101/2025.06.07.658443v1
If you are an enthusiast of molecular biology and want to reveal the secrets of infertility - join our team!🐭 🔬 🧬 🧫
Open positions for two PhD students.
We guarantee a lot of fun and satisfaction 😁 🎉 💻 🧬 🧪 🧫
More details:
Open positions for two PhD students.
We guarantee a lot of fun and satisfaction 😁 🎉 💻 🧬 🧪 🧫
More details:
May 13, 2025 at 3:31 PM
If you are an enthusiast of molecular biology and want to reveal the secrets of infertility - join our team!🐭 🔬 🧬 🧫
Open positions for two PhD students.
We guarantee a lot of fun and satisfaction 😁 🎉 💻 🧬 🧪 🧫
More details:
Open positions for two PhD students.
We guarantee a lot of fun and satisfaction 😁 🎉 💻 🧬 🧪 🧫
More details:
Reposted by Marta Olszewska, PhD
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 8, 2025 at 10:12 AM
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
Reposted by Marta Olszewska, PhD
Reposting in case anyone can help 😊
Does anybody have a Proofig (or similar) account who could help me out with one analysis? Thanks!
May 9, 2025 at 12:52 PM
Reposting in case anyone can help 😊
Reposted by Marta Olszewska, PhD
Gene Therapy Lab @uam-ibmib.bsky.social led by Prof. Krzysztof Sobczak is looking for enthusiastic PhD student for the EU MSCA Doctoral Network project on therapeutical potential of antisense oligonucleotides in myotonic dystrophy, check out link for details! #ASO euraxess.ec.europa.eu/jobs/324410
April 29, 2025 at 2:32 PM
Gene Therapy Lab @uam-ibmib.bsky.social led by Prof. Krzysztof Sobczak is looking for enthusiastic PhD student for the EU MSCA Doctoral Network project on therapeutical potential of antisense oligonucleotides in myotonic dystrophy, check out link for details! #ASO euraxess.ec.europa.eu/jobs/324410
Reposted by Marta Olszewska, PhD
🥂Congratulations to @jzylicz.bsky.social & co for their new study in our journal (@natcellbio.nature.com) showing that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic #StemCells.
@ucph.bsky.social
bit.ly/3EGflmL
@ucph.bsky.social
bit.ly/3EGflmL
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology
Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...
bit.ly
April 24, 2025 at 7:34 PM
🥂Congratulations to @jzylicz.bsky.social & co for their new study in our journal (@natcellbio.nature.com) showing that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic #StemCells.
@ucph.bsky.social
bit.ly/3EGflmL
@ucph.bsky.social
bit.ly/3EGflmL
Reposted by Marta Olszewska, PhD
Join Embryo Working Group co-chairs Amander Clark and Janet Rossant on 21 April! This webinar will summarize the group’s findings on stem cell-based embryo model research and discuss proposed revisions to ISSCR guidelines 👉 bit.ly/3DuRGoK
@gairdnerawards.bsky.social @uclastemcell.bsky.social
@gairdnerawards.bsky.social @uclastemcell.bsky.social
April 2, 2025 at 6:15 PM
Join Embryo Working Group co-chairs Amander Clark and Janet Rossant on 21 April! This webinar will summarize the group’s findings on stem cell-based embryo model research and discuss proposed revisions to ISSCR guidelines 👉 bit.ly/3DuRGoK
@gairdnerawards.bsky.social @uclastemcell.bsky.social
@gairdnerawards.bsky.social @uclastemcell.bsky.social
Reposted by Marta Olszewska, PhD
My most challenging postdoctoral project, where we show that histones but not nucleosomes are polyubiqutinated by the APC/C for a potential proteasomal degradation was just published in @naturecomms.bsky.social
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons - Nature Communications
The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying nucleosome-in...
www.nature.com
March 20, 2025 at 4:35 PM
My most challenging postdoctoral project, where we show that histones but not nucleosomes are polyubiqutinated by the APC/C for a potential proteasomal degradation was just published in @naturecomms.bsky.social
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
Reposted by Marta Olszewska, PhD
The 4th Reproductive Aging Conference program is stacked with amazing speakers!
Register today for the only international meeting dedicated solely to mechanisms of reproductive aging.
www.reproductiveagingconference.com
#ReproAging2025
@jennifergarrison.bsky.social @buckinstitute.org
Register today for the only international meeting dedicated solely to mechanisms of reproductive aging.
www.reproductiveagingconference.com
#ReproAging2025
@jennifergarrison.bsky.social @buckinstitute.org
March 19, 2025 at 4:57 PM
The 4th Reproductive Aging Conference program is stacked with amazing speakers!
Register today for the only international meeting dedicated solely to mechanisms of reproductive aging.
www.reproductiveagingconference.com
#ReproAging2025
@jennifergarrison.bsky.social @buckinstitute.org
Register today for the only international meeting dedicated solely to mechanisms of reproductive aging.
www.reproductiveagingconference.com
#ReproAging2025
@jennifergarrison.bsky.social @buckinstitute.org
Reposted by Marta Olszewska, PhD
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
Reposted by Marta Olszewska, PhD
We have just published our latest work about the different regulatory roles of DOT1L in male germ cells 🎉 find all details on @juliecocquet.bsky.social ‘s thread below 👇🏻
Super happy to see our latest work on the opposite effects of DOT1L on gene expression published !
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
#chromatin #DOT1L #sexchromosomes #malegermcells
www.nature.com/articles/s42...
Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells - Communications Biology
Epigenomic and transcriptomic analyses reveal that, during mouse spermatogenesis, the H3K79 methyltransferase DOT1L has opposite effects on autosomal and X-linked gene expression depending on local ch...
www.nature.com
January 29, 2025 at 12:03 PM
We have just published our latest work about the different regulatory roles of DOT1L in male germ cells 🎉 find all details on @juliecocquet.bsky.social ‘s thread below 👇🏻
Reposted by Marta Olszewska, PhD
What is the state of trust in scientists around the world? A study in Nature Human Behaviour reports on a survey of 71,922 respondents in 68 countries and finds that trust in scientists is moderately high. https://go.nature.com/3PLgKKU 🧪
January 22, 2025 at 6:34 PM
What is the state of trust in scientists around the world? A study in Nature Human Behaviour reports on a survey of 71,922 respondents in 68 countries and finds that trust in scientists is moderately high. https://go.nature.com/3PLgKKU 🧪
Reposted by Marta Olszewska, PhD
When the dog bites
When the bee stings
When I'm feeling sad
I simply remember my paper 𝑖𝑛 𝑝𝑟𝑒𝑠𝑠
And then I don't feel so bad
When the bee stings
When I'm feeling sad
I simply remember my paper 𝑖𝑛 𝑝𝑟𝑒𝑠𝑠
And then I don't feel so bad
January 17, 2025 at 10:33 AM
When the dog bites
When the bee stings
When I'm feeling sad
I simply remember my paper 𝑖𝑛 𝑝𝑟𝑒𝑠𝑠
And then I don't feel so bad
When the bee stings
When I'm feeling sad
I simply remember my paper 𝑖𝑛 𝑝𝑟𝑒𝑠𝑠
And then I don't feel so bad
Reposted by Marta Olszewska, PhD
A big mystery to me is what DNMT3B is doing in the male germline. It's expressed, but there is no strong KO phenotype like the other DNMTs. Antoine Peters and team @fmiscience.bsky.social do careful genetic dissection here, and show that DNMT3B indeed has a role www.nature.com/articles/s41...
DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos - Nature Communications
Here, the authors identify that reduced DNA methylation in developing germ cells alters nucleosome retention in sperm and allows H3K4me3 establishment on paternal DNA in early embryos, highlighting a ...
www.nature.com
January 17, 2025 at 4:46 PM
A big mystery to me is what DNMT3B is doing in the male germline. It's expressed, but there is no strong KO phenotype like the other DNMTs. Antoine Peters and team @fmiscience.bsky.social do careful genetic dissection here, and show that DNMT3B indeed has a role www.nature.com/articles/s41...
Reposted by Marta Olszewska, PhD
The International Workshop "Andrology and Reproductive Medicine" is taking place May 9 2025 in Riga, Latvia.
A great selection of speakers including several Andronet members. Details here: ivfriga.lv/en/participa...
The registration dealine is May 1 2025
A great selection of speakers including several Andronet members. Details here: ivfriga.lv/en/participa...
The registration dealine is May 1 2025
The International Workshop | Andrology and Reproductive Medicine
Join the international workshop 'Andrology and Reproductive Medicine'. Explore clinically significant issues in the field of male reproductive health.
ivfriga.lv
January 13, 2025 at 5:56 PM
The International Workshop "Andrology and Reproductive Medicine" is taking place May 9 2025 in Riga, Latvia.
A great selection of speakers including several Andronet members. Details here: ivfriga.lv/en/participa...
The registration dealine is May 1 2025
A great selection of speakers including several Andronet members. Details here: ivfriga.lv/en/participa...
The registration dealine is May 1 2025
Reposted by Marta Olszewska, PhD
The 16th century burial regalia were found wrapped in newspaper dated Sept 1939 and squirreled away in a wall under a staircase in the Vilnius Cathedral's crypt. 🏺🧪
Medieval crowns of Eastern European royalty hidden in cathedral wall since World War II finally recovered
A cache of precious metal regalia recently discovered in a Lithuanian cathedral sheds light on medieval royalty.
www.livescience.com
January 9, 2025 at 7:24 PM
The 16th century burial regalia were found wrapped in newspaper dated Sept 1939 and squirreled away in a wall under a staircase in the Vilnius Cathedral's crypt. 🏺🧪
Reposted by Marta Olszewska, PhD
The structural basis for de novo DNA methylation in chromatin www.biorxiv.org/content/10.1...
▶️DNMT3A2/3B3 preferentially binds di-nucleosomes separated by short DNA linkers
▶️Linker length and position of cytosines control DNA methylation
▶️a large fraction of linkers is resistant to DNMT3A2/3B3
▶️DNMT3A2/3B3 preferentially binds di-nucleosomes separated by short DNA linkers
▶️Linker length and position of cytosines control DNA methylation
▶️a large fraction of linkers is resistant to DNMT3A2/3B3
December 29, 2024 at 8:00 PM
The structural basis for de novo DNA methylation in chromatin www.biorxiv.org/content/10.1...
▶️DNMT3A2/3B3 preferentially binds di-nucleosomes separated by short DNA linkers
▶️Linker length and position of cytosines control DNA methylation
▶️a large fraction of linkers is resistant to DNMT3A2/3B3
▶️DNMT3A2/3B3 preferentially binds di-nucleosomes separated by short DNA linkers
▶️Linker length and position of cytosines control DNA methylation
▶️a large fraction of linkers is resistant to DNMT3A2/3B3
@ncngovpl.bsky.social Thanks to NCN I will be able to study human spermatogenesis and oogenesis on knockout mouse models with the spatial transcriptomics resolution 🧬🔬🐭I am pleased to start a new OPUS27 Project 😁
December 4, 2024 at 6:55 PM
@ncngovpl.bsky.social Thanks to NCN I will be able to study human spermatogenesis and oogenesis on knockout mouse models with the spatial transcriptomics resolution 🧬🔬🐭I am pleased to start a new OPUS27 Project 😁
Reposted by Marta Olszewska, PhD
A reason I am very wary of the loose ways we think about 'epigenetics' is because of these kinds of conclusions:
DNA methylation mediates the link between adversity and depressive symptoms.
www.nature.com/articles/s44...
DNA methylation mediates the link between adversity and depressive symptoms.
www.nature.com/articles/s44...
DNA methylation mediates the link between adversity and depressive symptoms - Nature Mental Health
Using epigenome-wide mediation analyses to investigate DNA methylation as a path between adversity and depression, the authors found 31 cytosine–guanine dinucleotides (CpGs) associated with risk and 3...
www.nature.com
December 2, 2024 at 7:21 PM
A reason I am very wary of the loose ways we think about 'epigenetics' is because of these kinds of conclusions:
DNA methylation mediates the link between adversity and depressive symptoms.
www.nature.com/articles/s44...
DNA methylation mediates the link between adversity and depressive symptoms.
www.nature.com/articles/s44...
Reposted by Marta Olszewska, PhD
📢 Preprint! How does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds
The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...
www.biorxiv.org
November 26, 2024 at 4:35 PM
📢 Preprint! How does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales🧵...
www.biorxiv.org/content/10.1...
Reposted by Marta Olszewska, PhD
Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg
November 19, 2024 at 3:04 PM
Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg
Reposted by Marta Olszewska, PhD
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
www.embl.org
November 18, 2024 at 5:28 PM
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...