Aleksandra Skrajna
@askrajna.bsky.social
Asst Prof at UC Santa Cruz, studying histones and chromatin, using CryoEM and proteomics. New mom. Dog lover. Athlete.
University of Warsaw -> Polish Academy of Sciences -> UNC Chapel Hill -> UCSC
University of Warsaw -> Polish Academy of Sciences -> UNC Chapel Hill -> UCSC
Reposted by Aleksandra Skrajna
Welp, i got halfway through the RPPR and then received notice the MOSAIC program, and thus my MOSAIC R00 has been terminated.
Thank you to those who made this program.
Thank you to the other #NIHMOSAIC fellows have supported me through my faculty journey and continue to inspire me.
Thank you to those who made this program.
Thank you to the other #NIHMOSAIC fellows have supported me through my faculty journey and continue to inspire me.
April 2, 2025 at 7:08 PM
Welp, i got halfway through the RPPR and then received notice the MOSAIC program, and thus my MOSAIC R00 has been terminated.
Thank you to those who made this program.
Thank you to the other #NIHMOSAIC fellows have supported me through my faculty journey and continue to inspire me.
Thank you to those who made this program.
Thank you to the other #NIHMOSAIC fellows have supported me through my faculty journey and continue to inspire me.
Reposted by Aleksandra Skrajna
John Mellnik, Jack Scannell: Tripartite models for estimating the value of drug candidates and decision tools https://arxiv.org/abs/2503.22117 https://arxiv.org/pdf/2503.22117 https://arxiv.org/html/2503.22117
March 31, 2025 at 6:18 AM
John Mellnik, Jack Scannell: Tripartite models for estimating the value of drug candidates and decision tools https://arxiv.org/abs/2503.22117 https://arxiv.org/pdf/2503.22117 https://arxiv.org/html/2503.22117
The Department of Chemistry and Biochemistry at UC Santa Cruz is looking for a General Chemistry Assistant Teaching Professor -
recruit.ucsc.edu/JPF01884
We truly value teaching and mentoring and looking for like minded applicants.
Please apply, share, and recommend people who might be interested.
recruit.ucsc.edu/JPF01884
We truly value teaching and mentoring and looking for like minded applicants.
Please apply, share, and recommend people who might be interested.
General Chemistry Assistant Teaching Professor (Initial Review Date: May 14, 2025)
University of California, Santa Cruz is hiring. Apply now!
recruit.ucsc.edu
March 29, 2025 at 4:16 AM
The Department of Chemistry and Biochemistry at UC Santa Cruz is looking for a General Chemistry Assistant Teaching Professor -
recruit.ucsc.edu/JPF01884
We truly value teaching and mentoring and looking for like minded applicants.
Please apply, share, and recommend people who might be interested.
recruit.ucsc.edu/JPF01884
We truly value teaching and mentoring and looking for like minded applicants.
Please apply, share, and recommend people who might be interested.
Reposted by Aleksandra Skrajna
Opinion piece in the @scsentinel.bsky.social by me, @carpenterlab.bsky.social and Carol Greider: Trump is turning off the lights on biomedical research: Why it matters for Santa Cruz
www.santacruzsentinel.com/2025/03/20/g...
www.santacruzsentinel.com/2025/03/20/g...
Guest Commentary | Trump is turning off the lights on biomedical research: Why it matters for Santa Cruz
“These cuts aren’t just about UCSC; they’re about Santa Cruz,” writes Needhi Bhalla, Susan Carpenter and Carol Greider in a Guest Commentary. “This crucial NIH support fuels our l…
www.santacruzsentinel.com
March 21, 2025 at 3:22 PM
Opinion piece in the @scsentinel.bsky.social by me, @carpenterlab.bsky.social and Carol Greider: Trump is turning off the lights on biomedical research: Why it matters for Santa Cruz
www.santacruzsentinel.com/2025/03/20/g...
www.santacruzsentinel.com/2025/03/20/g...
My most challenging postdoctoral project, where we show that histones but not nucleosomes are polyubiqutinated by the APC/C for a potential proteasomal degradation was just published in @naturecomms.bsky.social
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons - Nature Communications
The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying nucleosome-in...
www.nature.com
March 20, 2025 at 4:35 PM
My most challenging postdoctoral project, where we show that histones but not nucleosomes are polyubiqutinated by the APC/C for a potential proteasomal degradation was just published in @naturecomms.bsky.social
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
🎉
www.nature.com/articles/s41...
Big shout-out to all co-authors!!!
Reposted by Aleksandra Skrajna
UC Santa Cruz researcher Upasna Shrarma and team uncover four novel genes essential for male fertility in mice, contributing to her broader federally funded research on how a father’s life experiences & environment influence the health of his children.🔬👨🍼 #ScienceNews
news.ucsc.edu/2025/03/trna...
news.ucsc.edu/2025/03/trna...
March 5, 2025 at 6:25 PM
UC Santa Cruz researcher Upasna Shrarma and team uncover four novel genes essential for male fertility in mice, contributing to her broader federally funded research on how a father’s life experiences & environment influence the health of his children.🔬👨🍼 #ScienceNews
news.ucsc.edu/2025/03/trna...
news.ucsc.edu/2025/03/trna...
Really nice infographic of the cost of federally sponsored research.
www.cogr.edu/sites/defaul...
www.cogr.edu/sites/defaul...
March 11, 2025 at 6:58 PM
Really nice infographic of the cost of federally sponsored research.
www.cogr.edu/sites/defaul...
www.cogr.edu/sites/defaul...
Reposted by Aleksandra Skrajna
JEDI awards provide input on a manuscript, short grant proposal, or job application to scientists facing unfair, systemic barriers to career progression. Next deadline March 10th - please share & apply! lifescienceeditors.org/apply/
JEDI Award - Life Science Editors Foundation
Our Justice, Equity, Diversity and Inclusion (JEDI) awards provide Feedback on Your Scientific Writing from one of our expert volunteers. These awards are offered quarterly to scientists facing unfair...
lifescienceeditors.org
February 4, 2025 at 7:25 PM
JEDI awards provide input on a manuscript, short grant proposal, or job application to scientists facing unfair, systemic barriers to career progression. Next deadline March 10th - please share & apply! lifescienceeditors.org/apply/
After an exciting year of setting up my lab and life in Santa Cruz I am back on bluesky and hope to interact with y'all more.
I'm gearing up towards setting up an arrayed CRISPR screen and wonder what are your favorite companies to work with for guide RNAs. Edit Co, IDT, Horizon?
I'm gearing up towards setting up an arrayed CRISPR screen and wonder what are your favorite companies to work with for guide RNAs. Edit Co, IDT, Horizon?
December 9, 2024 at 11:55 PM
After an exciting year of setting up my lab and life in Santa Cruz I am back on bluesky and hope to interact with y'all more.
I'm gearing up towards setting up an arrayed CRISPR screen and wonder what are your favorite companies to work with for guide RNAs. Edit Co, IDT, Horizon?
I'm gearing up towards setting up an arrayed CRISPR screen and wonder what are your favorite companies to work with for guide RNAs. Edit Co, IDT, Horizon?
Reposted by Aleksandra Skrajna
Super useful and eminently readable demystification of writing a successful NIH grant application, written by NIH Program
Officers (POs) with LOTS of great guidance:
Officers (POs) with LOTS of great guidance:
Elements of successful NIH grant applications | Proceedings of the National Academy of Sciences
Is there a formula for a competitive NIH grant application? The Serenity Prayer may
provide one: "Grant me the serenity to accept the things I cann...
www.pnas.org
April 4, 2024 at 3:10 PM
Super useful and eminently readable demystification of writing a successful NIH grant application, written by NIH Program
Officers (POs) with LOTS of great guidance:
Officers (POs) with LOTS of great guidance:
It's hard to be a new PI and new mom without a daycare (yet). Sending ♥️ to all moms in academia.
February 14, 2024 at 8:05 PM
It's hard to be a new PI and new mom without a daycare (yet). Sending ♥️ to all moms in academia.
Happy International Day of Women and Girls in Science!!!
February 11, 2024 at 5:36 PM
Happy International Day of Women and Girls in Science!!!
Exciting news - my lab is hiring a junior scientist! Please apply if you are interested in learning lots of biochemistry and helping me run the lab.
recruit.ucsc.edu/JPF01676
recruit.ucsc.edu/JPF01676
January 25, 2024 at 8:57 PM
Exciting news - my lab is hiring a junior scientist! Please apply if you are interested in learning lots of biochemistry and helping me run the lab.
recruit.ucsc.edu/JPF01676
recruit.ucsc.edu/JPF01676
Great job opportunity at UNC Chapel Hill for anyone who wants to learn or dive deeper into CryoEM. Josh (core director) is fun to work with and continues to develop new approaches and methods in CryoEM. Therefore this appointment is not just a routine technical work it's actually very creative!
Research Technician
This position will be supporting the Med Admin- Research department and provide technical support for daily operations of the CryoEM Core. The CryoEM Core is a multi-user facility that provide researc...
unc.peopleadmin.com
November 29, 2023 at 4:19 PM
Great job opportunity at UNC Chapel Hill for anyone who wants to learn or dive deeper into CryoEM. Josh (core director) is fun to work with and continues to develop new approaches and methods in CryoEM. Therefore this appointment is not just a routine technical work it's actually very creative!
I opened the eggnog season today. A little balm to my heart in these difficult times. Cheers.
November 14, 2023 at 2:14 AM
I opened the eggnog season today. A little balm to my heart in these difficult times. Cheers.
Yesterday I received a Postdoctoral Award for Research Excellence 🎉 Having my friends and family in the audience was incredibly moving. What a year ?! 1) I got a dream job, 2) I had a baby and now 3) this award. I'm incredibly grateful for everyone who made it possible 😊
October 28, 2023 at 7:06 PM
Yesterday I received a Postdoctoral Award for Research Excellence 🎉 Having my friends and family in the audience was incredibly moving. What a year ?! 1) I got a dream job, 2) I had a baby and now 3) this award. I'm incredibly grateful for everyone who made it possible 😊
I'd also add that Alphafold doesn't predict interactions of nucleic acids with proteins, which are the basis of so many biological processes.
Scientists- please read this.
Recently I had a reviewer question why we even solved the crystal structure if Alphafold could predict it.
This editorial summarizes a lot of what I said in response and needs to be talked about more!
#structuralbiology
journals.iucr.org/d/issues/202...
Recently I had a reviewer question why we even solved the crystal structure if Alphafold could predict it.
This editorial summarizes a lot of what I said in response and needs to be talked about more!
#structuralbiology
journals.iucr.org/d/issues/202...
AlphaFold and the future of structural biology
AlphaFold and the future of structural biology
journals.iucr.org
October 20, 2023 at 4:01 PM
I'd also add that Alphafold doesn't predict interactions of nucleic acids with proteins, which are the basis of so many biological processes.
Reposted by Aleksandra Skrajna
Nice news and views article covering our recent manuscript on bacterial histones. Thanks for covering this! www.nature.com/articles/s41...
October 19, 2023 at 3:43 PM
Nice news and views article covering our recent manuscript on bacterial histones. Thanks for covering this! www.nature.com/articles/s41...
I'm trying to add my profile photo, I save changes, but it turns black when I go back to home view. Any advice?
October 19, 2023 at 9:52 PM
I'm trying to add my profile photo, I save changes, but it turns black when I go back to home view. Any advice?
UNC PARE ceremony is next Friday at 3PM (10/27/23) 🎉
research.unc.edu/2023/10/18/2...
research.unc.edu/2023/10/18/2...
October 19, 2023 at 7:16 PM
UNC PARE ceremony is next Friday at 3PM (10/27/23) 🎉
research.unc.edu/2023/10/18/2...
research.unc.edu/2023/10/18/2...